The cheapest and fastest buses from Florence, SC to Harrisburg, PA
Cheapest price
$291
Average price
$291
Fastest journey
1 d 6 h 20 m
Average duration
1 d 6 h 20 m
Buses per day
1
Distance
722 km
The best way to find a cheap bus ticket from Florence, SC to Harrisburg, PA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Florence, SC to Harrisburg, PA will cost around $291 if you buy it on the day, but the cheapest tickets can be found for only $291.
It's difficult to get from Florence, SC to Harrisburg, PA without transferring at least 2 times.


Travel Information
Compare train and bus for Florence, SC to Harrisburg, PA
Omio recommends booking the train as it is the most popular option from Florence, SC to Harrisburg, PA among Omio's users. If you are prioritising price take the bus with prices starting from €85. For those with little time consider booking a train which can get you there in 12h 9m. The ticket price range depends on the travel mode: a bus costs an average of €85, and a train costs an average of €222.
Distance: 448 miles (722 km)
Compare bus with
| Bus | Most popular Train |
|---|---|
€85 Average price Cheapest | €222 Average price |
22h 50m Average total duration 22h 20m Onboard + 30m Additional time* | 12h 39m Average total duration Fastest 12h 9m Onboard + 30m Additional time* |
Direct Options | Direct Options |
Live departures
Florence, SC to Harrisburg, PA bus times
The table below shows live departures for Florence, SC to Harrisburg, PA buses for tomorrow, Wednesday, February 4. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 2:25 PM Florence, SC | 30h20 | 8:45 PM Harrisburg, PA | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Florence, SC to Harrisburg, PA by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Feb 04
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Journey information
Overview: Bus from Florence, SC to Harrisburg, PA
Buses from Florence, SC to Harrisburg, PA run on average 1 times per day, taking around 22h 20m. Cheap bus tickets for this journey start at $106 (€85) if you book in advance.
The earliest bus runs at 00:05, the last at 23:20. The fastest bus covers the 448 miles (722 km) distance in 22h 20m.
Distance 448 miles (722 km) |
Average bus duration 22h 20m |
Cheapest ticket price $106 (€85) |
Buses per day 1 |
Fastest bus 22h 20m |
First bus 00:05 |
Last bus 23:20 |
Bus providers: Southeastern Stages from Florence, SC to Harrisburg, PAYou can travel by bus between Florence, SC to Harrisburg, PA with Southeastern Stages for as low as $106 (€85). When you search for schedules and tickets, Omio will show you the best journey
Southeastern Stages
FAQs: Bus from Florence, SC to Harrisburg, PA
Find answers to the most common questions about traveling from Florence, SC to Harrisburg, PA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Harrisburg, PA, this guide helps you travel smarter and with confidence.

- Pennsylvania State Capitol, an architectural marvel featuring a grand dome and exquisite interior murals
- National Civil War Museum, a comprehensive museum offering insights into the American Civil War with extensive exhibits
- The State Museum of Pennsylvania, showcasing the state's history, art, and natural sciences through diverse collections
- Fort Hunter Mansion and Park, a historic site with preserved buildings and beautiful grounds reflecting 18th and 19th-century life
- Wildwood Park, a nature preserve offering trails and a nature center for wildlife observation and environmental education.
- City Island, a recreational area featuring sports facilities, walking trails, and riverboat cruises
- Whitaker Center for Science and the Arts, a venue offering interactive science exhibits and live performances
- Broad Street Market, one of the oldest continuously operating farmers' markets in the country, offering diverse local foods and goods
- Susquehanna Art Museum, presenting contemporary art exhibitions and educational programs
- Riverfront Park, ideal for walking, biking, and enjoying views of the Susquehanna River.
popular bus stations
Popular bus stations from Florence, SC to Harrisburg, PA
Most popular bus connections from Florence, SC
More options for your journey from Florence, SC to Harrisburg, PA
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