Wilmington, DE to Florence, SC bus

Sun, Dec 21
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FlixBus
Alsa
BlaBlaCar Bus
Rede Expressos
Itabus
1,000+ travel companies
FlixBus
Alsa
BlaBlaCar Bus
Rede Expressos
Itabus
1,000+ travel companies
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Travel Information

Compare train for Wilmington, DE to Florence, SC

Omio recommends booking the train as it is the most popular option from Wilmington, DE to Florence, SC among Omio's users. If you are prioritising price take the bus with prices starting from €59. For those with little time consider booking a train which can get you there in 9h 55m. The ticket price range depends on the travel mode: a bus costs an average of €59, and a train costs an average of €124.

Distance: 448 miles (722 km)

Compare bus with

Bus
Most popular
Train

€59

Average price

Cheapest

€177

Average price

16h 25m

Average total duration

15h 55m

Onboard

+

30m

Additional time*

10h 25m

Average total duration

Fastest

9h 55m

Onboard

+

30m

Additional time*

Direct Options

Direct Options

Compare prices and tickets Wilmington, DE to Florence, SC by train

Compare train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

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Dec 21
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Journey information

Overview: Bus from Wilmington, DE to Florence, SC

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Buses from Wilmington, DE to Florence, SC run on average 2 times per day, taking around 15h 55m. Cheap bus tickets for this journey start at $74 (€59) if you book in advance.

The earliest bus runs at 00:05, the last at 21:25. The fastest bus covers the 448 miles (722 km) distance in 15h 55m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance
448 miles (722 km)
Average bus duration
15h 55m
Cheapest ticket price
$74 (€59)
Buses per day
2
Fastest bus
15h 55m
First bus
00:05
Last bus
21:25
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information

FAQs: Bus from Wilmington, DE to Florence, SC

Find answers to the most common questions about traveling from Wilmington, DE to Florence, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Florence, SC, this guide helps you travel smarter and with confidence.

FAQs
The first bus from Wilmington, DE to Florence, SC leaves at 12: 55AM. Plan your trip with the Journey Planner   from Omio.
The last bus from Wilmington, DE to Florence, SC leaves at 11: 50PM.
A day trip to Florence, SC from Wilmington, DE is worth doing with a journey time of min each way. Check with Omio app   the best way to travel.
Yes, you can take a train from Wilmington, DE to Florence, SC.
No, the bus from Wilmington, DE to Florence, SC has no accessibility options.
No, there are no bathrooms on board the bus from Wilmington, DE to Florence, SC.
No, bikes are not allowed on board the bus from Wilmington, DE to Florence, SC.

To find the cheapest bus tickets for your trip from Wilmington, DE to Florence, SC, follow these tips:

  • Book in advance: Tickets are often cheaper when booked early.
  • Be flexible with dates and times: Traveling during off-peak hours or on weekdays can help you save money.
  • Use our search filters: Sort results by price to quickly identify the most affordable options.
  • Look for special deals or discounts: Check for promotions or discounts available on our website and app.

    • Start your search now and compare ticket prices to find the best deal!

    Yes, there is food available to purchase on board the bus from Wilmington, DE to Florence, SC.
    No, luggage for the bus from Wilmington, DE to Florence, SC needs to be booked in addition.
    No, there are no additional luggage options for the bus from Wilmington, DE to Florence, SC.
    Unfortunately, pets are not allowed on the bus from Wilmington, DE to Florence, SC.
    No, there are no USB plugs on board the bus from Wilmington, DE to Florence, SC.
    No, there is no WiFi on board the bus from Wilmington, DE to Florence, SC.

    popular bus stations

    Popular bus stations from Wilmington, DE to Florence, SC

    Wilmington
    Florence
    The major bus station for departures in Wilmington is Wilmington, Amtrak Station @ ML King-French. Find all the information you need to know about services, amenities and connections at Wilmington, Amtrak Station @ ML King-French for your trip from Wilmington to Florence.
    Wilmington, Amtrak Station @ ML King-French
    information

    More options for your journey from Wilmington, DE to Florence, SC

    Here are some other resources that might have the information you need

    Return journeys for buses from Florence, SC to Wilmington, DE
    Tickets and more information for coaches to Wilmington, DE
    Tickets and more information for coaches to Florence, SC

    Most popular buses to and from Florence, SC and Wilmington, DE

    Bus Wilmington, DE - Boston, MA
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    Bus Wilmington, DE - Philadelphia, PA
    Bus Wilmington, DE - Orlando, FL
    Bus Wilmington, DE - Dallas, TX
    Bus Wilmington, DE - Atlanta, GA
    Bus Wilmington, DE - Miami, FL
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    Bus Wilmington, DE - Baltimore, MD
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    Bus Wilmington, DE - Nashville, TN
    Bus Wilmington, DE - Raleigh, NC
    Bus Wilmington, DE - Pittsburgh, PA
    Bus Wilmington, DE - Jacksonville, FL
    Bus Wilmington, DE - Cleveland, OH
    Bus Wilmington, DE - Richmond, VA
    Bus Wilmington, DE - Fort Lauderdale, FL
    Bus Boston, MA - Florence, SC
    Bus New York, NY - Florence, SC
    Bus Washington, DC - Florence, SC
    Bus Philadelphia, PA - Florence, SC
    Bus Orlando, FL - Florence, SC
    Bus Miami, FL - Florence, SC
    Bus Tampa, FL - Florence, SC
    Bus Baltimore, MD - Florence, SC
    Bus Newark, NJ - Florence, SC
    Bus Milwaukee, WI - Florence, SC
    Bus Charlotte, NC - Florence, SC
    Bus Raleigh, NC - Florence, SC
    Bus Pittsburgh, PA - Florence, SC
    Bus Jacksonville, FL - Florence, SC
    Bus Cleveland, OH - Florence, SC
    Bus Richmond, VA - Florence, SC
    Bus Fort Lauderdale, FL - Florence, SC
    Bus Syracuse, NY - Florence, SC
    Bus West Palm Beach, FL - Florence, SC
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    HomeBusesBuses in USABus tickets to Florence, SCWilmington, DE to Florence, SC bus

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