- Must visit
Bowers Museum
Major Orange County museum campus with art exhibitions, family programs, and rotating contemporary and historical shows.
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The cheapest and fastest buses from St. Louis, MO to Santa Ana, CA
Showing times, prices and bookable tickets for Nov 04
- Cheapest price on Nov 04
- $193
- Average ticket price on Nov 04
- $200
- Fastest journey on Nov 04
- 1 d 20 h 10 m
- Average journey duration on Nov 04
- 1 d 23 h 27 m
- Buses on Nov 04
- 3
- Distance
- 2532 km
Cheap tickets
The best way to find a cheap bus ticket from St. Louis, MO to Santa Ana, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from St. Louis, MO to Santa Ana, CA will cost around $200 if you buy it on the day, but the cheapest tickets can be found for only $193.
Fast buses
It's difficult to get from St. Louis, MO to Santa Ana, CA without transferring at least once.
· · · 9:10 AM 48h50 St. Louis, Lambert International Airport 8:00 AM Santa Ana, E Santa Ana Blvd (Train Station) $193 1 One-way 3 transfers- · · ·
8:40 AM 49h20 St. Louis, S 15th St (Civic center) 8:00 AM Santa Ana, E Santa Ana Blvd (Train Station) $196 1 One-way 3 transfers - ·
1:20 AM 44h10 St. Louis, S 15th St (Civic center) 7:30 PM Santa Ana, E Santa Ana Blvd (Train Station) $211 1 One-way 1 transfer
- ·
1:20 AM 44h10 St. Louis, S 15th St (Civic center) 7:30 PM Santa Ana, E Santa Ana Blvd (Train Station) $211 1 One-way 1 transfer - · · ·
9:10 AM 48h50 St. Louis, Lambert International Airport 8:00 AM Santa Ana, E Santa Ana Blvd (Train Station) $193 1 One-way 3 transfers - · · ·
8:40 AM 49h20 St. Louis, S 15th St (Civic center) 8:00 AM Santa Ana, E Santa Ana Blvd (Train Station) $196 1 One-way 3 transfers
Journey information
Overview: Bus from St. Louis, MO to Santa Ana, CA
USAUSA
Buses from St. Louis, MO to Santa Ana, CA run on average 4 times per day, taking around 39h 53m. Cheap bus tickets for this journey start at $142 (€119) if you book in advance.
The earliest bus runs at 01:20, the last at 21:20. The fastest bus covers the 1573 miles (2532 km) distance in 38h 15m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Plan this route
Journey facts
- Distance1573 miles (2532 km)
- Average bus duration39h 53m
- Cheapest ticket price$142 (€119)
- Buses per day4
- Fastest bus38h 15m
- First bus1:20 AM
- Last bus9:20 PM
- Cheapest MonthSep
- Cheapest DaySat
- High SeasonApr - Jun
- Low SeasonJul - Sep
Understand & plan this route
Book with confidence
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Frequently asked questions about your St. Louis, MO to Santa Ana, CA trip
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from St. Louis, MO to Santa Ana, CA.
Cheap bus tickets from St. Louis, MO to Santa Ana, CA can start from as little as $142 (€119) when you book in advance. The average bus ticket price for St. Louis, MO to Santa Ana, CA is $185 (€155) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The earliest bus from St. Louis, MO to Santa Ana, CA leaves at 1:20 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from St. Louis, MO to Santa Ana, CA leaves at 9:20 PM.
There are 4 buses a day from St. Louis, MO to Santa Ana, CA which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
St. Louis, MO to Santa Ana, CA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 01:20AM | Arrival Time 07:30PM | Duration 44h10 | Departure days Everyday | Cheapest price $183 |
Operator Greyhound | Departure Time 08:40AM | Arrival Time 08:00AM | Duration 49h20 | Departure days Everyday | Cheapest price $166 |
Operator Greyhound | Departure Time 09:10AM | Arrival Time 08:00AM | Duration 48h50 | Departure days Everyday | Cheapest price $168 |
Operator Greyhound | Departure Time 04:00PM | Arrival Time 07:30PM | Duration 53h30 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $186 |
Live departures
St. Louis, MO to Santa Ana, CA bus times
The table below shows live departures for St. Louis, MO to Santa Ana, CA buses for today, Tuesday, November 3. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| · · · | 8:40 AM St. Louis, S 15th St (Civic center) | 49h20 | 8:00 AM Santa Ana, E Santa Ana Blvd (Train Station) | 3 transfers | |
| · · · | 9:10 AM St. Louis, Lambert International Airport | 48h50 | 8:00 AM Santa Ana, E Santa Ana Blvd (Train Station) | 3 transfers | |
| Wednesday, November 4 | |||||
| · | 1:20 AM St. Louis, S 15th St (Civic center) | 44h10 | 7:30 PM Santa Ana, E Santa Ana Blvd (Train Station) | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Why should you book St. Louis, MO to Santa Ana, CA buses with Omio?
