- Must visit
Art Institute of Chicago
World-class art museum with masterpieces from Monet to Hopper and the famous Modern Wing.
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The cheapest and fastest buses from Florence, SC to Chicago, IL
Showing times, prices and bookable tickets for Sep 19
Cheapest price on Sep 19
€105
Average ticket price on Sep 19
€112
Fastest journey on Sep 19
1 d 3 h 15 m
Average journey duration on Sep 19
1 d 4 h 40 m
Buses on Sep 19
3
Distance
1095 km
Cheap tickets
The best way to find a cheap bus ticket from Florence, SC to Chicago, IL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Florence, SC to Chicago, IL will cost around €112 if you buy it on the day, but the cheapest tickets can be found for only €105.
Fast buses
It's difficult to get from Florence, SC to Chicago, IL without transferring at least 2 times.
FlixBus · FlixBus+
5:45 AM27h40Florence, W Lucas St (TA Gas Station), SC8:25 AMChicago, Greyhound Bus Station€1051One-way2 transfers- FlixBus · FlixBus+5:45 AM27h15Florence, W Lucas St (TA Gas Station), SC8:00 AMChicago, Union Station (Amtrak), IL€1051One-way2 transfers
- FlixBus · FlixBus+12:05 AM31h05Florence, W Lucas St (TA Gas Station), SC6:10 AMChicago, Greyhound Bus Station€1261One-way2 transfers
- FlixBus · FlixBus+5:45 AM27h15Florence, W Lucas St (TA Gas Station), SC8:00 AMChicago, Union Station (Amtrak), IL€1051One-way2 transfers
- FlixBus · FlixBus+5:45 AM27h40Florence, W Lucas St (TA Gas Station), SC8:25 AMChicago, Greyhound Bus Station€1051One-way2 transfers
- FlixBus · FlixBus+12:05 AM31h05Florence, W Lucas St (TA Gas Station), SC6:10 AMChicago, Greyhound Bus Station€1261One-way2 transfers
Travel Information
Compare train and bus for Florence, SC to Chicago, IL
Omio recommends booking the bus as it is the most popular option from Florence, SC to Chicago, IL among Omio's users. If you are prioritising price, take the bus, with an average ticket price of €146 For those with little time, consider booking a bus, which has an average total journey time of 25h 44m. Average ticket prices depend on the travel mode: a bus costs an average of €146, while a bus costs an average of €146.
Distance: 680 miles (1095 km)
Compare bus with
Most popular Bus | Driving |
|---|---|
€146 Average price Cheapest | €142 Average price (fuel + tolls) |
25h 44m Average total duration Fastest 25h 14m Onboard + 30m Additional time* | 13h 16m Average total duration (door-to-door) |
Most popular bus company | Your own car or car rental |
Direct Options | Direct Options |
The cheapest way to travel from Florence, SC to Chicago, IL is a bus with an average price of €146.
The fastest way to travel from Florence, SC to Chicago, IL is by bus with an average journey time of 25h 14m.
It's helpful to compare your options as there are 2 ways to travel between Florence, SC and Chicago, IL including taking a train and bus.
We recommend using the bus as it is the most popular way to get from Florence, SC to Chicago, IL among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.
Tickets start at around €146 compared to roughly €142 in fuel and tolls — a saving of about €-4.07. The journey takes 25h 14m versus 13h 16m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
Florence, SC to Chicago, IL Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 12:05AM | Arrival Time 06:10AM | Duration 31h05 | Departure days Mon, Fri, Sat, Sun | Cheapest price €98 |
Operator Greyhound | Departure Time 05:45AM | Arrival Time 08:00AM | Duration 27h15 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price €80 |
Operator Greyhound | Departure Time 03:55PM | Arrival Time 06:45PM | Duration 26h50 | Departure days Wed | Cheapest price €153 |
Operator FlixBus | Departure Time 08:30PM | Arrival Time 05:10AM | Duration 32h40 | Departure days Tue | Cheapest price €206 |
Live departures
Florence, SC to Chicago, IL bus times
The table below shows live departures for Florence, SC to Chicago, IL buses for today, Friday, September 18. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| FlixBus · FlixBus+ | 5:45 AM Florence, W Lucas St (TA Gas Station), SC | 27h40 | 8:25 AM Chicago, Greyhound Bus Station | 2 transfers | |
| FlixBus · FlixBus+ | 5:45 AM Florence, W Lucas St (TA Gas Station), SC | 27h15 | 8:00 AM Chicago, Union Station (Amtrak), IL | 2 transfers | |
| Saturday, September 19 | |||||
| FlixBus++FlixBus | 12:05 AM Florence, W Lucas St (TA Gas Station), SC | 31h05 | 6:10 AM Chicago, Greyhound Bus Station | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Florence, SC to Chicago, IL by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Sat
Sep 19
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Tue
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Sep 25
Why should you book Florence, SC to Chicago, IL buses with Omio?
