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Orlando Science Center
Hands-on science center popular with families, offering interactive exhibits, live programming, and observatory experiences.
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The cheapest and fastest buses from Florence, SC to Orlando, FL
Showing times, prices and bookable tickets for Sep 19
Cheapest price on Sep 19
$67
Average ticket price on Sep 19
$67
Fastest journey on Sep 19
8 h 25 m
Average journey duration on Sep 19
8 h 25 m
Buses on Sep 19
1
Distance
647 km
Cheap tickets
The best way to find a cheap bus ticket from Florence, SC to Orlando, FL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Florence, SC to Orlando, FL will cost around $67 if you buy it on the day, but the cheapest tickets can be found for only $67.
Fast buses
On Sat, Sep 19, we found 1 buses from Florence, SC to Orlando, FL, including 1 direct services.
On Sat, Sep 19 the direct buses cover the 647 km distance in an average of 8 h 25 m but if you time it right, some buses will get you there in just 8 h 25 m .
On Sat, Sep 19 the slowest buses will take 8 h 25 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
FlixBus5:45 AM8h25Florence, W Lucas St (TA Gas Station), SC2:10 PMOrlando, N John Young Pkwy (Greyhound Bus Station)$671One-way0 transfers
- FlixBus5:45 AM8h25Florence, W Lucas St (TA Gas Station), SC2:10 PMOrlando, N John Young Pkwy (Greyhound Bus Station)$671One-way0 transfers
Travel Information
Compare train and bus for Florence, SC to Orlando, FL
Omio recommends booking the train as it is the most popular option from Florence, SC to Orlando, FL among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $143 For those with little time, consider booking a train, which has an average total journey time of 10h 8m. Average ticket prices depend on the travel mode: a bus costs an average of $143, while a train costs an average of $157.
Distance: 402 miles (647 km)
Compare bus with
| Bus | Most popular Train | Driving |
|---|---|---|
$143 Average price Cheapest | $157 Average price | $92 Average price (fuel + tolls) |
13h 35m Average total duration 13h 5m Onboard + 30m Additional time* | 10h 8m Average total duration Fastest 9h 38m Onboard + 30m Additional time* | 6h 31m Average total duration (door-to-door) |
Most popular bus company |  Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Florence, SC to Orlando, FL is a bus with an average price of $143.
This is compared to other travel options from Florence, SC to Orlando, FL:
A bus is $14 less than a train for this route with tickets for a train from Florence, SC to Orlando, FL costing on average $157.
The fastest way to travel from Florence, SC to Orlando, FL is by train with an average journey time of 9h 38m.
Other travel options to Orlando, FL take longer:
Bus takes on average 13h 5m.
It's helpful to compare your options as there are 2 ways to travel between Florence, SC and Orlando, FL including taking a train and bus.
We recommend using the bus as it is the most popular way to get from Florence, SC to Orlando, FL among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.
Tickets start at around $143 compared to roughly $92 in fuel and tolls — a saving of about $-51.38. The journey takes 13h 5m versus 6h 31m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
Florence, SC to Orlando, FL Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 05:45AM | Arrival Time 02:10PM | Duration 8h25 | Departure days Thu, Sat, Sun | Cheapest price $60 |
Operator Flixbus USA | Departure Time 04:00PM | Arrival Time 12:55AM | Duration 8h55 | Departure days Tue | Cheapest price $86 |
Operator FlixBus | Departure Time 08:00PM | Arrival Time 04:55AM | Duration 8h55 | Departure days Mon, Wed, Fri | Cheapest price $76 |
Operator FlixBus | Departure Time 09:00PM | Arrival Time 05:55AM | Duration 8h55 | Departure days Mon, Fri | Cheapest price $67 |
Live departures
Florence, SC to Orlando, FL bus times
The table below shows live departures for Florence, SC to Orlando, FL buses for today, Friday, September 18. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 8:00 PM Florence, SC | 8h55 | 4:55 AM Orlando, FL | 0 transfersDirect | |
| 9:00 PM Florence, SC | 8h55 | 5:55 AM Orlando, FL | 0 transfersDirect | |
| Saturday, September 19 | |||||
| FlixBus | 5:45 AM Florence, W Lucas St (TA Gas Station), SC | 8h25 | 2:10 PM Orlando, N John Young Pkwy (Greyhound Bus Station) | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Florence, SC to Orlando, FL by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Sat
Sep 19
Sep 19
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Sep 20
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Sep 25
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Why should you book Florence, SC to Orlando, FL buses with Omio?
