- Must visit
The State Museum of Pennsylvania
Major regional museum with American art, natural history, and science exhibits. It is Harrisburg's best-known museum and a strong all-ages visit.
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The cheapest and fastest buses from St. Louis, MO to Harrisburg, PA
Showing times, prices and bookable tickets for Sep 18
Cheapest price on Sep 18
$92
Average ticket price on Sep 18
$99
Fastest journey on Sep 18
19 h 20 m
Average journey duration on Sep 18
23 h 10 m
Buses on Sep 18
5
Distance
1157 km
Cheap tickets
The best way to find a cheap bus ticket from St. Louis, MO to Harrisburg, PA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from St. Louis, MO to Harrisburg, PA will cost around $99 if you buy it on the day, but the cheapest tickets can be found for only $92.
Fast buses
On Fri, Sep 18, we found 5 buses from St. Louis, MO to Harrisburg, PA, including 3 direct services.
On Fri, Sep 18 the direct buses cover the 1157 km distance in an average of 23 h 10 m but if you time it right, some buses will get you there in just 19 h 20 m .
On Fri, Sep 18 the slowest buses will take 1 d 9 h 40 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
FlixBus+
· 11:30 PM22h45St. Louis, S 15th St (Civic center)11:15 PMHarrisburg, Market St (Bus Station), PA$921One-way2 transfers- FlixBus+ · 11:45 PM33h40St. Louis, S 15th St (Civic center)10:25 AMHarrisburg, Market St (Bus Station), PA$991One-way2 transfers
- 2:00 AM20h15St. Louis, S 15th St (Civic center)11:15 PMHarrisburg, Market St (Bus Station), PA$1001One-way0 transfers
- 8:45 AM19h50St. Louis, S 15th St (Civic center)5:35 AMHarrisburg, Market St (Bus Station), PA$1001One-way0 transfers
- 2:05 PM19h20St. Louis, S 15th St (Civic center)10:25 AMHarrisburg, Market St (Bus Station), PA$1031One-way0 transfers
- 2:05 PM19h20St. Louis, S 15th St (Civic center)10:25 AMHarrisburg, Market St (Bus Station), PA$1031One-way0 transfers
- 8:45 AM19h50St. Louis, S 15th St (Civic center)5:35 AMHarrisburg, Market St (Bus Station), PA$1001One-way0 transfers
- 2:00 AM20h15St. Louis, S 15th St (Civic center)11:15 PMHarrisburg, Market St (Bus Station), PA$1001One-way0 transfers
- FlixBus+ · 11:30 PM22h45St. Louis, S 15th St (Civic center)11:15 PMHarrisburg, Market St (Bus Station), PA$921One-way2 transfers
- FlixBus+ · 11:45 PM33h40St. Louis, S 15th St (Civic center)10:25 AMHarrisburg, Market St (Bus Station), PA$991One-way2 transfers
Travel Information
Compare train and bus for St. Louis, MO to Harrisburg, PA
Omio recommends booking the flight as it is the most popular option from St. Louis, MO to Harrisburg, PA among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $115 For those with little time, consider booking a flight, which has an average total journey time of 5h 33m. Average ticket prices depend on the travel mode: a bus costs an average of $115, while a flight costs an average of $477.
Distance: 718 miles (1157 km)
Compare bus with
| Bus | Most popular Flight | Train | Driving |
|---|---|---|---|
$115 Average price Cheapest | $477 Average price | $208 Average price | $159 Average price (fuel + tolls) |
20h 57m Average total duration 20h 27m Onboard + 30m Additional time* | 5h 33m Average total duration Fastest 3h 33m Onboard + 2h 0m Additional time* | 20h 59m Average total duration 20h 29m Onboard + 30m Additional time* | 12h 6m Average total duration (door-to-door) |
Most popular bus company |  Most popular airline |  Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from St. Louis, MO to Harrisburg, PA is a bus with an average price of $115.
This is compared to other travel options from St. Louis, MO to Harrisburg, PA:
A bus is $94 less than a train for this route with tickets for a train from St. Louis, MO to Harrisburg, PA costing on average $208.
A bus is $363 less than a flight for this route with tickets for a flight from St. Louis, MO to Harrisburg, PA costing on average $477.
The fastest way to travel from St. Louis, MO to Harrisburg, PA is by flight with an average journey time of 3h 33m.
Other travel options to Harrisburg, PA take longer:
Bus takes on average 20h 27m.
Train takes on average 20h 29m.
