- Must visit
Nasher Museum of Art
Major art museum at Duke with global collections, rotating exhibitions, and strong programs in modern and classical art.
2,000+ travel companies
2,000+ travel companies
Scan to get our free app
Use our app to get live travel updates and book mobile tickets for trains, buses, flights, and ferries.
App Store
4.942K ratings
Google Play
4.6136K reviews
The cheapest and fastest buses from Florence, SC to Durham, NC
Showing times, prices and bookable tickets for Nov 03
- Cheapest price on Nov 03
- $46
- Average ticket price on Nov 03
- $46
- Fastest journey on Nov 03
- 5 h 30 m
- Average journey duration on Nov 03
- 5 h 30 m
- Buses on Nov 03
- 1
- Distance
- 215 km
Cheap tickets
The best way to find a cheap bus ticket from Florence, SC to Durham, NC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Florence, SC to Durham, NC will cost around $46 if you buy it on the day, but the cheapest tickets can be found for only $46.
Fast buses
It's difficult to get from Florence, SC to Durham, NC without transferring at least once.
4:30 PM 5h30 Florence, SC 10:00 PM Durham, NC $46 1 One-way 1 transfer
4:30 PM 5h30 Florence, SC 10:00 PM Durham, NC $46 1 One-way 1 transfer
Journey information
Overview: Bus from Florence, SC to Durham, NC
USAUSA
Buses from Florence, SC to Durham, NC run on average 1 times per day, taking around 3h 15m. Cheap bus tickets for this journey start at $59 if you book in advance.
The earliest bus runs at 00:05, the last at 21:15. The fastest bus covers the 133 miles (215 km) distance in 3h 15m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Plan this route
Journey facts
- Distance133 miles (215 km)
- Average bus duration3h 15m
- Cheapest ticket price$59
- Buses per day1
- Fastest bus3h 15m
- First bus12:05 AM
- Last bus9:15 PM
- Cheapest MonthFeb
- Cheapest DayTue
- High SeasonJan - Mar
- Low SeasonOct - Dec
Understand & plan this route
Book with confidence
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Frequently asked questions about your Florence, SC to Durham, NC trip
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Florence, SC to Durham, NC.
Cheap bus tickets from Florence, SC to Durham, NC can start from as little as $59 when you book in advance. The average bus ticket price for Florence, SC to Durham, NC is $69 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The earliest bus from Florence, SC to Durham, NC leaves at 12:05 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Florence, SC to Durham, NC leaves at 9:15 PM.
There are 1 buses a day from Florence, SC to Durham, NC which require at least one change with FlixBus. Schedules can vary on holidays or weekends with fewer buses.
Florence, SC to Durham, NC Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound USA | Departure Time 04:30PM | Arrival Time 10:00PM | Duration 5h30 | Departure days Mon, Tue, Wed, Fri, Sun | Cheapest price $46 |
Operator Greyhound | Departure Time 08:30PM | Arrival Time 02:00AM | Duration 5h30 | Departure days Thu | Cheapest price $107 |
Live departures
Florence, SC to Durham, NC bus times
The table below shows live departures for Florence, SC to Durham, NC buses for today, Monday, November 2. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 4:30 PM Florence, SC | 5h30 | 10:00 PM Durham, NC | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Why should you book Florence, SC to Durham, NC buses with Omio?
FlixBus operates all buses services from Florence, SC to Durham, NC.
Omio is an official ticket reseller for all your travel options from Florence, SC to Durham, NC.
Why book with Omio vs FlixBus?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are train and bus to ensure you get the best deal for traveling from Florence, SC to Durham, NC.
Why book with Omio over Wanderu or Trainline?
- Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from Florence, SC to Durham, NC.
Bus companies
Bus companies from Florence, SC to Durham, NC
Buses from Florence, SC to Durham, NC with FlixBus. Use the details below to compare onboard facilities.
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average FlixBus Duration
3h 15m
Cheapest FlixBus Price
$59
FlixBus frequency
1 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Companies, tickets, and onboard amenities between Florence, SC and Durham, NC
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
When taking a bus from Florence, SC to Durham, NC, you can count on FlixBus for the best way to get you to Durham, NC. You can also check all possible bus companies who offer a service between Florence, SC and Durham, NC and compare the amenities they offer before buying a bus ticket.
Yes, the following accessibility options are available when taking the bus from Florence, SC to Durham, NC:
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Florence, SC to Durham, NC for bus company FlixBus.
Whether you can cancel your bus ticket from Florence, SC to Durham, NC depends on the bus companies:
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company {providersWithBike}.
Yes, there is food available to purchase on board the bus from Florence, SC to Durham, NC.
Yes, the following luggage options are included when booking a bus ticket from Florence, SC to Durham, NC:
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Florence, SC to Durham, NC:
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Florence, SC to Durham, NC. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from Florence, SC to Durham, NC with the following bus company: FlixBus
Yes, there are USB plugs on board the bus from Florence, SC to Durham, NC with the following bus company: FlixBus.
Yes, there is Wifi on board the bus from Florence, SC to Durham, NC with the following bus company: FlixBus.
Complete guide to Durham, NC
Things to do in Durham, NC
Discover the best of Durham, NC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Durham, NC trip today.
- Must visit
Museum of Life and Science
Hands-on science museum with aerospace, physics, wildlife, and family exhibits in downtown Durham.
