- Must visit
Bowers Museum
Major Orange County museum campus with art exhibitions, family programs, and rotating contemporary and historical shows.
2,000+ travel companies
2,000+ travel companies
Scan to get our free app
Use our app to get live travel updates and book mobile tickets for trains, buses, flights, and ferries.
App Store
4.942K ratings
Google Play
4.6136K reviews
The cheapest and fastest buses from San Francisco, CA to Santa Ana, CA
Showing times, prices and bookable tickets for Oct 15
Cheapest price on Oct 15
$55
Average ticket price on Oct 15
$72
Fastest journey on Oct 15
11 h 30 m
Average journey duration on Oct 15
13 h 57 m
Buses on Oct 15
3
Distance
608 km
Cheap tickets
The best way to find a cheap bus ticket from San Francisco, CA to Santa Ana, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from San Francisco, CA to Santa Ana, CA will cost around $72 if you buy it on the day, but the cheapest tickets can be found for only $55.
Fast buses
On Thu, Oct 15, we found 3 buses from San Francisco, CA to Santa Ana, CA, including 1 direct services.
On Thu, Oct 15 the direct buses cover the 608 km distance in an average of 13 h 57 m but if you time it right, some buses will get you there in just 11 h 30 m .
On Thu, Oct 15 the slowest buses will take 15 h 30 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
FlixBus+
7:10 AM14h50San Francisco, Townsend Street / 5th Street, CA10:00 PMSanta Ana, E Santa Ana Blvd (Train Station)$551One-way1 transfer- · 6:30 AM15h30San Francisco, Transit Center Bay 2910:00 PMSanta Ana, E Santa Ana Blvd (Train Station)$651One-way1 transfer
- 10:30 PM11h30San Francisco, Transit Center Bay 2910:00 AMSanta Ana, E Santa Ana Blvd (Train Station)$951One-way0 transfers
- 10:30 PM11h30San Francisco, Transit Center Bay 2910:00 AMSanta Ana, E Santa Ana Blvd (Train Station)$951One-way0 transfers
- FlixBus+7:10 AM14h50San Francisco, Townsend Street / 5th Street, CA10:00 PMSanta Ana, E Santa Ana Blvd (Train Station)$551One-way1 transfer
- · 6:30 AM15h30San Francisco, Transit Center Bay 2910:00 PMSanta Ana, E Santa Ana Blvd (Train Station)$651One-way1 transfer
Journey information
Overview: Bus from San Francisco, CA to Santa Ana, CA
USAUSA
Buses from San Francisco, CA to Santa Ana, CA run on average 3 times per day, taking around 12h 17m. Cheap bus tickets for this journey start at $42 (€35) if you book in advance.
There are 1 buses per day. The earliest bus runs at 00:15, the last at 23:55. The fastest bus covers the 377 miles (608 km) distance in 9h 25m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 377 miles (608 km) |
Average bus duration 12h 17m |
Cheapest ticket price $42 (€35) |
Buses per day 3 |
Direct buses 1 |
Fastest bus 9h 25m |
First bus 12:15 AM |
Last bus 11:55 PM |
Cheapest Month Apr |
Cheapest Day Tue |
High Season Jul - Sep |
Low Season Jan - Mar |
Best time to book 35 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
San Francisco, CA to Santa Ana, CA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 06:30AM | Arrival Time 10:00PM | Duration 15h30 | Departure days Everyday | Cheapest price $57 |
Operator FlixBus | Departure Time 07:10AM | Arrival Time 10:00PM | Duration 14h50 | Departure days Mon, Tue, Wed, Thu | Cheapest price $49 |
Operator Amtrak | Departure Time 07:45AM | Arrival Time 09:00PM | Duration 13h15 | Departure days Wed, Fri | Cheapest price $67 |
Operator Greyhound | Departure Time 06:05PM | Arrival Time 10:00AM | Duration 15h55 | Departure days Mon, Tue, Wed, Sun | Cheapest price $56 |
Operator Amtrak | Departure Time 08:50PM | Arrival Time 11:00AM | Duration 14h10 | Departure days Fri | Cheapest price $88 |
Operator Greyhound | Departure Time 10:30PM | Arrival Time 10:00AM | Duration 11h30 | Departure days Everyday | Cheapest price $74 |
Operator Amtrak | Departure Time 10:35PM | Arrival Time 11:00AM | Duration 12h25 | Departure days Wed, Fri | Cheapest price $67 |
