- Must visit
Bowers Museum
Major Orange County museum campus with art exhibitions, family programs, and rotating contemporary and historical shows.
2,000+ travel companies
2,000+ travel companies
Scan to get our free app
Use our app to get live travel updates and book mobile tickets for trains, buses, flights, and ferries.
App Store
4.942K ratings
Google Play
4.6136K reviews
The cheapest and fastest buses from Chicago, IL to Santa Ana, CA
Showing times, prices and bookable tickets for Nov 04
- Cheapest price on Nov 04
- $159
- Average ticket price on Nov 04
- $172
- Fastest journey on Nov 04
- 2 d 6 h 45 m
- Average journey duration on Nov 04
- 2 d 13 h 55 m
- Buses on Nov 04
- 4
- Distance
- 2787 km
Cheap tickets
The best way to find a cheap bus ticket from Chicago, IL to Santa Ana, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Chicago, IL to Santa Ana, CA will cost around $172 if you buy it on the day, but the cheapest tickets can be found for only $159.
Fast buses
It's difficult to get from Chicago, IL to Santa Ana, CA without transferring at least 3 times.
· · · 10:15 AM 59h15 Chicago, Union Station (Amtrak), IL 7:30 PM Santa Ana, E Santa Ana Blvd (Train Station) $159 1 One-way 3 transfers- · · ·
11:10 PM 58h50 Chicago, Union Station (Amtrak), IL 8:00 AM Santa Ana, E Santa Ana Blvd (Train Station) $170 1 One-way 5 transfers - · · ·
2:45 PM 54h45 Chicago, Greyhound Bus Station 7:30 PM Santa Ana, E Santa Ana Blvd (Train Station) $179 1 One-way 3 transfers - +
FlixBus++FlixBus7:10 AM 74h50 Chicago, Cumberland Blue Line Station, IL 8:00 AM Santa Ana, E Santa Ana Blvd (Train Station) $181 1 One-way 5 transfers
- · · ·
2:45 PM 54h45 Chicago, Greyhound Bus Station 7:30 PM Santa Ana, E Santa Ana Blvd (Train Station) $179 1 One-way 3 transfers - · · ·
11:10 PM 58h50 Chicago, Union Station (Amtrak), IL 8:00 AM Santa Ana, E Santa Ana Blvd (Train Station) $170 1 One-way 5 transfers - · · ·
10:15 AM 59h15 Chicago, Union Station (Amtrak), IL 7:30 PM Santa Ana, E Santa Ana Blvd (Train Station) $159 1 One-way 3 transfers - +FlixBus++FlixBus
7:10 AM 74h50 Chicago, Cumberland Blue Line Station, IL 8:00 AM Santa Ana, E Santa Ana Blvd (Train Station) $181 1 One-way 5 transfers
Journey information
Overview: Bus from Chicago, IL to Santa Ana, CA
USAUSA
Buses from Chicago, IL to Santa Ana, CA run on average 4 times per day, taking around 52h 50m. Cheap bus tickets for this journey start at $179 (€150) if you book in advance.
The earliest bus runs at 07:40, the last at 23:10. The fastest bus covers the 1731 miles (2787 km) distance in 45h 50m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Plan this route
Journey facts
- Distance1731 miles (2787 km)
- Average bus duration52h 50m
- Cheapest ticket price$179 (€150)
- Buses per day4
- Fastest bus45h 50m
- First bus7:40 AM
- Last bus11:10 PM
- Cheapest MonthJul
- Cheapest DayWed
- High SeasonApr - Jun
- Low SeasonJan - Mar
- Best time to book1 day
Understand & plan this route
Explore this journey
Book with confidence
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Frequently asked questions about your Chicago, IL to Santa Ana, CA trip
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Chicago, IL to Santa Ana, CA.
Cheap bus tickets from Chicago, IL to Santa Ana, CA can start from as little as $179 (€150) when you book in advance. The average bus ticket price for Chicago, IL to Santa Ana, CA is $225 (€189) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The earliest bus from Chicago, IL to Santa Ana, CA leaves at 7:40 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Chicago, IL to Santa Ana, CA leaves at 11:10 PM.
