- Must visit
Everson Museum of Art
Major regional museum covering art, science, and history. Best known for broad collections, family appeal, and exhibits on Central New York.
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Travel Information
Compare train and bus for Florence, SC to Syracuse, NY
Omio recommends booking the bus as it is the most popular option from Florence, SC to Syracuse, NY among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $178 For those with little time, consider booking a bus, which has an average total journey time of 22h 37m. Average ticket prices depend on the travel mode: a bus costs an average of $178, while a bus costs an average of $178.
Distance: 641 miles (1033 km)
Compare bus with
Most popular Bus | Driving |
|---|---|
$178 Average price Cheapest | $157 Average price (fuel + tolls) |
22h 37m Average total duration Fastest 22h 7m Onboard + 30m Additional time* | 11h 37m Average total duration (door-to-door) |
 Most popular bus company | Your own car or car rental |
Direct Options | Direct Options |
The cheapest way to travel from Florence, SC to Syracuse, NY is a bus with an average price of $178 (€144).
The fastest way to travel from Florence, SC to Syracuse, NY is by bus with an average journey time of 22h 7m.
It's helpful to compare your options as there are 2 ways to travel between Florence, SC and Syracuse, NY including taking a train and bus.
We recommend using the train as it is the most popular way to get from Florence, SC to Syracuse, NY among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.
Tickets start at around $178 (€144) compared to roughly $157 (€128) in fuel and tolls — a saving of about $-20.58 (€-16.75). The journey takes 22h 7m versus 11h 37m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
Florence, SC to Syracuse, NY Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 12:05AM | Arrival Time 08:10PM | Duration 20h05 | Departure days Fri, Sat | Cheapest price $134 |
Operator Greyhound | Departure Time 05:45AM | Arrival Time 01:35PM | Duration 31h50 | Departure days Fri | Cheapest price $117 |
Compare prices and tickets Florence, SC to Syracuse, NY by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Bus from Florence, SC to Syracuse, NY
USAUSA
Buses from Florence, SC to Syracuse, NY run on average 2 times per day, taking around 22h 7m. Cheap bus tickets for this journey start at $135 (€110) if you book in advance.
The earliest bus runs at 00:05, the last at 21:00. The fastest bus covers the 641 miles (1033 km) distance in 17h 40m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 641 miles (1033 km) |
Average bus duration 22h 7m |
Cheapest ticket price $135 (€110) |
Buses per day 2 |
Fastest bus 17h 40m |
First bus 12:05 AM |
Last bus 9:00 PM |
Cheapest Month Nov |
Cheapest Day Fri |
High Season Jul - Sep |
Low Season Oct - Dec |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound, FlixBus from Florence, SC to Syracuse, NYYou can travel by bus between Florence, SC to Syracuse, NY with Greyhound, FlixBus for as low as $135 (€110). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average FlixBus Duration
17h 40m
Cheapest FlixBus Price
$162 (€132)
FlixBus frequency
1 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
24h 45m
Cheapest Greyhound Price
$135 (€110)
Greyhound frequency
1 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Syracuse, NY
Things to do in Syracuse, NY
Discover the best of Syracuse, NY — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Syracuse, NY trip today.
- Must visit
Erie Canal Museum
Historic house museum preserving nineteenth-century Syracuse domestic life. Worth visiting for period rooms and insight into early city society.
- Recommended
Museum of Science and Technology
Interactive museum focused on science and technology, famous for hands-on exhibits and domed IMAX theater. Great for families and curious visitors.
- Must visit
Clinton Square
Historic downtown square and year-round gathering place, known for festivals, fountains, and winter skating. A central stop for city atmosphere.
- Must visit
Onondaga Lake Park
Scenic waterfront park with long trails, lake views, and birdlife. Popular for walking, cycling, and relaxing near Syracuse's restored shoreline.
- Must visit
Armory Square
Compact downtown district filled with galleries, murals, and restored warehouse buildings. Best explored on foot for arts culture and architecture.
- Vegetarian
- Gluten-free
Salt Potatoes
Salt potatoes are small potatoes boiled in heavily salted water, creating a crusty skin and creamy center. They are a Central New York summer staple, often served with butter.
Chicken Riggies
Chicken riggies is a spicy Utica pasta dish popular across Central New York, made with chicken, rigatoni, peppers, and a creamy tomato sauce.
Utica Greens
Utica greens are escarole sautéed with hot peppers, garlic, breadcrumbs, and often prosciutto. This Italian American side is beloved throughout the Syracuse area.
Columbus Bakery
Long running market cafe and bakery known for tomato pie, sandwiches, pastries, and a classic Syracuse neighborhood feel.
Pastabilities
Established Italian restaurant known for homemade pasta, regional Italian American dishes, and a polished but welcoming atmosphere.
Eden
Upscale downtown dining with seasonal American cuisine, thoughtful plating, and a refined setting popular for special occasions.
United States Dollar ($)
Moderate for a U.S. city. Hotels are often cheaper than NYC, dining is mid-priced, and most visitors need a car or rideshares as transit is limited.
Average meal costs
- Budget
- $10-15 for fast food or casual lunch.
- Mid-range
- $18-35 per person for a restaurant meal.
- Fine dining
- $50+ per person for upscale dining.
- Coffee
- $3-5 for coffee or cappuccino.
Tipping culture
Tip 18-20% at restaurants, $1-2 per drink at bars, and 10-15% for taxis. Cafes often have tip jars or screen prompts for small tips.
