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Major contemporary art museum with an outstanding modern and contemporary collection, large-scale installations, and strong photography holdings.
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The cheapest and fastest buses from Indianapolis, IN to San Francisco, CA
Showing times and prices for Jun 22
Cheapest price
$181
Average price
$210
Fastest journey
2 d 4 h 30 m
Average duration
2 d 7 h 22 m
Buses per day
10
Distance
3130 km
Cheap tickets
The best way to find a cheap bus ticket from Indianapolis, IN to San Francisco, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Indianapolis, IN to San Francisco, CA will cost around $210 if you buy it on the day, but the cheapest tickets can be found for only $181.
Fast buses
It's difficult to get from Indianapolis, IN to San Francisco, CA without transferring at least 3 times.
· · · 11:05 AM57h45Indianapolis, Illinois St (Greyhound Bus Station)5:50 PMSan Francisco, Townsend Street / 5th Street, CA$1811One-way4 transfers
FlixBus+ · · 11:30 PM64h05Indianapolis, E Washington St / N Delaware St (City/County Building), IN12:35 PMSan Francisco, Transit Center Bay 29$1831One-way4 transfers- · · · 5:00 AM53h10Indianapolis, Illinois St (Greyhound Bus Station)7:10 AMSan Francisco, Transit Center Bay 29$1951One-way3 transfers
- · · · 11:05 AM52h30Indianapolis, Illinois St (Greyhound Bus Station)12:35 PMSan Francisco, Transit Center Bay 29$1971One-way3 transfers
- FlixBus+ · · 6:25 PM63h45Indianapolis, E Washington St / N Delaware St (City/County Building), IN7:10 AMSan Francisco, Transit Center Bay 29$2011One-way4 transfers
- · · · 11:05 AM52h30Indianapolis, Illinois St (Greyhound Bus Station)12:35 PMSan Francisco, Transit Center Bay 29$1971One-way3 transfers
- · · · 5:00 AM53h10Indianapolis, Illinois St (Greyhound Bus Station)7:10 AMSan Francisco, Transit Center Bay 29$1951One-way3 transfers
- FlixBus+ · · 9:30 AM54h05Indianapolis, E Washington St / N Delaware St (City/County Building), IN12:35 PMSan Francisco, Transit Center Bay 29$2461One-way3 transfers
- · · · 11:05 AM57h45Indianapolis, Illinois St (Greyhound Bus Station)5:50 PMSan Francisco, Townsend Street / 5th Street, CA$1811One-way4 transfers
- FlixBus+ · · 9:30 AM59h20Indianapolis, E Washington St / N Delaware St (City/County Building), IN5:50 PMSan Francisco, Townsend Street / 5th Street, CA$2271One-way4 transfers
Travel Information
Compare bus, train, and flight for Indianapolis, IN to San Francisco, CA
Omio recommends booking the train as it is the most popular option from Indianapolis, IN to San Francisco, CA among Omio's users. If you are prioritising price take the flight with prices starting from $143. For those with little time consider booking a flight which can get you there in 6h 40m. The ticket price range depends on the travel mode: a flight costs an average of $143, and a train costs an average of $177.
Distance: 1944 miles (3130 km)
Compare bus with
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
$363 Average price | $758 Average price | $342 Average price Cheapest | $461 Average price (fuel + tolls) |
55h 0m Average total duration 54h 30m Onboard + 30m Additional time* | 58h 31m Average total duration 58h 1m Onboard + 30m Additional time* | 9h 40m Average total duration Fastest 6h 40m Onboard + 3h 0m Additional time* | 33h 2m Average total duration (door-to-door) |
Most popular bus company |  Most popular train company |  Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Indianapolis, IN to San Francisco, CA is a flight with an average price of $342 (€280).
This is compared to other travel options from Indianapolis, IN to San Francisco, CA:
A flight is $20 (€17) less than a bus for this route with tickets for a bus from Indianapolis, IN to San Francisco, CA costing on average $363 (€297).
A flight is $416 (€341) less than a train for this route with tickets for a train from Indianapolis, IN to San Francisco, CA costing on average $758 (€621).
