- Must visit
Delaware Art Museum
Top regional museum with outstanding American art, British Pre-Raphaelite works, and a serene riverside setting in downtown Wilmington.
Cheapest price
$118
Average price
$118
Fastest journey
13 h 25 m
Average duration
13 h 25 m
Buses per day
1
Distance
722 km
The best way to find a cheap bus ticket from Florence, SC to Wilmington, DE is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Florence, SC to Wilmington, DE will cost around $118 if you buy it on the day, but the cheapest tickets can be found for only $118.
It's difficult to get from Florence, SC to Wilmington, DE without transferring at least 2 times.


Buses from Florence, SC to Wilmington, DE run on average 2 times per day, taking around 13h 50m. Cheap bus tickets for this journey start at $122 (€99) if you book in advance.
The earliest bus runs at 00:05, the last at 21:25. The fastest bus covers the 448 miles (722 km) distance in 13h 25m.
Distance 448 miles (722 km) |
Average bus duration 13h 50m |
Cheapest ticket price $122 (€99) |
Buses per day 2 |
Fastest bus 13h 25m |
First bus 12:05 AM |
Last bus 9:25 PM |
Cheapest Month Oct |
Cheapest Day Tue |
High Season Apr - Jun |
Low Season Jul - Sep |
Busiest Day Fri |
Least Busy Day Fri |
Best time to book 1 day |
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 05:05AM | Arrival Time 09:50PM | Duration 16h45 | Departure days Sat | Cheapest price $171 |
Operator Greyhound USA | Departure Time 04:30PM | Arrival Time 05:55AM | Duration 13h25 | Departure days Tue, Sun | Cheapest price $118 |
Operator FlixBus | Departure Time 08:30PM | Arrival Time 09:55AM | Duration 13h25 | Departure days Mon, Wed, Thu, Fri, Sat | Cheapest price $122 |
Operator Greyhound | Departure Time 09:30PM | Arrival Time 10:55AM | Duration 13h25 | Departure days Wed | Cheapest price $200 |
The table below shows live departures for Florence, SC to Wilmington, DE buses for today, Saturday, August 1. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 8:30 PM Florence, SC | 13h25 | 9:55 AM Wilmington, DE | 0 transfersDirect | |
| Sunday, August 2 | |||||
![]() | 4:30 PM Florence, SC | 13h25 | 5:55 AM Wilmington, DE | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Discover the best of Wilmington, DE — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Wilmington, DE trip today.
Top regional museum with outstanding American art, British Pre-Raphaelite works, and a serene riverside setting in downtown Wilmington.
Major decorative arts museum in a grand du Pont estate. Period rooms, gardens, and research collections make it one of Delaware’s essential visits.
Industrial history museum on the Brandywine at the original du Pont gunpowder works. It blends river scenery, engineering, and family history.
Revitalized riverfront district with paths, public art, mini golf, and event spaces. It is one of Wilmington’s most popular areas for walking and views.
Large urban park with lawns, trails, gardens, and creek views. It is a favorite local green space beside major museums and historic sites.
Major downtown square framed by historic buildings, offices, and monuments. It is the city’s classic civic center and an easy orientation point.
Scrapple is a Mid-Atlantic breakfast loaf of pork scraps and cornmeal, sliced and fried crisp. It is a Delaware staple found in many local diners.
Blue crab cakes are common along the Delaware coast and nearby bay waters, prized for sweet lump crab with minimal filler and regional seafood tradition.
Boardwalk fries are hand-cut fries served hot with salt and vinegar. They are a beloved Delaware beach snack strongly associated with nearby coastal outings.
Refined Italian restaurant known for house-made pasta, seasonal ingredients, and polished service in an elegant downtown setting.
Historic fine-dining destination serving contemporary American cuisine with strong wine service in a grand, stately atmosphere.
Classic Delaware diner famous for scrapple, hearty breakfasts, and old-school local comfort food in a casual setting.
Moderate for U.S. city trips; hotels and dining are mid-priced, while transit and parking are manageable versus larger East Coast destinations.
Tip 18-20% at restaurants, $1-2 per drink at bars, and 10-15% for taxis. Small cafe tips are appreciated but optional.
Find answers to the most common questions about traveling from Florence, SC to Wilmington, DE by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Wilmington, DE, this guide helps you travel smarter and with confidence.

Most Florence, SC to Wilmington, DE buses use the Florence, S Irby St (Greyhound Bus Stop) to Wilmington, Amtrak Station @ ML King-French station pair. Use this guide to compare Florence, SC and Wilmington, DE bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Here are some other resources that might have the information you need