The cheapest and fastest buses from St. Louis, MO to Santa Ana, CA
Cheapest price
$245
Average price
$245
Fastest journey
2 d 2 h 25 m
Average duration
2 d 2 h 25 m
Buses per day
1
Distance
2532 km
The best way to find a cheap bus ticket from St. Louis, MO to Santa Ana, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from St. Louis, MO to Santa Ana, CA will cost around $245 if you buy it on the day, but the cheapest tickets can be found for only $245.
Of the 1 buses that leave St. Louis, MO for Santa Ana, CA on Thu, Feb 05, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Thu, Feb 05 the direct buses cover the 2532 km distance in an average of 2 d 2 h 25 m but if you time it right, some buses will get you there in just 2 d 2 h 25 m .
On Thu, Feb 05 the slowest buses will take 2 d 2 h 25 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.


Travel Information
Compare train, bus, and flight for St. Louis, MO to Santa Ana, CA
Omio recommends booking the bus as it is the most popular option from St. Louis, MO to Santa Ana, CA among Omio's users. If you are prioritising price take the bus with prices starting from €195. For those with little time consider booking a flight which can get you there in 8h 23m. The ticket price range depends on the travel mode: a bus costs an average of €195, and a flight costs an average of €415.
Distance: 1573 miles (2532 km)
Compare bus with
Most popular Bus | Flight | Train |
|---|---|---|
€264 Average price Cheapest | €415 Average price | €317 Average price |
47h 48m Average total duration 47h 18m Onboard + 30m Additional time* | 11h 23m Average total duration Fastest 8h 23m Onboard + 3h 0m Additional time* | 54h 55m Average total duration 54h 25m Onboard + 30m Additional time* |
Direct Options | Direct Options | Direct Options |
Live departures
St. Louis, MO to Santa Ana, CA bus times
The table below shows live departures for St. Louis, MO to Santa Ana, CA buses for tomorrow, Thursday, February 5. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 12:35 PM St. Louis, MO | 50h25 | 3:00 PM Santa Ana, CA | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets St. Louis, MO to Santa Ana, CA by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Feb 05
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Feb 11
Why should you book St. Louis, MO to Santa Ana, CA buses with Omio?
Why book with Omio vs Greyhound?
- Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of to find the best option for your trip from St. Louis, MO to Santa Ana, CA.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from St. Louis, MO to Santa Ana, CA.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from St. Louis, MO to Santa Ana, CA.
Journey information
Overview: Bus from St. Louis, MO to Santa Ana, CA
Buses from St. Louis, MO to Santa Ana, CA run on average 3 times per day, taking around 47h 18m. Cheap bus tickets for this journey start at $245 (€195) if you book in advance.
The earliest bus runs at 06:35, the last at 21:20. The fastest bus covers the 1573 miles (2532 km) distance in 44h 10m.
Distance 1573 miles (2532 km) |
Average bus duration 47h 18m |
Cheapest ticket price $245 (€195) |
Buses per day 3 |
Fastest bus 44h 10m |
First bus 06:35 |
Last bus 21:20 |
Bus providers: Greyhound from St. Louis, MO to Santa Ana, CAYou can travel by bus between St. Louis, MO to Santa Ana, CA with Greyhound for as low as $245 (€195). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from St. Louis, MO to Santa Ana, CA
Find answers to the most common questions about traveling from St. Louis, MO to Santa Ana, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Santa Ana, CA, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from St. Louis, MO to Santa Ana, CA
Most popular bus connections from St. Louis, MO
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