It's helpful to compare your options as there are 2 ways to travel between St. Louis, MO and Harrisburg, PA including taking a train and bus.
We recommend using the flight as it is the most popular way to get from St. Louis, MO to Harrisburg, PA among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.
Tickets start at around $115 compared to roughly $159 in fuel and tolls — a saving of about $45. The journey takes 20h 27m versus 12h 6m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by Greyhound.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
St. Louis, MO to Harrisburg, PA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound USA | Departure Time 02:00AM | Arrival Time 11:05PM | Duration 21h05 | Departure days Mon, Tue, Wed, Thu, Fri, Sun | Cheapest price $75 |
Operator Greyhound | Departure Time 08:00AM | Arrival Time 04:05AM | Duration 20h05 | Departure days Sat | Cheapest price $93 |
Operator Greyhound USA | Departure Time 08:45AM | Arrival Time 05:30AM | Duration 20h45 | Departure days Mon, Tue, Wed, Thu, Fri, Sun | Cheapest price $75 |
Operator Greyhound USA | Departure Time 01:55PM | Arrival Time 10:15AM | Duration 20h20 | Departure days Mon, Wed, Thu | Cheapest price $75 |
Operator Greyhound | Departure Time 02:05PM | Arrival Time 10:25AM | Duration 19h20 | Departure days Tue, Fri, Sun | Cheapest price $98 |
Operator Greyhound | Departure Time 02:45PM | Arrival Time 10:30AM | Duration 19h45 | Departure days Sat | Cheapest price $127 |
Operator Greyhound | Departure Time 11:30PM | Arrival Time 11:05PM | Duration 22h35 | Departure days Thu, Fri, Sun | Cheapest price $87 |
Operator Greyhound | Departure Time 11:45PM | Arrival Time 10:25AM | Duration 33h40 | Departure days Fri, Sun | Cheapest price $94 |
Live departures
St. Louis, MO to Harrisburg, PA bus times
The table below shows live departures for St. Louis, MO to Harrisburg, PA buses for today, Thursday, September 17. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| FlixBus+ · | 11:30 PM St. Louis, S 15th St (Civic center) | 22h35 | 11:05 PM Harrisburg, Market St (Bus Station), PA | 2 transfers | |
| Friday, September 18 | |||||
| 2:00 AM St. Louis, S 15th St (Civic center) | 20h15 | 11:15 PM Harrisburg, Market St (Bus Station), PA | 0 transfersDirect | |
| 8:45 AM St. Louis, S 15th St (Civic center) | 19h50 | 5:35 AM Harrisburg, Market St (Bus Station), PA | 0 transfersDirect | |
| 2:05 PM St. Louis, S 15th St (Civic center) | 19h20 | 10:25 AM Harrisburg, Market St (Bus Station), PA | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets St. Louis, MO to Harrisburg, PA by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Sep 18
Sep 18
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Sep 19
Sep 19
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Sep 20
Sep 20
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Why should you book St. Louis, MO to Harrisburg, PA buses with Omio?
Greyhound operates all buses services from St. Louis, MO to Harrisburg, PA.
Omio is an official ticket reseller for all your travel options from St. Louis, MO to Harrisburg, PA.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train and bus to ensure you get the best deal for traveling from St. Louis, MO to Harrisburg, PA.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from St. Louis, MO to Harrisburg, PA.
Journey information
Overview: Bus from St. Louis, MO to Harrisburg, PA
USAUSA
Buses from St. Louis, MO to Harrisburg, PA run on average 4 times per day, taking around 20h 27m. Cheap bus tickets for this journey start at $78 if you book in advance.
There are 3 buses per day. The earliest bus runs at 02:00, the last at 23:30. The fastest bus covers the 718 miles (1157 km) distance in 19h 20m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 718 miles (1157 km) |
Average bus duration 20h 27m |
Cheapest ticket price $78 |
Buses per day 4 |
Direct buses 3 |
Fastest bus 19h 20m |
First bus 2:00 AM |
Last bus 11:30 PM |
Cheapest Month Dec |
Cheapest Day Sun |
High Season Jul - Sep |
Low Season Oct - Dec |
Best time to book 42 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound from St. Louis, MO to Harrisburg, PAYou can travel by bus between St. Louis, MO to Harrisburg, PA with Greyhound for as low as $78. When you search for schedules and tickets, Omio will show you the best journey
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
19h 20m
Cheapest Greyhound Price
$88
Greyhound frequency
4 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Harrisburg, PA
Things to do in Harrisburg, PA
Discover the best of Harrisburg, PA — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Harrisburg, PA trip today.
