The cheapest and fastest buses from Indianapolis, IN to San Francisco, CA
Cheapest price
$166
Average price
$423
Fastest journey
2 d 9 h 40 m
Average duration
2 d 16 h 26 m
Buses per day
4
Distance
3130 km
The best way to find a cheap bus ticket from Indianapolis, IN to San Francisco, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Indianapolis, IN to San Francisco, CA will cost around $423 if you buy it on the day, but the cheapest tickets can be found for only $166.
Of the 4 buses that leave Indianapolis, IN for San Francisco, CA on Mon, Mar 23, 4 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Mon, Mar 23 the direct buses cover the 3130 km distance in an average of 2 d 16 h 26 m but if you time it right, some buses will get you there in just 2 d 9 h 40 m .
On Mon, Mar 23 the slowest buses will take 2 d 23 h 30 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.








Travel Information
Compare bus, train, and flight for Indianapolis, IN to San Francisco, CA
Omio recommends booking the train as it is the most popular option from Indianapolis, IN to San Francisco, CA among Omio's users. If you are prioritising price take the flight with prices starting from $158. For those with little time consider booking a flight which can get you there in 6h 40m. The ticket price range depends on the travel mode: a flight costs an average of $158, and a train costs an average of $206.
Distance: 1944 miles (3130 km)
Compare bus with
| Bus | Most popular Train | Flight |
|---|---|---|
$382 Average price | $671 Average price | $367 Average price Cheapest |
57h 5m Average total duration 56h 35m Onboard + 30m Additional time* | 58h 33m Average total duration 58h 3m Onboard + 30m Additional time* | 9h 40m Average total duration Fastest 6h 40m Onboard + 3h 0m Additional time* |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline |
Direct Options | Direct Options | Direct Options |
Live departures
Indianapolis, IN to San Francisco, CA bus times
The table below shows live departures for Indianapolis, IN to San Francisco, CA buses for today, Sunday, March 22. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 8:05 PM Indianapolis, IN | 67h10 | 3:15 PM San Francisco, CA | 0 transfersDirect | |
![]() | 11:25 PM Indianapolis, IN | 63h50 | 3:15 PM San Francisco, CA | 0 transfersDirect | |
| Monday, March 23 | |||||
![]() | 2:35 AM Indianapolis, IN | 71h30 | 2:05 AM San Francisco, CA | 0 transfersDirect | |
![]() | 4:30 AM Indianapolis, IN | 63h55 | 8:25 PM San Francisco, CA | 0 transfersDirect | |
![]() | 4:25 PM Indianapolis, IN | 57h40 | 2:05 AM San Francisco, CA | 0 transfersDirect | |
Find all the dates and times for this journey
Compare prices and tickets Indianapolis, IN to San Francisco, CA by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 23
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Mar 29
Why should you book Indianapolis, IN to San Francisco, CA buses with Omio?
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from Indianapolis, IN to San Francisco, CA.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from Indianapolis, IN to San Francisco, CA.
Journey information
Overview: Bus from Indianapolis, IN to San Francisco, CA
Buses from Indianapolis, IN to San Francisco, CA run on average 10 times per day, taking around 56h 35m. Cheap bus tickets for this journey start at $140 (€114) if you book in advance.
The earliest bus runs at 03:15, the last at 23:55. The fastest bus covers the 1944 miles (3130 km) distance in 52h 0m.
Distance 1944 miles (3130 km) |
Average bus duration 56h 35m |
Cheapest ticket price $140 (€114) |
Buses per day 10 |
Fastest bus 52h 0m |
First bus 03:15 |
Last bus 23:55 |
Cheapest month Jul |
Cheapest day Wed |
High season Jan - Mar |
Low season Jul - Sep |
Bus providers: Greyhound from Indianapolis, IN to San Francisco, CAYou can travel by bus between Indianapolis, IN to San Francisco, CA with Greyhound for as low as $140 (€114). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from Indianapolis, IN to San Francisco, CA
Find answers to the most common questions about traveling from Indianapolis, IN to San Francisco, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at San Francisco, CA, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Golden Gate Bridge, an iconic suspension bridge offering panoramic views of the San Francisco Bay
- Alcatraz Island, a historic site featuring the infamous former prison and informative audio tours
- Fisherman's Wharf, a bustling waterfront area known for seafood, shops, and sea lions
- Golden Gate Park, a large urban park with gardens, museums, and recreational activities
- Chinatown, the oldest and one of the largest Chinatowns in North America, offering vibrant culture and cuisine.
- Ride a cable car through the steep streets of San Francisco for a classic city experience
- Explore the vibrant murals and street art in the Mission District
- Visit the Exploratorium, an interactive science museum perfect for all ages
- Take a scenic walk along the Embarcadero, offering views of the Bay Bridge and access to the Ferry Building Marketplace
- Enjoy a wine tasting tour in nearby Napa Valley, a short drive from the city.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from Indianapolis, IN to San Francisco, CA
Most popular bus connections from Indianapolis, IN
More options for your journey from Indianapolis, IN to San Francisco, CA
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