The cheapest and fastest buses from Pittsburgh, PA to Florence, SC
Cheapest price
$177
Average price
$177
Fastest journey
15 h 15 m
Average duration
15 h 15 m
Buses per day
1
Distance
695 km
The best way to find a cheap bus ticket from Pittsburgh, PA to Florence, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Pittsburgh, PA to Florence, SC will cost around $177 if you buy it on the day, but the cheapest tickets can be found for only $177.
It's difficult to get from Pittsburgh, PA to Florence, SC without transferring at least 2 times.


Travel Information
Compare train and bus for Pittsburgh, PA to Florence, SC
Omio recommends booking the bus as it is the most popular option from Pittsburgh, PA to Florence, SC among Omio's users. If you are prioritising price take the train with prices starting from $255. For those with little time consider booking a bus which can get you there in 17h 30m. The ticket price range depends on the travel mode: a train costs an average of $255, and a bus costs an average of $312.
Distance: 431 miles (695 km)
Compare bus with
Most popular Bus | Train |
|---|---|
$312 Average price | $255 Average price Cheapest |
18h 0m Average total duration Fastest 17h 30m Onboard + 30m Additional time* | 24h 47m Average total duration 24h 17m Onboard + 30m Additional time* |
Direct Options | Direct Options |
Live departures
Pittsburgh, PA to Florence, SC bus times
The table below shows live departures for Pittsburgh, PA to Florence, SC buses for today, Saturday, March 21. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 8:00 PM Pittsburgh, PA | 43h30 | 3:30 PM Florence, SC | 3 transfers | |
![]() | 8:30 PM Pittsburgh, PA | 15h15 | 11:45 AM Florence, SC | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Pittsburgh, PA to Florence, SC by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 22
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Mar 28
Why should you book Pittsburgh, PA to Florence, SC buses with Omio?
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train and bus to ensure you get the best deal for traveling from Pittsburgh, PA to Florence, SC.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from Pittsburgh, PA to Florence, SC.
Journey information
Overview: Bus from Pittsburgh, PA to Florence, SC
Buses from Pittsburgh, PA to Florence, SC run on average 2 times per day, taking around 17h 30m. Cheap bus tickets for this journey start at $312 (€253) but you can travel from only $255 (€207) by train.
The earliest bus runs at 00:05, the last at 20:35. The fastest bus covers the 431 miles (695 km) distance in 17h 30m.
Distance 431 miles (695 km) |
Average bus duration 17h 30m |
Cheapest ticket price $312 (€253) |
Buses per day 2 |
Fastest bus 17h 30m |
First bus 00:05 |
Last bus 20:35 |
Bus providers: Greyhound from Pittsburgh, PA to Florence, SCYou can travel by bus between Pittsburgh, PA to Florence, SC with Greyhound for as low as $255 (€207). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from Pittsburgh, PA to Florence, SC
Find answers to the most common questions about traveling from Pittsburgh, PA to Florence, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Florence, SC, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from Pittsburgh, PA to Florence, SC
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