- Must visit
The State Museum of Pennsylvania
Major regional museum with American art, natural history, and science exhibits. It is Harrisburg's best-known museum and a strong all-ages visit.
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The cheapest and fastest buses from Florence, SC to Harrisburg, PA
Showing times, prices and bookable tickets for Sep 19
Cheapest price on Sep 19
Kč2749
Average ticket price on Sep 19
Kč2749
Fastest journey on Sep 19
13 h 25 m
Average journey duration on Sep 19
13 h 25 m
Buses on Sep 19
1
Distance
722 km
Cheap tickets
The best way to find a cheap bus ticket from Florence, SC to Harrisburg, PA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Florence, SC to Harrisburg, PA will cost around Kč2749 if you buy it on the day, but the cheapest tickets can be found for only Kč2749.
Fast buses
It's difficult to get from Florence, SC to Harrisburg, PA without transferring at least once.
FlixBus+
12:05 AM13h25Florence, W Lucas St (TA Gas Station), SC1:30 PMHarrisburg, Market St (Bus Station), PAKč27491One-way1 transfer
- FlixBus+12:05 AM13h25Florence, W Lucas St (TA Gas Station), SC1:30 PMHarrisburg, Market St (Bus Station), PAKč27491One-way1 transfer
Travel Information
Compare bus for Florence, SC to Harrisburg, PA
Omio recommends booking the bus as it is the most popular option from Florence, SC to Harrisburg, PA among Omio's users. If you are prioritising price, take the bus, with an average ticket price of Kč4263 For those with little time, consider booking a bus, which has an average total journey time of 11h 53m. Average ticket prices depend on the travel mode: a bus costs an average of Kč4263, while a train costs an average of Kč6445.
Distance: 448 miles (722 km)
Compare bus with
Most popular Bus | Train | Driving |
|---|---|---|
Kč4263 Average price Cheapest | Kč6445 Average price | Kč2213 Average price (fuel + tolls) |
11h 53m Average total duration Fastest 11h 23m Onboard + 30m Additional time* | 13h 1m Average total duration 12h 31m Onboard + 30m Additional time* | 8h 12m Average total duration (door-to-door) |
Most popular bus company |  Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Florence, SC to Harrisburg, PA is a bus with an average price of Kč4263.
This is compared to other travel options from Florence, SC to Harrisburg, PA:
A bus is Kč2181 less than a train for this route with tickets for a train from Florence, SC to Harrisburg, PA costing on average Kč6445.
The fastest way to travel from Florence, SC to Harrisburg, PA is by bus with an average journey time of 11h 23m.
Other travel options to Harrisburg, PA take longer:
Train takes on average 12h 31m.
Yes, you can take a bus between Florence, SC and Harrisburg, PA.
We recommend using the bus as it is the most popular way to get from Florence, SC to Harrisburg, PA among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.
Tickets start at around Kč4263 compared to roughly Kč2213 in fuel and tolls — a saving of about Kč-2050.81. The journey takes 11h 23m versus 8h 12m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
Florence, SC to Harrisburg, PA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 12:05AM | Arrival Time 01:30PM | Duration 13h25 | Departure days Sat | Cheapest price Kč2749 |
Operator Greyhound USA | Departure Time 04:30PM | Arrival Time 01:55PM | Duration 21h25 | Departure days Tue | Cheapest price Kč3082 |
Operator Greyhound | Departure Time 08:30PM | Arrival Time 05:55PM | Duration 21h25 | Departure days Wed, Thu, Fri | Cheapest price Kč3197 |
Operator Greyhound | Departure Time 09:30PM | Arrival Time 06:55PM | Duration 21h25 | Departure days Mon, Wed, Thu, Sun | Cheapest price Kč2551 |
Live departures
Florence, SC to Harrisburg, PA bus times
The table below shows live departures for Florence, SC to Harrisburg, PA buses for today, Friday, September 18. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 8:30 PM Florence, SC | 21h25 | 5:55 PM Harrisburg, PA | 0 transfersDirect | |
| Saturday, September 19 | |||||
| FlixBus+ | 12:05 AM Florence, W Lucas St (TA Gas Station), SC | 13h25 | 1:30 PM Harrisburg, Market St (Bus Station), PA | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Florence, SC to Harrisburg, PA by bus
Compare bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Sep 19
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Why should you book Florence, SC to Harrisburg, PA buses with Omio?