- Must visit
National Civil War Museum
National Civil War museum with broad exhibits on soldiers, civilians, and the war's legacy. It is one of the city's most important history stops.
- Recommended
Fort Hunter Mansion and Park Museum
Museum at Fort Hunter highlighting local river history, mansion life, and the Susquehanna landscape. A quieter favorite with a scenic setting.
- Must visit
Riverfront Park
Riverfront promenade and park system with skyline views, paths, and event spaces. It is one of the most pleasant walks in central Harrisburg.
- Recommended
City Island
Car-free island in the Susquehanna with walking paths, recreation, and broad water views. A classic local escape close to downtown.
- Recommended
Midtown
Victorian neighborhood known for colorful homes, local shops, and a creative atmosphere. It is ideal for strolling and seeing everyday Harrisburg charm.
Pennsylvania Dutch Chicken Pot Pie
Pennsylvania Dutch chicken pot pie is a rich stew with square noodles, chicken, and vegetables. It is a regional comfort food common around Harrisburg.
- Vegetarian
Shoofly Pie
Shoofly pie is a classic Pennsylvania Dutch dessert made with molasses crumb filling. Its deep sweetness makes it a traditional local bakery staple.
- Vegetarian
Whoopie Pie
Whoopie pie features two soft chocolate cake rounds with creamy filling. It is a beloved Amish and Pennsylvania Dutch treat found across the region.
Rubicon
Long-running local favorite serving creative American dishes and seafood in a comfortable, polished neighborhood setting.
Broad Street Market
Historic market with many established local vendors for Pennsylvania Dutch baked goods, pretzels, sandwiches, and regional specialties in a lively setting.
Zeroday Brewing Company
Popular casual tavern and brewery pouring local beer with pub fare. It is well known for a relaxed atmosphere and central location.
US dollar ($)
Moderate for US state capitals; hotels and dining are usually below major East Coast cities, while transit needs and limited cheap tourist areas can raise daily costs.
Average meal costs
- Budget
- $10-15 for fast food or a simple lunch.
- Mid-range
- $18-35 per person for a casual restaurant meal.
- Fine dining
- $50+ per person for upscale dining.
- Coffee
- $3-5 for coffee or a cappuccino.
Tipping culture
Tip 18-20% at restaurants, 15-20% for taxis, and $1-2 per drink or café order if service is provided.
FAQs: Bus from St. Louis, MO to Harrisburg, PA
Find answers to the most common questions about traveling from St. Louis, MO to Harrisburg, PA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Harrisburg, PA, this guide helps you travel smarter and with confidence.
Cheap bus tickets from St. Louis, MO to Harrisburg, PA can start from as little as $78 when you book in advance. The average bus ticket price for St. Louis, MO to Harrisburg, PA is $115 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from St. Louis, MO to Harrisburg, PA is 19h 20m to travel the 718 miles (1157 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from St. Louis, MO to Harrisburg, PA leaves at 2:00 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from St. Louis, MO to Harrisburg, PA leaves at 11:30 PM.
Yes, there are 3 direct buses a day from St. Louis, MO to Harrisburg, PA with Greyhound. Schedules can vary on holidays or weekends with fewer direct buses.
When taking a bus from St. Louis, MO to Harrisburg, PA, you can count on Greyhound for the best way to get you to Harrisburg, PA. You can also check all possible bus companies who offer a service between St. Louis, MO and Harrisburg, PA and compare the amenities they offer before buying a bus ticket.
Passengers board the bus most frequently from St. Louis, S 15th St (Civic center), which is located around away from the city centre, and they get off the bus at Harrisburg, Market St (Bus Station), PA, located 1 away from the city centre.
A trip to Harrisburg, PA from St. Louis, MO is worth doing but not as a day trip with a journey time of 19h 20m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from St. Louis, MO to Harrisburg, PA is December.
It's helpful to compare your options as there are 2 ways to travel between St. Louis, MO and Harrisburg, PA including taking a train and bus.
Yes, the following accessibility options are available when taking the bus from St. Louis, MO to Harrisburg, PA:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from St. Louis, MO to Harrisburg, PA for bus company Greyhound.
Some of the most interesting sights to explore in Harrisburg, PA are:
- Pennsylvania State Capitol, an architectural marvel featuring a grand dome and exquisite interior murals
- National Civil War Museum, a comprehensive museum offering insights into the American Civil War with extensive exhibits
- The State Museum of Pennsylvania, showcasing the state's history, art, and natural sciences through diverse collections
- Fort Hunter Mansion and Park, a historic site with preserved buildings and beautiful grounds reflecting 18th and 19th-century life
- Wildwood Park, a nature preserve offering trails and a nature center for wildlife observation and environmental education.