Live departures
San Francisco, CA to Santa Ana, CA bus times
The table below shows live departures for San Francisco, CA to Santa Ana, CA buses for today, Wednesday, October 14. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| FlixBus+ · · | 6:05 PM San Francisco, Townsend Street / 5th Street, CA | 15h55 | 10:00 AM Santa Ana, E Santa Ana Blvd (Train Station) | 3 transfers | |
| 10:30 PM San Francisco, Transit Center Bay 29 | 11h30 | 10:00 AM Santa Ana, E Santa Ana Blvd (Train Station) | 0 transfersDirect | |
 4770 Connecting Bus · 770 Pacific Surfliner | 10:35 PM San Francisco, CA | 12h25 | 11:00 AM Santa Ana Station, Santa Ana, CA | 1 transfer | |
| Thursday, October 15 | |||||
| · | 6:30 AM San Francisco, Transit Center Bay 29 | 15h30 | 10:00 PM Santa Ana, E Santa Ana Blvd (Train Station) | 1 transfer | |
| FlixBus+ | 7:10 AM San Francisco, Townsend Street / 5th Street, CA | 14h50 | 10:00 PM Santa Ana, E Santa Ana Blvd (Train Station) | 1 transfer | |
Find all the dates and times for this journey
Why should you book San Francisco, CA to Santa Ana, CA buses with Omio?
Greyhound as well as FlixBus offer buses services from San Francisco, CA to Santa Ana, CA.
Omio is an official ticket reseller for all your travel options from San Francisco, CA to Santa Ana, CA.
Why book with Omio vs Greyhound?
- Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of FlixBus to find the best option for your trip from San Francisco, CA to Santa Ana, CA.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus, flight and train to ensure you get the best deal for traveling from San Francisco, CA to Santa Ana, CA.
Why book with Omio over Wanderu or Trainline?
- Compare with other providers: On Omio, you can also compare tickets for the likes of FlixBus to find the best option for your trip from San Francisco, CA to Santa Ana, CA.
- Multiple modes of transport: Omio allows you to compare travel options including bus, flight and train to find the ideal travel option from San Francisco, CA to Santa Ana, CA.
Bus providers: Greyhound, FlixBus from San Francisco, CA to Santa Ana, CAYou can travel by bus between San Francisco, CA to Santa Ana, CA with Greyhound, FlixBus for as low as $42 (€35). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average FlixBus Duration
9h 25m
Cheapest FlixBus Price
$42 (€35)
FlixBus frequency
1 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
11h 20m
Cheapest Greyhound Price
$53 (€44)
Greyhound frequency
2 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Santa Ana, CA
Things to do in Santa Ana, CA
Discover the best of Santa Ana, CA — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Santa Ana, CA trip today.
- Recommended
Discovery Cube Orange County
Hands-on science museum with interactive exhibits, a Discovery Cube, and family-friendly learning in downtown Santa Ana.
- Recommended
Lyon Air Museum
Small local museum preserving Orange County aviation and aerospace history with artifacts, photos, and volunteer-led interpretation.
- Must visit
Downtown Santa Ana
Walkable downtown district with historic buildings, murals, shops, galleries, and regular arts and community events.
- Recommended
East 4th Street
Lively pedestrian-friendly arts corridor known for galleries, murals, boutiques, and monthly art-focused street activity.
- Recommended
Floral Park
Historic neighborhood of preserved early 20th-century homes, ideal for architecture walks and seasonal house tours.
- Vegetarian
- Gluten-free
Bionico
Classic Orange County Mexican street snack of fresh fruit, cucumber, jicama and peanuts with lime, chili and chamoy. Common in Santa Ana's Latino neighborhoods.
- Vegetarian
- Gluten-free
Atole
Warm masa drink with cinnamon and piloncillo, traditionally sold by tamale vendors and panaderías. A comforting local favorite in Santa Ana's Mexican community.