Greyhound as well as FlixBus offer buses services from Florence, SC to Harrisburg, PA.
Omio is an official ticket reseller for all your travel options from Florence, SC to Harrisburg, PA.
Why book with Omio vs Greyhound?
- Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of FlixBus to find the best option for your trip from Florence, SC to Harrisburg, PA.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
Why book with Omio over Wanderu or Trainline?
- Compare with other providers: On Omio, you can also compare tickets for the likes of FlixBus to find the best option for your trip from Florence, SC to Harrisburg, PA.
Journey information
Overview: Bus from Florence, SC to Harrisburg, PA
USAUSA
Buses from Florence, SC to Harrisburg, PA run on average 1 times per day, taking around 11h 23m. Cheap bus tickets for this journey start at Kč2628 if you book in advance.
The earliest bus runs at 00:05, the last at 23:20. The fastest bus covers the 448 miles (722 km) distance in 10h 45m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 448 miles (722 km) |
Average bus duration 11h 23m |
Cheapest ticket price Kč2628 |
Buses per day 1 |
Fastest bus 10h 45m |
First bus 12:05 AM |
Last bus 11:20 PM |
Cheapest Month Sep |
Cheapest Day Tue |
High Season Jul - Sep |
Low Season Oct - Dec |
Best time to book 2 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: FlixBus, Greyhound from Florence, SC to Harrisburg, PAYou can travel by bus between Florence, SC to Harrisburg, PA with FlixBus, Greyhound for as low as Kč2628. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average FlixBus Duration
11h 5m
Cheapest FlixBus Price
Kč2213
FlixBus frequency
2 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
10h 45m
Cheapest Greyhound Price
Kč3754
Greyhound frequency
1 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Harrisburg, PA
Things to do in Harrisburg, PA
Discover the best of Harrisburg, PA — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Harrisburg, PA trip today.
- Must visit
National Civil War Museum
National Civil War museum with broad exhibits on soldiers, civilians, and the war's legacy. It is one of the city's most important history stops.
- Recommended
Fort Hunter Mansion and Park Museum
Museum at Fort Hunter highlighting local river history, mansion life, and the Susquehanna landscape. A quieter favorite with a scenic setting.
- Must visit
Riverfront Park
Riverfront promenade and park system with skyline views, paths, and event spaces. It is one of the most pleasant walks in central Harrisburg.
- Recommended
City Island
Car-free island in the Susquehanna with walking paths, recreation, and broad water views. A classic local escape close to downtown.
- Recommended
Midtown
Victorian neighborhood known for colorful homes, local shops, and a creative atmosphere. It is ideal for strolling and seeing everyday Harrisburg charm.
Pennsylvania Dutch Chicken Pot Pie
Pennsylvania Dutch chicken pot pie is a rich stew with square noodles, chicken, and vegetables. It is a regional comfort food common around Harrisburg.
- Vegetarian
Shoofly Pie
Shoofly pie is a classic Pennsylvania Dutch dessert made with molasses crumb filling. Its deep sweetness makes it a traditional local bakery staple.
- Vegetarian
Whoopie Pie
Whoopie pie features two soft chocolate cake rounds with creamy filling. It is a beloved Amish and Pennsylvania Dutch treat found across the region.
Rubicon
Long-running local favorite serving creative American dishes and seafood in a comfortable, polished neighborhood setting.
Broad Street Market
Historic market with many established local vendors for Pennsylvania Dutch baked goods, pretzels, sandwiches, and regional specialties in a lively setting.
Zeroday Brewing Company
Popular casual tavern and brewery pouring local beer with pub fare. It is well known for a relaxed atmosphere and central location.
