- Must visit
The Neon Museum
Outdoor museum preserving iconic Las Vegas signs, with guided visits through the Neon Boneyard. One of the city’s most distinctive cultural attractions.
Omio recommends booking the train as it is the most popular option from Florence, SC to Las Vegas, NV among Omio's users. If you are prioritising price take the bus with prices starting from $229. For those with little time consider booking a bus which can get you there in 61h 45m. The ticket price range depends on the travel mode: a bus costs an average of $229, and a train costs an average of $893.
Distance: 1991 miles (3205 km)
| Bus | Most popular Train | Driving |
|---|---|---|
$261 Average price Cheapest | $1420 Average price | $452 Average price (fuel + tolls) |
62h 15m Average total duration Fastest 61h 45m Onboard + 30m Additional time* | 79h 48m Average total duration 79h 18m Onboard + 30m Additional time* | 32h 33m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Florence, SC to Las Vegas, NV:
A bus is $1159 (€954) less than a train for this route with tickets for a train from Florence, SC to Las Vegas, NV costing on average $1420 (€1168).
Other travel options to Las Vegas, NV take longer:
Train takes on average 79h 18m.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 10:45AM | Arrival Time 01:50AM | Duration 63h05 | Departure days Thu | Cheapest price $229 |
Operator Greyhound | Departure Time 08:10PM | Arrival Time 08:35AM | Duration 60h25 | Departure days Tue | Cheapest price $292 |
Compare bus and train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Florence, SC to Las Vegas, NV run on average 7 times per day, taking around 61h 45m. Cheap bus tickets for this journey start at $229 (€188) if you book in advance.
The earliest bus runs at 00:35, the last at 22:32. The fastest bus covers the 1991 miles (3205 km) distance in 60h 25m.
Distance 1991 miles (3205 km) |
Average bus duration 61h 45m |
Cheapest ticket price $229 (€188) |
Buses per day 7 |
Fastest bus 60h 25m |
First bus 12:35 AM |
Last bus 10:32 PM |
Cheapest Month Feb |
Cheapest Day Thu |
High Season Jan - Mar |
Low Season Jul - Sep |
Discover the best of Las Vegas — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Las Vegas trip today.
Outdoor museum preserving iconic Las Vegas signs, with guided visits through the Neon Boneyard. One of the city’s most distinctive cultural attractions.
Officially the National Museum of Organized Crime and Law Enforcement, covering the history of organized crime and policing through immersive exhibits.
Family-friendly museum with dinosaur, marine life, and natural science exhibits. A solid local favorite away from the Strip.
The city’s central resort corridor, packed with major hotels, landmark attractions, and nonstop people-watching.
Pedestrian entertainment district in downtown Las Vegas with a huge LED canopy, live performances, and classic casino facades.
Popular desert landscape area west of the city, known for red rock views, short hikes, and a scenic driving loop.
A classic Las Vegas steakhouse staple, often served chilled with spicy cocktail sauce and closely tied to the city’s old casino dining culture.
Slow-roasted beef carved thick and traditionally served in casino coffee shops and steakhouses, reflecting vintage Las Vegas dining traditions.
A longtime Las Vegas late-night special associated with casino cafes, valued for being hearty, affordable, and available around the clock.
Historic old-school steakhouse known for prime rib, classic tableside service, and a vintage Vegas atmosphere.
Widely known Thai restaurant celebrated for Northern Thai specialties and a long-established local reputation.
Busy casual favorite for Tijuana-style tacos, especially adobada, with a lively and fast-paced atmosphere.
Tourist areas are pricey, especially hotels, drinks, and dining. Good budget eats exist off the Strip, but overall costs run high for most visitors.
Tip 15-20% in restaurants and bars; USD 1-2 per drink. Taxis: 10-15%. Hotel staff: USD 2-5 for bags, USD 2-5 nightly for housekeeping. Valet: USD 2-5 when car is returned.
Find answers to the most common questions about traveling from Florence, SC to Las Vegas, NV by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Las Vegas, NV, this guide helps you travel smarter and with confidence.

Most Florence, SC to Las Vegas, NV buses use the Florence, S Irby St (Greyhound Bus Stop) to Las Vegas, S Las Vegas Blvd (Forever 21) station pair, with some services arriving at Las Vegas, 1st St (Downtown). Use this guide to compare Florence, SC and Las Vegas, NV bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
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