- Must visit
Uffizi Gallery
Celebrated art museum with Botticelli, Leonardo, and Michelangelo. A cornerstone visit for Renaissance painting and one of Florence’s defining experiences.
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The cheapest and fastest buses from Jacksonville, FL to Florence, SC
Showing times, prices and bookable tickets for Sep 19
Cheapest price on Sep 19
€55
Average ticket price on Sep 19
€55
Fastest journey on Sep 19
5 h 35 m
Average journey duration on Sep 19
5 h 35 m
Buses on Sep 19
1
Distance
465 km
Cheap tickets
The best way to find a cheap bus ticket from Jacksonville, FL to Florence, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Jacksonville, FL to Florence, SC will cost around €55 if you buy it on the day, but the cheapest tickets can be found for only €55.
Fast buses
On Sat, Sep 19, we found 1 buses from Jacksonville, FL to Florence, SC, including 1 direct services.
On Sat, Sep 19 the direct buses cover the 465 km distance in an average of 5 h 35 m but if you time it right, some buses will get you there in just 5 h 35 m .
On Sat, Sep 19 the slowest buses will take 5 h 35 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
11:30 PM5h35Jacksonville, FL5:05 AMFlorence, SC€551One-way0 transfers
- 11:30 PM5h35Jacksonville, FL5:05 AMFlorence, SC€551One-way0 transfers
Travel Information
Compare bus and train for Jacksonville, FL to Florence, SC
Omio recommends booking the train as it is the most popular option from Jacksonville, FL to Florence, SC among Omio's users. If you are prioritising price, take the bus, with an average ticket price of €50 For those with little time, consider booking a bus, which has an average total journey time of 6h 16m. Average ticket prices depend on the travel mode: a bus costs an average of €50, while a train costs an average of €78.
Distance: 288 miles (465 km)
Compare bus with
| Bus | Most popular Train | Driving |
|---|---|---|
€50 Average price Cheapest | €78 Average price | €52 Average price (fuel + tolls) |
6h 16m Average total duration Fastest 5h 46m Onboard + 30m Additional time* | 6h 23m Average total duration 5h 53m Onboard + 30m Additional time* | 4h 25m Average total duration (door-to-door) |
Most popular bus company |  Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Jacksonville, FL to Florence, SC is a bus with an average price of €50.
This is compared to other travel options from Jacksonville, FL to Florence, SC:
A bus is €29 less than a train for this route with tickets for a train from Jacksonville, FL to Florence, SC costing on average €78.
The fastest way to travel from Jacksonville, FL to Florence, SC is by bus with an average journey time of 5h 46m.
Other travel options to Florence, SC take longer:
Train takes on average 5h 53m.
It's helpful to compare your options as there are 2 ways to travel between Jacksonville, FL and Florence, SC including taking a bus and train.
We recommend using the train as it is the most popular way to get from Jacksonville, FL to Florence, SC among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.
Tickets start at around €50 compared to roughly €52 in fuel and tolls — a saving of about €2. The journey takes 5h 46m versus 4h 25m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by FlixBus.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
Jacksonville, FL to Florence, SC Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Flixbus USA | Departure Time 08:15AM | Arrival Time 01:25PM | Duration 5h10 | Departure days Tue, Wed, Sun | Cheapest price €50 |
Operator FlixBus | Departure Time 06:30PM | Arrival Time 12:05AM | Duration 5h35 | Departure days Fri | Cheapest price €48 |
Operator FlixBus | Departure Time 10:30PM | Arrival Time 04:05AM | Duration 5h35 | Departure days Mon, Thu | Cheapest price €51 |
Operator FlixBus | Departure Time 11:30PM | Arrival Time 05:05AM | Duration 5h35 | Departure days Sat | Cheapest price €55 |
Live departures
Jacksonville, FL to Florence, SC bus times
The table below shows live departures for Jacksonville, FL to Florence, SC buses for today, Friday, September 18. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| FlixBus | 6:30 PM Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St | 5h35 | 12:05 AM Florence, W Lucas St (TA Gas Station), SC | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Jacksonville, FL to Florence, SC by bus or train
Compare bus and train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Sep 19
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Why should you book Jacksonville, FL to Florence, SC buses with Omio?
FlixBus operates all buses services from Jacksonville, FL to Florence, SC.
Omio is an official ticket reseller for all your travel options from Jacksonville, FL to Florence, SC.
Why book with Omio vs FlixBus?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are bus and train to ensure you get the best deal for traveling from Jacksonville, FL to Florence, SC.
