The cheapest and fastest buses from Florence, SC to New Orleans, LA
Cheapest price
$315
Average price
$323
Fastest journey
20 h 30 m
Average duration
20 h 58 m
Buses per day
2
Distance
1079 km
The best way to find a cheap bus ticket from Florence, SC to New Orleans, LA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Florence, SC to New Orleans, LA will cost around $323 if you buy it on the day, but the cheapest tickets can be found for only $315.
It's difficult to get from Florence, SC to New Orleans, LA without transferring at least once.




Travel Information
Compare bus and train for Florence, SC to New Orleans, LA
Omio recommends booking the train as it is the most popular option from Florence, SC to New Orleans, LA among Omio's users. If you are prioritising price take the bus with prices starting from €126. For those with little time consider booking a bus which can get you there in 22h 2m. The ticket price range depends on the travel mode: a bus costs an average of €126, and a train costs an average of €300.
Distance: 670 miles (1079 km)
Compare bus with
| Bus | Most popular Train |
|---|---|
€140 Average price Cheapest | €301 Average price |
22h 32m Average total duration Fastest 22h 2m Onboard + 30m Additional time* | 35h 48m Average total duration 35h 18m Onboard + 30m Additional time* |
Direct Options | Direct Options |
Florence, SC to New Orleans, LA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 05:45AM | Arrival Time 05:30AM | Duration 24h45 | Departure days Thu, Fri | Cheapest price $129 |
Operator Greyhound | Departure Time 11:55AM | Arrival Time 05:30AM | Duration 18h35 | Departure days Thu, Fri | Cheapest price $113 |
Operator Greyhound | Departure Time 04:10PM | Arrival Time 08:35AM | Duration 17h25 | Departure days Thu, Fri | Cheapest price $114 |
Operator Greyhound | Departure Time 04:30PM | Arrival Time 04:55PM | Duration 25h25 | Departure days Thu, Fri | Cheapest price $118 |
Live departures
Florence, SC to New Orleans, LA bus times
The table below shows live departures for Florence, SC to New Orleans, LA buses for tomorrow, Wednesday, February 4. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 8:05 AM Florence, SC | 21h25 | 5:30 AM New Orleans, LA | 1 transfer | |
![]() | 12:10 PM Florence, SC | 20h30 | 8:40 AM New Orleans, LA | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Florence, SC to New Orleans, LA by bus or train
Compare bus and train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Feb 04
Feb 05
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Feb 10
Journey information
Overview: Bus from Florence, SC to New Orleans, LA
Buses from Florence, SC to New Orleans, LA run on average 3 times per day, taking around 22h 2m. Cheap bus tickets for this journey start at $159 (€126) if you book in advance.
The earliest bus runs at 05:20, the last at 21:10. The fastest bus covers the 670 miles (1079 km) distance in 20h 40m.
Distance 670 miles (1079 km) |
Average bus duration 22h 2m |
Cheapest ticket price $159 (€126) |
Buses per day 3 |
Fastest bus 20h 40m |
First bus 05:20 |
Last bus 21:10 |
Bus providers: Southeastern Stages from Florence, SC to New Orleans, LAYou can travel by bus between Florence, SC to New Orleans, LA with Southeastern Stages for as low as $159 (€126). When you search for schedules and tickets, Omio will show you the best journey
Southeastern Stages
FAQs: Bus from Florence, SC to New Orleans, LA
Find answers to the most common questions about traveling from Florence, SC to New Orleans, LA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at New Orleans, LA, this guide helps you travel smarter and with confidence.

- French Quarter, a historic district known for its vibrant nightlife, colorful buildings, and rich cultural heritage
- Jackson Square, a historic park in the heart of the French Quarter surrounded by iconic landmarks and street performers
- St. Louis Cathedral, a stunning example of French Gothic architecture and the oldest continuously active Roman Catholic cathedral in the United States
- Garden District, a picturesque neighborhood famous for its well-preserved antebellum mansions and lush gardens
- National WWII Museum, an extensive museum offering immersive exhibits and artifacts detailing the American experience in World War II.
- Preservation Hall, enjoy traditional New Orleans jazz performances in an intimate and historic setting
- Audubon Park, relax in this beautiful urban park featuring walking paths, a zoo, and a golf course
- Frenchmen Street, experience the vibrant music scene with live performances in numerous bars and clubs
- Steamboat Natchez, take a scenic cruise along the Mississippi River on an authentic paddlewheel steamboat
- City Park, explore this expansive park with botanical gardens, an art museum, and outdoor activities.
popular bus stations
Popular bus stations from Florence, SC to New Orleans, LA
Most popular bus connections from Florence, SC
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