US dollar ($)
Moderate for US state capitals; hotels and dining are usually below major East Coast cities, while transit needs and limited cheap tourist areas can raise daily costs.
Average meal costs
- Budget
- $10-15 for fast food or a simple lunch.
- Mid-range
- $18-35 per person for a casual restaurant meal.
- Fine dining
- $50+ per person for upscale dining.
- Coffee
- $3-5 for coffee or a cappuccino.
Tipping culture
Tip 18-20% at restaurants, 15-20% for taxis, and $1-2 per drink or café order if service is provided.
FAQs: Bus from Florence, SC to Harrisburg, PA
Find answers to the most common questions about traveling from Florence, SC to Harrisburg, PA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Harrisburg, PA, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Florence, SC to Harrisburg, PA can start from as little as Kč2628 when you book in advance. The average bus ticket price for Florence, SC to Harrisburg, PA is Kč4263 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Florence, SC to Harrisburg, PA is 10h 45m to travel the 448 miles (722 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Florence, SC to Harrisburg, PA leaves at 12:05 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Florence, SC to Harrisburg, PA leaves at 11:20 PM.
There are 1 buses a day from Florence, SC to Harrisburg, PA which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Florence, SC to Harrisburg, PA, you can count on Greyhound for the best way to get you to Harrisburg, PA. You can also check all possible bus companies who offer a service between Florence, SC and Harrisburg, PA and compare the amenities they offer before buying a bus ticket.
When departing from Florence, SC , you have various bus station options to start your journey from including Florence, W Lucas St (TA Gas Station), SC, Florence, S Irby St (Greyhound Bus Stop), SC . When arriving in Harrisburg, PA , you can end your journey in bus stations like Harrisburg, Market St (Bus Station), PA .Passengers board the bus most frequently from Florence, W Lucas St (TA Gas Station), SC, which is located around 3 miles (6 km) away from the city centre, and they get off the bus at Harrisburg, Market St (Bus Station), PA, located 1 away from the city centre.
A trip to Harrisburg, PA from Florence, SC is worth doing but not as a day trip with a journey time of 10h 45m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Florence, SC to Harrisburg, PA is September.
Yes, you can take a bus between Florence, SC and Harrisburg, PA.
Yes, the following accessibility options are available when taking the bus from Florence, SC to Harrisburg, PA:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Florence, SC to Harrisburg, PA for bus company Greyhound.
Some of the most interesting sights to explore in Harrisburg, PA are:
- Pennsylvania State Capitol, an architectural marvel featuring a grand dome and exquisite interior murals
- National Civil War Museum, a comprehensive museum offering insights into the American Civil War with extensive exhibits
- The State Museum of Pennsylvania, showcasing the state's history, art, and natural sciences through diverse collections
- Fort Hunter Mansion and Park, a historic site with preserved buildings and beautiful grounds reflecting 18th and 19th-century life
- Wildwood Park, a nature preserve offering trails and a nature center for wildlife observation and environmental education.
The best things to do in Harrisburg, PA include:
- City Island, a recreational area featuring sports facilities, walking trails, and riverboat cruises
- Whitaker Center for Science and the Arts, a venue offering interactive science exhibits and live performances
- Broad Street Market, one of the oldest continuously operating farmers' markets in the country, offering diverse local foods and goods
- Susquehanna Art Museum, presenting contemporary art exhibitions and educational programs
- Riverfront Park, ideal for walking, biking, and enjoying views of the Susquehanna River.
Whether you can cancel your bus ticket from Florence, SC to Harrisburg, PA depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Florence, SC to Harrisburg, PA.
Yes, the following luggage options are included when booking a bus ticket from Florence, SC to Harrisburg, PA:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from Florence, SC to Harrisburg, PA:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from Florence, SC to Harrisburg, PA.
You can reserve your seat on the bus from Florence, SC to Harrisburg, PA with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from Florence, SC to Harrisburg, PA with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from Florence, SC to Harrisburg, PA with the following bus company: Greyhound.
