- Must visit
Uffizi Galleries
World-famous museum of Renaissance art with masterpieces by Botticelli, Leonardo, Michelangelo, and Raphael. Timed entry is strongly advised due to very high demand.
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The cheapest and fastest buses from Pittsburgh, PA to Florence, SC
Showing times and prices for Jun 20
Cheapest price
$164
Average price
$170
Fastest journey
15 h 15 m
Average duration
1 d 5 h 23 m
Buses per day
2
Distance
695 km
Cheap tickets
The best way to find a cheap bus ticket from Pittsburgh, PA to Florence, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Pittsburgh, PA to Florence, SC will cost around $170 if you buy it on the day, but the cheapest tickets can be found for only $164.
Fast buses
It's difficult to get from Pittsburgh, PA to Florence, SC without transferring at least 2 times.
8:00 PM43h30Pittsburgh, PA3:30 PMFlorence, SC$1641One-way3 transfers- 8:30 PM15h15Pittsburgh, PA11:45 AMFlorence, SC$1761One-way2 transfers
- 8:30 PM15h15Pittsburgh, PA11:45 AMFlorence, SC$1761One-way2 transfers
- 8:00 PM43h30Pittsburgh, PA3:30 PMFlorence, SC$1641One-way3 transfers
Travel Information
Compare train and bus for Pittsburgh, PA to Florence, SC
Omio recommends booking the train as it is the most popular option from Pittsburgh, PA to Florence, SC among Omio's users. If you are prioritising price take the train with prices starting from $264. For those with little time consider booking a bus which can get you there in 15h 15m. The ticket price range depends on the travel mode: a train costs an average of $264, and a bus costs an average of $344.
Distance: 431 miles (695 km)
Compare bus with
| Bus | Most popular Train | Driving |
|---|---|---|
$344 Average price | $264 Average price Cheapest | $110 Average price (fuel + tolls) |
15h 45m Average total duration Fastest 15h 15m Onboard + 30m Additional time* | 22h 20m Average total duration 21h 50m Onboard + 30m Additional time* | 8h 49m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Pittsburgh, PA to Florence, SC is a train with an average price of $264 (€216).
This is compared to other travel options from Pittsburgh, PA to Florence, SC:
A train is $80 (€66) less than a bus for this route with tickets for a bus from Pittsburgh, PA to Florence, SC costing on average $344 (€282).
The fastest way to travel from Pittsburgh, PA to Florence, SC is by bus with an average journey time of 15h 15m.
Other travel options to Florence, SC take longer:
Train takes on average 21h 50m.
It's helpful to compare your options as there are 2 ways to travel between Pittsburgh, PA and Florence, SC including taking a train and bus.
We recommend using the bus as it is the most popular way to get from Pittsburgh, PA to Florence, SC among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Pittsburgh, PA to Florence, SC Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 12:30AM | Arrival Time 03:45PM | Duration 15h15 | Departure days Thu | Cheapest price $344 |
Operator FlixBus | Departure Time 11:45AM | Arrival Time 05:45AM | Duration 18h00 | Departure days Thu | Cheapest price $137 |
Operator Greyhound | Departure Time 06:50PM | Arrival Time 11:45AM | Duration 16h55 | Departure days Thu | Cheapest price $111 |
Operator Greyhound USA | Departure Time 08:00PM | Arrival Time 03:30PM | Duration 43h30 | Departure days Tue, Fri, Sat | Cheapest price $164 |
Operator Greyhound USA | Departure Time 08:30PM | Arrival Time 11:45AM | Duration 15h15 | Departure days Tue, Fri, Sat, Sun | Cheapest price $176 |
Live departures
Pittsburgh, PA to Florence, SC bus times
The table below shows live departures for Pittsburgh, PA to Florence, SC buses for tomorrow, Saturday, June 20. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 8:00 PM Pittsburgh, PA | 43h30 | 3:30 PM Florence, SC | 3 transfers | |
| 8:30 PM Pittsburgh, PA | 15h15 | 11:45 AM Florence, SC | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Pittsburgh, PA to Florence, SC by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Sat
Jun 20
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Why should you book Pittsburgh, PA to Florence, SC buses with Omio?
Greyhound operates all buses services from Pittsburgh, PA to Florence, SC.
Omio is an official ticket reseller for all your travel options from Pittsburgh, PA to Florence, SC.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train and bus to ensure you get the best deal for traveling from Pittsburgh, PA to Florence, SC.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from Pittsburgh, PA to Florence, SC.
Journey information
Overview: Bus from Pittsburgh, PA to Florence, SC
USAUSA
Buses from Pittsburgh, PA to Florence, SC run on average 2 times per day, taking around 15h 15m. Cheap bus tickets for this journey start at $344 (€282) but you can travel from only $264 (€216) by train.
The earliest bus runs at 00:05, the last at 20:35. The fastest bus covers the 431 miles (695 km) distance in 15h 15m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Train from $264 (€216)
Distance 431 miles (695 km) |
Average bus duration 15h 15m |
Cheapest ticket price $344 (€282) |
Buses per day 2 |
Fastest bus 15h 15m |
First bus 12:05 AM |
Last bus 8:35 PM |
Cheapest Month Aug |
Cheapest Day Mon |
High Season Jul - Sep |
Low Season Jan - Mar |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Train from $264 (€216)
Bus providers: Greyhound from Pittsburgh, PA to Florence, SCYou can travel by bus between Pittsburgh, PA to Florence, SC with Greyhound for as low as $264 (€216). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
15h 15m
Cheapest Price
$344 (€282)
Greyhound frequency
1 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Florence
Things to do in Florence
Discover the best of Florence — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Florence trip today.
- Must visit
Accademia Gallery
Best known for Michelangelo’s David, this compact museum is one of Florence’s essential stops. Advance booking is commonly recommended because queues can be long.
