- Must visit
Uffizi Galleries
World-famous museum of Renaissance art with masterpieces by Botticelli, Leonardo, Michelangelo, and Raphael. Timed entry is strongly advised due to very high demand.
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Travel Information
Compare train and bus for Wilmington, DE to Florence, SC
Omio recommends booking the train as it is the most popular option from Wilmington, DE to Florence, SC among Omio's users. If you are prioritising price take the bus with prices starting from $112. For those with little time consider booking a train which can get you there in 9h 55m. The ticket price range depends on the travel mode: a bus costs an average of $112, and a train costs an average of $257.
Distance: 448 miles (722 km)
Compare bus with
| Bus | Most popular Train | Driving |
|---|---|---|
$112 Average price Cheapest | $257 Average price | $103 Average price (fuel + tolls) |
14h 50m Average total duration 14h 20m Onboard + 30m Additional time* | 10h 25m Average total duration Fastest 9h 55m Onboard + 30m Additional time* | 8h 1m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Wilmington, DE to Florence, SC is a bus with an average price of $112 (€92).
This is compared to other travel options from Wilmington, DE to Florence, SC:
A bus is $144 (€118) less than a train for this route with tickets for a train from Wilmington, DE to Florence, SC costing on average $257 (€210).
The fastest way to travel from Wilmington, DE to Florence, SC is by train with an average journey time of 9h 55m.
Other travel options to Florence, SC take longer:
Bus takes on average 14h 20m.
It's helpful to compare your options as there are 2 ways to travel between Wilmington, DE and Florence, SC including taking a train and bus.
We recommend using the train as it is the most popular way to get from Wilmington, DE to Florence, SC among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Wilmington, DE to Florence, SC Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound USA | Departure Time 09:25PM | Arrival Time 11:45AM | Duration 14h20 | Departure days Mon, Tue, Wed, Thu, Fri, Sun | Cheapest price $112 |
Live departures
Wilmington, DE to Florence, SC bus times
The table below shows live departures for Wilmington, DE to Florence, SC buses for today, Friday, June 19. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
 | 9:25 PM Wilmington, DE | 14h20 | 11:45 AM Florence, SC | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Wilmington, DE to Florence, SC by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Wilmington, DE to Florence, SC buses with Omio?
Greyhound operates all buses services from Wilmington, DE to Florence, SC.
Omio is an official ticket reseller for all your travel options from Wilmington, DE to Florence, SC.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train and bus to ensure you get the best deal for traveling from Wilmington, DE to Florence, SC.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from Wilmington, DE to Florence, SC.
Journey information
Overview: Bus from Wilmington, DE to Florence, SC
USAUSA
Buses from Wilmington, DE to Florence, SC run on average 2 times per day, taking around 14h 20m. Cheap bus tickets for this journey start at $112 (€92) if you book in advance.
The earliest bus runs at 00:05, the last at 21:25. The fastest bus covers the 448 miles (722 km) distance in 14h 20m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 448 miles (722 km) |
Average bus duration 14h 20m |
Cheapest ticket price $112 (€92) |
Buses per day 2 |
Fastest bus 14h 20m |
First bus 12:05 AM |
Last bus 9:25 PM |
Cheapest Month Oct |
Cheapest Day Tue |
High Season Apr - Jun |
Low Season Jan - Mar |
Best time to book 5 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound from Wilmington, DE to Florence, SCYou can travel by bus between Wilmington, DE to Florence, SC with Greyhound for as low as $112 (€92). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
14h 20m
Cheapest Price
$112 (€92)
Greyhound frequency
1 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Florence
Things to do in Florence
Discover the best of Florence — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Florence trip today.
- Must visit
Accademia Gallery
Best known for Michelangelo’s David, this compact museum is one of Florence’s essential stops. Advance booking is commonly recommended because queues can be long.
- Recommended
Palazzo Pitti
Large palace museum complex with royal apartments, paintings, and design collections. Worth visiting for its scale, courtly interiors, and links to Medici history.
- Must visit
Piazza del Duomo
The monumental heart of Florence, surrounded by the cathedral, dome, baptistery, and bell tower. Essential for first-time visitors and classic city views.
- Must visit
Piazza della Signoria
Historic square lined with civic architecture and open-air sculptures. One of Florence’s liveliest public spaces and a key stop on any walking route.
- Must visit
Piazzale Michelangelo
The city’s most famous viewpoint, especially popular at sunset for sweeping skyline photos. A social media favorite and classic Florence panorama.
- Gluten-free
Pulled Pork Barbecue
Slow-smoked pork shoulder, usually chopped or pulled and served with a tangy Southern barbecue sauce. It is a staple across the Carolinas and common in Florence-area smokehouses.