Greyhound as well as FlixBus offer buses services from Florence, SC to Orlando, FL.
Omio is an official ticket reseller for all your travel options from Florence, SC to Orlando, FL.
Why book with Omio vs Greyhound?
- Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of FlixBus to find the best option for your trip from Florence, SC to Orlando, FL.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train and bus to ensure you get the best deal for traveling from Florence, SC to Orlando, FL.
Why book with Omio over Wanderu or Trainline?
- Compare with other providers: On Omio, you can also compare tickets for the likes of FlixBus to find the best option for your trip from Florence, SC to Orlando, FL.
- Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from Florence, SC to Orlando, FL.
Journey information
Overview: Bus from Florence, SC to Orlando, FL
USAUSA
Buses from Florence, SC to Orlando, FL run on average 3 times per day, taking around 13h 5m. Cheap bus tickets for this journey start at $65 if you book in advance.
There are 1 buses per day. The earliest bus runs at 04:00, the last at 22:55. The fastest bus covers the 402 miles (647 km) distance in 8h 25m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 402 miles (647 km) |
Average bus duration 13h 5m |
Cheapest ticket price $65 |
Buses per day 3 |
Direct buses 1 |
Fastest bus 8h 25m |
First bus 4:00 AM |
Last bus 10:55 PM |
Cheapest Month Aug |
Cheapest Day Sun |
High Season Jul - Sep |
Low Season Apr - Jun |
Busiest Day Wed |
Least Busy Day Wed |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: FlixBus, Greyhound from Florence, SC to Orlando, FLYou can travel by bus between Florence, SC to Orlando, FL with FlixBus, Greyhound for as low as $65. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average FlixBus Duration
8h 25m
Cheapest FlixBus Price
$65
FlixBus frequency
1 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
10h 10m
Cheapest Greyhound Price
$96
Greyhound frequency
2 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Orlando, FL
Things to do in Orlando, FL
Discover the best of Orlando, FL — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Orlando, FL trip today.
- Recommended
Orange County Regional History Center
Major local history museum in a restored 1927 courthouse, covering Central Florida's past through engaging permanent and special exhibits.
- Recommended
Rollins Museum of Art
Smithsonian-affiliated art museum with American, African, and ancient works, plus strong rotating exhibitions in Winter Park.
- Must visit
Lake Eola Park
Orlando's signature urban park with lake views, swan boats, skyline scenes, and frequent festivals in the city center.
- Must visit
Park Avenue
Upscale main street area famous for boutiques, brick streets, and a polished small-town atmosphere in nearby Winter Park.
- Recommended
Church Street District
Lively entertainment district with nightlife, murals, and historic architecture around downtown's Church Street corridor.
Florida Catfish
A Central Florida favorite of smoked or fried local catfish, often served with hushpuppies and grits. It reflects the region's freshwater fishing and Southern roots.
- Gluten-free
Florida Shrimp
Fresh Atlantic or Gulf shrimp, commonly peel-and-eat, grilled, or fried. It is a staple across Florida and prized in Orlando seafood spots for its regional freshness.
- Vegetarian
- Vegan
- Gluten-free
Cafecito
Cuban coffee sweetened during brewing for a bold, syrupy shot. Popular in Central Florida's Latin communities, it is a daily ritual and local caffeine classic.
Black Bean Deli
Popular Cuban cafe serving strong cafecito, Cuban sandwiches, and pastries in a busy, no-frills neighborhood setting.
Linda's La Cantina
Historic casual seafood house known for Florida gator tail, frog legs, and laid-back Old Florida charm near downtown Orlando.
The Ravenous Pig
Refined restaurant in Winter Park highlighting Florida seafood and seasonal Southern ingredients in an elegant but relaxed space.
US Dollar ($)
Moderate for a major US tourist city. Theme parks and hotels raise trip costs, while casual dining and ride-hailing are widely available at typical US urban prices.
Average meal costs
- Budget
- $10-15 for fast food or casual counter service.
- Mid-range
- $20-40 per person for a mid-range restaurant meal.
- Fine dining
- $75+ per person for upscale restaurants.