- Recommended
Duke Homestead State Historic Site
Historic site and museum exploring Washington Duke, tobacco farming, and Durham's industrial origins.
- Must visit
Sarah P. Duke Gardens
Beloved public garden with terraces, woodland paths, and seasonal blooms, ideal for a scenic walk near Duke.
- Must visit
Downtown Durham
Lively downtown district for walking among warehouses, public art, music venues, and restored tobacco-era spaces.
- Must visit
American Tobacco Trail
Scenic riverside greenway for walking and cycling, connecting downtown with quiet stretches of restored nature.
- Gluten-free
Eastern NC Pork Barbecue
Eastern North Carolina chopped pork barbecue with a tangy vinegar-pepper sauce. A defining regional staple widely loved across Durham and the Triangle.
Pulled Pork Plate
Slow-cooked pork shoulder or whole hog, often served on a plate with slaw and hush puppies. It reflects the area’s deep barbecue tradition.
- Vegetarian
Hush Puppies
Fried cornmeal batter balls served with barbecue or seafood. They are a classic Southern side found on many Durham menus.
M Pocha
Refined restaurant showcasing seasonal North Carolina ingredients with polished service. Known for elevated Southern cooking and a stylish setting.
Guglhupf Bakery & Cafe
Beloved local bakery and café serving excellent pastries, breads, and coffee. A dependable stop for breakfast, lunch, or a quick snack.
True Flavors Diner
Popular casual spot for inventive biscuit sandwiches, shrimp and grits, and Southern brunch favorites in a lively downtown atmosphere.
US Dollar ($)
Moderate for a US college city; hotels and dining are mid-priced, transit is limited, but many casual meals and coffee shops are affordable.
Average meal costs
- Budget
- $10-15 for fast food or casual lunch.
- Mid-range
- $20-40 per person for a mid-range meal.
- Fine dining
- $60+ per person for upscale dining.
- Coffee
- $3-6 for coffee or cappuccino.
Tipping culture
Tip 18-20% at restaurants, 15-20% for taxis, and $1-2 per drink or café order if service is provided.
Plan your visit to Durham, NC
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Durham, NC.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Durham, NC, travelers should stay alert to common urban safety concerns such as petty theft, especially in crowded areas and public transit. Scams may include overcharging by unofficial taxi services or ride-share drivers, so using reputable transportation apps is advised. It's also important to avoid isolated areas after dark and keep personal belongings secure to reduce risk.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
FAQs: Bus from Florence, SC to Durham, NC
Find answers to the most common questions about traveling from Florence, SC to Durham, NC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Durham, NC, this guide helps you travel smarter and with confidence.
It's helpful to compare your options as there are 2 ways to travel between Florence, SC and Durham, NC including taking a train and bus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
popular bus stations
Popular bus stations from Florence, SC to Durham, NC
Most Florence, SC to Durham, NC buses use the Florence, W Lucas St (TA Gas Station) to Durham, W Pettigrew St (Greyhound Bus Station) station pair. Use this guide to compare Florence, SC and Durham, NC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Florence
Arrival bus stations in Durham
Which Florence, SC station do buses to Durham, NC leave from?
Buses from Florence, SC to Durham, NC leave from Florence, W Lucas St (TA Gas Station). The station is 3 miles (6 km) from Florence, SC city centre at Florence, SC, USA.
Florence, W Lucas St (TA Gas Station)Florence, SC, USA
City-centre transport
Getting to Florence, W Lucas St (TA Gas Station) from Florence city centre
Florence, W Lucas St (TA Gas Station) is 6 km from Florence city centre. Public transport options include:
TRUE
Florence, W Lucas St (TA Gas Station) bus station facilities and services
Florence, W Lucas St (TA Gas Station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Food and snacks available at the gas station.
Wi-Fi and ATMs
Wi-Fi is available at Florence, W Lucas St (TA Gas Station). ATMs are available at Florence, W Lucas St (TA Gas Station).
Tickets and information
Ticket office support is available at Florence, W Lucas St (TA Gas Station).
Parking, taxis and toilets
Available at Florence, W Lucas St (TA Gas Station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Florence, W Lucas St (TA Gas Station): Basic accessibility features available.
Florence, S Irby St (Greyhound Bus Stop)S Irby St, Florence, SC, USA
City-centre transport
Getting to Florence, S Irby St (Greyhound Bus Stop) from Florence city centre
TRUE
Florence, S Irby St (Greyhound Bus Stop) bus station facilities and services
Florence, S Irby St (Greyhound Bus Stop) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Florence, S Irby St (Greyhound Bus Stop). ATMs are available at Florence, S Irby St (Greyhound Bus Stop).
Tickets and information
Ticket office support is available at Florence, S Irby St (Greyhound Bus Stop).
Parking, taxis and toilets
Available at Florence, S Irby St (Greyhound Bus Stop): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Florence, S Irby St (Greyhound Bus Stop): Bus stop accessible for disabled persons.
Durham, W Pettigrew St (Greyhound Bus Station)Durham W Pettigrew St Bus Station,515 W Pettigrew St,27701
City-centre transport
Getting to Durham, W Pettigrew St (Greyhound Bus Station) from Durham city centre
Bus2, 9, 12, 12B · 5m · $2 · every ~12 min
Most popular buses to and from Durham, NC and Florence, SC
Most popular bus connections to Durham, NC
The Omio App Makes Travel Planning Easy
We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.
