- Must visit
Cummer Museum of Art & Gardens
Major art museum with American and European works, a notable sculpture garden, and one of Jacksonville's top cultural stops.
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Travel Information
Compare bus and train for Florence, SC to Jacksonville, FL
Omio recommends booking the bus as it is the most popular option from Florence, SC to Jacksonville, FL among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $66 For those with little time, consider booking a bus, which has an average total journey time of 6h 22m. Average ticket prices depend on the travel mode: a bus costs an average of $66, while a train costs an average of $106.
Distance: 288 miles (465 km)
Compare bus with
Most popular Bus | Train |
|---|---|
$66 Average price Cheapest | $106 Average price |
6h 22m Average total duration Fastest 5h 52m Onboard + 30m Additional time* | 6h 32m Average total duration 6h 2m Onboard + 30m Additional time* |
 Most popular bus company |  Most popular train company |
Direct Options | Direct Options |
The cheapest way to travel from Florence, SC to Jacksonville, FL is a bus with an average price of $66.
This is compared to other travel options from Florence, SC to Jacksonville, FL:
A bus is $40 less than a train for this route with tickets for a train from Florence, SC to Jacksonville, FL costing on average $106.
The fastest way to travel from Florence, SC to Jacksonville, FL is by bus with an average journey time of 5h 52m.
Other travel options to Jacksonville, FL take longer:
Train takes on average 6h 2m.
It's helpful to compare your options as there are 2 ways to travel between Florence, SC and Jacksonville, FL including taking a bus and train.
We recommend using the bus as it is the most popular way to get from Florence, SC to Jacksonville, FL among Omio's users.
Why should you book Florence, SC to Jacksonville, FL buses with Omio?
FlixBus as well as Greyhound offer buses services from Florence, SC to Jacksonville, FL.
Omio is an official ticket reseller for all your travel options from Florence, SC to Jacksonville, FL.
Why book with Omio vs FlixBus?
- Compare with other providers: On Omio, you can not only buy tickets for FlixBus, but also compare tickets for the likes of Greyhound to find the best option for your trip from Florence, SC to Jacksonville, FL.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are bus and train to ensure you get the best deal for traveling from Florence, SC to Jacksonville, FL.
Why book with Omio over Wanderu or Trainline?
- Compare with other providers: On Omio, you can also compare tickets for the likes of Greyhound to find the best option for your trip from Florence, SC to Jacksonville, FL.
- Multiple modes of transport: Omio allows you to compare travel options including bus and train to find the ideal travel option from Florence, SC to Jacksonville, FL.
Journey information
Overview: Bus from Florence, SC to Jacksonville, FL
USAUSA
Buses from Florence, SC to Jacksonville, FL run on average 2 times per day, taking around 5h 52m. Cheap bus tickets for this journey start at $49 if you book in advance.
There are 2 buses per day. The earliest bus runs at 05:35, the last at 18:30. The fastest bus covers the 288 miles (465 km) distance in 5h 25m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 288 miles (465 km) |
Average bus duration 5h 52m |
Cheapest ticket price $49 |
Buses per day 2 |
Direct buses 2 |
Fastest bus 5h 25m |
First bus 5:35 AM |
Last bus 6:30 PM |
Cheapest Month Jul |
Cheapest Day Thu |
High Season Jul - Sep |
Low Season Jan - Mar |
Busiest Day Fri |
Least Busy Day Fri |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: FlixBus from Florence, SC to Jacksonville, FLYou can travel by bus between Florence, SC to Jacksonville, FL with FlixBus for as low as $49. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average FlixBus Duration
5h 25m
Cheapest FlixBus Price
$49
FlixBus frequency
2 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Complete guide to Jacksonville, FL
Things to do in Jacksonville, FL
Discover the best of Jacksonville, FL — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Jacksonville, FL trip today.
- Recommended
Museum of Science & History
Regional history museum covering Northeast Florida through engaging exhibits on city growth, culture, and key local events.
- Recommended
Museum of Contemporary Art Jacksonville
Contemporary art museum in the university district, presenting rotating exhibitions and thoughtful programs by living artists.