Fried Catfish
Cornmeal-coated catfish fillets fried until crisp, often served with hush puppies and slaw. This is a classic Pee Dee and broader South Carolina comfort dish.
- Gluten-free
Shrimp And Grits
Creamy stone-ground grits topped with shrimp, often with bacon, gravy, or a light sauce. A defining Lowcountry and South Carolina dish regularly found in Florence.
Wholly Smokin' Downtown
Established downtown barbecue spot specializing in smoked meats, Southern sides, and a casual local atmosphere.
Victors
Upscale, long-running Florence restaurant known for steaks, seafood, and polished Southern-American dining in an elegant setting.
Tubb's Shrimp & Fish Co.
Well-known casual seafood restaurant recognized for fried seafood platters, shrimp, fish, and regional comfort fare.
United States Dollar
Costs are moderate for the U.S. Budget eats are easy to find, while hotels and fine dining can raise daily costs.
Average meal costs
- Budget
- USD 8-15 for fast food or a simple lunch.
- Mid-range
- USD 18-35 per person at a casual sit-down restaurant.
- Fine dining
- USD 50-100+ per person before drinks and tip.
- Coffee
- USD 3-6 for drip coffee or a latte.
Tipping culture
Tip 18-20% at restaurants. Tip USD 1-2 per drink at bars, round up or tip 10-15% for taxis, and tip hotel staff USD 2-5 for helpful service.
FAQs: Bus from Wilmington, DE to Florence, SC
Find answers to the most common questions about traveling from Wilmington, DE to Florence, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Florence, SC, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Wilmington, DE to Florence, SC can start from as little as $112 (€92) when you book in advance. The average bus ticket price for Wilmington, DE to Florence, SC is $112 (€92) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Wilmington, DE to Florence, SC is 14h 20m to travel the 448 miles (722 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Wilmington, DE to Florence, SC leaves at 12:05 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Wilmington, DE to Florence, SC leaves at 9:25 PM.
There are 2 buses a day from Wilmington, DE to Florence, SC which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Wilmington, DE to Florence, SC, you can count on Greyhound for the best way to get you to Florence, SC. You can also check all possible bus companies who offer a service between Wilmington, DE and Florence, SC and compare the amenities they offer before buying a bus ticket.
A trip to Florence, SC from Wilmington, DE is worth doing but not as a day trip with a journey time of 14h 20m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Wilmington, DE to Florence, SC is October.
It's helpful to compare your options as there are 2 ways to travel between Wilmington, DE and Florence, SC including taking a train and bus.
Yes, the following accessibility options are available when taking the bus from Wilmington, DE to Florence, SC:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Wilmington, DE to Florence, SC for bus company Greyhound.
Whether you can cancel your bus ticket from Wilmington, DE to Florence, SC depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Wilmington, DE to Florence, SC.
Yes, the following luggage options are included when booking a bus ticket from Wilmington, DE to Florence, SC:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from Wilmington, DE to Florence, SC:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from Wilmington, DE to Florence, SC.
You can reserve your seat on the bus from Wilmington, DE to Florence, SC with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from Wilmington, DE to Florence, SC with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from Wilmington, DE to Florence, SC with the following bus company: Greyhound.
Since neither Wilmington, DE nor Florence, SC are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the train as it is the most popular way to get from Wilmington, DE to Florence, SC among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Florence, SC, travelers should be cautious of petty crimes like pickpocketing and vehicle break-ins, especially in less crowded areas. It's advisable to stay in well-lit, populated places and avoid displaying valuables openly. Common scams include overcharging by taxi drivers and unofficial ticket sellers; always use licensed transportation and purchase tickets from authorized vendors. Staying aware of surroundings and securing personal belongings helps ensure a safe visit.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Wilmington, DE to Florence, SC
Most Wilmington, DE to Florence, SC buses use the Wilmington, Amtrak Station @ ML King-French to Florence, S Irby St (Greyhound Bus Stop) station pair. Use this guide to compare Wilmington, DE and Florence, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Wilmington
Arrival bus stations in Florence
Wilmington, Amtrak Station @ ML King-French
City-centre transport
Getting to Wilmington, Amtrak Station @ ML King-French from Wilmington city centre
Bus002, 006, 035 · 4m · $2 · every ~9 min
013, 020 · 4m · $2 · every ~5 min
Florence, S Irby St (Greyhound Bus Stop)
Most popular bus connections from Wilmington, DE
More options for your journey from Wilmington, DE to Florence, SC
Here are some other resources that might have the information you need
Most popular buses to and from Florence, SC and Wilmington, DE
Most popular bus connections to Florence, SC
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