- Gluten-free
Tamales
Corn husks filled with masa and meats or chiles, then steamed. A staple for holidays and weekend breakfasts in Santa Ana's long-established Mexican families.
Knife Pleat
Refined restaurant focused on seasonal Californian cuisine with French influences. Stylish dining room suited for a more upscale meal.
Tacos Manuel
Casual taquería known for Tijuana-style tacos, adobada and handmade tortillas. Busy, straightforward and highly regarded for flavorful meats.
Mariscos Valle Hermoso
Lively mariscos spot serving ceviches, aguachiles and seafood cocktails. Colorful, casual atmosphere with a strong local following.
US Dollar ($)
Moderate for Southern California; hotels and dining are mid-priced, while local transit is affordable and many casual food options are available.
Average meal costs
- Budget
- $10-18 for fast food or casual takeout.
- Mid-range
- $20-40 per person for a restaurant meal.
- Fine dining
- $60+ per person for upscale dining.
- Coffee
- $3-6 for coffee or cappuccino.
Tipping culture
Tip 15-20% at restaurants, $1-2 per drink at bars, and round up or add 10-15% for taxis. Cafes often have tip jars or card prompts.
FAQs: Bus from San Francisco, CA to Santa Ana, CA
Find answers to the most common questions about traveling from San Francisco, CA to Santa Ana, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Santa Ana, CA, this guide helps you travel smarter and with confidence.
Cheap bus tickets from San Francisco, CA to Santa Ana, CA can start from as little as $42 (€35) when you book in advance. The average bus ticket price for San Francisco, CA to Santa Ana, CA is $98 (€82) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from San Francisco, CA to Santa Ana, CA is 9h 25m to travel the 377 miles (608 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from San Francisco, CA to Santa Ana, CA leaves at 12:15 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from San Francisco, CA to Santa Ana, CA leaves at 11:55 PM.
Yes, there are 1 direct buses a day from San Francisco, CA to Santa Ana, CA with Greyhound. Schedules can vary on holidays or weekends with fewer direct buses.
When taking a bus from San Francisco, CA to Santa Ana, CA, you can count on Greyhound, FlixBus for the best way to get you to Santa Ana, CA. You can also check all possible bus companies who offer a service between San Francisco, CA and Santa Ana, CA and compare the amenities they offer before buying a bus ticket.
When departing from San Francisco, CA , you have various bus station options to start your journey from including San Francisco, Transit Center Bay 29, San Francisco, Townsend Street / 5th Street, CA, Oakland, West Oakland BART Station, CA, Hayward BART Station . When arriving in Santa Ana, CA , you can end your journey in bus stations like Santa Ana, E Santa Ana Blvd (Train Station), Anaheim, Regional Transportation Intermodal Center (ARTIC) .Passengers board the bus most frequently from San Francisco, Transit Center Bay 29, which is located around 1 miles (2 km) away from the city centre, and they get off the bus at Santa Ana, E Santa Ana Blvd (Train Station), located 1 away from the city centre.
It's helpful to compare your options as there are 3 ways to travel between San Francisco, CA and Santa Ana, CA including taking a bus, flight, and train.
Yes, the following accessibility options are available when taking the bus from San Francisco, CA to Santa Ana, CA:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from San Francisco, CA to Santa Ana, CA for bus company Greyhound, FlixBus.
Whether you can cancel your bus ticket from San Francisco, CA to Santa Ana, CA depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company Greyhound, FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from San Francisco, CA to Santa Ana, CA.
Yes, the following luggage options are included when booking a bus ticket from San Francisco, CA to Santa Ana, CA:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from San Francisco, CA to Santa Ana, CA:
- Greyhound
- $15 per additional bag.
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from San Francisco, CA to Santa Ana, CA. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from San Francisco, CA to Santa Ana, CA with the following bus company: Greyhound, FlixBus
Yes, there are USB plugs on board the bus from San Francisco, CA to Santa Ana, CA with the following bus company: Greyhound, FlixBus.