Why book with Omio over Wanderu or Trainline?
- Multiple modes of transport: Omio allows you to compare travel options including bus and train to find the ideal travel option from Jacksonville, FL to Florence, SC.
Journey information
Overview: Bus from Jacksonville, FL to Florence, SC
USAUSA
Buses from Jacksonville, FL to Florence, SC run on average 1 times per day, taking around 5h 46m. Cheap bus tickets for this journey start at €39 if you book in advance.
There are 1 buses per day. The earliest bus runs at 05:30, the last at 18:30. The fastest bus covers the 288 miles (465 km) distance in 5h 10m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 288 miles (465 km) |
Average bus duration 5h 46m |
Cheapest ticket price €39 |
Buses per day 1 |
Direct buses 1 |
Fastest bus 5h 10m |
First bus 5:30 AM |
Last bus 6:30 PM |
Cheapest Month Jul |
Cheapest Day Tue |
High Season Jul - Sep |
Low Season Apr - Jun |
Busiest Day Thu |
Least Busy Day Thu |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: FlixBus from Jacksonville, FL to Florence, SCYou can travel by bus between Jacksonville, FL to Florence, SC with FlixBus for as low as €39. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average FlixBus Duration
5h 10m
Cheapest FlixBus Price
€39
FlixBus frequency
1 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Complete guide to Florence, SC
Things to do in Florence, SC
Discover the best of Florence, SC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Florence, SC trip today.
- Must visit
Galleria dell'Accademia
Museum centered on Michelangelo’s David, plus sculptures and paintings. Essential for seeing one of Florence’s most famous masterpieces up close.
- Recommended
Museo dell'Opera del Duomo
Interactive museum inside the cathedral complex exploring Brunelleschi’s dome, tools, and original artworks. Ideal for understanding Florence’s cathedral story.
- Must visit
Piazza della Signoria
Grand civic square framed by Palazzo Vecchio and open-air sculptures. It is one of Florence’s key meeting points and a natural starting place for exploration.
- Must visit
Piazzale Michelangelo
Hilltop terrace with sweeping city views, especially at sunset. A classic Florence panorama and a rewarding walk or short bus ride from the center.
- Recommended
Boboli Gardens
Large formal garden behind Pitti Palace with paths, fountains, and viewpoints. Excellent for a slower visit combining greenery, sculpture, and city vistas.
FAQs: Bus from Jacksonville, FL to Florence, SC
Find answers to the most common questions about traveling from Jacksonville, FL to Florence, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Florence, SC, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Jacksonville, FL to Florence, SC can start from as little as €39 when you book in advance. The average bus ticket price for Jacksonville, FL to Florence, SC is €50 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Jacksonville, FL to Florence, SC is 5h 10m to travel the 288 miles (465 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Jacksonville, FL to Florence, SC leaves at 5:30 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Jacksonville, FL to Florence, SC leaves at 6:30 PM.
Yes, there are 1 direct buses a day from Jacksonville, FL to Florence, SC with FlixBus. Schedules can vary on holidays or weekends with fewer direct buses.
When taking a bus from Jacksonville, FL to Florence, SC, you can count on FlixBus for the best way to get you to Florence, SC. You can also check all possible bus companies who offer a service between Jacksonville, FL and Florence, SC and compare the amenities they offer before buying a bus ticket.
When departing from Jacksonville, FL , you have various bus station options to start your journey from including Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St . When arriving in Florence, SC , you can end your journey in bus stations like Florence, W Lucas St (TA Gas Station), SC, Florence, S Irby St (Greyhound Bus Stop), SC .Passengers board the bus most frequently from Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St, which is located around 0 miles (1 km) away from the city centre, and they get off the bus at Florence, W Lucas St (TA Gas Station), SC, located 6 away from the city centre.
A trip to Florence, SC from Jacksonville, FL is worth doing but not as a day trip with a journey time of 5h 10m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Jacksonville, FL to Florence, SC is July.
It's helpful to compare your options as there are 2 ways to travel between Jacksonville, FL and Florence, SC including taking a bus and train.
Yes, the following accessibility options are available when taking the bus from Jacksonville, FL to Florence, SC:
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Jacksonville, FL to Florence, SC for bus company FlixBus.
Whether you can cancel your bus ticket from Jacksonville, FL to Florence, SC depends on the bus companies:
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Jacksonville, FL to Florence, SC.