Greyhound as well as FlixBus offer buses services from Florence, SC to Chicago, IL.
Omio is an official ticket reseller for all your travel options from Florence, SC to Chicago, IL.
Why book with Omio vs Greyhound?
- Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of FlixBus to find the best option for your trip from Florence, SC to Chicago, IL.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train and bus to ensure you get the best deal for traveling from Florence, SC to Chicago, IL.
Why book with Omio over Wanderu or Trainline?
- Compare with other providers: On Omio, you can also compare tickets for the likes of FlixBus to find the best option for your trip from Florence, SC to Chicago, IL.
- Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from Florence, SC to Chicago, IL.
Journey information
Overview: Bus from Florence, SC to Chicago, IL
USAUSA
Buses from Florence, SC to Chicago, IL run on average 3 times per day, taking around 25h 14m. Cheap bus tickets for this journey start at €96 if you book in advance.
The earliest bus runs at 00:05, the last at 23:15. The fastest bus covers the 680 miles (1095 km) distance in 23h 15m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 680 miles (1095 km) |
Average bus duration 25h 14m |
Cheapest ticket price €96 |
Buses per day 3 |
Fastest bus 23h 15m |
First bus 12:05 AM |
Last bus 11:15 PM |
Cheapest Month Jul |
Cheapest Day Sun |
High Season Jul - Sep |
Low Season Oct - Dec |
Busiest Day Tue |
Least Busy Day Tue |
Best time to book 3 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound, FlixBus from Florence, SC to Chicago, ILYou can travel by bus between Florence, SC to Chicago, IL with Greyhound, FlixBus for as low as €96. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average FlixBus Duration
27h 35m
Cheapest FlixBus Price
€117
FlixBus frequency
1 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
23h 15m
Cheapest Greyhound Price
€96
Greyhound frequency
2 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Chicago, IL
Things to do in Chicago, IL
Discover the best of Chicago, IL — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Chicago, IL trip today.
- Must visit
Field Museum
Major natural history museum with Sue the T. rex, ancient cultures, and strong family appeal.
- Must visit
Museum of Science and Industry
Hands-on science museum in a grand former fair building, popular for exhibits and a U-505 submarine.
- Must visit
Millennium Park
Lively lakefront park with Cloud Gate, Crown Fountain, gardens, and major public art in central Chicago.
- Must visit
Magnificent Mile
Famous shopping boulevard lined with architecture, hotels, riverfront views, and major city energy.
- Must visit
Chicago Riverwalk
Scenic pedestrian-friendly riverwalk with boat docks, public art, bridges, and standout skyline perspectives.
Deep-Dish Pizza
Deep-dish pizza is Chicago’s iconic pie with a tall buttery crust, layers of cheese and toppings, and chunky tomato sauce baked on top.
Chicago-Style Hot Dog
The Chicago-style hot dog is an all-beef frank on a poppy seed bun with mustard, relish, onion, tomato, pickle, peppers, and celery salt.
Italian Beef Sandwich
Italian beef is thin-sliced roast beef piled onto a roll, often dipped in savory juices and topped with sweet peppers or spicy giardiniera.
Johnnie's Beef
Classic spot for juicy Italian beef sandwiches, especially dipped and topped with spicy giardiniera, with a casual local feel.
Superdawg Drive-In
Legendary stand for Chicago-style hot dogs and char-grilled sausages, served fast in a no-frills local landmark.
