San Francisco, CA to Santa Ana, CA bus with Greyhound

Mon, Aug 31
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The cheapest and fastest buses from San Francisco, CA to Santa Ana, CA

Showing times, prices and bookable tickets for Aug 31

Cheapest price on Aug 31

kr537

Average ticket price on Aug 31

kr729

Fastest journey on Aug 31

11 h 30 m

Average journey duration on Aug 31

13 h 30 m

Buses on Aug 31

6

Distance

608 km

Cheap tickets

The best way to find a cheap bus ticket from San Francisco, CA to Santa Ana, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.

The average ticket from San Francisco, CA to Santa Ana, CA will cost around kr729 if you buy it on the day, but the cheapest tickets can be found for only kr537.

Fast buses

On Mon, Aug 31, we found 6 buses from San Francisco, CA to Santa Ana, CA, including 1 direct services.

On Mon, Aug 31 the direct buses cover the 608 km distance in an average of 13 h 30 m but if you time it right, some buses will get you there in just 11 h 30 m .

On Mon, Aug 31 the slowest buses will take 15 h 30 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

  • FlixBusFlixBus+Greyhound · ·
    6:05 PM15h55
    San Francisco, Townsend Street / 5th Street, CA
    10:00 AMSanta Ana, E Santa Ana Blvd (Train Station)
    kr5371One-way
    3 transfers
  • Amtrak4790 AMTRAK · 790 Pacific Surfliner
    7:45 AM13h15
    San Francisco, CA
    9:00 PMSanta Ana Station, Santa Ana, CA
    kr6171One-way
    1 transfer
  • Amtrak4770 AMTRAK · 770 Pacific Surfliner
    10:35 PM12h25
    San Francisco, CA
    11:00 AMSanta Ana Station, Santa Ana, CA
    kr6171One-way
    1 transfer
  • Greyhound ·
    6:30 AM15h30
    San Francisco, Transit Center Bay 29
    10:00 PMSanta Ana, E Santa Ana Blvd (Train Station)
    kr6761One-way
    1 transfer
  • FlixBusFlixBus+Greyhound
    7:10 AM14h50
    San Francisco, Townsend Street / 5th Street, CA
    10:00 PMSanta Ana, E Santa Ana Blvd (Train Station)
    kr7461One-way
    1 transfer

Travel Information

Compare bus, flight, and train for San Francisco, CA to Santa Ana, CA

Omio recommends booking the train as it is the most popular option from San Francisco, CA to Santa Ana, CA among Omio's users. If you are prioritising price, take the train, with an average ticket price of kr642 For those with little time, consider booking a flight, which has an average total journey time of 3h 33m. Average ticket prices depend on the travel mode: a train costs an average of kr642, while a flight costs an average of kr1785.

Distance: 377 miles (608 km)

Compare bus with

Bus
Most popular
Train
Flight
Driving

kr735

Average price

kr642

Average price

Cheapest

kr1785

Average price

kr808

Average price

(fuel + tolls)

11h 41m

Average total duration

11h 11m

Onboard

+

30m

Additional time*

12h 1m

Average total duration

11h 31m

Onboard

+

30m

Additional time*

3h 33m

Average total duration

Fastest

1h 33m

Onboard

+

2h 0m

Additional time*

6h 17m

Average total duration

(door-to-door)

Greyhound

Most popular bus company

Amtrak

Most popular train company

Alaska Airlines

Most popular airline

Your own car or car rental

Direct Options

Direct Options

Direct Options

Direct Options

The cheapest way to travel from San Francisco, CA to Santa Ana, CA is a train with an average price of kr642.

This is compared to other travel options from San Francisco, CA to Santa Ana, CA:

A train is kr93 less than a bus for this route with tickets for a bus from San Francisco, CA to Santa Ana, CA costing on average kr735.

A train is kr1143 less than a flight for this route with tickets for a flight from San Francisco, CA to Santa Ana, CA costing on average kr1785.

The fastest way to travel from San Francisco, CA to Santa Ana, CA is by flight with an average journey time of 1h 33m.