- Coffee
- $3-6 for coffee or cappuccino.
Tipping culture
Tip 18-20% at restaurants, $1-2 per drink at bars, 10-15% for taxis or ride-hailing, and small change or up to 10% at cafes if table service is provided.
FAQs: Bus from Florence, SC to Orlando, FL
Find answers to the most common questions about traveling from Florence, SC to Orlando, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Orlando, FL, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Florence, SC to Orlando, FL can start from as little as $65 when you book in advance. The average bus ticket price for Florence, SC to Orlando, FL is $143 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Florence, SC to Orlando, FL is 8h 25m to travel the 402 miles (647 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Florence, SC to Orlando, FL leaves at 4:00 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Florence, SC to Orlando, FL leaves at 10:55 PM.
Yes, there are 1 direct buses a day from Florence, SC to Orlando, FL with FlixBus. Schedules can vary on holidays or weekends with fewer direct buses.
When taking a bus from Florence, SC to Orlando, FL, you can count on Greyhound, FlixBus for the best way to get you to Orlando, FL. You can also check all possible bus companies who offer a service between Florence, SC and Orlando, FL and compare the amenities they offer before buying a bus ticket.
When departing from Florence, SC , you have various bus station options to start your journey from including Florence, S Irby St (Greyhound Bus Stop), SC, Florence, W Lucas St (TA Gas Station), SC . When arriving in Orlando, FL , you can end your journey in bus stations like Orlando, N John Young Pkwy (Greyhound Bus Station), Orlando, The Florida Mall, FL .Passengers board the bus most frequently from Florence, S Irby St (Greyhound Bus Stop), SC, which is located around away from the city centre, and they get off the bus at Orlando, N John Young Pkwy (Greyhound Bus Station), located 3 away from the city centre.
A trip to Orlando, FL from Florence, SC is worth doing but not as a day trip with a journey time of 8h 25m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Florence, SC to Orlando, FL is August.
It's helpful to compare your options as there are 2 ways to travel between Florence, SC and Orlando, FL including taking a train and bus.
Yes, there are bathrooms on board the bus from Florence, SC to Orlando, FL for bus company Greyhound, FlixBus.
Yes, the following accessibility options are available when taking the bus from Florence, SC to Orlando, FL:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Some of the most interesting sights to explore in Orlando, FL are:
- Walt Disney World Resort, a massive entertainment complex featuring theme parks, water parks, and resorts
- Universal Orlando Resort, a popular destination with thrilling rides, shows, and attractions based on movies and TV shows
- SeaWorld Orlando, a marine-themed park offering animal exhibits, shows, and rides
- Kennedy Space Center Visitor Complex, an educational attraction showcasing NASA's space exploration history and offering interactive exhibits
- Leu Gardens, a beautiful botanical garden with a variety of plant collections and scenic landscapes.
The best things to do in Orlando, FL include:
- ICON Park, a vibrant entertainment complex with dining, shopping, and the iconic Wheel for panoramic views
- Explore the vibrant nightlife and live entertainment at Church Street District
- Enjoy a day of shopping and dining at The Mall at Millenia
- Experience the natural beauty and wildlife at Wekiwa Springs State Park
- Visit the Orlando Science Center for interactive exhibits and planetarium shows.
Whether you can cancel your bus ticket from Florence, SC to Orlando, FL depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company Greyhound, FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Florence, SC to Orlando, FL.
Yes, the following luggage options are included when booking a bus ticket from Florence, SC to Orlando, FL:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Florence, SC to Orlando, FL:
- Greyhound
- $15 per additional bag.
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Florence, SC to Orlando, FL. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from Florence, SC to Orlando, FL with the following bus company: Greyhound, FlixBus
Yes, there are USB plugs on board the bus from Florence, SC to Orlando, FL with the following bus company: Greyhound, FlixBus.
Yes, there is Wifi on board the bus from Florence, SC to Orlando, FL with the following bus company: Greyhound, FlixBus.
