- Must visit
National Air and Space Museum
This world-class museum presents aviation and space history through iconic aircraft, spacecraft, and hands-on science exhibits.
The best way to find a cheap bus ticket from Florence, SC to Washington, DC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Florence, SC to Washington, DC will cost around $154 if you buy it on the day, but the cheapest tickets can be found for only $154.
On Tue, Nov 03, we found 1 buses from Florence, SC to Washington, DC, including 1 direct services.
On Tue, Nov 03 the direct buses cover the 576 km distance in an average of 9 h 25 m but if you time it right, some buses will get you there in just 9 h 25 m .
On Tue, Nov 03 the slowest buses will take 9 h 25 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

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Buses from Florence, SC to Washington, DC run on average 1 times per day, taking around 8h 17m. Cheap bus tickets for this journey start at $66 if you book in advance.
There are 1 buses per day. The earliest bus runs at 00:05, the last at 22:10. The fastest bus covers the 357 miles (576 km) distance in 7h 15m.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Florence, SC to Washington, DC.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 12:05AM | Arrival Time 08:15AM | Duration 8h10 | Departure days Mon, Sat, Sun | Cheapest price $79 |
Operator Greyhound | Departure Time 08:30PM | Arrival Time 05:55AM | Duration 9h25 | Departure days Tue, Wed, Thu, Fri | Cheapest price $101 |
Operator Greyhound | Departure Time 09:30PM | Arrival Time 06:55AM | Duration 9h25 | Departure days Thu, Fri | Cheapest price $75 |
Buses from Florence, SC to Washington, DC with FlixBus and Greyhound. Overnight buses available on this route with FlixBus and Greyhound. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Washington, DC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Washington, DC trip today.
This world-class museum presents aviation and space history through iconic aircraft, spacecraft, and hands-on science exhibits.
Housed in a Beaux-Arts building, this museum explores natural wonders with dinosaurs, gems, fossils, and global biodiversity.
A landmark museum documenting African American history and culture through powerful exhibitions, artifacts, and storytelling.
The National Mall is Washington's grand civic promenade, lined with museums, memorials, and classic views ideal for first-time visitors.
Georgetown charms with historic streets, rowhouses, waterfront paths, and independent shops that make it one of the city's best walking areas.
The Tidal Basin loop offers famous cherry blossoms, water views, and easy access to several of Washington's most iconic memorials.
Half-smoke sausage, usually smoked pork and beef, served on a bun with chili, mustard, and onions. It is DC's signature street food, strongly tied to Ben's Chili Bowl.
Jumbo slice is an oversized late-night pizza slice popular in Adams Morgan. It is a recognizable DC nightlife food known for its huge foldable portions.
Mumbo sauce is a sweet tangy red sauce commonly served with fried chicken and wings at DC carryouts. It is a beloved local condiment with roots in Black DC food culture.
Acclaimed fine-dining restaurant focused on Mid-Atlantic ingredients and refined tasting menus in an elegant, contemporary dining room.
Polished seafood institution at the municipal fish market, best known for regional oysters, crab cakes, and classic Chesapeake flavors.
Historic casual landmark famous for half-smokes, chili, and a classic diner feel. A must for trying DC's best-known street food tradition.
DC is pricier than many US cities. Hotels and dining run high in central areas, but Metro and many free museums help balance daily travel costs.
Tip 18-20% at restaurants, more for great service. Taxis usually 10-15%. Cafes: round up or add $1-2.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Washington, DC.
Find answers to the most common questions about traveling from Florence, SC to Washington, DC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Washington, DC, this guide helps you travel smarter and with confidence.

Most Florence, SC to Washington, DC buses use the Florence, W Lucas St (TA Gas Station) to Washington, Columbus Circle, Union Station station pair. Use this guide to compare Florence, SC and Washington, DC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Florence, W Lucas St (TA Gas Station) is 6 km from Florence city centre. Public transport options include:
Florence, W Lucas St (TA Gas Station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Food and snacks available at the gas station.
Wi-Fi is available at Florence, W Lucas St (TA Gas Station). ATMs are available at Florence, W Lucas St (TA Gas Station).
Ticket office support is available at Florence, W Lucas St (TA Gas Station).
Available at Florence, W Lucas St (TA Gas Station): Parking, Taxis, WC.
Accessibility facilities are available at Florence, W Lucas St (TA Gas Station): Basic accessibility features available.
Florence, S Irby St (Greyhound Bus Stop) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Florence, S Irby St (Greyhound Bus Stop). ATMs are available at Florence, S Irby St (Greyhound Bus Stop).
Ticket office support is available at Florence, S Irby St (Greyhound Bus Stop).
Available at Florence, S Irby St (Greyhound Bus Stop): Parking, Taxis, WC.
Accessibility facilities are available at Florence, S Irby St (Greyhound Bus Stop): Bus stop accessible for disabled persons.
Washington, Columbus Circle, Union Station is 2 km from Washington city centre. Public transport options include:
Washington, Columbus Circle, Union Station has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: McDonald's (in the station), Shake Shack (in the station)
Free Wi-Fi. ATMs are located near the main entrance and food court.
Ticket office support is available at Washington, Columbus Circle, Union Station.
Available at Washington, Columbus Circle, Union Station: Parking, Taxis, WC.
Accessibility facilities are available at Washington, Columbus Circle, Union Station: Elevators, ramps.
Check bus stations information for Florence, SC and Washington, DC, including where buses depart and arrive on this route.