Alinea
World-famous fine dining destination offering a highly creative tasting menu and refined service in an elegant setting.
US dollar ($)
Moderate for a major US city: hotels can be pricey, but transit is affordable and dining ranges from cheap eats to upscale options.
Average meal costs
- Budget
- $10-18 for fast food or casual takeout.
- Mid-range
- $20-40 per person for a restaurant meal.
- Fine dining
- $75+ per person for upscale restaurants.
- Coffee
- $3-6 for coffee or cappuccino.
Tipping culture
Tip 18-20% at restaurants, $1-2 per drink at bars, 10-15% for taxis, and optional small change at cafes.
FAQs: Bus from Florence, SC to Chicago, IL
Find answers to the most common questions about traveling from Florence, SC to Chicago, IL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Florence, SC to Chicago, IL can start from as little as €96 when you book in advance. The average bus ticket price for Florence, SC to Chicago, IL is €146 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Florence, SC to Chicago, IL is 23h 15m to travel the 680 miles (1095 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Florence, SC to Chicago, IL leaves at 12:05 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Florence, SC to Chicago, IL leaves at 11:15 PM.
There are 3 buses a day from Florence, SC to Chicago, IL which require at least one change with Greyhound, FlixBus. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Florence, SC to Chicago, IL, you can count on Greyhound, FlixBus for the best way to get you to Chicago, IL. You can also check all possible bus companies who offer a service between Florence, SC and Chicago, IL and compare the amenities they offer before buying a bus ticket.
When departing from Florence, SC , you have various bus station options to start your journey from including Florence, W Lucas St (TA Gas Station), SC . When arriving in Chicago, IL , you can end your journey in bus stations like Chicago, Greyhound Bus Station, Chicago, Union Station (Amtrak), IL .Passengers board the bus most frequently from Florence, W Lucas St (TA Gas Station), SC, which is located around 3 miles (6 km) away from the city centre, and they get off the bus at Chicago, Greyhound Bus Station, located 2 away from the city centre.
A trip to Chicago, IL from Florence, SC is worth doing but not as a day trip with a journey time of 23h 15m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Florence, SC to Chicago, IL is July.
It's helpful to compare your options as there are 2 ways to travel between Florence, SC and Chicago, IL including taking a train and bus.
Yes, the following accessibility options are available when taking the bus from Florence, SC to Chicago, IL:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Florence, SC to Chicago, IL for bus company Greyhound, FlixBus.
Some of the most interesting sights to explore in Chicago, IL are:
- Millennium Park, a public park known for its modern art installations and the iconic Cloud Gate sculpture
- Art Institute of Chicago, a renowned museum housing an extensive collection of art from around the world
- Navy Pier, a popular entertainment destination featuring rides, restaurants, and lakefront views
- Willis Tower Skydeck, an observation deck offering panoramic views of the city from one of the tallest buildings in the Western Hemisphere
- Field Museum, a natural history museum with vast exhibits including the famous T. rex skeleton, Sue.
The best things to do in Chicago, IL include:
- Museum of Science and Industry, an interactive museum featuring exhibits on science, technology, and industry
- Explore the vibrant neighborhoods of Chicago, such as Wicker Park and Lincoln Park, known for their unique shops and eateries
- Take a river cruise to see the city's iconic architecture from a different perspective
- Attend a live performance at the historic Chicago Theatre
- Enjoy a day at Lincoln Park Zoo, one of the oldest zoos in the U.S., offering free admission.
Whether you can cancel your bus ticket from Florence, SC to Chicago, IL depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company Greyhound, FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Florence, SC to Chicago, IL.
Yes, the following luggage options are included when booking a bus ticket from Florence, SC to Chicago, IL:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Florence, SC to Chicago, IL:
- Greyhound
- $15 per additional bag.
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Florence, SC to Chicago, IL. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from Florence, SC to Chicago, IL with the following bus company: Greyhound, FlixBus
Yes, there are USB plugs on board the bus from Florence, SC to Chicago, IL with the following bus company: Greyhound, FlixBus.
Yes, there is Wifi on board the bus from Florence, SC to Chicago, IL with the following bus company: Greyhound, FlixBus.
