2,000+ travel companies
2,000+ travel companies
Scan to get our free app
Use our app to get live travel updates and book mobile tickets for trains, buses, flights, and ferries.
App Store
4.942K ratings
Google Play
4.6136K reviews
The cheapest and fastest buses from Florence, SC to Louisville, KY
Showing times and prices for Jun 17
Cheapest price
$179
Average price
$179
Fastest journey
15 h 50 m
Average duration
15 h 50 m
Buses per day
1
Distance
702 km
Cheap tickets
The best way to find a cheap bus ticket from Florence, SC to Louisville, KY is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Florence, SC to Louisville, KY will cost around $179 if you buy it on the day, but the cheapest tickets can be found for only $179.
Fast buses
It's difficult to get from Florence, SC to Louisville, KY without transferring at least 2 times.
4:10 PM15h50Florence, SC8:00 AMLouisville, KY$1791One-way2 transfers
- 4:10 PM15h50Florence, SC8:00 AMLouisville, KY$1791One-way2 transfers
Travel Information
Compare bus for Florence, SC to Louisville, KY
Omio recommends booking the bus as it is the most popular option from Florence, SC to Louisville, KY among Omio's users. If you are prioritising price take the bus with prices starting from $137. For those with little time consider booking a bus which can get you there in 15h 25m. The ticket price range depends on the travel mode: a bus costs an average of $137, and a bus costs an average of $137.
Distance: 436 miles (702 km)
Compare bus with
Most popular Bus | Driving |
|---|---|
$191 Average price Cheapest | $112 Average price (fuel + tolls) |
15h 55m Average total duration Fastest 15h 25m Onboard + 30m Additional time* | 9h 0m Average total duration (door-to-door) |
 Most popular bus company | Your own car or car rental |
Direct Options | Direct Options |
The cheapest way to travel from Florence, SC to Louisville, KY is a bus with an average price of $191 (€155).
The fastest way to travel from Florence, SC to Louisville, KY is by bus with an average journey time of 15h 25m.
Yes, you can take a bus between Florence, SC and Louisville, KY.
We recommend using the bus as it is the most popular way to get from Florence, SC to Louisville, KY among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Florence, SC to Louisville, KY Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound USA | Departure Time 04:10PM | Arrival Time 08:00AM | Duration 15h50 | Departure days Tue, Wed, Thu | Cheapest price $179 |
Operator FlixBus | Departure Time 04:55PM | Arrival Time 09:40AM | Duration 16h45 | Departure days Sun | Cheapest price $137 |
Operator Greyhound | Departure Time 08:10PM | Arrival Time 01:35PM | Duration 17h25 | Departure days Mon, Fri | Cheapest price $183 |
Operator Greyhound | Departure Time 08:30PM | Arrival Time 11:20PM | Duration 26h50 | Departure days Fri | Cheapest price $168 |
Operator Greyhound | Departure Time 09:30PM | Arrival Time 12:20AM | Duration 26h50 | Departure days Fri | Cheapest price $228 |
Live departures
Florence, SC to Louisville, KY bus times
The table below shows live departures for Florence, SC to Louisville, KY buses for today, Tuesday, June 16. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 4:10 PM Florence, SC | 15h50 | 8:00 AM Louisville, KY | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Florence, SC to Louisville, KY by bus
Compare bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Wed
Jun 17
Jun 17
Thu
Jun 18
Jun 18
Fri
Jun 19
Jun 19
Sat
Jun 20
Jun 20
Sun
Jun 21
Jun 21
Mon
Jun 22
Jun 22
Tue
Jun 23
Jun 23
Why should you book Florence, SC to Louisville, KY buses with Omio?
FlixBus as well as Greyhound offer buses services from Florence, SC to Louisville, KY.
Omio is an official ticket reseller for all your travel options from Florence, SC to Louisville, KY.
Why book with Omio vs FlixBus?
- Compare with other providers: On Omio, you can not only buy tickets for FlixBus, but also compare tickets for the likes of Greyhound to find the best option for your trip from Florence, SC to Louisville, KY.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
Why book with Omio over Wanderu or Trainline?
- Compare with other providers: On Omio, you can also compare tickets for the likes of Greyhound to find the best option for your trip from Florence, SC to Louisville, KY.
Journey information
Overview: Bus from Florence, SC to Louisville, KY
USAUSA
Buses from Florence, SC to Louisville, KY run on average 3 times per day, taking around 15h 25m. Cheap bus tickets for this journey start at $137 (€111) if you book in advance.