Since neither Florence, SC nor Orlando, FL are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the train as it is the most popular way to get from Florence, SC to Orlando, FL among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Orlando, FL, travelers should be cautious of pickpocketing and petty theft, especially in crowded areas like theme parks and popular tourist spots. Common scams include overpriced taxi rides, timeshare presentations that pressure visitors, and fake ticket sellers near major attractions. It's important to use authorized transportation services and purchase tickets from official vendors to avoid fraud. Additionally, travelers should stay aware of their surroundings and avoid poorly lit or isolated areas at night.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Florence, SC to Orlando, FL
Most Florence, SC to Orlando, FL buses use the Florence, S Irby St (Greyhound Bus Stop) to Orlando, N John Young Pkwy (Greyhound Bus Station) station pair, with some services arriving at Orlando, The Florida Mall. Use this guide to compare Florence, SC and Orlando, FL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Florence
Arrival bus stations in Orlando
Which Florence, SC station do buses to Orlando, FL leave from?
Buses from Florence, SC to Orlando, FL leave from Florence, S Irby St (Greyhound Bus Stop). The station is 0 miles (1 km) from Florence, SC city centre at S Irby St, Florence, SC, USA.
Florence, S Irby St (Greyhound Bus Stop)S Irby St, Florence, SC, USA
City-centre transport
Getting to Florence, S Irby St (Greyhound Bus Stop) from Florence city centre
TRUE
Florence, S Irby St (Greyhound Bus Stop) bus station facilities and services
Florence, S Irby St (Greyhound Bus Stop) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Florence, S Irby St (Greyhound Bus Stop). ATMs are available at Florence, S Irby St (Greyhound Bus Stop).
Tickets and information
Ticket office support is available at Florence, S Irby St (Greyhound Bus Stop).
Parking, taxis and toilets
Available at Florence, S Irby St (Greyhound Bus Stop): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Florence, S Irby St (Greyhound Bus Stop): Bus stop accessible for disabled persons.
Florence, W Lucas St (TA Gas Station)Florence, SC, USA
City-centre transport
Getting to Florence, W Lucas St (TA Gas Station) from Florence city centre
Florence, W Lucas St (TA Gas Station) is 6 km from Florence city centre. Public transport options include:
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Florence, W Lucas St (TA Gas Station) bus station facilities and services
Florence, W Lucas St (TA Gas Station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Food and snacks available at the gas station.
Wi-Fi and ATMs
Wi-Fi is available at Florence, W Lucas St (TA Gas Station). ATMs are available at Florence, W Lucas St (TA Gas Station).
Tickets and information
Ticket office support is available at Florence, W Lucas St (TA Gas Station).
Parking, taxis and toilets
Available at Florence, W Lucas St (TA Gas Station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Florence, W Lucas St (TA Gas Station): Basic accessibility features available.
Which Orlando, FL station do buses from Florence, SC arrive at?
Buses from Florence, SC to Orlando, FL most often arrive at Orlando, N John Young Pkwy (Greyhound Bus Station). Some services arrive at Orlando, The Florida Mall, so check your ticket before travel to confirm your Orlando, FL arrival station.
Orlando, N John Young Pkwy (Greyhound Bus Station)555 John Young Pkwy, Orlando, FL 32805, USA
City-centre transport
Getting to Orlando, N John Young Pkwy (Greyhound Bus Station) from Orlando city centre
Orlando, N John Young Pkwy (Greyhound Bus Station) is 3 km from Orlando city centre. Public transport options include:
Bus125 · 40m · $2 · every ~6 min
125 · 41m · $2 · every ~6 min
Orlando, N John Young Pkwy (Greyhound Bus Station) bus station facilities and services
Orlando, N John Young Pkwy (Greyhound Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Orlando, N John Young Pkwy (Greyhound Bus Station). ATMs are available at Orlando, N John Young Pkwy (Greyhound Bus Station).
Tickets and information
Ticket office support is available at Orlando, N John Young Pkwy (Greyhound Bus Station).
Parking, taxis and toilets
Available at Orlando, N John Young Pkwy (Greyhound Bus Station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Orlando, N John Young Pkwy (Greyhound Bus Station): The station is accessible for individuals with disabilities.
Orlando, The Florida MallOrlando Florida Mall Ave,Florida Mall Ave 1632,32809
City-centre transport
Getting to Orlando, The Florida Mall from Orlando city centre
Bus42 · 26m · $2 · every ~5 min
Most popular bus connections from Florence, SC
More options for your journey from Florence, SC to Orlando, FL
Here are some other resources that might have the information you need
Most popular buses to and from Orlando, FL and Florence, SC
Most popular bus connections to Orlando, FL
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