The cheapest and fastest buses from Indianapolis, IN to San Francisco, CA
Cheapest price
$235
Average price
$262
Fastest journey
2 d 4 h 20 m
Average duration
2 d 7 h 45 m
Buses per day
10
Distance
3130 km
The best way to find a cheap bus ticket from Indianapolis, IN to San Francisco, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Indianapolis, IN to San Francisco, CA will cost around $262 if you buy it on the day, but the cheapest tickets can be found for only $235.
It's difficult to get from Indianapolis, IN to San Francisco, CA without transferring at least 3 times.
FlixBus+
undefined · undefined · undefined11:30 PM63h55Indianapolis, E Washington St / N Delaware St (City/County Building), IN12:25 PMSan Francisco, Transit Center Bay 29$2351One-way4 transfers
FlixBus+
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FlixBus11:30 PM69h20Indianapolis, E Washington St / N Delaware St (City/County Building), IN5:50 PMSan Francisco, Townsend Street / 5th Street, CA$2371One-way3 transfers
undefined · undefined · undefined · undefined11:05 AM52h20Indianapolis, Illinois St (Greyhound Bus Station)12:25 PMSan Francisco, Transit Center Bay 29$2441One-way3 transfers
FlixBus+
undefined · undefined · undefined6:25 PM63h50Indianapolis, E Washington St / N Delaware St (City/County Building), IN7:15 AMSan Francisco, Transit Center Bay 29$2581One-way4 transfers
FlixBus+
undefined · undefined · undefined9:30 AM53h55Indianapolis, E Washington St / N Delaware St (City/County Building), IN12:25 PMSan Francisco, Transit Center Bay 29$2601One-way3 transfers
undefined · undefined · undefined · undefined11:05 AM52h20Indianapolis, Illinois St (Greyhound Bus Station)12:25 PMSan Francisco, Transit Center Bay 29$2441One-way3 transfers
undefined · undefined · undefined · undefined5:00 AM53h15Indianapolis, Illinois St (Greyhound Bus Station)7:15 AMSan Francisco, Transit Center Bay 29$2731One-way3 transfers
FlixBus+
undefined · undefined · undefined9:30 AM53h55Indianapolis, E Washington St / N Delaware St (City/County Building), IN12:25 PMSan Francisco, Transit Center Bay 29$2601One-way3 transfers
undefined · undefined · undefined · undefined5:00 AM57h05Indianapolis, Illinois St (Greyhound Bus Station)11:05 AMSan Francisco, Townsend Street / 5th Street, CA$2791One-way4 transfers
undefined · undefined · undefined · undefined8:05 PM62h10Indianapolis, Illinois St (Greyhound Bus Station)7:15 AMSan Francisco, Transit Center Bay 29$2851One-way3 transfers
Travel Information
Compare bus, train, and flight for Indianapolis, IN to San Francisco, CA
Omio recommends booking the train as it is the most popular option from Indianapolis, IN to San Francisco, CA among Omio's users. If you are prioritising price take the flight with prices starting from $161. For those with little time consider booking a flight which can get you there in 6h 40m. The ticket price range depends on the travel mode: a flight costs an average of $161, and a train costs an average of $209.
Distance: 1944 miles (3130 km)
Compare bus with
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
$388 Average price | $680 Average price | $372 Average price Cheapest | $474 Average price (fuel + tolls) |
57h 5m Average total duration 56h 35m Onboard + 30m Additional time* | 58h 33m Average total duration 58h 3m Onboard + 30m Additional time* | 9h 40m Average total duration Fastest 6h 40m Onboard + 3h 0m Additional time* | 33h 2m Average total duration (door-to-door) |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Indianapolis, IN to San Francisco, CA:
A flight is $16 (€13) less than a bus for this route with tickets for a bus from Indianapolis, IN to San Francisco, CA costing on average $388 (€310).
A flight is $308 (€246) less than a train for this route with tickets for a train from Indianapolis, IN to San Francisco, CA costing on average $680 (€544).
Other travel options to San Francisco, CA take longer:
Bus takes on average 56h 35m.