The earliest bus runs at 01:35, the last at 22:55. The fastest bus covers the 436 miles (702 km) distance in 16h 45m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 436 miles (702 km) |
Average bus duration 15h 25m |
Cheapest ticket price $137 (€111) |
Buses per day 3 |
Fastest bus 16h 45m |
First bus 1:35 AM |
Last bus 10:55 PM |
Cheapest Month Dec |
Cheapest Day Thu |
High Season Apr - Jun |
Low Season Jul - Sep |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: FlixBus, Greyhound from Florence, SC to Louisville, KYYou can travel by bus between Florence, SC to Louisville, KY with FlixBus, Greyhound for as low as $137 (€111). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average Duration
16h 45m
Cheapest Price
$137 (€111)
FlixBus frequency
1 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
17h 25m
Cheapest Price
$168 (€136)
Greyhound frequency
3 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
FAQs: Bus from Florence, SC to Louisville, KY
Find answers to the most common questions about traveling from Florence, SC to Louisville, KY by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Louisville, KY, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Florence, SC to Louisville, KY can start from as little as $137 (€111) when you book in advance. The average bus ticket price for Florence, SC to Louisville, KY is $191 (€155) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Florence, SC to Louisville, KY is 16h 45m to travel the 436 miles (702 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Florence, SC to Louisville, KY leaves at 1:35 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Florence, SC to Louisville, KY leaves at 10:55 PM.
There are 3 buses a day from Florence, SC to Louisville, KY which require at least one change with FlixBus, Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Florence, SC to Louisville, KY, you can count on FlixBus, Greyhound for the best way to get you to Louisville, KY. You can also check all possible bus companies who offer a service between Florence, SC and Louisville, KY and compare the amenities they offer before buying a bus ticket.
A trip to Louisville, KY from Florence, SC is worth doing but not as a day trip with a journey time of 16h 45m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Florence, SC to Louisville, KY is December.
Yes, you can take a bus between Florence, SC and Louisville, KY.
Yes, the following accessibility options are available when taking the bus from Florence, SC to Louisville, KY:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Florence, SC to Louisville, KY for bus company FlixBus, Greyhound.
Whether you can cancel your bus ticket from Florence, SC to Louisville, KY depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company FlixBus, Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Florence, SC to Louisville, KY.
Yes, the following luggage options are included when booking a bus ticket from Florence, SC to Louisville, KY:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Florence, SC to Louisville, KY:
- Greyhound
- $15 per additional bag.
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Florence, SC to Louisville, KY. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from Florence, SC to Louisville, KY with the following bus company: FlixBus, Greyhound
Yes, there are USB plugs on board the bus from Florence, SC to Louisville, KY with the following bus company: FlixBus, Greyhound.
Yes, there is Wifi on board the bus from Florence, SC to Louisville, KY with the following bus company: FlixBus, Greyhound.
Since neither Florence, SC nor Louisville, KY are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the bus as it is the most popular way to get from Florence, SC to Louisville, KY among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Louisville, KY, travelers should be cautious of pickpocketing and petty theft, especially in crowded areas like downtown and around popular attractions. Scams involving overcharging by taxi or ride-share drivers can occur, so using reputable services and confirming fares upfront is advised. Travelers should also be aware of distracted driver risks and practice standard safety precautions at night. Staying vigilant and securing personal belongings helps ensure a safe visit.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Florence, SC to Louisville, KY
Florence
Louisville
The major bus station for departures in Florence is Florence, S Irby St (Greyhound Bus Stop). Find all the information you need to know about services, amenities and connections at Florence, S Irby St (Greyhound Bus Stop) for your trip from Florence to Louisville.
Florence, S Irby St (Greyhound Bus Stop)
information
The major bus station for arrivals in Louisville is Louisville, W Broadway (Greyhound Bus Station). Find all the information you need to know about services, amenities and connections at Louisville, W Broadway (Greyhound Bus Station) for your trip to Louisville from Florence.
Louisville, W Broadway (Greyhound Bus Station)
information
Most popular bus connections from Florence, SC
More options for your journey from Florence, SC to Louisville, KY
Here are some other resources that might have the information you need
Most popular buses to and from Louisville, KY and Florence, SC
Most popular bus connections to Louisville, KY
The Omio App Makes Travel Planning Easy
We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.