Other travel options to Santa Ana, CA take longer:

Bus takes on average 11h 11m.

Train takes on average 11h 31m.

It's helpful to compare your options as there are 3 ways to travel between San Francisco, CA and Santa Ana, CA including taking a bus, flight, and train.
We recommend using the train as it is the most popular way to get from San Francisco, CA to Santa Ana, CA among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.

Tickets start at around kr735 compared to roughly kr808 in fuel and tolls — a saving of about kr74. The journey takes 11h 11m versus 6h 17m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.

Direct services are operated by Greyhound.

Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.

San Francisco, CA to Santa Ana, CA Bus Timetables

OperatorDeparture TimeArrival TimeDurationDeparture daysCheapest price
Operator
Greyhound
Departure Time
06:30AM
Arrival Time
10:00PM
Duration
15h30
Departure days
Everyday
Cheapest price
kr665
Operator
FlixBus
Departure Time
07:10AM
Arrival Time
10:00PM
Duration
14h50
Departure days
Mon, Tue, Wed, Thu
Cheapest price
kr670
Operator
Amtrak
Departure Time
07:45AM
Arrival Time
09:00PM
Duration
13h15
Departure days
Mon, Thu, Fri, Sat
Cheapest price
kr617
Operator
Greyhound
Departure Time
06:05PM
Arrival Time
10:00AM
Duration
15h55
Departure days
Mon, Tue, Wed, Sun
Cheapest price
kr537
Operator
Greyhound
Departure Time
10:30PM
Arrival Time
10:00AM
Duration
11h30
Departure days
Everyday
Cheapest price
kr902
Operator
Amtrak
Departure Time
10:35PM
Arrival Time
11:00AM
Duration
12h25
Departure days
Mon, Thu, Fri, Sat
Cheapest price
kr617

Live departures

San Francisco, CA to Santa Ana, CA bus times

The table below shows live departures for San Francisco, CA to Santa Ana, CA buses for today, Sunday, August 30. You can also manually refresh the results below to see updated bus journeys.

Last updated at
ProviderDepartsDurationArrivesTransfers
Tickets
Greyhound · 6:30 AM San Francisco, Transit Center Bay 29
15h30
10:00 PM Santa Ana, E Santa Ana Blvd (Train Station)1 transfer
FlixBusFlixBus+Greyhound · · 6:05 PM San Francisco, Townsend Street / 5th Street, CA
15h55
10:00 AM Santa Ana, E Santa Ana Blvd (Train Station)3 transfers
Greyhound10:30 PM San Francisco, Transit Center Bay 29
11h30
10:00 AM Santa Ana, E Santa Ana Blvd (Train Station)0 transfersDirect

This is the last bus of the day.

Find all the dates and times for this journey

Compare prices and tickets San Francisco, CA to Santa Ana, CA by bus, flight, or train

Compare bus, flight, and train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

Mon
Aug 31
Tue
Sep 01
Wed
Sep 02
Thu
Sep 03
Fri
Sep 04
Sat
Sep 05
Sun
Sep 06

Why should you book San Francisco, CA to Santa Ana, CA buses with Omio?

Greyhound as well as FlixBus offer buses services from San Francisco, CA to Santa Ana, CA.
Omio is an official ticket reseller for all your travel options from San Francisco, CA to Santa Ana, CA.

Why book with Omio vs Greyhound?

  • Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of FlixBus to find the best option for your trip from San Francisco, CA to Santa Ana, CA.
  • Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
  • Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus, flight and train to ensure you get the best deal for traveling from San Francisco, CA to Santa Ana, CA.

Why book with Omio over Wanderu or Trainline?

  • Compare with other providers: On Omio, you can also compare tickets for the likes of FlixBus to find the best option for your trip from San Francisco, CA to Santa Ana, CA.
  • Multiple modes of transport: Omio allows you to compare travel options including bus, flight and train to find the ideal travel option from San Francisco, CA to Santa Ana, CA.