FAQs: Bus from Florence, SC to Syracuse, NY
Find answers to the most common questions about traveling from Florence, SC to Syracuse, NY by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Syracuse, NY, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Florence, SC to Syracuse, NY can start from as little as $135 (€110) when you book in advance. The average bus ticket price for Florence, SC to Syracuse, NY is $178 (€144) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Florence, SC to Syracuse, NY is 17h 40m to travel the 641 miles (1033 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Florence, SC to Syracuse, NY leaves at 12:05 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Florence, SC to Syracuse, NY leaves at 9:00 PM.
There are 2 buses a day from Florence, SC to Syracuse, NY which require at least one change with Greyhound, FlixBus. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Florence, SC to Syracuse, NY, you can count on Greyhound, FlixBus for the best way to get you to Syracuse, NY. You can also check all possible bus companies who offer a service between Florence, SC and Syracuse, NY and compare the amenities they offer before buying a bus ticket.
Passengers board the bus most frequently from Florence, W Lucas St (TA Gas Station), SC, which is located around 3 miles (6 km) away from the city centre, and they get off the bus at Syracuse, Walsh Cir (Syracuse Bus Station), NY, located 3 away from the city centre.
A trip to Syracuse, NY from Florence, SC is worth doing but not as a day trip with a journey time of 17h 40m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Florence, SC to Syracuse, NY is November.
It's helpful to compare your options as there are 2 ways to travel between Florence, SC and Syracuse, NY including taking a train and bus.
Yes, the following accessibility options are available when taking the bus from Florence, SC to Syracuse, NY:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Florence, SC to Syracuse, NY for bus company Greyhound, FlixBus.
Whether you can cancel your bus ticket from Florence, SC to Syracuse, NY depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company Greyhound, FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Florence, SC to Syracuse, NY.
Yes, the following luggage options are included when booking a bus ticket from Florence, SC to Syracuse, NY:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Florence, SC to Syracuse, NY:
- Greyhound
- $15 per additional bag.
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Florence, SC to Syracuse, NY. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from Florence, SC to Syracuse, NY with the following bus company: Greyhound, FlixBus
Yes, there are USB plugs on board the bus from Florence, SC to Syracuse, NY with the following bus company: Greyhound, FlixBus.
Yes, there is Wifi on board the bus from Florence, SC to Syracuse, NY with the following bus company: Greyhound, FlixBus.
Since neither Florence, SC nor Syracuse, NY are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the bus as it is the most popular way to get from Florence, SC to Syracuse, NY among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Syracuse, NY, travelers should be cautious of pickpocketing and vehicle break-ins, especially in crowded areas and parking lots. Common scams include overcharging by taxis or ride services and fraudulent ticket sales for local events. It's advisable to use authorized transportation providers and remain vigilant when handling cash or personal belongings.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Florence, SC to Syracuse, NY
Most Florence, SC to Syracuse, NY buses use the Florence, W Lucas St (TA Gas Station) to Syracuse, Walsh Cir (Syracuse Bus Station) station pair. Use this guide to compare Florence, SC and Syracuse, NY bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Florence
Arrival bus stations in Syracuse
Which Florence, SC station do buses to Syracuse, NY leave from?
Buses from Florence, SC to Syracuse, NY leave from Florence, W Lucas St (TA Gas Station). The station is 3 miles (6 km) from Florence, SC city centre at Florence, SC, USA.
Florence, W Lucas St (TA Gas Station)Florence, SC, USA
City-centre transport
Getting to Florence, W Lucas St (TA Gas Station) from Florence city centre
Florence, W Lucas St (TA Gas Station) is 6 km from Florence city centre. Public transport options include:
TRUE
Florence, W Lucas St (TA Gas Station) bus station facilities and services
Florence, W Lucas St (TA Gas Station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Food and snacks available at the gas station.
Wi-Fi and ATMs
Wi-Fi is available at Florence, W Lucas St (TA Gas Station). ATMs are available at Florence, W Lucas St (TA Gas Station).
Tickets and information
Ticket office support is available at Florence, W Lucas St (TA Gas Station).
Parking, taxis and toilets
Available at Florence, W Lucas St (TA Gas Station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Florence, W Lucas St (TA Gas Station): Basic accessibility features available.
Which Syracuse, NY station do buses from Florence, SC arrive at?
Buses from Florence, SC to Syracuse, NY arrive at Syracuse, Walsh Cir (Syracuse Bus Station). Syracuse, Walsh Cir (Syracuse Bus Station) is 2 miles (4 km) from Syracuse, NY city centre.
Syracuse, Walsh Cir (Syracuse Bus Station)Syracuse, 1 Walsh Circle Ste 30, Syracuse, NY 13208, USA
City-centre transport
Getting to Syracuse, Walsh Cir (Syracuse Bus Station) from Syracuse city centre
Syracuse, Walsh Cir (Syracuse Bus Station) is 3 km from Syracuse city centre. Public transport options include:
TRUE
Syracuse, Walsh Cir (Syracuse Bus Station) bus station facilities and services
Syracuse, Walsh Cir (Syracuse Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Free Wi-Fi available throughout the station. ATMs are aTMs are located near the entrance.
Tickets and information
Ticket office support is available at Syracuse, Walsh Cir (Syracuse Bus Station).
Parking, taxis and toilets
Available at Syracuse, Walsh Cir (Syracuse Bus Station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Syracuse, Walsh Cir (Syracuse Bus Station): The station is wheelchair accessible.
Most popular bus connections from Florence, SC
More options for your journey from Florence, SC to Syracuse, NY
Here are some other resources that might have the information you need
Most popular buses to and from Syracuse, NY and Florence, SC
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