Yes, the following luggage options are included when booking a bus ticket from Jacksonville, FL to Florence, SC:
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Jacksonville, FL to Florence, SC:
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Jacksonville, FL to Florence, SC. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from Jacksonville, FL to Florence, SC with the following bus company: FlixBus
Yes, there are USB plugs on board the bus from Jacksonville, FL to Florence, SC with the following bus company: FlixBus.
Yes, there is Wifi on board the bus from Jacksonville, FL to Florence, SC with the following bus company: FlixBus.
Since neither Jacksonville, FL nor Florence, SC are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the train as it is the most popular way to get from Jacksonville, FL to Florence, SC among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Florence, SC, travelers should be cautious of petty crimes like pickpocketing and vehicle break-ins, especially in less crowded areas. It's advisable to stay in well-lit, populated places and avoid displaying valuables openly. Common scams include overcharging by taxi drivers and unofficial ticket sellers; always use licensed transportation and purchase tickets from authorized vendors. Staying aware of surroundings and securing personal belongings helps ensure a safe visit.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Jacksonville, FL to Florence, SC
Most Jacksonville, FL to Florence, SC buses use the Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St to Florence, W Lucas St (TA Gas Station) station pair, with some services arriving at Florence, S Irby St (Greyhound Bus Stop). Use this guide to compare Jacksonville, FL and Florence, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Jacksonville
Arrival bus stations in Florence
Which Jacksonville, FL station do buses to Florence, SC leave from?
Buses from Jacksonville, FL to Florence, SC leave from Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St. The station is 1 miles (2 km) from Jacksonville, FL city centre at 1111 W Forsyth St, Jacksonville, FL 32204, USA.
Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St1111 W Forsyth St, Jacksonville, FL 32204, USA
City-centre transport
Getting to Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St from Jacksonville city centre
Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St is 1 km from Jacksonville city centre. Public transport options include:
Bus1, 11, 18, 205, 3, Nassau, St. Johns, Clay · 12m · €3 · every ~18 min
1, 19, 3 · 17m · €3 · every ~17 min
SubwaySky · 10m · every ~4 min
Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St bus station facilities and services
Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St. ATMs are available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St.
Tickets and information
Ticket office support is available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St.
Parking, taxis and toilets
Available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St: Wheelchair accessible entrances.
Which Florence, SC station do buses from Jacksonville, FL arrive at?
Buses from Jacksonville, FL to Florence, SC most often arrive at Florence, W Lucas St (TA Gas Station). Some services arrive at Florence, S Irby St (Greyhound Bus Stop), so check your ticket before travel to confirm your Florence, SC arrival station.
Florence, W Lucas St (TA Gas Station)Florence, SC, USA
City-centre transport
Getting to Florence, W Lucas St (TA Gas Station) from Florence city centre
Florence, W Lucas St (TA Gas Station) is 6 km from Florence city centre. Public transport options include:
TRUE
Florence, W Lucas St (TA Gas Station) bus station facilities and services
Florence, W Lucas St (TA Gas Station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Food and snacks available at the gas station.
Wi-Fi and ATMs
Wi-Fi is available at Florence, W Lucas St (TA Gas Station). ATMs are available at Florence, W Lucas St (TA Gas Station).
Tickets and information
Ticket office support is available at Florence, W Lucas St (TA Gas Station).
Parking, taxis and toilets
Available at Florence, W Lucas St (TA Gas Station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Florence, W Lucas St (TA Gas Station): Basic accessibility features available.
Florence, S Irby St (Greyhound Bus Stop)S Irby St, Florence, SC, USA
City-centre transport
Getting to Florence, S Irby St (Greyhound Bus Stop) from Florence city centre
TRUE
Florence, S Irby St (Greyhound Bus Stop) bus station facilities and services
Florence, S Irby St (Greyhound Bus Stop) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Florence, S Irby St (Greyhound Bus Stop). ATMs are available at Florence, S Irby St (Greyhound Bus Stop).
Tickets and information
Ticket office support is available at Florence, S Irby St (Greyhound Bus Stop).
Parking, taxis and toilets
Available at Florence, S Irby St (Greyhound Bus Stop): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Florence, S Irby St (Greyhound Bus Stop): Bus stop accessible for disabled persons.
Most popular bus connections from Jacksonville, FL
More options for your journey from Jacksonville, FL to Florence, SC
Here are some other resources that might have the information you need
Most popular buses to and from Florence, SC and Jacksonville, FL
Most popular bus connections to Florence, SC
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