- Must visit
Northbank Riverwalk
Lively riverfront district with museums, restaurants nearby, public art, and one of Jacksonville's best skyline strolls.
- Must visit
Southbank Riverwalk
Scenic promenade across the river from downtown, ideal for walks, bridge views, and sunset photos along the Southbank.
- Recommended
Five Points
Creative historic neighborhood known for murals, local shops, nightlife, and a walkable mix of old Jacksonville character.
- Gluten-free
Mayport Shrimp
Mayport shrimp are local Atlantic shrimp, prized for their sweet flavor. They are a Jacksonville seafood staple, often served fried, grilled, or in baskets near the coast.
- Gluten-free
Low Country Boil
A Low Country boil with shrimp, sausage, corn, and potatoes reflects Northeast Florida’s coastal Southern cooking and is popular at casual local seafood spots.
- Gluten-free
Florida Oysters
Fresh local oysters from nearby Florida waters are served raw, baked, or chargrilled. They are a classic Jacksonville choice tied to the region’s seafood culture.
Safe Harbor Seafood Restaurant
Popular casual seafood restaurant in Mayport, best known for fresh local shrimp, fried seafood platters, and a laid-back dockside feel.
Ruth's Chris Steak House
Refined riverfront steakhouse known for prime steaks, seafood, and polished service in an upscale setting on the Southbank.
Blue Fish Restaurant and Oyster Bar
Established upscale seafood restaurant with an extensive wine list, elegant atmosphere, and strong reputation for fresh fish and fine dining.
US dollar ($)
Moderate for US beach cities. Hotels vary by season; meals and coffee are typical US prices, and most visitors need a car as transit is limited.
Average meal costs
- Budget
- $10-18 for fast food or casual takeout.
- Mid-range
- $20-40 per person for a restaurant meal.
- Fine dining
- $60+ per person for upscale restaurants.
- Coffee
- $3-6 for drip coffee or cappuccino.
Tipping culture
Tip 18-20% at restaurants, more for great service. Taxis usually get 10-15%. Cafes often use tip jars or screens; $1-2 is common.
FAQs: Bus from Florence, SC to Jacksonville, FL
Find answers to the most common questions about traveling from Florence, SC to Jacksonville, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Jacksonville, FL, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Florence, SC to Jacksonville, FL can start from as little as $49 when you book in advance. The average bus ticket price for Florence, SC to Jacksonville, FL is $66 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Florence, SC to Jacksonville, FL is 5h 25m to travel the 288 miles (465 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Florence, SC to Jacksonville, FL leaves at 5:35 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Florence, SC to Jacksonville, FL leaves at 6:30 PM.
Yes, there are 2 direct buses a day from Florence, SC to Jacksonville, FL with FlixBus. Schedules can vary on holidays or weekends with fewer direct buses.
When taking a bus from Florence, SC to Jacksonville, FL, you can count on FlixBus for the best way to get you to Jacksonville, FL. You can also check all possible bus companies who offer a service between Florence, SC and Jacksonville, FL and compare the amenities they offer before buying a bus ticket.
When departing from Florence, SC , you have various bus station options to start your journey from including Florence, S Irby St (Greyhound Bus Stop), SC, Florence, W Lucas St (TA Gas Station), SC . When arriving in Jacksonville, FL , you can end your journey in bus stations like Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St .Passengers board the bus most frequently from Florence, S Irby St (Greyhound Bus Stop), SC, which is located around away from the city centre, and they get off the bus at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St, located 1 away from the city centre.
A trip to Jacksonville, FL from Florence, SC is worth doing but not as a day trip with a journey time of 5h 25m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Florence, SC to Jacksonville, FL is July.
It's helpful to compare your options as there are 2 ways to travel between Florence, SC and Jacksonville, FL including taking a bus and train.
Yes, the following accessibility options are available when taking the bus from Florence, SC to Jacksonville, FL:
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Florence, SC to Jacksonville, FL for bus company FlixBus.
Whether you can cancel your bus ticket from Florence, SC to Jacksonville, FL depends on the bus companies:
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Florence, SC to Jacksonville, FL.