Yes, there is Wifi on board the bus from San Francisco, CA to Santa Ana, CA with the following bus company: Greyhound, FlixBus.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Santa Ana, CA, travelers should be alert to petty crimes such as pickpocketing and vehicle break-ins, especially in crowded areas and parking lots. Common scams include overcharging by unlicensed taxi or ride-share drivers and street vendors selling counterfeit goods. Staying in well-populated areas, using official transportation services, and safeguarding personal belongings help minimize risks.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from San Francisco, CA to Santa Ana, CA
Most San Francisco, CA to Santa Ana, CA buses use the San Francisco, Transit Center Bay 29 to Santa Ana, E Santa Ana Blvd (Train Station) station pair. Use this guide to compare San Francisco, CA and Santa Ana, CA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in San Francisco
Arrival bus stations in Santa Ana
Which San Francisco, CA station do buses to Santa Ana, CA leave from?
Buses from San Francisco, CA to Santa Ana, CA leave from San Francisco, Transit Center Bay 29. The station is 1 miles (3 km) from San Francisco, CA city centre at Transit Center Bay 29, San Francisco, CA 94105, USA.
San Francisco, Transit Center Bay 29Transit Center Bay 29, San Francisco, CA 94105, USA
City-centre transport
Getting to San Francisco, Transit Center Bay 29 from San Francisco city centre
San Francisco, Transit Center Bay 29 is 2 km from San Francisco city centre. Public transport options include:
Bus397 · 8m · $3
14, 14R · 13m · $3 · every ~30 min
101, 120 · 14m · $6 · every ~9 min
7 · 21m · $3 · every ~10 min
SubwayYellow-N, Green-N, Red-N, Blue-N · 10m · $3 · every ~27 min
San Francisco, Transit Center Bay 29 bus station facilities and services
San Francisco, Transit Center Bay 29 has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at San Francisco, Transit Center Bay 29. ATMs are available at San Francisco, Transit Center Bay 29.
Tickets and information
Ticket office support is available at San Francisco, Transit Center Bay 29.
Parking, taxis and toilets
Available at San Francisco, Transit Center Bay 29: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at San Francisco, Transit Center Bay 29: Wheelchair accessible areas present.
San Francisco, Townsend Street / 5th StreetSan Francisco Bus Station,401 Townsend St,94107
City-centre transport
Getting to San Francisco, Townsend Street / 5th Street from San Francisco city centre
BusEast, West · 20m · every ~4 min
Nbus, Nowl · 24m · $3 · every ~2 min
TramN · 23m · $3 · every ~11 min
Which Santa Ana, CA station do buses from San Francisco, CA arrive at?
Buses from San Francisco, CA to Santa Ana, CA most often arrive at Santa Ana, E Santa Ana Blvd (Train Station). Some services arrive at Anaheim, Regional Transportation Intermodal Center (ARTIC), so check your ticket before travel to confirm your Santa Ana, CA arrival station.
Santa Ana, E Santa Ana Blvd (Train Station)Santa Ana, 1000 E Santa Ana Blvd, Santa Ana, CA 92701, USA
City-centre transport
Getting to Santa Ana, E Santa Ana Blvd (Train Station) from Santa Ana city centre
Santa Ana, E Santa Ana Blvd (Train Station) is 1 km from Santa Ana city centre. Public transport options include:
TRUE
Santa Ana, E Santa Ana Blvd (Train Station) bus station facilities and services
Santa Ana, E Santa Ana Blvd (Train Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Santa Ana, E Santa Ana Blvd (Train Station). ATMs are available at Santa Ana, E Santa Ana Blvd (Train Station).
Tickets and information
Ticket office support is available at Santa Ana, E Santa Ana Blvd (Train Station).
Parking, taxis and toilets
Available at Santa Ana, E Santa Ana Blvd (Train Station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Santa Ana, E Santa Ana Blvd (Train Station): Bus access is available.
Most popular bus connections from San Francisco, CA
More options for your journey from San Francisco, CA to Santa Ana, CA
Here are some other resources that might have the information you need
Most popular buses to and from Santa Ana, CA and San Francisco, CA
Most popular bus connections to Santa Ana, CA
The Omio App Makes Travel Planning Easy
We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.