The best things to do in Harrisburg, PA include:
- City Island, a recreational area featuring sports facilities, walking trails, and riverboat cruises
- Whitaker Center for Science and the Arts, a venue offering interactive science exhibits and live performances
- Broad Street Market, one of the oldest continuously operating farmers' markets in the country, offering diverse local foods and goods
- Susquehanna Art Museum, presenting contemporary art exhibitions and educational programs
- Riverfront Park, ideal for walking, biking, and enjoying views of the Susquehanna River.
Whether you can cancel your bus ticket from St. Louis, MO to Harrisburg, PA depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from St. Louis, MO to Harrisburg, PA.
Yes, the following luggage options are included when booking a bus ticket from St. Louis, MO to Harrisburg, PA:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from St. Louis, MO to Harrisburg, PA:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from St. Louis, MO to Harrisburg, PA.
You can reserve your seat on the bus from St. Louis, MO to Harrisburg, PA with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from St. Louis, MO to Harrisburg, PA with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from St. Louis, MO to Harrisburg, PA with the following bus company: Greyhound.
Since neither St. Louis, MO nor Harrisburg, PA are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the flight as it is the most popular way to get from St. Louis, MO to Harrisburg, PA among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Harrisburg, PA, travelers should be cautious of pickpocketing and vehicle break-ins, especially in crowded areas and parking lots. Common scams include overpriced taxi services and fraudulent ticket sellers near popular attractions. Staying aware of surroundings and using authorized transportation options helps enhance safety.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from St. Louis, MO to Harrisburg, PA
Most St. Louis, MO to Harrisburg, PA buses use the St. Louis, S 15th St (Civic center) to Harrisburg, Market St (Bus Station) station pair. Use this guide to compare St. Louis, MO and Harrisburg, PA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in St. Louis
Arrival bus stations in Harrisburg
Which St. Louis, MO station do buses to Harrisburg, PA leave from?
Buses from St. Louis, MO to Harrisburg, PA leave from St. Louis, S 15th St (Civic center). The station is 0 miles (1 km) from St. Louis, MO city centre at S 15th St, St. Louis, MO, USA.
St. Louis, S 15th St (Civic center)S 15th St, St. Louis, MO, USA
City-centre transport
Getting to St. Louis, S 15th St (Civic center) from St. Louis city centre
TrainMlb, Mlr · 4m · $4 · every ~14 min
Bus19, 32, 40 · 8m · $1 · every ~9 min
St. Louis, S 15th St (Civic center) bus station facilities and services
St. Louis, S 15th St (Civic center) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at St. Louis, S 15th St (Civic center). ATMs are available at St. Louis, S 15th St (Civic center).
Tickets and information
Ticket office support is available at St. Louis, S 15th St (Civic center).
Parking, taxis and toilets
Available at St. Louis, S 15th St (Civic center): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at St. Louis, S 15th St (Civic center): Wheelchair accessible routes available.
Which Harrisburg, PA station do buses from St. Louis, MO arrive at?
Buses from St. Louis, MO to Harrisburg, PA arrive at Harrisburg, Market St (Bus Station). Harrisburg, Market St (Bus Station) is 0 miles (1 km) from Harrisburg, PA city centre.
Harrisburg, Market St (Bus Station)Harrisburg, 411 Market St, Harrisburg, PA 17101, USA
City-centre transport
Getting to Harrisburg, Market St (Bus Station) from Harrisburg city centre
Harrisburg, Market St (Bus Station) is 1 km from Harrisburg city centre. Public transport options include:
Bus6/13, W · 29m · $4 · every ~4 min
Harrisburg, Market St (Bus Station) bus station facilities and services
Harrisburg, Market St (Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Free WiFi inside the station. ATMs are available at Harrisburg, Market St (Bus Station).
Tickets and information
Ticket office support is available at Harrisburg, Market St (Bus Station).
Parking, taxis and toilets
Available at Harrisburg, Market St (Bus Station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Harrisburg, Market St (Bus Station): Wheelchair accessible with ramps.
Most popular bus connections from St. Louis, MO
More options for your journey from St. Louis, MO to Harrisburg, PA
Here are some other resources that might have the information you need
Most popular buses to and from Harrisburg, PA and St. Louis, MO
Most popular bus connections to Harrisburg, PA
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