San Francisco, CA to Santa Ana, CA bus with Greyhound

Mon, Dec 01
+ Add return
Greyhound
FlixBus
Alsa
BlaBlaCar Bus
Rede Expressos
1,000+ travel companies
Greyhound
FlixBus
Alsa
BlaBlaCar Bus
Rede Expressos
1,000+ travel companies
QR-Code
Scan to get our free app
Use our app to get live travel updates and book mobile tickets for trains, buses, flights, and ferries.
App Store
rate4.9
42K ratings
Google Play
rate4.6
136K reviews

The cheapest and fastest buses from San Francisco, CA to Santa Ana, CA

Showing times and prices for Dec 01

Cheapest price

$66

Average price

$149

Fastest journey

11 h 20 m

Average duration

12 h 20 m

Buses per day

6

Distance

608 km

Cheap tickets

The best way to find a cheap bus ticket from San Francisco, CA to Santa Ana, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.

The average ticket from San Francisco, CA to Santa Ana, CA will cost around $149 if you buy it on the day, but the cheapest tickets can be found for only $66.

Fast buses

Of the 6 buses that leave San Francisco, CA for Santa Ana, CA on Mon, Dec 01, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.

On Mon, Dec 01 the direct buses cover the 608 km distance in an average of 12 h 20 m but if you time it right, some buses will get you there in just 11 h 20 m .

On Mon, Dec 01 the slowest buses will take 13 h 10 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

Amtrak4790 AMTRAK · 790 Pacific Surfliner
07:50AM13h10
San Francisco, CA
09:00PMSanta Ana Station, Santa Ana, CA
$661One-way
1 transfer
Amtrak4770 AMTRAK · 770 Pacific Surfliner
10:35PM12h25
San Francisco, CA
11:00AMSanta Ana Station, Santa Ana, CA
$661One-way
1 transfer
Amtrak4784 AMTRAK · 784 Pacific Surfliner
05:15AM12h45
San Francisco, CA
06:00PMSanta Ana Station, Santa Ana, CA
$661One-way
1 transfer
Greyhoundundefined · undefined
06:30AM15h30
San Francisco, Transit Center Bay 29
10:00PMSanta Ana, E Santa Ana Blvd (Train Station)
$2161One-way
1 transfer
Greyhound
10:40PM11h20
San Francisco, Transit Center Bay 29
10:00AMSanta Ana, E Santa Ana Blvd (Train Station)
$2241One-way
0 transfers

Travel Information

Compare train, bus, and flight for San Francisco, CA to Santa Ana, CA

Omio recommends booking the train as it is the most popular option from San Francisco, CA to Santa Ana, CA among Omio's users. If you are prioritising price take the train with prices starting from €55. For those with little time consider booking a flight which can get you there in 1h 33m. The ticket price range depends on the travel mode: a train costs an average of €55, and a flight costs an average of €68.

Distance: 377 miles (608 km)

Compare bus with

Bus
Most popular
Train
Flight

€60

Average price

€59

Average price

Cheapest

€137

Average price

11h 57m

Average total duration

11h 27m

Onboard

+

30m

Additional time*

12h 1m

Average total duration

11h 31m

Onboard

+

30m

Additional time*

4h 33m

Average total duration

Fastest

1h 33m

Onboard

+

3h 0m

Additional time*

Greyhound

Most popular bus company

Amtrak

Most popular train company

Alaska Airlines

Most popular airline

Direct Options

Direct Options

Direct Options

San Francisco, CA to Santa Ana, CA Bus Timetables

OperatorDeparture TimeArrival TimeDurationDeparture daysCheapest price
Operator
Amtrak
Departure Time
05:15AM
Arrival Time
06:00PM
Duration
12h45
Departure days
Mon, Fri
Cheapest price
$66
Operator
Greyhound
Departure Time
06:30AM
Arrival Time
10:00PM
Duration
15h30
Departure days
Mon, Fri, Sun
Cheapest price
$91
Operator
Amtrak
Departure Time
07:50AM
Arrival Time
09:00PM
Duration
13h10
Departure days
Mon, Fri
Cheapest price
$66
Operator
FlixBus
Departure Time
10:00AM
Arrival Time
10:00PM
Duration
12h00
Departure days
Mon
Cheapest price
$256
Operator
Greyhound
Departure Time
07:10PM
Arrival Time
10:00AM
Duration
14h50
Departure days
Sun
Cheapest price
$200
Operator
Amtrak
Departure Time
10:35PM
Arrival Time
11:00AM
Duration
12h25
Departure days
Mon, Fri, Sun
Cheapest price
$66
Operator
Greyhound
Departure Time
10:40PM
Arrival Time
10:00AM
Duration
11h20
Departure days
Mon, Fri, Sun
Cheapest price
$100