- Recommended
Palazzo Pitti
Large palace museum complex with royal apartments, paintings, and design collections. Worth visiting for its scale, courtly interiors, and links to Medici history.
- Must visit
Piazza del Duomo
The monumental heart of Florence, surrounded by the cathedral, dome, baptistery, and bell tower. Essential for first-time visitors and classic city views.
- Must visit
Piazza della Signoria
Historic square lined with civic architecture and open-air sculptures. One of Florence’s liveliest public spaces and a key stop on any walking route.
- Must visit
Piazzale Michelangelo
The city’s most famous viewpoint, especially popular at sunset for sweeping skyline photos. A social media favorite and classic Florence panorama.
- Gluten-free
Pulled Pork Barbecue
Slow-smoked pork shoulder, usually chopped or pulled and served with a tangy Southern barbecue sauce. It is a staple across the Carolinas and common in Florence-area smokehouses.
Fried Catfish
Cornmeal-coated catfish fillets fried until crisp, often served with hush puppies and slaw. This is a classic Pee Dee and broader South Carolina comfort dish.
- Gluten-free
Shrimp And Grits
Creamy stone-ground grits topped with shrimp, often with bacon, gravy, or a light sauce. A defining Lowcountry and South Carolina dish regularly found in Florence.
Wholly Smokin' Downtown
Established downtown barbecue spot specializing in smoked meats, Southern sides, and a casual local atmosphere.
Victors
Upscale, long-running Florence restaurant known for steaks, seafood, and polished Southern-American dining in an elegant setting.
Tubb's Shrimp & Fish Co.
Well-known casual seafood restaurant recognized for fried seafood platters, shrimp, fish, and regional comfort fare.
United States Dollar
Costs are moderate for the U.S. Budget eats are easy to find, while hotels and fine dining can raise daily costs.
Average meal costs
- Budget
- USD 8-15 for fast food or a simple lunch.
- Mid-range
- USD 18-35 per person at a casual sit-down restaurant.
- Fine dining
- USD 50-100+ per person before drinks and tip.
- Coffee
- USD 3-6 for drip coffee or a latte.
Tipping culture
Tip 18-20% at restaurants. Tip USD 1-2 per drink at bars, round up or tip 10-15% for taxis, and tip hotel staff USD 2-5 for helpful service.
FAQs: Bus from Pittsburgh, PA to Florence, SC
Find answers to the most common questions about traveling from Pittsburgh, PA to Florence, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Florence, SC, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Pittsburgh, PA to Florence, SC can start from as little as $344 (€282) when you book in advance. The average bus ticket price for Pittsburgh, PA to Florence, SC is $344 (€282) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Pittsburgh, PA to Florence, SC is 15h 15m to travel the 431 miles (695 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Pittsburgh, PA to Florence, SC leaves at 12:05 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Pittsburgh, PA to Florence, SC leaves at 8:35 PM.
There are 2 buses a day from Pittsburgh, PA to Florence, SC which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Pittsburgh, PA to Florence, SC, you can count on Greyhound for the best way to get you to Florence, SC. You can also check all possible bus companies who offer a service between Pittsburgh, PA and Florence, SC and compare the amenities they offer before buying a bus ticket.
A trip to Florence, SC from Pittsburgh, PA is worth doing but not as a day trip with a journey time of 15h 15m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Pittsburgh, PA to Florence, SC is August.
It's helpful to compare your options as there are 2 ways to travel between Pittsburgh, PA and Florence, SC including taking a train and bus.
Yes, the following accessibility options are available when taking the bus from Pittsburgh, PA to Florence, SC:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Pittsburgh, PA to Florence, SC for bus company Greyhound.
Whether you can cancel your bus ticket from Pittsburgh, PA to Florence, SC depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Pittsburgh, PA to Florence, SC.
Yes, the following luggage options are included when booking a bus ticket from Pittsburgh, PA to Florence, SC:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from Pittsburgh, PA to Florence, SC:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from Pittsburgh, PA to Florence, SC.
You can reserve your seat on the bus from Pittsburgh, PA to Florence, SC with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from Pittsburgh, PA to Florence, SC with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from Pittsburgh, PA to Florence, SC with the following bus company: Greyhound.
Since neither Pittsburgh, PA nor Florence, SC are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the train as it is the most popular way to get from Pittsburgh, PA to Florence, SC among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Florence, SC, travelers should be cautious of petty crimes like pickpocketing and vehicle break-ins, especially in less crowded areas. It's advisable to stay in well-lit, populated places and avoid displaying valuables openly. Common scams include overcharging by taxi drivers and unofficial ticket sellers; always use licensed transportation and purchase tickets from authorized vendors. Staying aware of surroundings and securing personal belongings helps ensure a safe visit.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Pittsburgh, PA to Florence, SC
Most Pittsburgh, PA to Florence, SC buses use the Pittsburgh, Greyhound Bus Station to Florence, S Irby St (Greyhound Bus Stop) station pair. Use this guide to compare Pittsburgh, PA and Florence, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Pittsburgh
Arrival bus stations in Florence
Pittsburgh, Greyhound Bus Station
City-centre transport
Getting to Pittsburgh, Greyhound Bus Station from Pittsburgh city centre
Bus29, 31, 39, 40, 41, 44, G3, G31, P1 · 3m · every ~27 min
M · 7m
1F, 2F, 3F, 14F · 12m · $1
Florence, S Irby St (Greyhound Bus Stop)
Most popular bus connections from Pittsburgh, PA
More options for your journey from Pittsburgh, PA to Florence, SC
Here are some other resources that might have the information you need
Most popular buses to and from Florence, SC and Pittsburgh, PA
Most popular bus connections to Florence, SC
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