- Must visit
The State Museum of Pennsylvania
Major regional museum with American art, natural history, and science exhibits. It is Harrisburg's best-known museum and a strong all-ages visit.
The best way to find a cheap bus ticket from Syracuse, NY to Harrisburg, PA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Syracuse, NY to Harrisburg, PA will cost around $104 if you buy it on the day, but the cheapest tickets can be found for only $86.
On Thu, Nov 05, we found 2 buses from Syracuse, NY to Harrisburg, PA, including 2 direct services.
On Thu, Nov 05 the direct buses cover the 315 km distance in an average of 14 h 40 m but if you time it right, some buses will get you there in just 12 h 25 m .
On Thu, Nov 05 the slowest buses will take 16 h 55 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

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Buses from Syracuse, NY to Harrisburg, PA run on average 6 times per day, taking around 9h 5m. Cheap bus tickets for this journey start at $58 (€48) if you book in advance.
The earliest bus runs at 00:20, the last at 23:20. The fastest bus covers the 195 miles (315 km) distance in 7h 20m.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Syracuse, NY to Harrisburg, PA.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 01:00AM | Arrival Time 05:55PM | Duration 16h55 | Departure days Tue | Cheapest price $111 |
Operator Greyhound | Departure Time 02:00AM | Arrival Time 06:55PM | Duration 16h55 | Departure days Tue, Thu, Sat | Cheapest price $86 |
Operator FlixBus | Departure Time 05:15AM | Arrival Time 05:55PM | Duration 12h40 | Departure days Thu, Fri | Cheapest price $85 |
Operator FlixBus | Departure Time 06:15AM | Arrival Time 06:55PM | Duration 12h40 | Departure days Tue | Cheapest price $94 |
Operator FlixBus | Departure Time 07:15AM | Arrival Time 06:35PM | Duration 11h20 | Departure days Tue | Cheapest price $181 |
Operator FlixBus | Departure Time 08:00AM | Arrival Time 07:35PM | Duration 11h35 | Departure days Thu, Sat | Cheapest price $65 |
Operator Greyhound | Departure Time 11:30AM | Arrival Time 09:20PM | Duration 9h50 | Departure days Thu | Cheapest price $125 |
Operator Greyhound | Departure Time 01:25PM | Arrival Time 11:30PM | Duration 10h05 | Departure days Mon, Thu | Cheapest price $80 |
Operator Greyhound | Departure Time 02:25PM | Arrival Time 12:30AM | Duration 10h05 | Departure days Fri | Cheapest price $76 |
Operator FlixBus | Departure Time 06:00PM | Arrival Time 06:25AM | Duration 12h25 | Departure days Tue, Wed | Cheapest price $123 |
Operator FlixBus | Departure Time 07:00PM | Arrival Time 06:25AM | Duration 11h25 | Departure days Thu, Fri | Cheapest price $103 |
The table below shows live departures for Syracuse, NY to Harrisburg, PA buses for tomorrow, Wednesday, November 4. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 2:00 AM Syracuse, NY | 16h55 | 6:55 PM Harrisburg, PA | 0 transfersDirect | |
![]() | 6:00 PM Syracuse, NY | 12h25 | 6:25 AM Harrisburg, PA | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Buses from Syracuse, NY to Harrisburg, PA with Greyhound and FlixBus. Overnight buses available on this route with Greyhound and FlixBus. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Harrisburg, PA — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Harrisburg, PA trip today.
Major regional museum with American art, natural history, and science exhibits. It is Harrisburg's best-known museum and a strong all-ages visit.
National Civil War museum with broad exhibits on soldiers, civilians, and the war's legacy. It is one of the city's most important history stops.
Museum at Fort Hunter highlighting local river history, mansion life, and the Susquehanna landscape. A quieter favorite with a scenic setting.
Riverfront promenade and park system with skyline views, paths, and event spaces. It is one of the most pleasant walks in central Harrisburg.
Car-free island in the Susquehanna with walking paths, recreation, and broad water views. A classic local escape close to downtown.
Victorian neighborhood known for colorful homes, local shops, and a creative atmosphere. It is ideal for strolling and seeing everyday Harrisburg charm.
Pennsylvania Dutch chicken pot pie is a rich stew with square noodles, chicken, and vegetables. It is a regional comfort food common around Harrisburg.
Shoofly pie is a classic Pennsylvania Dutch dessert made with molasses crumb filling. Its deep sweetness makes it a traditional local bakery staple.
Whoopie pie features two soft chocolate cake rounds with creamy filling. It is a beloved Amish and Pennsylvania Dutch treat found across the region.
Long-running local favorite serving creative American dishes and seafood in a comfortable, polished neighborhood setting.
Historic market with many established local vendors for Pennsylvania Dutch baked goods, pretzels, sandwiches, and regional specialties in a lively setting.
Popular casual tavern and brewery pouring local beer with pub fare. It is well known for a relaxed atmosphere and central location.
Moderate for US state capitals; hotels and dining are usually below major East Coast cities, while transit needs and limited cheap tourist areas can raise daily costs.
Tip 18-20% at restaurants, 15-20% for taxis, and $1-2 per drink or café order if service is provided.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Harrisburg, PA.
Find answers to the most common questions about traveling from Syracuse, NY to Harrisburg, PA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Harrisburg, PA, this guide helps you travel smarter and with confidence.

Most Syracuse, NY to Harrisburg, PA buses use the Syracuse, Walsh Cir (Syracuse Bus Station) to Harrisburg, Market St (Bus Station) station pair. Use this guide to compare Syracuse, NY and Harrisburg, PA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Syracuse, Walsh Cir (Syracuse Bus Station) is 3 km from Syracuse city centre. Public transport options include:
Syracuse, Walsh Cir (Syracuse Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Free Wi-Fi available throughout the station. ATMs are aTMs are located near the entrance.
Ticket office support is available at Syracuse, Walsh Cir (Syracuse Bus Station).
Available at Syracuse, Walsh Cir (Syracuse Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Syracuse, Walsh Cir (Syracuse Bus Station): The station is wheelchair accessible.
Harrisburg, Market St (Bus Station) is 1 km from Harrisburg city centre. Public transport options include:
Harrisburg, Market St (Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Free WiFi inside the station. ATMs are available at Harrisburg, Market St (Bus Station).
Ticket office support is available at Harrisburg, Market St (Bus Station).
Available at Harrisburg, Market St (Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Harrisburg, Market St (Bus Station): Wheelchair accessible with ramps.
Check bus stations information for Syracuse, NY and Harrisburg, PA, including where buses depart and arrive on this route.