The fastest way to travel from Indianapolis, IN to San Francisco, CA is by flight with an average journey time of 6h 40m.
Other travel options to San Francisco, CA take longer:
Bus takes on average 54h 30m.
Train takes on average 58h 1m.
It's helpful to compare your options as there are 3 ways to travel between Indianapolis, IN and San Francisco, CA including taking a bus, train, and flight.
We recommend using the train as it is the most popular way to get from Indianapolis, IN to San Francisco, CA among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Indianapolis, IN to San Francisco, CA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 01:05AM | Arrival Time 03:15PM | Duration 62h10 | Departure days Thu | Cheapest price $549 |
Operator Greyhound | Departure Time 02:35AM | Arrival Time 08:25PM | Duration 65h50 | Departure days Wed | Cheapest price $577 |
Operator Greyhound | Departure Time 03:30AM | Arrival Time 07:25PM | Duration 63h55 | Departure days Thu | Cheapest price $262 |
Operator Greyhound | Departure Time 05:00AM | Arrival Time 07:10AM | Duration 53h10 | Departure days Mon, Thu, Fri, Sat | Cheapest price $153 |
Operator Greyhound | Departure Time 09:30AM | Arrival Time 12:25PM | Duration 53h55 | Departure days Mon, Thu, Fri, Sat | Cheapest price $159 |
Operator Greyhound | Departure Time 11:05AM | Arrival Time 12:25PM | Duration 52h20 | Departure days Mon, Thu, Fri, Sat | Cheapest price $152 |
Operator Greyhound | Departure Time 01:35PM | Arrival Time 08:25PM | Duration 54h50 | Departure days Sun | Cheapest price $297 |
Operator Greyhound | Departure Time 03:05PM | Arrival Time 07:25PM | Duration 52h20 | Departure days Tue | Cheapest price $232 |
Operator Greyhound | Departure Time 03:15PM | Arrival Time 07:25PM | Duration 52h10 | Departure days Wed, Sun | Cheapest price $175 |
Operator Greyhound | Departure Time 04:25PM | Arrival Time 08:25PM | Duration 52h00 | Departure days Tue, Wed | Cheapest price $536 |
Operator Greyhound | Departure Time 06:25PM | Arrival Time 11:05AM | Duration 67h40 | Departure days Mon, Thu, Fri, Sat | Cheapest price $151 |
Operator Greyhound | Departure Time 07:35PM | Arrival Time 07:10AM | Duration 62h35 | Departure days Mon, Thu, Fri, Sat | Cheapest price $153 |
Operator Greyhound | Departure Time 11:25PM | Arrival Time 03:15PM | Duration 63h50 | Departure days Sun | Cheapest price $139 |
Operator Greyhound | Departure Time 11:30PM | Arrival Time 12:25PM | Duration 63h55 | Departure days Mon, Fri, Sat | Cheapest price $150 |
Live departures
Indianapolis, IN to San Francisco, CA bus times
The table below shows live departures for Indianapolis, IN to San Francisco, CA buses for today, Sunday, June 21. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 1:35 PM Indianapolis, IN | 54h50 | 8:25 PM San Francisco, CA | 0 transfersDirect | |
| 3:15 PM Indianapolis, IN | 57h50 | 1:05 AM San Francisco, CA | 0 transfersDirect | |
| 11:25 PM Indianapolis, IN | 63h50 | 3:15 PM San Francisco, CA | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Indianapolis, IN to San Francisco, CA by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Indianapolis, IN to San Francisco, CA buses with Omio?
Greyhound operates all buses services from Indianapolis, IN to San Francisco, CA.
Omio is an official ticket reseller for all your travel options from Indianapolis, IN to San Francisco, CA.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from Indianapolis, IN to San Francisco, CA.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from Indianapolis, IN to San Francisco, CA.
Journey information
Overview: Bus from Indianapolis, IN to San Francisco, CA
USAUSA
Buses from Indianapolis, IN to San Francisco, CA run on average 10 times per day, taking around 54h 30m. Cheap bus tickets for this journey start at $133 (€109) if you book in advance.