There are 4 buses a day from Chicago, IL to Santa Ana, CA which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
Chicago, IL to Santa Ana, CA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 07:10AM | Arrival Time 08:00AM | Duration 74h50 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $160 |
Operator Greyhound | Departure Time 10:15AM | Arrival Time 07:30PM | Duration 59h15 | Departure days Everyday | Cheapest price $154 |
Operator Greyhound | Departure Time 12:25PM | Arrival Time 11:30AM | Duration 49h05 | Departure days Tue | Cheapest price $456 |
Operator Greyhound | Departure Time 02:45PM | Arrival Time 07:30PM | Duration 54h45 | Departure days Wed | Cheapest price $179 |
Operator Greyhound | Departure Time 05:05PM | Arrival Time 07:30PM | Duration 52h25 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $164 |
Operator Greyhound | Departure Time 11:10PM | Arrival Time 08:00AM | Duration 58h50 | Departure days Everyday | Cheapest price $167 |
Live departures
Chicago, IL to Santa Ana, CA bus times
The table below shows live departures for Chicago, IL to Santa Ana, CA buses for today, Tuesday, November 3. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| · · · | 10:15 AM Chicago, Union Station (Amtrak), IL | 59h15 | 7:30 PM Santa Ana, E Santa Ana Blvd (Train Station) | 3 transfers | |
| · · | 12:25 PM Chicago, Greyhound Bus Station | 49h05 | 11:30 AM Santa Ana, E Santa Ana Blvd (Train Station) | 2 transfers | |
| · · · | 11:10 PM Chicago, Union Station (Amtrak), IL | 58h50 | 8:00 AM Santa Ana, E Santa Ana Blvd (Train Station) | 5 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Why should you book Chicago, IL to Santa Ana, CA buses with Omio?
Greyhound operates all buses services from Chicago, IL to Santa Ana, CA.
Omio is an official ticket reseller for all your travel options from Chicago, IL to Santa Ana, CA.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus, flight and train to ensure you get the best deal for traveling from Chicago, IL to Santa Ana, CA.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including bus, flight and train to find the ideal travel option from Chicago, IL to Santa Ana, CA.
Bus companies
Bus companies from Chicago, IL to Santa Ana, CA
Buses from Chicago, IL to Santa Ana, CA with Greyhound. Overnight buses available on this route with Greyhound. Use the details below to compare onboard facilities.
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
45h 50m
Cheapest Greyhound Price
$179 (€150)
Greyhound frequency
4 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Companies, tickets, and onboard amenities between Chicago, IL and Santa Ana, CA
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
When taking a bus from Chicago, IL to Santa Ana, CA, you can count on Greyhound for the best way to get you to Santa Ana, CA. You can also check all possible bus companies who offer a service between Chicago, IL and Santa Ana, CA and compare the amenities they offer before buying a bus ticket.
Yes, the following accessibility options are available when taking the bus from Chicago, IL to Santa Ana, CA:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Chicago, IL to Santa Ana, CA for bus company Greyhound.
Whether you can cancel your bus ticket from Chicago, IL to Santa Ana, CA depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company {providersWithBike}.
Yes, there is food available to purchase on board the bus from Chicago, IL to Santa Ana, CA.
Yes, the following luggage options are included when booking a bus ticket from Chicago, IL to Santa Ana, CA:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from Chicago, IL to Santa Ana, CA:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from Chicago, IL to Santa Ana, CA.
You can reserve your seat on the bus from Chicago, IL to Santa Ana, CA with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from Chicago, IL to Santa Ana, CA with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from Chicago, IL to Santa Ana, CA with the following bus company: Greyhound.
Complete guide to Santa Ana, CA
Things to do in Santa Ana, CA
Discover the best of Santa Ana, CA — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Santa Ana, CA trip today.
- Recommended
Discovery Cube Orange County
Hands-on science museum with interactive exhibits, a Discovery Cube, and family-friendly learning in downtown Santa Ana.
- Recommended
Lyon Air Museum
Small local museum preserving Orange County aviation and aerospace history with artifacts, photos, and volunteer-led interpretation.
