The cheapest and fastest trains from Florence, SC to Harrisburg, PA
Cheapest price
$269
Average price
$269
Fastest journey
13 h 2 m
Average duration
13 h 6 m
Trains per day
2
Distance
722 km
The best way to find a cheap train ticket from Florence, SC to Harrisburg, PA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Florence, SC to Harrisburg, PA will cost around $269 if you buy it on the day, but the cheapest tickets can be found for only $269.
It's difficult to get from Florence, SC to Harrisburg, PA without transferring at least once.




Travel Information
Compare train and bus for Florence, SC to Harrisburg, PA
Omio recommends booking the train as it is the most popular option from Florence, SC to Harrisburg, PA among Omio's users. If you are prioritising price take the bus with prices starting from €85. For those with little time consider booking a train which can get you there in 12h 9m. The ticket price range depends on the travel mode: a bus costs an average of €85, and a train costs an average of €222.
Distance: 448 miles (722 km)
Compare train with
Most popular Train | Bus |
|---|---|
€222 Average price | €85 Average price Cheapest |
12h 39m Average total duration Fastest 12h 9m Onboard + 30m Additional time* | 22h 50m Average total duration 22h 20m Onboard + 30m Additional time* |
Direct Options | Direct Options |
Live departures
Florence, SC to Harrisburg, PA train times
The table below shows live departures for Florence, SC to Harrisburg, PA trains for today, Thursday, November 6. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 10:54 AM Florence, SC | 13h02 | 11:56 PM Harrisburg, PA | 1 transfer | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Florence, SC to Harrisburg, PA by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Nov 07
Nov 08
Nov 09
Nov 10
Nov 11
Nov 12
Nov 13
Journey information
Overview: Train from Florence, SC to Harrisburg, PA
Trains from Florence, SC to Harrisburg, PA run on average 2 times per day, taking around 12h 9m. Cheap train tickets for this journey start at $272 (€222) but you can travel from only $104 (€85) by bus.
The earliest train runs at 05:00, the last at 23:32. The fastest train covers the 448 miles (722 km) distance in 13h 2m.
Distance 448 miles (722 km) |
Average train duration 12h 9m |
Cheapest ticket price $272 (€222) |
Trains per day 2 |
Fastest train 13h 2m |
First train 05:00 |
Last train 23:32 |
Train companies: Amtrak from Florence, SC to Harrisburg, PA trainsAmtrak trains will get you between Florence, SC and Harrisburg, PA from $104 (€85). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Amtrak
FAQs: Trains from Florence, SC to Harrisburg, PA
Find answers to the most common questions about traveling from Florence, SC to Harrisburg, PA by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Harrisburg, PA, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Florence, SC to Harrisburg, PA
- 6:00 AM - 11:00 PM Monday - Sunday
- Parking is available at the station.
- Outside the main entrance.
- Elevators, ramps.
- Aloft Florence
- Hyatt Place Florence Downtown
- Hotel Florence, Tapestry Collection by Hilton
- Located in the main hall
- Located in the main hall
- Free
- The station has an enclosed waiting area.
- Bus: Greyhound services available nearby
- 6:00 AM - 10:00 PM Monday - Sunday
- Free
- Parking available on-site with both short-term and long-term options.
- The Millworks
- Bricco
- Outside the main entrance.
- Elevators, ramps, restrooms.
- $0.50
- Hilton Harrisburg
- Crowne Plaza Harrisburg-Hershey
- Radisson Hotel Harrisburg
- Located in the main hall
- Enterprise
- Hertz
- Located in the main hall
- Free
- Hall 1: main entrance, ticket office, and waiting area
- Hall 2: platforms for Amtrak and regional trains
- Hall 3: bus connections and car rental services
- Bus: CAT (Capital Area Transit) services available
- Greyhound and other intercity bus services
Most popular train connections from Florence, SC
More options for your journey from Florence, SC to Harrisburg, PA
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