Wilmington, DE to Florence, SC bus with Greyhound

Sat, Sep 19
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Rede Expressos
2,000+ travel companies
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Travel Information

Compare train and bus for Wilmington, DE to Florence, SC

Omio recommends booking the train as it is the most popular option from Wilmington, DE to Florence, SC among Omio's users. If you are prioritising price, take the bus, with an average ticket price of Kč4352 For those with little time, consider booking a train, which has an average total journey time of 11h 20m. Average ticket prices depend on the travel mode: a bus costs an average of Kč4352, while a train costs an average of Kč6451.

Distance: 448 miles (722 km)

Compare bus with

Bus
Most popular
Train
Driving

Kč4352

Average price

Cheapest

Kč6451

Average price

Kč2215

Average price

(fuel + tolls)

18h 18m

Average total duration

17h 48m

Onboard

+

30m

Additional time*

11h 20m

Average total duration

Fastest

10h 50m

Onboard

+

30m

Additional time*

8h 1m

Average total duration

(door-to-door)

Greyhound

Most popular bus company

Amtrak

Most popular train company

Your own car or car rental

Direct Options

Direct Options

Direct Options

The cheapest way to travel from Wilmington, DE to Florence, SC is a bus with an average price of Kč4352.

This is compared to other travel options from Wilmington, DE to Florence, SC:

A bus is Kč2098 less than a train for this route with tickets for a train from Wilmington, DE to Florence, SC costing on average Kč6451.

A bus is Kč12296 less than a flight for this route with tickets for a flight from Wilmington, DE to Florence, SC costing on average Kč16648.

The fastest way to travel from Wilmington, DE to Florence, SC is by flight with an average journey time of 3h 52m.

Other travel options to Florence, SC take longer:

Train takes on average 10h 50m.

Bus takes on average 17h 48m.

It's helpful to compare your options as there are 2 ways to travel between Wilmington, DE and Florence, SC including taking a train and bus.
We recommend using the train as it is the most popular way to get from Wilmington, DE to Florence, SC among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.

Tickets start at around Kč4352 compared to roughly Kč2215 in fuel and tolls — a saving of about Kč-2137.30. The journey takes 17h 48m versus 8h 1m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.

Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.

Wilmington, DE to Florence, SC Bus Timetables

OperatorDeparture TimeArrival TimeDurationDeparture daysCheapest price
Operator
Greyhound
Departure Time
12:55AM
Arrival Time
12:05AM
Duration
23h10
Departure days
Sun
Cheapest price
Kč1799
Operator
FlixBus
Departure Time
01:50PM
Arrival Time
05:45AM
Duration
15h55
Departure days
Sun
Cheapest price
Kč1786
Operator
Greyhound
Departure Time
08:10PM
Arrival Time
12:05AM
Duration
27h55
Departure days
Sun
Cheapest price
Kč1578
Operator
Greyhound USA
Departure Time
09:25PM
Arrival Time
11:45AM
Duration
14h20
Departure days
Mon, Tue, Wed, Thu, Fri
Cheapest price
Kč2383

Live departures

Wilmington, DE to Florence, SC bus times

The table below shows live departures for Wilmington, DE to Florence, SC buses for today, Friday, September 18. You can also manually refresh the results below to see updated bus journeys.

Last updated at
ProviderDepartsDurationArrivesTransfers
Tickets
Greyhound USA9:25 PM Wilmington, DE
14h20
11:45 AM Florence, SC2 transfers

This is the last bus of the day.

Find all the dates and times for this journey

Compare prices and tickets Wilmington, DE to Florence, SC by train or bus

Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

Sat
Sep 19
Sun
Sep 20
Mon
Sep 21
Tue
Sep 22
Wed
Sep 23
Thu
Sep 24
Fri
Sep 25

Why should you book Wilmington, DE to Florence, SC buses with Omio?

Greyhound operates all buses services from Wilmington, DE to Florence, SC.
Omio is an official ticket reseller for all your travel options from Wilmington, DE to Florence, SC.

Why book with Omio vs Greyhound?

  • Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
  • Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train and bus to ensure you get the best deal for traveling from Wilmington, DE to Florence, SC.

Why book with Omio over Wanderu?

  • Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from Wilmington, DE to Florence, SC.

Journey information

Overview: Bus from Wilmington, DE to Florence, SC

USAUSA
USAUSA
Icon of bus

Buses from Wilmington, DE to Florence, SC run on average 3 times per day, taking around 17h 48m. Cheap bus tickets for this journey start at Kč3760 if you book in advance.