- Must visit
Downtown Santa Ana
Walkable downtown district with historic buildings, murals, shops, galleries, and regular arts and community events.
- Recommended
East 4th Street
Lively pedestrian-friendly arts corridor known for galleries, murals, boutiques, and monthly art-focused street activity.
- Recommended
Floral Park
Historic neighborhood of preserved early 20th-century homes, ideal for architecture walks and seasonal house tours.
- Vegetarian
- Gluten-free
Bionico
Classic Orange County Mexican street snack of fresh fruit, cucumber, jicama and peanuts with lime, chili and chamoy. Common in Santa Ana's Latino neighborhoods.
- Vegetarian
- Gluten-free
Atole
Warm masa drink with cinnamon and piloncillo, traditionally sold by tamale vendors and panaderías. A comforting local favorite in Santa Ana's Mexican community.
- Gluten-free
Tamales
Corn husks filled with masa and meats or chiles, then steamed. A staple for holidays and weekend breakfasts in Santa Ana's long-established Mexican families.
Knife Pleat
Refined restaurant focused on seasonal Californian cuisine with French influences. Stylish dining room suited for a more upscale meal.
Tacos Manuel
Casual taquería known for Tijuana-style tacos, adobada and handmade tortillas. Busy, straightforward and highly regarded for flavorful meats.
Mariscos Valle Hermoso
Lively mariscos spot serving ceviches, aguachiles and seafood cocktails. Colorful, casual atmosphere with a strong local following.
US Dollar ($)
Moderate for Southern California; hotels and dining are mid-priced, while local transit is affordable and many casual food options are available.
Average meal costs
- Budget
- $10-18 for fast food or casual takeout.
- Mid-range
- $20-40 per person for a restaurant meal.
- Fine dining
- $60+ per person for upscale dining.
- Coffee
- $3-6 for coffee or cappuccino.
Tipping culture
Tip 15-20% at restaurants, $1-2 per drink at bars, and round up or add 10-15% for taxis. Cafes often have tip jars or card prompts.
Plan your visit to Santa Ana, CA
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Santa Ana, CA.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Santa Ana, CA, travelers should be alert to petty crimes such as pickpocketing and vehicle break-ins, especially in crowded areas and parking lots. Common scams include overcharging by unlicensed taxi or ride-share drivers and street vendors selling counterfeit goods. Staying in well-populated areas, using official transportation services, and safeguarding personal belongings help minimize risks.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
FAQs: Bus from Chicago, IL to Santa Ana, CA
Find answers to the most common questions about traveling from Chicago, IL to Santa Ana, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Santa Ana, CA, this guide helps you travel smarter and with confidence.
It's helpful to compare your options as there are 3 ways to travel between Chicago, IL and Santa Ana, CA including taking a bus, flight, and train.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
popular bus stations
Popular bus stations from Chicago, IL to Santa Ana, CA
Most Chicago, IL to Santa Ana, CA buses use the Chicago, Union Station (Amtrak) to Santa Ana, E Santa Ana Blvd (Train Station) station pair. Use this guide to compare Chicago, IL and Santa Ana, CA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Chicago
Arrival bus stations in Santa Ana
Which Chicago, IL station do buses to Santa Ana, CA leave from?
Buses from Chicago, IL to Santa Ana, CA leave from Chicago, Union Station (Amtrak). The station is 1 miles (3 km) from Chicago, IL city centre at Chicago Union Station, 225 S Canal St, Chicago, IL 60606, USA.
Chicago, Union Station (Amtrak)Chicago Union Station, 225 S Canal St, Chicago, IL 60606, USA
City-centre transport
Getting to Chicago, Union Station (Amtrak) from Chicago city centre
Chicago, Union Station (Amtrak) is 3 km from Chicago city centre. Public transport options include:
Bus28, 151 · 7m · $4 · every ~13 min
Chicago, Union Station (Amtrak) bus station facilities and services
Chicago, Union Station (Amtrak) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Multiple dining options are available inside the station.
Wi-Fi and ATMs
Free Wi-Fi is available in waiting areas. ATMs are aTMs are located near the main entrance.
Tickets and information
Ticket office support is available at Chicago, Union Station (Amtrak).
