- Must visit
Bowers Museum
Major Orange County museum campus with art exhibitions, family programs, and rotating contemporary and historical shows.
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The cheapest and fastest buses from St. Louis, MO to Santa Ana, CA
Showing times, prices and bookable tickets for Sep 20
Cheapest price on Sep 20
$187
Average ticket price on Sep 20
$189
Fastest journey on Sep 20
1 d 20 h 10 m
Average journey duration on Sep 20
2 d 58 m
Buses on Sep 20
4
Distance
2532 km
Cheap tickets
The best way to find a cheap bus ticket from St. Louis, MO to Santa Ana, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from St. Louis, MO to Santa Ana, CA will cost around $189 if you buy it on the day, but the cheapest tickets can be found for only $187.
Fast buses
It's difficult to get from St. Louis, MO to Santa Ana, CA without transferring at least once.
· · · 8:40 AM49h20St. Louis, S 15th St (Civic center)8:00 AMSanta Ana, E Santa Ana Blvd (Train Station)$1871One-way3 transfers- · · · 9:10 AM48h50St. Louis, Lambert International Airport8:00 AMSanta Ana, E Santa Ana Blvd (Train Station)$1881One-way3 transfers
FlixBus+ · · 4:00 PM53h30St. Louis, S 15th St (Civic center)7:30 PMSanta Ana, E Santa Ana Blvd (Train Station)$1911One-way3 transfers- · 1:20 AM44h10St. Louis, S 15th St (Civic center)7:30 PMSanta Ana, E Santa Ana Blvd (Train Station)$1921One-way1 transfer
- · 1:20 AM44h10St. Louis, S 15th St (Civic center)7:30 PMSanta Ana, E Santa Ana Blvd (Train Station)$1921One-way1 transfer
- · · · 9:10 AM48h50St. Louis, Lambert International Airport8:00 AMSanta Ana, E Santa Ana Blvd (Train Station)$1881One-way3 transfers
- · · · 8:40 AM49h20St. Louis, S 15th St (Civic center)8:00 AMSanta Ana, E Santa Ana Blvd (Train Station)$1871One-way3 transfers
- FlixBus+ · · 4:00 PM53h30St. Louis, S 15th St (Civic center)7:30 PMSanta Ana, E Santa Ana Blvd (Train Station)$1911One-way3 transfers
St. Louis, MO to Santa Ana, CA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 01:20AM | Arrival Time 07:30PM | Duration 44h10 | Departure days Everyday | Cheapest price $161 |
Operator Greyhound | Departure Time 08:40AM | Arrival Time 08:00AM | Duration 49h20 | Departure days Everyday | Cheapest price $153 |
Operator Greyhound | Departure Time 09:10AM | Arrival Time 08:00AM | Duration 48h50 | Departure days Everyday | Cheapest price $154 |
Operator Greyhound | Departure Time 04:00PM | Arrival Time 07:30PM | Duration 53h30 | Departure days Everyday | Cheapest price $170 |
Live departures
St. Louis, MO to Santa Ana, CA bus times
The table below shows live departures for St. Louis, MO to Santa Ana, CA buses for today, Saturday, September 19. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| · · · | 8:40 AM St. Louis, S 15th St (Civic center) | 49h20 | 8:00 AM Santa Ana, E Santa Ana Blvd (Train Station) | 3 transfers | |
| · · · | 9:10 AM St. Louis, Lambert International Airport | 48h50 | 8:00 AM Santa Ana, E Santa Ana Blvd (Train Station) | 3 transfers | |
| FlixBus+ · · | 4:00 PM St. Louis, S 15th St (Civic center) | 53h30 | 7:30 PM Santa Ana, E Santa Ana Blvd (Train Station) | 3 transfers | |
| Sunday, September 20 | |||||
| · | 1:20 AM St. Louis, S 15th St (Civic center) | 44h10 | 7:30 PM Santa Ana, E Santa Ana Blvd (Train Station) | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets St. Louis, MO to Santa Ana, CA by train or bus
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Why should you book St. Louis, MO to Santa Ana, CA buses with Omio?
Greyhound operates all buses services from St. Louis, MO to Santa Ana, CA.
Omio is an official ticket reseller for all your travel options from St. Louis, MO to Santa Ana, CA.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train and bus to ensure you get the best deal for traveling from St. Louis, MO to Santa Ana, CA.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from St. Louis, MO to Santa Ana, CA.
Journey information
Overview: Bus from St. Louis, MO to Santa Ana, CA
USAUSA
Take a bus from St. Louis, MO to Santa Ana, CA and enjoy the approximately 1573 miles (2532 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
The earliest bus runs at 01:20, the last at 21:20.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 1573 miles (2532 km) |
First bus 1:20 AM |
Last bus 9:20 PM |
Cheapest Month Feb |
Cheapest Day Tue |
High Season Apr - Jun |
Low Season Jul - Sep |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound from St. Louis, MO to Santa Ana, CAYou can travel by bus between St. Louis, MO to Santa Ana, CA with Greyhound. When you search for schedules and tickets, Omio will show you the best journey
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
44h 10m
Cheapest Greyhound Price
$145
Greyhound frequency
1 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Santa Ana, CA
Things to do in Santa Ana, CA
Discover the best of Santa Ana, CA — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Santa Ana, CA trip today.