Greyhound operates all buses services from St. Louis, MO to Santa Ana, CA.
Omio is an official ticket reseller for all your travel options from St. Louis, MO to Santa Ana, CA.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train and bus to ensure you get the best deal for traveling from St. Louis, MO to Santa Ana, CA.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from St. Louis, MO to Santa Ana, CA.
Bus companies
Bus companies from St. Louis, MO to Santa Ana, CA
Buses from St. Louis, MO to Santa Ana, CA with Greyhound. Overnight buses available on this route with Greyhound. Use the details below to compare onboard facilities.
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
38h 15m
Cheapest Greyhound Price
$142 (€119)
Greyhound frequency
4 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Companies, tickets, and onboard amenities between St. Louis, MO and Santa Ana, CA
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
When taking a bus from St. Louis, MO to Santa Ana, CA, you can count on Greyhound for the best way to get you to Santa Ana, CA. You can also check all possible bus companies who offer a service between St. Louis, MO and Santa Ana, CA and compare the amenities they offer before buying a bus ticket.
Yes, the following accessibility options are available when taking the bus from St. Louis, MO to Santa Ana, CA:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from St. Louis, MO to Santa Ana, CA for bus company Greyhound.
Whether you can cancel your bus ticket from St. Louis, MO to Santa Ana, CA depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company {providersWithBike}.
Yes, there is food available to purchase on board the bus from St. Louis, MO to Santa Ana, CA.
Yes, the following luggage options are included when booking a bus ticket from St. Louis, MO to Santa Ana, CA:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from St. Louis, MO to Santa Ana, CA:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from St. Louis, MO to Santa Ana, CA.
You can reserve your seat on the bus from St. Louis, MO to Santa Ana, CA with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from St. Louis, MO to Santa Ana, CA with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from St. Louis, MO to Santa Ana, CA with the following bus company: Greyhound.
Complete guide to Santa Ana, CA
Things to do in Santa Ana, CA
Discover the best of Santa Ana, CA — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Santa Ana, CA trip today.
- Recommended
Discovery Cube Orange County
Hands-on science museum with interactive exhibits, a Discovery Cube, and family-friendly learning in downtown Santa Ana.
- Recommended
Lyon Air Museum
Small local museum preserving Orange County aviation and aerospace history with artifacts, photos, and volunteer-led interpretation.
- Must visit
Downtown Santa Ana
Walkable downtown district with historic buildings, murals, shops, galleries, and regular arts and community events.
- Recommended
East 4th Street
Lively pedestrian-friendly arts corridor known for galleries, murals, boutiques, and monthly art-focused street activity.
- Recommended
Floral Park
Historic neighborhood of preserved early 20th-century homes, ideal for architecture walks and seasonal house tours.
- Vegetarian
- Gluten-free
Bionico
Classic Orange County Mexican street snack of fresh fruit, cucumber, jicama and peanuts with lime, chili and chamoy. Common in Santa Ana's Latino neighborhoods.
- Vegetarian
- Gluten-free
Atole
Warm masa drink with cinnamon and piloncillo, traditionally sold by tamale vendors and panaderías. A comforting local favorite in Santa Ana's Mexican community.
- Gluten-free
Tamales
Corn husks filled with masa and meats or chiles, then steamed. A staple for holidays and weekend breakfasts in Santa Ana's long-established Mexican families.
Knife Pleat
Refined restaurant focused on seasonal Californian cuisine with French influences. Stylish dining room suited for a more upscale meal.
Tacos Manuel
Casual taquería known for Tijuana-style tacos, adobada and handmade tortillas. Busy, straightforward and highly regarded for flavorful meats.
Mariscos Valle Hermoso
Lively mariscos spot serving ceviches, aguachiles and seafood cocktails. Colorful, casual atmosphere with a strong local following.
US Dollar ($)
Moderate for Southern California; hotels and dining are mid-priced, while local transit is affordable and many casual food options are available.
Average meal costs
- Budget
- $10-18 for fast food or casual takeout.
- Mid-range
- $20-40 per person for a restaurant meal.
- Fine dining
- $60+ per person for upscale dining.
- Coffee
- $3-6 for coffee or cappuccino.
Tipping culture
Tip 15-20% at restaurants, $1-2 per drink at bars, and round up or add 10-15% for taxis. Cafes often have tip jars or card prompts.
Plan your visit to Santa Ana, CA
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Santa Ana, CA.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Santa Ana, CA, travelers should be alert to petty crimes such as pickpocketing and vehicle break-ins, especially in crowded areas and parking lots. Common scams include overcharging by unlicensed taxi or ride-share drivers and street vendors selling counterfeit goods. Staying in well-populated areas, using official transportation services, and safeguarding personal belongings help minimize risks.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
FAQs: Bus from St. Louis, MO to Santa Ana, CA
Find answers to the most common questions about traveling from St. Louis, MO to Santa Ana, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Santa Ana, CA, this guide helps you travel smarter and with confidence.
