Denver, CO to Santa Ana, CA bus with Greyhound

Sun, Sep 06
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Rede Expressos
2,000+ travel companies
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The cheapest and fastest buses from Denver, CO to Santa Ana, CA

Showing times, prices and bookable tickets for Sep 06

Cheapest price on Sep 06

$116

Average ticket price on Sep 06

$118

Fastest journey on Sep 06

1 d 1 h 25 m

Average journey duration on Sep 06

1 d 10 h 23 m

Buses on Sep 06

3

Distance

1325 km

Cheap tickets

The best way to find a cheap bus ticket from Denver, CO to Santa Ana, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.

The average ticket from Denver, CO to Santa Ana, CA will cost around $118 if you buy it on the day, but the cheapest tickets can be found for only $116.

Fast buses

It's difficult to get from Denver, CO to Santa Ana, CA without transferring at least once.

  • Greyhound ·
    11:05 AM25h25
    Denver, Union Station
    11:30 AMSanta Ana, E Santa Ana Blvd (Train Station)
    $1161One-way
    1 transfer
  • Greyhound · ·
    7:35 PM37h25
    Denver, Union Station
    8:00 AMSanta Ana, E Santa Ana Blvd (Train Station)
    $1181One-way
    2 transfers
  • Greyhound · · ·
    8:10 PM40h20
    Denver, Union Station
    11:30 AMSanta Ana, E Santa Ana Blvd (Train Station)
    $1191One-way
    4 transfers

Travel Information

Compare bus, train, and flight for Denver, CO to Santa Ana, CA

Omio recommends booking the bus as it is the most popular option from Denver, CO to Santa Ana, CA among Omio's users. If you are prioritising price, take the flight, with an average ticket price of $133 For those with little time, consider booking a flight, which has an average total journey time of 4h 27m. Average ticket prices depend on the travel mode: a flight costs an average of $133, while a train costs an average of $574.

Distance: 823 miles (1325 km)

Compare bus with

Most popular
Bus
Flight
Train
Driving

$136

Average price

$133

Average price

Cheapest

$574

Average price

$210

Average price

(fuel + tolls)

28h 23m

Average total duration

27h 53m

Onboard

+

30m

Additional time*

4h 27m

Average total duration

Fastest

2h 27m

Onboard

+

2h 0m

Additional time*

44h 24m

Average total duration

43h 54m

Onboard

+

30m

Additional time*

14h 51m

Average total duration

(door-to-door)

Direct Options

Direct Options

Direct Options

Direct Options

The cheapest way to travel from Denver, CO to Santa Ana, CA is a flight with an average price of $133 (€108).

This is compared to other travel options from Denver, CO to Santa Ana, CA:

A flight is $3 (€3) less than a bus for this route with tickets for a bus from Denver, CO to Santa Ana, CA costing on average $136 (€110).

A flight is $441 (€356) less than a train for this route with tickets for a train from Denver, CO to Santa Ana, CA costing on average $574 (€464).

The fastest way to travel from Denver, CO to Santa Ana, CA is by flight with an average journey time of 2h 27m.

Other travel options to Santa Ana, CA take longer:

Bus takes on average 27h 53m.

Train takes on average 43h 54m.

It's helpful to compare your options as there are 3 ways to travel between Denver, CO and Santa Ana, CA including taking a bus, train, and flight.
We recommend using the bus as it is the most popular way to get from Denver, CO to Santa Ana, CA among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.

Tickets start at around $136 (€110) compared to roughly $210 (€170) in fuel and tolls — a saving of about $74 (€60). The journey takes 27h 53m versus 14h 51m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.

Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.

Denver, CO to Santa Ana, CA Bus Timetables

OperatorDeparture TimeArrival TimeDurationDeparture daysCheapest price
Operator
Greyhound
Departure Time
11:05AM
Arrival Time
11:30AM
Duration
25h25
Departure days
Everyday
Cheapest price
$109
Operator
Greyhound
Departure Time
02:10PM
Arrival Time
08:00AM
Duration
42h50
Departure days
Wed
Cheapest price
$111
Operator
Greyhound
Departure Time
07:35PM
Arrival Time
08:00AM
Duration
37h25
Departure days
Mon, Tue, Fri, Sat, Sun
Cheapest price
$113
Operator
Greyhound
Departure Time
08:10PM
Arrival Time
11:30AM
Duration
40h20
Departure days
Everyday
Cheapest price
$112

Live departures

Denver, CO to Santa Ana, CA bus times

The table below shows live departures for Denver, CO to Santa Ana, CA buses for today, Saturday, September 5. You can also manually refresh the results below to see updated bus journeys.

Last updated at
ProviderDepartsDurationArrivesTransfers
Tickets
Greyhound · 11:05 AM Denver, Union Station
25h25
11:30 AM Santa Ana, E Santa Ana Blvd (Train Station)1 transfer
Greyhound · · 7:35 PM Denver, Union Station
37h25
8:00 AM Santa Ana, E Santa Ana Blvd (Train Station)2 transfers

This is the last bus of the day.