- Recommended
Discovery Cube Orange County
Hands-on science museum with interactive exhibits, a Discovery Cube, and family-friendly learning in downtown Santa Ana.
- Recommended
Lyon Air Museum
Small local museum preserving Orange County aviation and aerospace history with artifacts, photos, and volunteer-led interpretation.
- Must visit
Downtown Santa Ana
Walkable downtown district with historic buildings, murals, shops, galleries, and regular arts and community events.
- Recommended
East 4th Street
Lively pedestrian-friendly arts corridor known for galleries, murals, boutiques, and monthly art-focused street activity.
- Recommended
Floral Park
Historic neighborhood of preserved early 20th-century homes, ideal for architecture walks and seasonal house tours.
FAQs: Bus from St. Louis, MO to Santa Ana, CA
Find answers to the most common questions about traveling from St. Louis, MO to Santa Ana, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Santa Ana, CA, this guide helps you travel smarter and with confidence.
popular bus stations
Popular bus stations from St. Louis, MO to Santa Ana, CA
Most St. Louis, MO to Santa Ana, CA buses use the St. Louis, S 15th St (Civic center) to Santa Ana, E Santa Ana Blvd (Train Station) station pair. Use this guide to compare St. Louis, MO and Santa Ana, CA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in St. Louis
Arrival bus stations in Santa Ana
Which St. Louis, MO station do buses to Santa Ana, CA leave from?
Buses from St. Louis, MO to Santa Ana, CA leave from St. Louis, S 15th St (Civic center). The station is 0 miles (1 km) from St. Louis, MO city centre at S 15th St, St. Louis, MO, USA.
St. Louis, S 15th St (Civic center)S 15th St, St. Louis, MO, USA
City-centre transport
Getting to St. Louis, S 15th St (Civic center) from St. Louis city centre
TrainMlb, Mlr · 4m · $4 · every ~14 min
Bus19, 32, 40 · 8m · $1 · every ~9 min
St. Louis, S 15th St (Civic center) bus station facilities and services
St. Louis, S 15th St (Civic center) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at St. Louis, S 15th St (Civic center). ATMs are available at St. Louis, S 15th St (Civic center).
Tickets and information
Ticket office support is available at St. Louis, S 15th St (Civic center).
Parking, taxis and toilets
Available at St. Louis, S 15th St (Civic center): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at St. Louis, S 15th St (Civic center): Wheelchair accessible routes available.
St. Louis, Lambert International AirportSt. Louis Lambert International Airport (STL), 10701 Lambert International Blvd, St. Louis, MO 63145, USA
City-centre transport
Getting to St. Louis, Lambert International Airport from St. Louis city centre
St. Louis, Lambert International Airport is 19 km from St. Louis city centre. Public transport options include:
TrainMlr · 31m · $4 · every ~7 min
Bus4 · 1h 3m · $31 · every ~4 min
St. Louis, Lambert International Airport bus station facilities and services
St. Louis, Lambert International Airport has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Multiple dining options available in terminals.
Wi-Fi and ATMs
Free Wi-Fi available throughout the airport. ATMs are aTMs available in terminal areas.
Tickets and information
Ticket office support is available at St. Louis, Lambert International Airport.
Parking, taxis and toilets
Available at St. Louis, Lambert International Airport: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at St. Louis, Lambert International Airport: Wheelchair accessible facilities available.
Which Santa Ana, CA station do buses from St. Louis, MO arrive at?
Buses from St. Louis, MO to Santa Ana, CA arrive at Santa Ana, E Santa Ana Blvd (Train Station). Santa Ana, E Santa Ana Blvd (Train Station) is 0 miles (1 km) from Santa Ana, CA city centre.
Santa Ana, E Santa Ana Blvd (Train Station)Santa Ana, 1000 E Santa Ana Blvd, Santa Ana, CA 92701, USA
City-centre transport
Getting to Santa Ana, E Santa Ana Blvd (Train Station) from Santa Ana city centre
Santa Ana, E Santa Ana Blvd (Train Station) is 1 km from Santa Ana city centre. Public transport options include:
TRUE
Santa Ana, E Santa Ana Blvd (Train Station) bus station facilities and services
Santa Ana, E Santa Ana Blvd (Train Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Santa Ana, E Santa Ana Blvd (Train Station). ATMs are available at Santa Ana, E Santa Ana Blvd (Train Station).
Tickets and information
Ticket office support is available at Santa Ana, E Santa Ana Blvd (Train Station).
Parking, taxis and toilets
Available at Santa Ana, E Santa Ana Blvd (Train Station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Santa Ana, E Santa Ana Blvd (Train Station): Bus access is available.
Most popular bus connections from St. Louis, MO
More options for your journey from St. Louis, MO to Santa Ana, CA
Here are some other resources that might have the information you need
Most popular buses to and from Santa Ana, CA and St. Louis, MO
Most popular bus connections to Santa Ana, CA
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