It's helpful to compare your options as there are 2 ways to travel between St. Louis, MO and Santa Ana, CA including taking a train and bus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
popular bus stations
Popular bus stations from St. Louis, MO to Santa Ana, CA
Most St. Louis, MO to Santa Ana, CA buses use the St. Louis, S 15th St (Civic center) to Santa Ana, E Santa Ana Blvd (Train Station) station pair. Use this guide to compare St. Louis, MO and Santa Ana, CA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in St. Louis
Arrival bus stations in Santa Ana
Which St. Louis, MO station do buses to Santa Ana, CA leave from?
Buses from St. Louis, MO to Santa Ana, CA leave from St. Louis, S 15th St (Civic center). The station is 0 miles (1 km) from St. Louis, MO city centre at S 15th St, St. Louis, MO, USA.
St. Louis, S 15th St (Civic center)S 15th St, St. Louis, MO, USA
City-centre transport
Getting to St. Louis, S 15th St (Civic center) from St. Louis city centre
TrainMlb, Mlr · 4m · $4 · every ~14 min
Bus19, 32, 40 · 8m · $2 · every ~9 min
St. Louis, S 15th St (Civic center) bus station facilities and services
St. Louis, S 15th St (Civic center) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at St. Louis, S 15th St (Civic center). ATMs are available at St. Louis, S 15th St (Civic center).
Tickets and information
Ticket office support is available at St. Louis, S 15th St (Civic center).
Parking, taxis and toilets
Available at St. Louis, S 15th St (Civic center): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at St. Louis, S 15th St (Civic center): Wheelchair accessible routes available.
St. Louis, Lambert International AirportSt. Louis Lambert International Airport (STL), 10701 Lambert International Blvd, St. Louis, MO 63145, USA
City-centre transport
Getting to St. Louis, Lambert International Airport from St. Louis city centre
St. Louis, Lambert International Airport is 19 km from St. Louis city centre. Public transport options include:
TrainMlr · 31m · $4 · every ~7 min
Bus4 · 1h 3m · $30 · every ~4 min
St. Louis, Lambert International Airport bus station facilities and services
St. Louis, Lambert International Airport has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Multiple dining options available in terminals.
Wi-Fi and ATMs
Free Wi-Fi available throughout the airport. ATMs are aTMs available in terminal areas.
Tickets and information
Ticket office support is available at St. Louis, Lambert International Airport.
Parking, taxis and toilets
Available at St. Louis, Lambert International Airport: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at St. Louis, Lambert International Airport: Wheelchair accessible facilities available.
Which Santa Ana, CA station do buses from St. Louis, MO arrive at?
Buses from St. Louis, MO to Santa Ana, CA arrive at Santa Ana, E Santa Ana Blvd (Train Station). Santa Ana, E Santa Ana Blvd (Train Station) is 0 miles (1 km) from Santa Ana, CA city centre.
Santa Ana, E Santa Ana Blvd (Train Station)Santa Ana, 1000 E Santa Ana Blvd, Santa Ana, CA 92701, USA
City-centre transport
Getting to Santa Ana, E Santa Ana Blvd (Train Station) from Santa Ana city centre
Santa Ana, E Santa Ana Blvd (Train Station) is 1 km from Santa Ana city centre. Public transport options include:
TRUE
Santa Ana, E Santa Ana Blvd (Train Station) bus station facilities and services
Santa Ana, E Santa Ana Blvd (Train Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Santa Ana, E Santa Ana Blvd (Train Station). ATMs are available at Santa Ana, E Santa Ana Blvd (Train Station).
Tickets and information
Ticket office support is available at Santa Ana, E Santa Ana Blvd (Train Station).
Parking, taxis and toilets
Available at Santa Ana, E Santa Ana Blvd (Train Station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Santa Ana, E Santa Ana Blvd (Train Station): Bus access is available.
Bus stations for St. Louis, MO to Santa Ana, CA
Check bus stations information for St. Louis, MO and Santa Ana, CA, including where buses depart and arrive on this route.
When departing from St. Louis, MO , you have various bus station options to start your journey from including St. Louis, S 15th St (Civic center), St. Louis, Lambert International Airport . When arriving in Santa Ana, CA , you can end your journey in bus stations like Santa Ana, E Santa Ana Blvd (Train Station) .Passengers board the bus most frequently from St. Louis, S 15th St (Civic center), which is located around 0 miles (1 km) away from the city centre, and they get off the bus at Santa Ana, E Santa Ana Blvd (Train Station), located 1 away from the city centre.
Most popular bus connections from St. Louis, MO
Most popular buses to and from Santa Ana, CA and St. Louis, MO
Most popular bus connections to Santa Ana, CA
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