The cheapest and fastest buses from Jacksonville, FL to Florence, SC
Cheapest price
$67
Average price
$67
Fastest journey
5 h 35 m
Average duration
5 h 35 m
Buses per day
1
Distance
465 km
The best way to find a cheap bus ticket from Jacksonville, FL to Florence, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Jacksonville, FL to Florence, SC will cost around $67 if you buy it on the day, but the cheapest tickets can be found for only $67.
Of the 1 buses that leave Jacksonville, FL for Florence, SC on Thu, Feb 05, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Thu, Feb 05 the direct buses cover the 465 km distance in an average of 5 h 35 m but if you time it right, some buses will get you there in just 5 h 35 m .
On Thu, Feb 05 the slowest buses will take 5 h 35 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.


Travel Information
Compare bus and train for Jacksonville, FL to Florence, SC
Omio recommends booking the train as it is the most popular option from Jacksonville, FL to Florence, SC among Omio's users. If you are prioritising price take the bus with prices starting from €40. For those with little time consider booking a bus which can get you there in 5h 30m. The ticket price range depends on the travel mode: a bus costs an average of €40, and a train costs an average of €67.
Distance: 288 miles (465 km)
Compare bus with
| Bus | Most popular Train |
|---|---|
€54 Average price Cheapest | €71 Average price |
6h 0m Average total duration Fastest 5h 30m Onboard + 30m Additional time* | 6h 13m Average total duration 5h 43m Onboard + 30m Additional time* |
![]() Most popular bus company | ![]() Most popular train company |
Direct Options | Direct Options |
Compare prices and tickets Jacksonville, FL to Florence, SC by bus or train
Compare bus and train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Feb 05
Feb 06
Feb 07
Feb 08
Feb 09
Feb 10
Feb 11
Why should you book Jacksonville, FL to Florence, SC buses with Omio?
Why book with Omio vs FlixBus?
- Compare with other providers: On Omio, you can not only buy tickets for FlixBus, but also compare tickets for the likes of to find the best option for your trip from Jacksonville, FL to Florence, SC.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are bus and train to ensure you get the best deal for traveling from Jacksonville, FL to Florence, SC.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including bus and train to find the ideal travel option from Jacksonville, FL to Florence, SC.
Journey information
Overview: Bus from Jacksonville, FL to Florence, SC
Buses from Jacksonville, FL to Florence, SC run on average 2 times per day, taking around 5h 30m. Cheap bus tickets for this journey start at $50 (€40) if you book in advance.
There are 1 buses per day. The earliest bus runs at 05:30, the last at 18:30. The fastest bus covers the 288 miles (465 km) distance in 5h 35m.
Distance 288 miles (465 km) |
Average bus duration 5h 30m |
Cheapest ticket price $50 (€40) |
Buses per day 2 |
Direct buses 1 |
Fastest bus 5h 35m |
First bus 05:30 |
Last bus 18:30 |
Bus providers: FlixBus from Jacksonville, FL to Florence, SCYou can travel by bus between Jacksonville, FL to Florence, SC with FlixBus for as low as $50 (€40). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
FAQs: Bus from Jacksonville, FL to Florence, SC
Find answers to the most common questions about traveling from Jacksonville, FL to Florence, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Florence, SC, this guide helps you travel smarter and with confidence.

- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- FlixBus
- Additional luggage can be purchased for a fee.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
popular bus stations
Popular bus stations from Jacksonville, FL to Florence, SC
Most popular bus connections from Jacksonville, FL
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