Train takes on average 58h 3m.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Indianapolis, IN to San Francisco, CA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 05:00AM | Arrival Time 07:15AM | Duration 53h15 | Departure days Everyday | Cheapest price $220 |
Operator Greyhound | Departure Time 08:35AM | Arrival Time 12:25PM | Duration 54h50 | Departure days Tue | Cheapest price $193 |
Operator Greyhound | Departure Time 09:30AM | Arrival Time 12:25PM | Duration 53h55 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $257 |
Operator Greyhound | Departure Time 11:05AM | Arrival Time 12:25PM | Duration 52h20 | Departure days Everyday | Cheapest price $201 |
Operator Greyhound | Departure Time 06:25PM | Arrival Time 07:15AM | Duration 63h50 | Departure days Everyday | Cheapest price $249 |
Operator Greyhound | Departure Time 08:05PM | Arrival Time 07:15AM | Duration 62h10 | Departure days Everyday | Cheapest price $233 |
Operator Greyhound | Departure Time 11:30PM | Arrival Time 12:25PM | Duration 63h55 | Departure days Everyday | Cheapest price $190 |
Live departures
Indianapolis, IN to San Francisco, CA bus times
The table below shows live departures for Indianapolis, IN to San Francisco, CA buses for today, Wednesday, May 6. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus+ undefined · undefined · undefined | 6:25 PM Indianapolis, E Washington St / N Delaware St (City/County Building), IN | 63h50 | 7:15 AM San Francisco, Transit Center Bay 29 | 4 transfers | |
FlixBus+ undefined · undefined · undefined | 6:25 PM Indianapolis, E Washington St / N Delaware St (City/County Building), IN | 67h40 | 11:05 AM San Francisco, Townsend Street / 5th Street, CA | 5 transfers | |
undefined · undefined · undefined · undefined | 8:05 PM Indianapolis, Illinois St (Greyhound Bus Station) | 66h00 | 11:05 AM San Francisco, Townsend Street / 5th Street, CA | 4 transfers | |
undefined · undefined · undefined · undefined | 8:05 PM Indianapolis, Illinois St (Greyhound Bus Station) | 62h10 | 7:15 AM San Francisco, Transit Center Bay 29 | 3 transfers | |
FlixBus+ undefined · undefined · undefined | 11:30 PM Indianapolis, E Washington St / N Delaware St (City/County Building), IN | 63h55 | 12:25 PM San Francisco, Transit Center Bay 29 | 4 transfers | |
undefined · undefined · undefined · undefined | 5:00 AM Indianapolis, Illinois St (Greyhound Bus Station) | 53h15 | 7:15 AM San Francisco, Transit Center Bay 29 | 3 transfers | |
undefined · undefined · undefined · undefined | 5:00 AM Indianapolis, Illinois St (Greyhound Bus Station) | 57h05 | 11:05 AM San Francisco, Townsend Street / 5th Street, CA | 4 transfers | |
FlixBus+ undefined · undefined · undefined | 9:30 AM Indianapolis, E Washington St / N Delaware St (City/County Building), IN | 53h55 | 12:25 PM San Francisco, Transit Center Bay 29 | 3 transfers | |
undefined · undefined · undefined · undefined | 11:05 AM Indianapolis, Illinois St (Greyhound Bus Station) | 52h20 | 12:25 PM San Francisco, Transit Center Bay 29 | 3 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Indianapolis, IN to San Francisco, CA by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
May 07
May 08
May 09
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May 11
May 12
May 13
Why should you book Indianapolis, IN to San Francisco, CA buses with Omio?
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from Indianapolis, IN to San Francisco, CA.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from Indianapolis, IN to San Francisco, CA.
Journey information
Overview: Bus from Indianapolis, IN to San Francisco, CA
Buses from Indianapolis, IN to San Francisco, CA run on average 10 times per day, taking around 56h 35m. Cheap bus tickets for this journey start at $142 (€114) if you book in advance.
The earliest bus runs at 03:15, the last at 23:55. The fastest bus covers the 1944 miles (3130 km) distance in 52h 0m.
Distance 1944 miles (3130 km) |
Average bus duration 56h 35m |
Cheapest ticket price $142 (€114) |
Buses per day 10 |
Fastest bus 52h 0m |
First bus 3:15 AM |
Last bus 11:55 PM |
Cheapest Month Jul |
Cheapest Day Wed |
High Season Jan - Mar |
Low Season Jul - Sep |
Bus providers: Greyhound from Indianapolis, IN to San Francisco, CAYou can travel by bus between Indianapolis, IN to San Francisco, CA with Greyhound for as low as $142 (€114). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from Indianapolis, IN to San Francisco, CA
Find answers to the most common questions about traveling from Indianapolis, IN to San Francisco, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at San Francisco, CA, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Golden Gate Bridge, an iconic suspension bridge offering panoramic views of the San Francisco Bay
- Alcatraz Island, a historic site featuring the infamous former prison and informative audio tours
- Fisherman's Wharf, a bustling waterfront area known for seafood, shops, and sea lions
- Golden Gate Park, a large urban park with gardens, museums, and recreational activities
- Chinatown, the oldest and one of the largest Chinatowns in North America, offering vibrant culture and cuisine.
- Ride a cable car through the steep streets of San Francisco for a classic city experience
- Explore the vibrant murals and street art in the Mission District
- Visit the Exploratorium, an interactive science museum perfect for all ages
- Take a scenic walk along the Embarcadero, offering views of the Bay Bridge and access to the Ferry Building Marketplace
- Enjoy a wine tasting tour in nearby Napa Valley, a short drive from the city.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from Indianapolis, IN to San Francisco, CA
Most popular bus connections from Indianapolis, IN
More options for your journey from Indianapolis, IN to San Francisco, CA
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