Journey information

Overview: Bus from San Francisco, CA to Santa Ana, CA

USAUSA
USAUSA
Icon of bus

Buses from San Francisco, CA to Santa Ana, CA run on average 5 times per day, taking around 11h 11m. Cheap bus tickets for this journey start at kr399 if you book in advance.

There are 1 buses per day. The earliest bus runs at 00:15, the last at 23:55. The fastest bus covers the 377 miles (608 km) distance in 11h 30m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance
377 miles (608 km)
Average bus duration
11h 11m
Cheapest ticket price
kr399
Buses per day
5
Direct buses
1
Fastest bus
11h 30m
First bus
12:15 AM
Last bus
11:55 PM
Cheapest Month
Apr
Cheapest Day
Tue
High Season
Jul - Sep
Low Season
Jan - Mar
Best time to book
35 days
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information

Bus providers: Greyhound, FlixBus from San Francisco, CA to Santa Ana, CAYou can travel by bus between San Francisco, CA to Santa Ana, CA with Greyhound, FlixBus for as low as kr399. When you search for schedules and tickets, Omio will show you the best journey

FlixBus

About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average FlixBus Duration
14h 30m
Cheapest FlixBus Price
kr399
FlixBus frequency
1 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.

Greyhound

About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
11h 30m
Cheapest Greyhound Price
kr485
Greyhound frequency
2 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.

FAQs: Bus from San Francisco, CA to Santa Ana, CA

Find answers to the most common questions about traveling from San Francisco, CA to Santa Ana, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Santa Ana, CA, this guide helps you travel smarter and with confidence.

FAQs
Cheap bus tickets from San Francisco, CA to Santa Ana, CA can start from as little as kr399 when you book in advance. The average bus ticket price for San Francisco, CA to Santa Ana, CA is kr735 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from San Francisco, CA to Santa Ana, CA is 11h 30m to travel the 377 miles (608 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from San Francisco, CA to Santa Ana, CA leaves at 12:15 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from San Francisco, CA to Santa Ana, CA leaves at 11:55 PM.
Yes, there are 1 direct buses a day from San Francisco, CA to Santa Ana, CA with Greyhound. Schedules can vary on holidays or weekends with fewer direct buses.
When taking a bus from San Francisco, CA to Santa Ana, CA, you can count on Greyhound, FlixBus for the best way to get you to Santa Ana, CA. You can also check all possible bus companies who offer a service between San Francisco, CA and Santa Ana, CA and compare the amenities they offer before buying a bus ticket.
When departing from San Francisco, CA , you have various bus station options to start your journey from including San Francisco, Transit Center Bay 29, San Francisco, Townsend Street / 5th Street, CA, Oakland, West Oakland BART Station, CA, Hayward BART Station . When arriving in Santa Ana, CA , you can end your journey in bus stations like Santa Ana, E Santa Ana Blvd (Train Station), Anaheim, Regional Transportation Intermodal Center (ARTIC), Irvine, UCI Crawford Hall (West Peltason Dr), CA .Passengers board the bus most frequently from San Francisco, Transit Center Bay 29, which is located around 1 miles (2 km) away from the city centre, and they get off the bus at Santa Ana, E Santa Ana Blvd (Train Station), located 1 away from the city centre.
A trip to Santa Ana, CA from San Francisco, CA is worth doing but not as a day trip with a journey time of 11h 30m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from San Francisco, CA to Santa Ana, CA is April.
It's helpful to compare your options as there are 3 ways to travel between San Francisco, CA and Santa Ana, CA including taking a bus, flight, and train.
Yes, there are bathrooms on board the bus from San Francisco, CA to Santa Ana, CA for bus company Greyhound, FlixBus.
Yes, the following accessibility options are available when taking the bus from San Francisco, CA to Santa Ana, CA:
  • Greyhound
    • Assistance
    • Priority seating
    • Wheelchair-accessible buses.
  • FlixBus
    • Assistance
    • Priority boarding
    • Wheelchair-accessible buses.
Whether you can cancel your bus ticket from San Francisco, CA to Santa Ana, CA depends on the bus companies:
  • Greyhound
    • You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
  • FlixBus
    • You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company Greyhound, FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from San Francisco, CA to Santa Ana, CA.
Yes, the following luggage options are included when booking a bus ticket from San Francisco, CA to Santa Ana, CA:
  • Greyhound
    • One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
  • FlixBus
    • One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from San Francisco, CA to Santa Ana, CA:
  • Greyhound
    • $15 per additional bag.
  • FlixBus
    • Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from San Francisco, CA to Santa Ana, CA. The following conditions apply:
  • FlixBus
    • Small pets in carriers allowed
    • guide dogs travel for free.
You can reserve your seat on the bus from San Francisco, CA to Santa Ana, CA with the following bus company: Greyhound, FlixBus
Yes, there are USB plugs on board the bus from San Francisco, CA to Santa Ana, CA with the following bus company: Greyhound, FlixBus.
Yes, there is Wifi on board the bus from San Francisco, CA to Santa Ana, CA with the following bus company: Greyhound, FlixBus.
Since neither San Francisco, CA nor Santa Ana, CA are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the train as it is the most popular way to get from San Francisco, CA to Santa Ana, CA among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Santa Ana, CA, travelers should be alert to petty crimes such as pickpocketing and vehicle break-ins, especially in crowded areas and parking lots. Common scams include overcharging by unlicensed taxi or ride-share drivers and street vendors selling counterfeit goods. Staying in well-populated areas, using official transportation services, and safeguarding personal belongings help minimize risks.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.

