The cheapest and fastest buses from St. Louis, MO to Harrisburg, PA
Cheapest price
$234
Average price
$234
Fastest journey
20 h 20 m
Average duration
20 h 33 m
Buses per day
2
Distance
1157 km
The best way to find a cheap bus ticket from St. Louis, MO to Harrisburg, PA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from St. Louis, MO to Harrisburg, PA will cost around $234 if you buy it on the day, but the cheapest tickets can be found for only $234.
Of the 2 buses that leave St. Louis, MO for Harrisburg, PA on Sun, Mar 22, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sun, Mar 22 the direct buses cover the 1157 km distance in an average of 20 h 33 m but if you time it right, some buses will get you there in just 20 h 20 m .
On Sun, Mar 22 the slowest buses will take 20 h 45 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.




Travel Information
Compare train, bus, and flight for St. Louis, MO to Harrisburg, PA
Omio recommends booking the bus as it is the most popular option from St. Louis, MO to Harrisburg, PA among Omio's users. If you are prioritising price take the bus with prices starting from $93. For those with little time consider booking a flight which can get you there in 4h 18m. The ticket price range depends on the travel mode: a bus costs an average of $93, and a flight costs an average of $251.
Distance: 718 miles (1157 km)
Compare bus with
Most popular Bus | Flight | Train |
|---|---|---|
$116 Average price Cheapest | $285 Average price | $196 Average price |
19h 43m Average total duration 19h 13m Onboard + 30m Additional time* | 7h 18m Average total duration Fastest 4h 18m Onboard + 3h 0m Additional time* | 30h 12m Average total duration 29h 42m Onboard + 30m Additional time* |
Direct Options | Direct Options | Direct Options |
Live departures
St. Louis, MO to Harrisburg, PA bus times
The table below shows live departures for St. Louis, MO to Harrisburg, PA buses for today, Saturday, March 21. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 2:45 PM St. Louis, MO | 19h45 | 10:30 AM Harrisburg, PA | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets St. Louis, MO to Harrisburg, PA by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 22
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Mar 28
Why should you book St. Louis, MO to Harrisburg, PA buses with Omio?
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from St. Louis, MO to Harrisburg, PA.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from St. Louis, MO to Harrisburg, PA.
Journey information
Overview: Bus from St. Louis, MO to Harrisburg, PA
Buses from St. Louis, MO to Harrisburg, PA run on average 5 times per day, taking around 19h 13m. Cheap bus tickets for this journey start at $93 (€76) if you book in advance.
There are 3 buses per day. The earliest bus runs at 02:00, the last at 23:30. The fastest bus covers the 718 miles (1157 km) distance in 19h 20m.
Distance 718 miles (1157 km) |
Average bus duration 19h 13m |
Cheapest ticket price $93 (€76) |
Buses per day 5 |
Direct buses 3 |
Fastest bus 19h 20m |
First bus 02:00 |
Last bus 23:30 |
Cheapest month Dec |
Cheapest day Fri |
High season Apr - Jun |
Low season Jul - Sep |
Best day to book ahead 42 days |
Bus providers: Greyhound from St. Louis, MO to Harrisburg, PAYou can travel by bus between St. Louis, MO to Harrisburg, PA with Greyhound for as low as $93 (€76). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from St. Louis, MO to Harrisburg, PA
Find answers to the most common questions about traveling from St. Louis, MO to Harrisburg, PA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Harrisburg, PA, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Pennsylvania State Capitol, an architectural marvel featuring a grand dome and exquisite interior murals
- National Civil War Museum, a comprehensive museum offering insights into the American Civil War with extensive exhibits
- The State Museum of Pennsylvania, showcasing the state's history, art, and natural sciences through diverse collections
- Fort Hunter Mansion and Park, a historic site with preserved buildings and beautiful grounds reflecting 18th and 19th-century life
- Wildwood Park, a nature preserve offering trails and a nature center for wildlife observation and environmental education.
- City Island, a recreational area featuring sports facilities, walking trails, and riverboat cruises
- Whitaker Center for Science and the Arts, a venue offering interactive science exhibits and live performances
- Broad Street Market, one of the oldest continuously operating farmers' markets in the country, offering diverse local foods and goods
- Susquehanna Art Museum, presenting contemporary art exhibitions and educational programs
- Riverfront Park, ideal for walking, biking, and enjoying views of the Susquehanna River.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from St. Louis, MO to Harrisburg, PA
Most popular bus connections from St. Louis, MO
More options for your journey from St. Louis, MO to Harrisburg, PA
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