Live departures

San Francisco, CA to Santa Ana, CA bus times

The table below shows live departures for San Francisco, CA to Santa Ana, CA buses for tomorrow, Monday, December 1. You can also manually refresh the results below to see updated bus journeys.

Last updated at 4:50 PM
ProviderDepartsDurationArrivesTransfers
Tickets
meinfernbus_flixbusFlixBus+greyhoundundefined · undefined3:10 AM San Francisco, Townsend Street / 5th Street, CA
14h50
6:00 PM Santa Ana, E Santa Ana Blvd (Train Station)2 transfers
amtrak4770 AMTRAK · 770 Pacific Surfliner6:35 AM San Francisco, CA
12h25
7:00 PM Santa Ana Station, Santa Ana, CA1 transfer
greyhound6:40 AM San Francisco, Transit Center Bay 29
11h20
6:00 PM Santa Ana, E Santa Ana Blvd (Train Station)0 transfersDirect
amtrak4784 AMTRAK · 784 Pacific Surfliner1:15 PM San Francisco, CA
12h45
2:00 AM Santa Ana Station, Santa Ana, CA1 transfer
greyhoundundefined · undefined2:30 PM San Francisco, Transit Center Bay 29
15h30
6:00 AM Santa Ana, E Santa Ana Blvd (Train Station)1 transfer
amtrak4790 AMTRAK · 790 Pacific Surfliner3:50 PM San Francisco, CA
13h10
5:00 AM Santa Ana Station, Santa Ana, CA1 transfer

This is the last bus of the day.

Find all the dates and times for this journey

Compare prices and tickets San Francisco, CA to Santa Ana, CA by train, bus, or flight

Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

Mon
Dec 01
Tue
Dec 02
Wed
Dec 03
Thu
Dec 04
Fri
Dec 05
Sat
Dec 06
Sun
Dec 07

Journey information

Overview: Bus from San Francisco, CA to Santa Ana, CA

USAUSA
USAUSA
Icon of bus

Buses from San Francisco, CA to Santa Ana, CA run on average 14 times per day, taking around 11h 27m. Cheap bus tickets for this journey start at $55 (€44) if you book in advance.

There are 1 buses per day. The earliest bus runs at 00:05, the last at 23:45. The fastest bus covers the 377 miles (608 km) distance in 13h 30m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance
377 miles (608 km)
Average bus duration
11h 27m
Cheapest ticket price
$55 (€44)
Buses per day
14
Direct buses
1
Fastest bus
13h 30m
First bus
00:05
Last bus
23:45
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information

Bus providers: Greyhound, FlixBus from San Francisco, CA to Santa Ana, CAYou can travel by bus between San Francisco, CA to Santa Ana, CA with Greyhound, FlixBus for as low as $55 (€44). When you search for schedules and tickets, Omio will show you the best journey

FlixBus

About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average Duration
13h 5m
Cheapest Price
$62 (€50)
FlixBus frequency
1 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.

Greyhound

About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
15h 30m
Cheapest Price
$141 (€114)
Greyhound frequency
1 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.

FAQs: Bus from San Francisco, CA to Santa Ana, CA

Find answers to the most common questions about traveling from San Francisco, CA to Santa Ana, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Santa Ana, CA, this guide helps you travel smarter and with confidence.