The earliest bus runs at 00:05, the last at 21:25. The fastest bus covers the 448 miles (722 km) distance in 12h 25m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance
448 miles (722 km)
Average bus duration
17h 48m
Cheapest ticket price
Kč3760
Buses per day
3
Fastest bus
12h 25m
First bus
12:05 AM
Last bus
9:25 PM
Cheapest Month
Oct
Cheapest Day
Tue
High Season
Apr - Jun
Low Season
Jan - Mar
Best time to book
5 days
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information

Bus providers: Greyhound, FlixBus from Wilmington, DE to Florence, SCYou can travel by bus between Wilmington, DE to Florence, SC with Greyhound, FlixBus for as low as Kč3760. When you search for schedules and tickets, Omio will show you the best journey

FlixBus

About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average FlixBus Duration
12h 25m
Cheapest FlixBus Price
Kč4186
FlixBus frequency
1 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Learn more about FlixBus

Greyhound

About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
20h 30m
Cheapest Greyhound Price
Kč3760
Greyhound frequency
2 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Learn more about Greyhound

FAQs: Bus from Wilmington, DE to Florence, SC

Find answers to the most common questions about traveling from Wilmington, DE to Florence, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Florence, SC, this guide helps you travel smarter and with confidence.

FAQs
Cheap bus tickets from Wilmington, DE to Florence, SC can start from as little as Kč3760 when you book in advance. The average bus ticket price for Wilmington, DE to Florence, SC is Kč4352 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Wilmington, DE to Florence, SC is 12h 25m to travel the 448 miles (722 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Wilmington, DE to Florence, SC leaves at 12:05 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Wilmington, DE to Florence, SC leaves at 9:25 PM.
There are 3 buses a day from Wilmington, DE to Florence, SC which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Wilmington, DE to Florence, SC, you can count on Greyhound for the best way to get you to Florence, SC. You can also check all possible bus companies who offer a service between Wilmington, DE and Florence, SC and compare the amenities they offer before buying a bus ticket.
A trip to Florence, SC from Wilmington, DE is worth doing but not as a day trip with a journey time of 12h 25m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Wilmington, DE to Florence, SC is October.
It's helpful to compare your options as there are 2 ways to travel between Wilmington, DE and Florence, SC including taking a train and bus.
Yes, the following accessibility options are available when taking the bus from Wilmington, DE to Florence, SC:
  • Greyhound
    • Assistance
    • Priority seating
    • Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Wilmington, DE to Florence, SC for bus company Greyhound.
Whether you can cancel your bus ticket from Wilmington, DE to Florence, SC depends on the bus companies:
  • Greyhound
    • You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Wilmington, DE to Florence, SC.
Yes, the following luggage options are included when booking a bus ticket from Wilmington, DE to Florence, SC:
  • Greyhound
    • One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from Wilmington, DE to Florence, SC:
  • Greyhound
    • $15 per additional bag.
Unfortunately, pets are not allowed on the bus from Wilmington, DE to Florence, SC.
You can reserve your seat on the bus from Wilmington, DE to Florence, SC with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from Wilmington, DE to Florence, SC with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from Wilmington, DE to Florence, SC with the following bus company: Greyhound.
Since neither Wilmington, DE nor Florence, SC are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the train as it is the most popular way to get from Wilmington, DE to Florence, SC among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Florence, SC, travelers should be cautious of petty crimes like pickpocketing and vehicle break-ins, especially in less crowded areas. It's advisable to stay in well-lit, populated places and avoid displaying valuables openly. Common scams include overcharging by taxi drivers and unofficial ticket sellers; always use licensed transportation and purchase tickets from authorized vendors. Staying aware of surroundings and securing personal belongings helps ensure a safe visit.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.

popular bus stations

Popular bus stations from Wilmington, DE to Florence, SC

Most Wilmington, DE to Florence, SC buses use the Wilmington, Amtrak Station @ ML King-French to Florence, W Lucas St (TA Gas Station) station pair, with some services arriving at Florence, S Irby St (Greyhound Bus Stop). Use this guide to compare Wilmington, DE and Florence, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.

Departure bus stations in Wilmington
Arrival bus stations in Florence
Wilmington, Amtrak Station @ ML King-French
City-centre transport

Getting to Wilmington, Amtrak Station @ ML King-French from Wilmington city centre

Bus002, 006, 035 · 4m · Kč52 · every ~9 min
013, 020 · 4m · Kč52 · every ~5 min

More options for your journey from Wilmington, DE to Florence, SC

Here are some other resources that might have the information you need

Return journeys for buses from Florence, SC to Wilmington, DE
Tickets and more information for coaches to Wilmington, DE
Tickets and more information for coaches to Florence, SC

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