- Must visit
National Civil Rights Museum
World-class civil rights museum at the Lorraine Motel. Essential for understanding the movement, Dr. King, and the American struggle for justice.
Omio recommends booking the bus as it is the most popular option from Florence, SC to Memphis, TN among Omio's users. If you are prioritising price, take the bus, with an average ticket price of €105 For those with little time, consider booking a bus, which has an average total journey time of 16h 50m. Average ticket prices depend on the travel mode: a bus costs an average of €105, while a bus costs an average of €105.
Distance: 587 miles (946 km)
Most popular Bus | Driving |
|---|---|
€105 Average price Cheapest | €112 Average price (fuel + tolls) |
16h 50m Average total duration Fastest 16h 20m Onboard + 30m Additional time* | 10h 2m Average total duration (door-to-door) |
![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options |
Tickets start at around €105 compared to roughly €112 in fuel and tolls — a saving of about €8. The journey takes 16h 20m versus 10h 2m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound USA | Departure Time 04:10PM | Arrival Time 10:00AM | Duration 17h50 | Departure days Mon, Tue, Wed, Thu, Fri, Sun | Cheapest price €156 |
Compare bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Florence, SC to Memphis, TN run on average 1 times per day, taking around 16h 20m. Cheap bus tickets for this journey start at €87 if you book in advance.
The earliest bus runs at 00:15, the last at 22:45. The fastest bus covers the 587 miles (946 km) distance in 15h 15m.
Distance 587 miles (946 km) |
Average bus duration 16h 20m |
Cheapest ticket price €87 |
Buses per day 1 |
Fastest bus 15h 15m |
First bus 12:15 AM |
Last bus 10:45 PM |
Cheapest Month May |
Cheapest Day Sun |
High Season Jul - Sep |
Low Season Apr - Jun |
Discover the best of Memphis, TN — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Memphis, TN trip today.
World-class civil rights museum at the Lorraine Motel. Essential for understanding the movement, Dr. King, and the American struggle for justice.
Major museum of Memphis music history inside a former recording studio. A must for soul, blues, and rock fans exploring the city's sound.
Interactive museum on Stax Records and Southern soul legends. Worth visiting for Otis Redding, Isaac Hayes, and immersive music storytelling.
Memphis's legendary entertainment street, famous for live music, neon, and history. A classic walk for atmosphere, nightlife, and cultural identity.
Mississippi riverfront park with broad lawns, monuments, and skyline views. Ideal for an easy walk and classic river scenery.
Large urban park with old-growth forest, trails, playgrounds, and zoo access. Excellent for nature, families, and a break from downtown.
Memphis-style pork ribs are slow-smoked over hardwood, usually served dry-rubbed or lightly sauced. They are the city’s most iconic barbecue tradition.
Pulled pork shoulder is smoked until tender, chopped or shredded, and often topped with slaw. It is a staple of Memphis barbecue joints.
Barbecue spaghetti mixes smoked pork, tomato-based sauce, and spaghetti. This quirky Memphis specialty reflects the city’s barbecue creativity.
Beloved traditional barbecue spot famous for pulled pork sandwiches, ribs, and barbecue spaghetti. Casual and deeply tied to Memphis food culture.
Historic fine dining destination serving refined Southern cuisine and an acclaimed brunch. Elegant setting inside a former mansion in Midtown.
Long-running Memphis institution for fried chicken and Southern sides. Bustling, family-friendly atmosphere with a strong local following.
Moderate for U.S. city breaks: hotels and dining are generally below New York or Miami, while car, rideshare, and attraction costs can add up.
Tip 18-20% in restaurants, more for great service. Taxis usually 10-15%. Cafes often have tip jars or card prompts; small tips are appreciated.
Find answers to the most common questions about traveling from Florence, SC to Memphis, TN by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Memphis, TN, this guide helps you travel smarter and with confidence.

Most Florence, SC to Memphis, TN buses use the Florence, W Lucas St (TA Gas Station) to Memphis, Airways Transit Center station pair. Use this guide to compare Florence, SC and Memphis, TN bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Florence, W Lucas St (TA Gas Station) is 6 km from Florence city centre. Public transport options include:
Florence, W Lucas St (TA Gas Station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Food and snacks available at the gas station.
Wi-Fi is available at Florence, W Lucas St (TA Gas Station). ATMs are available at Florence, W Lucas St (TA Gas Station).
Ticket office support is available at Florence, W Lucas St (TA Gas Station).
Available at Florence, W Lucas St (TA Gas Station): Parking, Taxis, WC.
Accessibility facilities are available at Florence, W Lucas St (TA Gas Station): Basic accessibility features available.
Florence, S Irby St (Greyhound Bus Stop) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Florence, S Irby St (Greyhound Bus Stop). ATMs are available at Florence, S Irby St (Greyhound Bus Stop).
Ticket office support is available at Florence, S Irby St (Greyhound Bus Stop).
Available at Florence, S Irby St (Greyhound Bus Stop): Parking, Taxis, WC.
Accessibility facilities are available at Florence, S Irby St (Greyhound Bus Stop): Bus stop accessible for disabled persons.
Memphis, Airways Transit Center is 11 km from Memphis city centre. Public transport options include:
Memphis, Airways Transit Center has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Multiple restaurants and food services available.
Free Wi-Fi available throughout the station. ATMs are aTMs available inside the station building.
Ticket office support is available at Memphis, Airways Transit Center.
Available at Memphis, Airways Transit Center: Parking, Taxis, WC.
Accessibility facilities are available at Memphis, Airways Transit Center: Wheelchair accessible with assistance available.
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