Parking, taxis and toilets
Available at Chicago, Union Station (Amtrak): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Chicago, Union Station (Amtrak): Station is accessible with elevators and ramps.
Chicago, Greyhound Bus Station630 W Harrison St, Chicago, IL 60607, USA
City-centre transport
Getting to Chicago, Greyhound Bus Station from Chicago city centre
Chicago, Greyhound Bus Station is 2 km from Chicago city centre. Public transport options include:
Bus7 · 8m · $4 · every ~6 min
Chicago, Greyhound Bus Station bus station facilities and services
Chicago, Greyhound Bus Station has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Snack shop and vending machines available
Wi-Fi and ATMs
Free Wi-Fi in waiting area. ATMs are located near entrance.
Tickets and information
Ticket office support is available at Chicago, Greyhound Bus Station.
Parking, taxis and toilets
Available at Chicago, Greyhound Bus Station: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Chicago, Greyhound Bus Station: Wheelchair accessible entrances and seating.
Chicago, Cumberland Blue Line StationCumberland Blue Line Station, Chicago, IL 60631, USA
City-centre transport
Getting to Chicago, Cumberland Blue Line Station from Chicago city centre
Chicago, Cumberland Blue Line Station is 21 km from Chicago city centre. Public transport options include:
BusGreyhound US0150S · 30m · $3
SubwayBlue Line · 39m · $6 · every ~23 min
Chicago, Cumberland Blue Line Station bus station facilities and services
Chicago, Cumberland Blue Line Station has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Chicago, Cumberland Blue Line Station. ATMs are available at Chicago, Cumberland Blue Line Station.
Tickets and information
Ticket office support is available at Chicago, Cumberland Blue Line Station.
Parking, taxis and toilets
Available at Chicago, Cumberland Blue Line Station: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Chicago, Cumberland Blue Line Station: Wheelchair accessible with elevator service.
Which Santa Ana, CA station do buses from Chicago, IL arrive at?
Buses from Chicago, IL to Santa Ana, CA arrive at Santa Ana, E Santa Ana Blvd (Train Station). Santa Ana, E Santa Ana Blvd (Train Station) is 0 miles (1 km) from Santa Ana, CA city centre.
Santa Ana, E Santa Ana Blvd (Train Station)Santa Ana, 1000 E Santa Ana Blvd, Santa Ana, CA 92701, USA
City-centre transport
Getting to Santa Ana, E Santa Ana Blvd (Train Station) from Santa Ana city centre
Santa Ana, E Santa Ana Blvd (Train Station) is 1 km from Santa Ana city centre. Public transport options include:
TRUE
Santa Ana, E Santa Ana Blvd (Train Station) bus station facilities and services
Santa Ana, E Santa Ana Blvd (Train Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Santa Ana, E Santa Ana Blvd (Train Station). ATMs are available at Santa Ana, E Santa Ana Blvd (Train Station).
Tickets and information
Ticket office support is available at Santa Ana, E Santa Ana Blvd (Train Station).
Parking, taxis and toilets
Available at Santa Ana, E Santa Ana Blvd (Train Station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Santa Ana, E Santa Ana Blvd (Train Station): Bus access is available.
Bus stations for Chicago, IL to Santa Ana, CA
Check bus stations information for Chicago, IL and Santa Ana, CA, including where buses depart and arrive on this route.
When departing from Chicago, IL , you have various bus station options to start your journey from including Chicago, Union Station (Amtrak), Chicago, Greyhound Bus Station, Chicago, Cumberland Blue Line Station . When arriving in Santa Ana, CA , you can end your journey in bus stations like Santa Ana, E Santa Ana Blvd (Train Station) .Passengers board the bus most frequently from Chicago, Union Station (Amtrak), which is located around 1 miles (3 km) away from the city centre, and they get off the bus at Santa Ana, E Santa Ana Blvd (Train Station), located 1 away from the city centre.
Most popular bus connections from Chicago, IL
Most popular buses to and from Santa Ana, CA and Chicago, IL
Most popular bus connections to Santa Ana, CA
The Omio App Makes Travel Planning Easy
We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.