Since neither Florence, SC nor Chicago, IL are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the bus as it is the most popular way to get from Florence, SC to Chicago, IL among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Chicago, IL, travelers should be cautious of pickpocketing and purse snatching, especially in crowded areas like public transit and popular tourist spots. Common scams include fake charity solicitations and distraction thefts. It is advisable to stay alert in neighborhoods outside downtown after dark and use authorized transportation services to avoid unlicensed taxi scams. Keeping valuables secure and being aware of surroundings helps mitigate these risks.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Florence, SC to Chicago, IL
Most Florence, SC to Chicago, IL buses use the Florence, W Lucas St (TA Gas Station) to Chicago, Greyhound Bus Station station pair, with some services arriving at Chicago, Union Station (Amtrak). Use this guide to compare Florence, SC and Chicago, IL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Florence
Arrival bus stations in Chicago
Which Florence, SC station do buses to Chicago, IL leave from?
Buses from Florence, SC to Chicago, IL leave from Florence, W Lucas St (TA Gas Station). The station is 3 miles (6 km) from Florence, SC city centre at Florence, SC, USA.
Florence, W Lucas St (TA Gas Station)Florence, SC, USA
City-centre transport
Getting to Florence, W Lucas St (TA Gas Station) from Florence city centre
Florence, W Lucas St (TA Gas Station) is 6 km from Florence city centre. Public transport options include:
TRUE
Florence, W Lucas St (TA Gas Station) bus station facilities and services
Florence, W Lucas St (TA Gas Station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Food and snacks available at the gas station.
Wi-Fi and ATMs
Wi-Fi is available at Florence, W Lucas St (TA Gas Station). ATMs are available at Florence, W Lucas St (TA Gas Station).
Tickets and information
Ticket office support is available at Florence, W Lucas St (TA Gas Station).
Parking, taxis and toilets
Available at Florence, W Lucas St (TA Gas Station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Florence, W Lucas St (TA Gas Station): Basic accessibility features available.
Which Chicago, IL station do buses from Florence, SC arrive at?
Buses from Florence, SC to Chicago, IL most often arrive at Chicago, Greyhound Bus Station. Some services arrive at Chicago, Union Station (Amtrak), so check your ticket before travel to confirm your Chicago, IL arrival station.
Chicago, Greyhound Bus Station630 W Harrison St, Chicago, IL 60607, USA
City-centre transport
Getting to Chicago, Greyhound Bus Station from Chicago city centre
Chicago, Greyhound Bus Station is 2 km from Chicago city centre. Public transport options include:
Bus7 · 8m · €3 · every ~6 min
Chicago, Greyhound Bus Station bus station facilities and services
Chicago, Greyhound Bus Station has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Snack shop and vending machines available
Wi-Fi and ATMs
Free Wi-Fi in waiting area. ATMs are located near entrance.
Tickets and information
Ticket office support is available at Chicago, Greyhound Bus Station.
Parking, taxis and toilets
Available at Chicago, Greyhound Bus Station: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Chicago, Greyhound Bus Station: Wheelchair accessible entrances and seating.
Chicago, Union Station (Amtrak)Chicago Union Station, 225 S Canal St, Chicago, IL 60606, USA
City-centre transport
Getting to Chicago, Union Station (Amtrak) from Chicago city centre
Chicago, Union Station (Amtrak) is 3 km from Chicago city centre. Public transport options include:
Bus28, 151 · 7m · €3 · every ~13 min
Chicago, Union Station (Amtrak) bus station facilities and services
Chicago, Union Station (Amtrak) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Multiple dining options are available inside the station.
Wi-Fi and ATMs
Free Wi-Fi is available in waiting areas. ATMs are aTMs are located near the main entrance.
Tickets and information
Ticket office support is available at Chicago, Union Station (Amtrak).
Parking, taxis and toilets
Available at Chicago, Union Station (Amtrak): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Chicago, Union Station (Amtrak): Station is accessible with elevators and ramps.
Most popular bus connections from Florence, SC
More options for your journey from Florence, SC to Chicago, IL
Here are some other resources that might have the information you need
Most popular buses to and from Chicago, IL and Florence, SC
Most popular bus connections to Chicago, IL
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