Since neither Florence, SC nor Harrisburg, PA are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the train as it is the most popular way to get from Florence, SC to Harrisburg, PA among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Harrisburg, PA, travelers should be cautious of pickpocketing and vehicle break-ins, especially in crowded areas and parking lots. Common scams include overpriced taxi services and fraudulent ticket sellers near popular attractions. Staying aware of surroundings and using authorized transportation options helps enhance safety.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Florence, SC to Harrisburg, PA
Most Florence, SC to Harrisburg, PA buses use the Florence, W Lucas St (TA Gas Station) to Harrisburg, Market St (Bus Station) station pair. Use this guide to compare Florence, SC and Harrisburg, PA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Florence
Arrival bus stations in Harrisburg
Which Florence, SC station do buses to Harrisburg, PA leave from?
Buses from Florence, SC to Harrisburg, PA leave from Florence, W Lucas St (TA Gas Station). The station is 3 miles (6 km) from Florence, SC city centre at Florence, SC, USA.
Florence, W Lucas St (TA Gas Station)Florence, SC, USA
City-centre transport
Getting to Florence, W Lucas St (TA Gas Station) from Florence city centre
Florence, W Lucas St (TA Gas Station) is 6 km from Florence city centre. Public transport options include:
TRUE
Florence, W Lucas St (TA Gas Station) bus station facilities and services
Florence, W Lucas St (TA Gas Station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Food and snacks available at the gas station.
Wi-Fi and ATMs
Wi-Fi is available at Florence, W Lucas St (TA Gas Station). ATMs are available at Florence, W Lucas St (TA Gas Station).
Tickets and information
Ticket office support is available at Florence, W Lucas St (TA Gas Station).
Parking, taxis and toilets
Available at Florence, W Lucas St (TA Gas Station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Florence, W Lucas St (TA Gas Station): Basic accessibility features available.
Florence, S Irby St (Greyhound Bus Stop)S Irby St, Florence, SC, USA
City-centre transport
Getting to Florence, S Irby St (Greyhound Bus Stop) from Florence city centre
TRUE
Florence, S Irby St (Greyhound Bus Stop) bus station facilities and services
Florence, S Irby St (Greyhound Bus Stop) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Florence, S Irby St (Greyhound Bus Stop). ATMs are available at Florence, S Irby St (Greyhound Bus Stop).
Tickets and information
Ticket office support is available at Florence, S Irby St (Greyhound Bus Stop).
Parking, taxis and toilets
Available at Florence, S Irby St (Greyhound Bus Stop): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Florence, S Irby St (Greyhound Bus Stop): Bus stop accessible for disabled persons.
Which Harrisburg, PA station do buses from Florence, SC arrive at?
Buses from Florence, SC to Harrisburg, PA arrive at Harrisburg, Market St (Bus Station). Harrisburg, Market St (Bus Station) is 0 miles (1 km) from Harrisburg, PA city centre.
Harrisburg, Market St (Bus Station)Harrisburg, 411 Market St, Harrisburg, PA 17101, USA
City-centre transport
Getting to Harrisburg, Market St (Bus Station) from Harrisburg city centre
Harrisburg, Market St (Bus Station) is 1 km from Harrisburg city centre. Public transport options include:
Bus6/13, W · 29m · Kč78 · every ~4 min
Harrisburg, Market St (Bus Station) bus station facilities and services
Harrisburg, Market St (Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Free WiFi inside the station. ATMs are available at Harrisburg, Market St (Bus Station).
Tickets and information
Ticket office support is available at Harrisburg, Market St (Bus Station).
Parking, taxis and toilets
Available at Harrisburg, Market St (Bus Station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Harrisburg, Market St (Bus Station): Wheelchair accessible with ramps.
Most popular bus connections from Florence, SC
More options for your journey from Florence, SC to Harrisburg, PA
Here are some other resources that might have the information you need
Most popular buses to and from Harrisburg, PA and Florence, SC
Most popular bus connections to Harrisburg, PA
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