Find all the dates and times for this journey

Compare prices and tickets Denver, CO to Santa Ana, CA by bus, train, or flight

Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

Sun
Sep 06
Mon
Sep 07
Tue
Sep 08
Wed
Sep 09
Thu
Sep 10
Fri
Sep 11
Sat
Sep 12

Why should you book Denver, CO to Santa Ana, CA buses with Omio?

Greyhound operates all buses services from Denver, CO to Santa Ana, CA.
Omio is an official ticket reseller for all your travel options from Denver, CO to Santa Ana, CA.

Why book with Omio vs Greyhound?

  • Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
  • Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from Denver, CO to Santa Ana, CA.

Why book with Omio over Wanderu?

  • Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from Denver, CO to Santa Ana, CA.

Journey information

Overview: Bus from Denver, CO to Santa Ana, CA

USAUSA
USAUSA
Icon of bus

Buses from Denver, CO to Santa Ana, CA run on average 2 times per day, taking around 27h 53m. Cheap bus tickets for this journey start at $100 (€80) but you can travel from only $95 (€77) by flight.

The earliest bus runs at 08:46, the last at 21:20. The fastest bus covers the 823 miles (1325 km) distance in 25h 25m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from $95 (€77)
Distance
823 miles (1325 km)
Average bus duration
27h 53m
Cheapest ticket price
$100 (€80)
Buses per day
2
Fastest bus
25h 25m
First bus
8:46 AM
Last bus
9:20 PM
Cheapest Month
May
Cheapest Day
Tue
High Season
Jul - Sep
Low Season
Oct - Dec
Best time to book
35 days
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from $95 (€77)

Bus providers: Greyhound from Denver, CO to Santa Ana, CAYou can travel by bus between Denver, CO to Santa Ana, CA with Greyhound for as low as $95 (€77). When you search for schedules and tickets, Omio will show you the best journey

Greyhound

About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
25h 25m
Cheapest Greyhound Price
$100 (€80)
Greyhound frequency
1 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.

FAQs: Bus from Denver, CO to Santa Ana, CA

Find answers to the most common questions about traveling from Denver, CO to Santa Ana, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Santa Ana, CA, this guide helps you travel smarter and with confidence.

FAQs
Cheap bus tickets from Denver, CO to Santa Ana, CA can start from as little as $100 (€80) when you book in advance. The average bus ticket price for Denver, CO to Santa Ana, CA is $136 (€110) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Denver, CO to Santa Ana, CA is 25h 25m to travel the 823 miles (1325 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Denver, CO to Santa Ana, CA leaves at 8:46 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Denver, CO to Santa Ana, CA leaves at 9:20 PM.
There are 2 buses a day from Denver, CO to Santa Ana, CA which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Denver, CO to Santa Ana, CA, you can count on Greyhound for the best way to get you to Santa Ana, CA. You can also check all possible bus companies who offer a service between Denver, CO and Santa Ana, CA and compare the amenities they offer before buying a bus ticket.
A trip to Santa Ana, CA from Denver, CO is worth doing but not as a day trip with a journey time of 25h 25m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Denver, CO to Santa Ana, CA is May.
It's helpful to compare your options as there are 3 ways to travel between Denver, CO and Santa Ana, CA including taking a bus, train, and flight.
Yes, the following accessibility options are available when taking the bus from Denver, CO to Santa Ana, CA:
  • Greyhound
    • Assistance
    • Priority seating
    • Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Denver, CO to Santa Ana, CA for bus company Greyhound.
Whether you can cancel your bus ticket from Denver, CO to Santa Ana, CA depends on the bus companies:
  • Greyhound
    • You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Denver, CO to Santa Ana, CA.
Yes, the following luggage options are included when booking a bus ticket from Denver, CO to Santa Ana, CA:
  • Greyhound
    • One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from Denver, CO to Santa Ana, CA:
  • Greyhound
    • $15 per additional bag.
Unfortunately, pets are not allowed on the bus from Denver, CO to Santa Ana, CA.
You can reserve your seat on the bus from Denver, CO to Santa Ana, CA with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from Denver, CO to Santa Ana, CA with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from Denver, CO to Santa Ana, CA with the following bus company: Greyhound.
Since neither Denver, CO nor Santa Ana, CA are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the bus as it is the most popular way to get from Denver, CO to Santa Ana, CA among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Santa Ana, CA, travelers should be alert to petty crimes such as pickpocketing and vehicle break-ins, especially in crowded areas and parking lots. Common scams include overcharging by unlicensed taxi or ride-share drivers and street vendors selling counterfeit goods. Staying in well-populated areas, using official transportation services, and safeguarding personal belongings help minimize risks.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.

popular bus stations

Popular bus stations from Denver, CO to Santa Ana, CA

Most Denver, CO to Santa Ana, CA buses use the Denver, Union Station to Santa Ana, E Santa Ana Blvd (Train Station) station pair. Use this guide to compare Denver, CO and Santa Ana, CA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.

Departure bus stations in Denver
Arrival bus stations in Santa Ana
Denver, Union Station
City-centre transport

Getting to Denver, Union Station from Denver city centre

Bus0, 10, 15, 19 · 10m · $4 · every ~27 min
15 · 13m · $4 · every ~12 min

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