popular bus stations

Popular bus stations from San Francisco, CA to Santa Ana, CA

Most San Francisco, CA to Santa Ana, CA buses use the San Francisco, Transit Center Bay 29 to Santa Ana, E Santa Ana Blvd (Train Station) station pair. Use this guide to compare San Francisco, CA and Santa Ana, CA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.

Departure bus stations in San Francisco
Arrival bus stations in Santa Ana

Which San Francisco, CA station do buses to Santa Ana, CA leave from?

Buses from San Francisco, CA to Santa Ana, CA leave from San Francisco, Transit Center Bay 29. The station is 1 miles (3 km) from San Francisco, CA city centre at Transit Center Bay 29, San Francisco, CA 94105, USA.
San Francisco, Transit Center Bay 29Transit Center Bay 29, San Francisco, CA 94105, USAWifiParkingATMTaxisAccessibilityWCShowerTicket Office
City-centre transport

Getting to San Francisco, Transit Center Bay 29 from San Francisco city centre

San Francisco, Transit Center Bay 29 is 2 km from San Francisco city centre. Public transport options include:

Bus397 · 8m · kr23
14, 14R · 13m · kr23 · every ~30 min
101, 120 · 14m · kr58 · every ~9 min
7 · 21m · kr23 · every ~10 min
SubwayYellow-N, Green-N, Red-N, Blue-N · 10m · kr23 · every ~27 min

San Francisco, Transit Center Bay 29 bus station facilities and services

San Francisco, Transit Center Bay 29 has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.

Wi-Fi and ATMs

Wi-Fi is available at San Francisco, Transit Center Bay 29. ATMs are available at San Francisco, Transit Center Bay 29.

Tickets and information

Ticket office support is available at San Francisco, Transit Center Bay 29.

Parking, taxis and toilets

Available at San Francisco, Transit Center Bay 29: Parking, Taxis, WC.

Accessibility

Accessibility facilities are available at San Francisco, Transit Center Bay 29: Wheelchair accessible areas present.

San Francisco, Townsend Street / 5th StreetSan Francisco Bus Station,401 Townsend St,94107
City-centre transport

Getting to San Francisco, Townsend Street / 5th Street from San Francisco city centre

BusEast, West · 20m · every ~4 min
Nbus, Nowl · 24m · kr23 · every ~2 min
TramN · 23m · kr23 · every ~11 min

Most popular buses to and from Santa Ana, CA and San Francisco, CA

HomeBusesBuses in USABus tickets to Santa Ana, CASan Francisco, CA to Santa Ana, CA bus

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