- Must visit
Uffizi Galleries
World-famous museum of Renaissance art with masterpieces by Botticelli, Leonardo, Michelangelo, and Raphael. Timed entry is strongly advised due to very high demand.
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Journey information
Overview: Bus from Syracuse, NY to Florence, SC
USAUSA
Take a bus from Syracuse, NY to Florence, SC and enjoy the approximately 641 miles (1033 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
The earliest bus runs at 00:05, the last at 21:00.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 641 miles (1033 km) |
Buses per day 2 |
First bus 12:05 AM |
Last bus 9:00 PM |
Cheapest Month Sep |
Cheapest Day Mon |
High Season Oct - Dec |
Low Season Apr - Jun |
Best time to book 14 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Complete guide to Florence
Things to do in Florence
Discover the best of Florence — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Florence trip today.
- Must visit
Accademia Gallery
Best known for Michelangelo’s David, this compact museum is one of Florence’s essential stops. Advance booking is commonly recommended because queues can be long.
- Recommended
Palazzo Pitti
Large palace museum complex with royal apartments, paintings, and design collections. Worth visiting for its scale, courtly interiors, and links to Medici history.
- Must visit
Piazza del Duomo
The monumental heart of Florence, surrounded by the cathedral, dome, baptistery, and bell tower. Essential for first-time visitors and classic city views.
- Must visit
Piazza della Signoria
Historic square lined with civic architecture and open-air sculptures. One of Florence’s liveliest public spaces and a key stop on any walking route.
- Must visit
Piazzale Michelangelo
The city’s most famous viewpoint, especially popular at sunset for sweeping skyline photos. A social media favorite and classic Florence panorama.
- Gluten-free
Pulled Pork Barbecue
Slow-smoked pork shoulder, usually chopped or pulled and served with a tangy Southern barbecue sauce. It is a staple across the Carolinas and common in Florence-area smokehouses.
Fried Catfish
Cornmeal-coated catfish fillets fried until crisp, often served with hush puppies and slaw. This is a classic Pee Dee and broader South Carolina comfort dish.
- Gluten-free
Shrimp And Grits
Creamy stone-ground grits topped with shrimp, often with bacon, gravy, or a light sauce. A defining Lowcountry and South Carolina dish regularly found in Florence.
Wholly Smokin' Downtown
Established downtown barbecue spot specializing in smoked meats, Southern sides, and a casual local atmosphere.
Victors
Upscale, long-running Florence restaurant known for steaks, seafood, and polished Southern-American dining in an elegant setting.
Tubb's Shrimp & Fish Co.
Well-known casual seafood restaurant recognized for fried seafood platters, shrimp, fish, and regional comfort fare.
United States Dollar
Costs are moderate for the U.S. Budget eats are easy to find, while hotels and fine dining can raise daily costs.
Average meal costs
- Budget
- USD 8-15 for fast food or a simple lunch.
- Mid-range
- USD 18-35 per person at a casual sit-down restaurant.
- Fine dining
- USD 50-100+ per person before drinks and tip.
- Coffee
- USD 3-6 for drip coffee or a latte.
Tipping culture
Tip 18-20% at restaurants. Tip USD 1-2 per drink at bars, round up or tip 10-15% for taxis, and tip hotel staff USD 2-5 for helpful service.
FAQs: Bus from Syracuse, NY to Florence, SC
Find answers to the most common questions about traveling from Syracuse, NY to Florence, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Florence, SC, this guide helps you travel smarter and with confidence.
The earliest bus from Syracuse, NY to Florence, SC leaves at 12:05 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Syracuse, NY to Florence, SC leaves at 9:00 PM.
The cheapest month for a bus from Syracuse, NY to Florence, SC is September.
Yes, you can take a between Syracuse, NY and Florence, SC.
No, the bus from Syracuse, NY to Florence, SC has no accessibility options.
No, there are no bathrooms on board the bus from Syracuse, NY to Florence, SC.
No, bikes are not allowed on board the bus from Syracuse, NY to Florence, SC.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
No, there is no food available to purchase on board the bus from Syracuse, NY to Florence, SC.
No, luggage for the bus from Syracuse, NY to Florence, SC needs to be booked in addition.
No, there are no additional luggage options for the bus from Syracuse, NY to Florence, SC.
Unfortunately, pets are not allowed on the bus from Syracuse, NY to Florence, SC.
No, there are no USB plugs on board the bus from Syracuse, NY to Florence, SC.
No, there is no WiFi on board the bus from Syracuse, NY to Florence, SC.
Since neither Syracuse, NY nor Florence, SC are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Florence, SC, travelers should be cautious of petty crimes like pickpocketing and vehicle break-ins, especially in less crowded areas. It's advisable to stay in well-lit, populated places and avoid displaying valuables openly. Common scams include overcharging by taxi drivers and unofficial ticket sellers; always use licensed transportation and purchase tickets from authorized vendors. Staying aware of surroundings and securing personal belongings helps ensure a safe visit.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Syracuse, NY to Florence, SC
Syracuse
Florence
The major bus station for departures in Syracuse is Syracuse, Walsh Cir (Syracuse Bus Station). Find all the information you need to know about services, amenities and connections at Syracuse, Walsh Cir (Syracuse Bus Station) for your trip from Syracuse to Florence.
Syracuse, Walsh Cir (Syracuse Bus Station)
information
The major bus station for arrivals in Florence is Florence, S Irby St (Greyhound Bus Stop). Find all the information you need to know about services, amenities and connections at Florence, S Irby St (Greyhound Bus Stop) for your trip to Florence from Syracuse.
Florence, S Irby St (Greyhound Bus Stop)
information
More options for your journey from Syracuse, NY to Florence, SC
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Most popular buses to and from Florence, SC and Syracuse, NY
Most popular bus connections to Florence, SC
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