FAQs
Cheap bus tickets from San Francisco, CA to Santa Ana, CA can start from as little as $41 (€33) when you book in advance. The average bus ticket price for San Francisco, CA to Santa Ana, CA is $76 (€62); however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The bus time from San Francisco, CA to Santa Ana, CA is on average 12 h 45 min   for the 376 mile (607 km) long journey, but the time it takes to go to Santa Ana, CA from San Francisco, CA by bus can vary depending on specific dates or if traveling on weekends and holidays.
The first bus from San Francisco, CA to Santa Ana, CA leaves at 12: 05AM. Plan your trip with the Journey Planner   from Omio.
The last bus from San Francisco, CA to Santa Ana, CA leaves at 11: 45PM.
Yes, it is possible to travel from San Francisco, CA to Santa Ana, CA without having to change trains with Greyhound. There is 1 direct bus from San Francisco, CA to Santa Ana, CA each day. There may be fewer direct services available on weekends or holidays.
For the journey from San Francisco, CA to Santa Ana, CA you can take a bus with Greyhound or FlixBus. Be sure to check out all possible bus companies that offer services between San Francisco, CA and Santa Ana, CA on Omio to compare what amenities they may have.
The cheapest month for a bus from San Francisco, CA to Santa Ana, CA is January.
It's helpful to compare your options as there are 3 ways to travel from San Francisco, CA to Santa Ana, CA including taking a train, bus or flight.
Yes, the following accessibility options are available when taking the bus from San Francisco, CA to Santa Ana, CA:
  • Greyhound
    • Assistance
    • Priority seating
    • Wheelchair-accessible buses.
  • FlixBus
    • Assistance
    • Priority boarding
    • Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from San Francisco, CA to Santa Ana, CA for bus companies Greyhound and FlixBus.
Yes, bikes are allowed on board the bus with bus companies Greyhound and FlixBus.
Whether you can cancel your bus ticket from San Francisco, CA to Santa Ana, CA depends on the bus providers:
  • Greyhound
    • You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
  • FlixBus
    • You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.

To find the cheapest bus tickets for your trip from San Francisco, CA to Santa Ana, CA, follow these tips:

  • Book in advance: Tickets are often cheaper when booked early.
  • Be flexible with dates and times: Traveling during off-peak hours or on weekdays can help you save money.
  • Use our search filters: Sort results by price to quickly identify the most affordable options.
  • Look for special deals or discounts: Check for promotions or discounts available on our website and app.
  • Start your search now and compare ticket prices to find the best deal!

    Yes, there is food available to purchase on board the bus from San Francisco, CA to Santa Ana, CA.
    Yes, the following luggage options are included when booking a bus ticket from San Francisco, CA to Santa Ana, CA:
    • Greyhound
      • One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
    • FlixBus
      • One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
    Yes, the following additional luggage options are available when booking a bus ticket from San Francisco, CA to Santa Ana, CA:
    • Greyhound
      • $15 per additional bag.
    • FlixBus
      • Additional luggage can be purchased for a fee.
    Yes, you can bring your pet on the bus from San Francisco, CA to Santa Ana, CA. The following conditions apply:
    • FlixBus
      • Small pets in carriers allowed
      • Guide dogs travel for free.
    You can reserve your seat on the bus from San Francisco, CA to Santa Ana, CA with the following bus providers: Greyhound and FlixBus
    Yes, there are USB plugs on board the bus from San Francisco, CA to Santa Ana, CA with the following bus companies: Greyhound and FlixBus.
    Yes, there is Wifi on board the bus from San Francisco, CA to Santa Ana, CA with the following bus providers: Greyhound and FlixBus.

    popular bus stations

    Popular bus stations from San Francisco, CA to Santa Ana, CA

    San Francisco
    Santa Ana
    The major bus station for departures in San Francisco is San Francisco, Townsend Street / 5th Street. Find all the information you need to know about services, amenities and connections at San Francisco, Townsend Street / 5th Street for your trip from San Francisco to Santa Ana.
    San Francisco, Townsend Street / 5th Street
    San Francisco, Transit Center Bay 29
    information

    Most popular buses to and from Santa Ana, CA and San Francisco, CA

    HomeBusesBuses in USABus tickets to Santa Ana, CASan Francisco, CA to Santa Ana, CA bus

    The Omio App Makes Travel Planning Easy

    We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.

    ios-badge
    android-badge
    Hand With Phone