The earliest bus runs at 03:15, the last at 23:30. The fastest bus covers the 1944 miles (3130 km) distance in 52h 0m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 1944 miles (3130 km) |
Average bus duration 54h 30m |
Cheapest ticket price $133 (€109) |
Buses per day 10 |
Fastest bus 52h 0m |
First bus 3:15 AM |
Last bus 11:30 PM |
Cheapest Month Jul |
Cheapest Day Sun |
High Season Jan - Mar |
Low Season Jul - Sep |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound from Indianapolis, IN to San Francisco, CAYou can travel by bus between Indianapolis, IN to San Francisco, CA with Greyhound for as low as $133 (€109). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
52h 0m
Cheapest Price
$133 (€109)
Greyhound frequency
9 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to San Francisco
Things to do in San Francisco
Discover the best of San Francisco — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect San Francisco trip today.
- Must visit
Exploratorium
Interactive science and art museum on the Embarcadero, especially popular for hands-on exhibits and bayfront setting.
- Recommended
de Young Museum
Fine arts museum in Golden Gate Park known for American art, textiles, rotating exhibitions, and its panoramic observation tower.
- Must visit
Lombard Street
The famously crooked block lined with flowers and city views, one of San Francisco's most photographed streets.
- Must visit
Golden Gate Park
Massive urban park with gardens, lakes, museums, and broad walking space that rewards both short visits and full-day exploration.
- Must visit
Twin Peaks
High viewpoint with sweeping panoramic views over the city and bay, especially popular at sunset and on clear mornings.
- Gluten-free
Cioppino
A tomato-based seafood stew created by Italian fishermen in San Francisco, usually filled with crab, clams, mussels, shrimp, and fish. It is one of the city’s signature dishes.
- Vegetarian
- Vegan
Sourdough Bread
San Francisco sourdough is famous for its tangy flavor and chewy crust, shaped by the city’s historic baking culture and local wild yeast tradition.
Mission-Style Burrito
A large burrito associated with the Mission District, typically packed with rice, beans, meat, salsa, and extras. It is a defining San Francisco street food.
Sotto Mare
North Beach favorite specializing in cioppino and classic seafood in a lively, casual setting.
La Taqueria
Iconic Mission District taqueria celebrated for Mission-style burritos and tacos with a no-frills local vibe.
The Buena Vista
Classic waterfront cafe famous for Irish Coffee, hearty breakfasts, and historic cable-car-adjacent charm.
United States Dollar
One of the priciest U.S. cities. Hotels, dining, parking, and taxes add up quickly, though transit and casual food can help control costs.
Average meal costs
- Budget
- USD 12-20 for fast casual or food trucks.
- Mid-range
- USD 25-45 per person at a standard restaurant.
- Fine dining
- USD 90+ per person before drinks and tax.
- Coffee
- USD 4-7 for drip coffee or a latte.
Tipping culture
Restaurants: 18-22% is standard before or after tax depending on the screen shown. Bars: USD 1-2 per drink. Taxis/rideshare: 10-15% or round up. Hotel staff: USD 2-5 for porters, a few USD nightly for housekeeping.
FAQs: Bus from Indianapolis, IN to San Francisco, CA
Find answers to the most common questions about traveling from Indianapolis, IN to San Francisco, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at San Francisco, CA, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Indianapolis, IN to San Francisco, CA can start from as little as $133 (€109) when you book in advance. The average bus ticket price for Indianapolis, IN to San Francisco, CA is $363 (€297) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Indianapolis, IN to San Francisco, CA is 52h 0m to travel the 1944 miles (3130 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Indianapolis, IN to San Francisco, CA leaves at 3:15 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Indianapolis, IN to San Francisco, CA leaves at 11:30 PM.
There are 10 buses a day from Indianapolis, IN to San Francisco, CA which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Indianapolis, IN to San Francisco, CA, you can count on Greyhound for the best way to get you to San Francisco, CA. You can also check all possible bus companies who offer a service between Indianapolis, IN and San Francisco, CA and compare the amenities they offer before buying a bus ticket.
