The cheapest and fastest buses from San Francisco, CA to Santa Ana, CA
Cheapest price
$104
Average price
$104
Fastest journey
13 h 30 m
Average duration
13 h 30 m
Buses per day
1
Distance
608 km
The best way to find a cheap bus ticket from San Francisco, CA to Santa Ana, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from San Francisco, CA to Santa Ana, CA will cost around $104 if you buy it on the day, but the cheapest tickets can be found for only $104.
Of the 1 buses that leave San Francisco, CA for Santa Ana, CA on Fri, Jan 16, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Fri, Jan 16 the direct buses cover the 608 km distance in an average of 13 h 30 m but if you time it right, some buses will get you there in just 13 h 30 m .
On Fri, Jan 16 the slowest buses will take 13 h 30 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.


Travel Information
Compare train, bus, and flight for San Francisco, CA to Santa Ana, CA
Omio recommends booking the train as it is the most popular option from San Francisco, CA to Santa Ana, CA among Omio's users. If you are prioritising price take the train with prices starting from €55. For those with little time consider booking a flight which can get you there in 1h 33m. The ticket price range depends on the travel mode: a train costs an average of €55, and a flight costs an average of €68.
Distance: 377 miles (608 km)
Compare bus with
| Bus | Most popular Train | Flight |
|---|---|---|
€60 Average price | €59 Average price Cheapest | €137 Average price |
11h 57m Average total duration 11h 27m Onboard + 30m Additional time* | 12h 1m Average total duration 11h 31m Onboard + 30m Additional time* | 4h 33m Average total duration Fastest 1h 33m Onboard + 3h 0m Additional time* |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline |
Direct Options | Direct Options | Direct Options |
Live departures
San Francisco, CA to Santa Ana, CA bus times
The table below shows live departures for San Francisco, CA to Santa Ana, CA buses for tomorrow, Friday, January 16. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 3:30 PM San Francisco, CA | 13h30 | 5:00 AM Santa Ana, CA | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets San Francisco, CA to Santa Ana, CA by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Jan 16
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Jan 21
Jan 22
Journey information
Overview: Bus from San Francisco, CA to Santa Ana, CA
Buses from San Francisco, CA to Santa Ana, CA run on average 14 times per day, taking around 11h 27m. Cheap bus tickets for this journey start at $55 (€44) if you book in advance.
There are 1 buses per day. The earliest bus runs at 00:05, the last at 23:45. The fastest bus covers the 377 miles (608 km) distance in 13h 30m.
Distance 377 miles (608 km) |
Average bus duration 11h 27m |
Cheapest ticket price $55 (€44) |
Buses per day 14 |
Direct buses 1 |
Fastest bus 13h 30m |
First bus 00:05 |
Last bus 23:45 |
Key Takeaways
Train Ticket Prices
- Budget Options: Train tickets from San Francisco, CA to Santa Ana, CA start from as low as $55 (€44) if booked well in advance.
- Standard Fares: Typically, trains cost $74 (€60) depending on the train type and class.
Journey Duration & Frequency
- On average there are 14 daily trains from San Francisco, CA to Santa Ana, CA with 1 direct service.
- The fastest trains can take as little as 13h 30m but the average duration is 11h 27m
Train Operators
- Travel from San Francisco, CA to Santa Ana, CA with Greyhound and FlixBus
- The most booked train company for this route on Omio is Greyhound.
Stations & Schedule
- Most trains depart from San Francisco, Transit Center Bay 29 and arrive in Santa Ana, E Santa Ana Blvd (Train Station)
- First train typically departs at 12:05 AM and the last at 11:45 PM
Bus providers: Greyhound, FlixBus from San Francisco, CA to Santa Ana, CAYou can travel by bus between San Francisco, CA to Santa Ana, CA with Greyhound, FlixBus for as low as $55 (€44). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
Greyhound
FAQs: Bus from San Francisco, CA to Santa Ana, CA
Find answers to the most common questions about traveling from San Francisco, CA to Santa Ana, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Santa Ana, CA, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
To find the cheapest bus tickets for your trip from San Francisco, CA to Santa Ana, CA, follow these tips:
Start your search now and compare ticket prices to find the best deal!
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Greyhound
- $15 per additional bag.
- FlixBus
- Additional luggage can be purchased for a fee.
- FlixBus
- Small pets in carriers allowed
- Guide dogs travel for free.
popular bus stations
Popular bus stations from San Francisco, CA to Santa Ana, CA
Most popular bus connections from San Francisco, CA
More options for your journey from San Francisco, CA to Santa Ana, CA
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