The cheapest and fastest buses from Florence, SC to Chicago, IL
Cheapest price
$180
Average price
$232
Fastest journey
23 h 5 m
Average duration
1 d 36 m
Buses per day
4
Distance
1095 km
The best way to find a cheap bus ticket from Florence, SC to Chicago, IL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Florence, SC to Chicago, IL will cost around $232 if you buy it on the day, but the cheapest tickets can be found for only $180.
It's difficult to get from Florence, SC to Chicago, IL without transferring at least once.








Travel Information
Compare train and bus for Florence, SC to Chicago, IL
Omio recommends booking the train as it is the most popular option from Florence, SC to Chicago, IL among Omio's users. If you are prioritising price take the bus with prices starting from $151. For those with little time consider booking a bus which can get you there in 24h 5m. The ticket price range depends on the travel mode: a bus costs an average of $151, and a train costs an average of $260.
Distance: 680 miles (1095 km)
Compare bus with
| Bus | Most popular Train |
|---|---|
$164 Average price Cheapest | $310 Average price |
24h 35m Average total duration Fastest 24h 5m Onboard + 30m Additional time* | 36h 26m Average total duration 35h 56m Onboard + 30m Additional time* |
Direct Options | Direct Options |
Live departures
Florence, SC to Chicago, IL bus times
The table below shows live departures for Florence, SC to Chicago, IL buses for today, Saturday, March 21. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 9:10 PM Florence, SC | 24h05 | 9:15 PM Chicago, IL | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Florence, SC to Chicago, IL by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 22
Mar 23
Mar 24
Mar 25
Mar 26
Mar 27
Mar 28
Journey information
Overview: Bus from Florence, SC to Chicago, IL
Buses from Florence, SC to Chicago, IL run on average 6 times per day, taking around 24h 5m. Cheap bus tickets for this journey start at $151 (€122) if you book in advance.
The earliest bus runs at 00:05, the last at 23:15. The fastest bus covers the 680 miles (1095 km) distance in 24h 5m.
Distance 680 miles (1095 km) |
Average bus duration 24h 5m |
Cheapest ticket price $151 (€122) |
Buses per day 6 |
Fastest bus 24h 5m |
First bus 00:05 |
Last bus 23:15 |
Cheapest month May |
Cheapest day Mon |
High season Jan - Mar |
Low season Jul - Sep |
Best day to book ahead 3 days |
Bus providers: Southeastern Stages from Florence, SC to Chicago, ILYou can travel by bus between Florence, SC to Chicago, IL with Southeastern Stages for as low as $151 (€122). When you search for schedules and tickets, Omio will show you the best journey
Southeastern Stages
FAQs: Bus from Florence, SC to Chicago, IL
Find answers to the most common questions about traveling from Florence, SC to Chicago, IL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.

- Millennium Park, a public park known for its modern art installations and the iconic Cloud Gate sculpture
- Art Institute of Chicago, a renowned museum housing an extensive collection of art from around the world
- Navy Pier, a popular entertainment destination featuring rides, restaurants, and lakefront views
- Willis Tower Skydeck, an observation deck offering panoramic views of the city from one of the tallest buildings in the Western Hemisphere
- Field Museum, a natural history museum with vast exhibits including the famous T. rex skeleton, Sue.
- Museum of Science and Industry, an interactive museum featuring exhibits on science, technology, and industry
- Explore the vibrant neighborhoods of Chicago, such as Wicker Park and Lincoln Park, known for their unique shops and eateries
- Take a river cruise to see the city's iconic architecture from a different perspective
- Attend a live performance at the historic Chicago Theatre
- Enjoy a day at Lincoln Park Zoo, one of the oldest zoos in the U.S., offering free admission.
popular bus stations
Popular bus stations from Florence, SC to Chicago, IL
Most popular bus connections from Florence, SC
More options for your journey from Florence, SC to Chicago, IL
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