A trip to San Francisco, CA from Indianapolis, IN is worth doing but not as a day trip with a journey time of 52h 0m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Indianapolis, IN to San Francisco, CA is July.
It's helpful to compare your options as there are 3 ways to travel between Indianapolis, IN and San Francisco, CA including taking a bus, train, and flight.
Yes, there are bathrooms on board the bus from Indianapolis, IN to San Francisco, CA for bus company Greyhound.
Yes, the following accessibility options are available when taking the bus from Indianapolis, IN to San Francisco, CA:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Some of the most interesting sights to explore in San Francisco, CA are:
- Golden Gate Bridge, an iconic suspension bridge offering panoramic views of the San Francisco Bay
- Alcatraz Island, a historic site featuring the infamous former prison and informative audio tours
- Fisherman's Wharf, a bustling waterfront area known for seafood, shops, and sea lions
- Golden Gate Park, a large urban park with gardens, museums, and recreational activities
- Chinatown, the oldest and one of the largest Chinatowns in North America, offering vibrant culture and cuisine.
The best things to do in San Francisco, CA include:
- Ride a cable car through the steep streets of San Francisco for a classic city experience
- Explore the vibrant murals and street art in the Mission District
- Visit the Exploratorium, an interactive science museum perfect for all ages
- Take a scenic walk along the Embarcadero, offering views of the Bay Bridge and access to the Ferry Building Marketplace
- Enjoy a wine tasting tour in nearby Napa Valley, a short drive from the city.
Whether you can cancel your bus ticket from Indianapolis, IN to San Francisco, CA depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Indianapolis, IN to San Francisco, CA.
Yes, the following luggage options are included when booking a bus ticket from Indianapolis, IN to San Francisco, CA:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from Indianapolis, IN to San Francisco, CA:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from Indianapolis, IN to San Francisco, CA.
You can reserve your seat on the bus from Indianapolis, IN to San Francisco, CA with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from Indianapolis, IN to San Francisco, CA with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from Indianapolis, IN to San Francisco, CA with the following bus company: Greyhound.
Since neither Indianapolis, IN nor San Francisco, CA are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the train as it is the most popular way to get from Indianapolis, IN to San Francisco, CA among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In San Francisco, travelers should be cautious of pickpocketing and petty theft, especially in crowded areas like Fisherman's Wharf and Union Square. Common scams include distraction techniques used by groups to steal wallets and fake charity solicitations. It's advisable to avoid poorly lit or isolated areas at night and be wary of unofficial taxi services to ensure safety.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Indianapolis, IN to San Francisco, CA
Most Indianapolis, IN to San Francisco, CA buses use the Indianapolis, Illinois St (Greyhound Bus Station) to San Francisco, Transit Center Bay 29 station pair, with some services arriving at San Francisco, Townsend Street / 5th Street. Use this guide to compare Indianapolis, IN and San Francisco, CA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Indianapolis
Arrival bus stations in San Francisco
Indianapolis, E Washington St / N Delaware St (City/County Building)
Indianapolis, Illinois St (Greyhound Bus Station)
San Francisco, Transit Center Bay 29
City-centre transport
Getting to San Francisco, Transit Center Bay 29 from San Francisco city centre
Bus397 · 8m · $2
14, 14R · 13m · $2 · every ~30 min
101, 120 · 14m · $6 · every ~9 min
7 · 21m · $2 · every ~10 min
SubwayYellow-N, Green-N, Red-N, Blue-N · 10m · $2 · every ~27 min
San Francisco, Townsend Street / 5th StreetSan Francisco Bus Station,401 Townsend St,94107
City-centre transport
Getting to San Francisco, Townsend Street / 5th Street from San Francisco city centre
BusEast, West · 20m · every ~4 min
Nbus, Nowl · 24m · $2 · every ~2 min
TramN · 23m · $2 · every ~11 min
Most popular bus connections from Indianapolis, IN
More options for your journey from Indianapolis, IN to San Francisco, CA
Here are some other resources that might have the information you need
Most popular buses to and from San Francisco, CA and Indianapolis, IN
Most popular bus connections to San Francisco, CA
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