Yes, the following luggage options are included when booking a bus ticket from Florence, SC to Jacksonville, FL:
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Florence, SC to Jacksonville, FL:
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Florence, SC to Jacksonville, FL. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from Florence, SC to Jacksonville, FL with the following bus company: FlixBus
Yes, there are USB plugs on board the bus from Florence, SC to Jacksonville, FL with the following bus company: FlixBus.
Yes, there is Wifi on board the bus from Florence, SC to Jacksonville, FL with the following bus company: FlixBus.
Since neither Florence, SC nor Jacksonville, FL are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the bus as it is the most popular way to get from Florence, SC to Jacksonville, FL among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Jacksonville, FL, travelers should be cautious of pickpocketing and vehicle break-ins, especially in crowded areas and popular tourist spots. Common scams include overcharging by unlicensed taxi or ride-share drivers and fake ticket sellers near attractions. Staying aware of surroundings, using reputable transportation services, and avoiding isolated areas at night can help ensure safety.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Florence, SC to Jacksonville, FL
Most Florence, SC to Jacksonville, FL buses use the Florence, S Irby St (Greyhound Bus Stop) to Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St station pair. Use this guide to compare Florence, SC and Jacksonville, FL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Florence
Arrival bus stations in Jacksonville
Which Florence, SC station do buses to Jacksonville, FL leave from?
Buses from Florence, SC to Jacksonville, FL leave from Florence, S Irby St (Greyhound Bus Stop). The station is 0 miles (1 km) from Florence, SC city centre at S Irby St, Florence, SC, USA.
Florence, S Irby St (Greyhound Bus Stop)S Irby St, Florence, SC, USA
City-centre transport
Getting to Florence, S Irby St (Greyhound Bus Stop) from Florence city centre
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Florence, S Irby St (Greyhound Bus Stop) bus station facilities and services
Florence, S Irby St (Greyhound Bus Stop) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Florence, S Irby St (Greyhound Bus Stop). ATMs are available at Florence, S Irby St (Greyhound Bus Stop).
Tickets and information
Ticket office support is available at Florence, S Irby St (Greyhound Bus Stop).
Parking, taxis and toilets
Available at Florence, S Irby St (Greyhound Bus Stop): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Florence, S Irby St (Greyhound Bus Stop): Bus stop accessible for disabled persons.
Florence, W Lucas St (TA Gas Station)Florence, SC, USA
City-centre transport
Getting to Florence, W Lucas St (TA Gas Station) from Florence city centre
Florence, W Lucas St (TA Gas Station) is 6 km from Florence city centre. Public transport options include:
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Florence, W Lucas St (TA Gas Station) bus station facilities and services
Florence, W Lucas St (TA Gas Station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Food and snacks available at the gas station.
Wi-Fi and ATMs
Wi-Fi is available at Florence, W Lucas St (TA Gas Station). ATMs are available at Florence, W Lucas St (TA Gas Station).
Tickets and information
Ticket office support is available at Florence, W Lucas St (TA Gas Station).
Parking, taxis and toilets
Available at Florence, W Lucas St (TA Gas Station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Florence, W Lucas St (TA Gas Station): Basic accessibility features available.
Which Jacksonville, FL station do buses from Florence, SC arrive at?
Buses from Florence, SC to Jacksonville, FL arrive at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St. Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St is 1 miles (2 km) from Jacksonville, FL city centre.
Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St1111 W Forsyth St, Jacksonville, FL 32204, USA
City-centre transport
Getting to Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St from Jacksonville city centre
Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St is 1 km from Jacksonville city centre. Public transport options include:
Bus1, 11, 18, 205, 3, Nassau, St. Johns, Clay · 12m · $4 · every ~18 min
1, 19, 3 · 17m · $4 · every ~17 min
SubwaySky · 10m · every ~4 min
Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St bus station facilities and services
Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St. ATMs are available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St.
Tickets and information
Ticket office support is available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St.
Parking, taxis and toilets
Available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St: Wheelchair accessible entrances.
Most popular bus connections from Florence, SC
More options for your journey from Florence, SC to Jacksonville, FL
Here are some other resources that might have the information you need
Most popular buses to and from Jacksonville, FL and Florence, SC
Most popular bus connections to Jacksonville, FL
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