- Must visit
The State Museum Of Pennsylvania
The Commonwealth’s flagship history museum with exhibits on archaeology, industry, Civil War history, natural history, and fine art. A strong first stop for understanding Pennsylvania’s story.
2,000+ travel companies
2,000+ travel companies
Scan to get our free app
Use our app to get live travel updates and book mobile tickets for trains, buses, flights, and ferries.
App Store
4.942K ratings
Google Play
4.6136K reviews
The cheapest and fastest buses from St. Louis, MO to Harrisburg, PA
Showing times and prices for Jun 20
Cheapest price
$93
Average price
$110
Fastest journey
19 h 45 m
Average duration
19 h 55 m
Buses per day
2
Distance
1157 km
Cheap tickets
The best way to find a cheap bus ticket from St. Louis, MO to Harrisburg, PA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from St. Louis, MO to Harrisburg, PA will cost around $110 if you buy it on the day, but the cheapest tickets can be found for only $93.
Fast buses
Of the 2 buses that leave St. Louis, MO for Harrisburg, PA on Sat, Jun 20, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sat, Jun 20 the direct buses cover the 1157 km distance in an average of 19 h 55 m but if you time it right, some buses will get you there in just 19 h 45 m .
On Sat, Jun 20 the slowest buses will take 20 h 5 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
8:00 AM20h05St. Louis, MO4:05 AMHarrisburg, PA$931One-way0 transfers- 2:45 PM19h45St. Louis, MO10:30 AMHarrisburg, PA$1271One-way0 transfers
- 2:45 PM19h45St. Louis, MO10:30 AMHarrisburg, PA$1271One-way0 transfers
- 8:00 AM20h05St. Louis, MO4:05 AMHarrisburg, PA$931One-way0 transfers
Travel Information
Compare train, bus, and flight for St. Louis, MO to Harrisburg, PA
Omio recommends booking the flight as it is the most popular option from St. Louis, MO to Harrisburg, PA among Omio's users. If you are prioritising price take the bus with prices starting from $93. For those with little time consider booking a flight which can get you there in 3h 20m. The ticket price range depends on the travel mode: a bus costs an average of $93, and a flight costs an average of $270.
Distance: 718 miles (1157 km)
Compare bus with
| Bus | Most popular Flight | Train | Driving |
|---|---|---|---|
$123 Average price Cheapest | $343 Average price | $205 Average price | $157 Average price (fuel + tolls) |
20h 1m Average total duration 19h 31m Onboard + 30m Additional time* | 6h 20m Average total duration Fastest 3h 20m Onboard + 3h 0m Additional time* | 31h 10m Average total duration 30h 40m Onboard + 30m Additional time* | 12h 6m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from St. Louis, MO to Harrisburg, PA is a bus with an average price of $123 (€101).
This is compared to other travel options from St. Louis, MO to Harrisburg, PA:
A bus is $82 (€67) less than a train for this route with tickets for a train from St. Louis, MO to Harrisburg, PA costing on average $205 (€168).
A bus is $221 (€181) less than a flight for this route with tickets for a flight from St. Louis, MO to Harrisburg, PA costing on average $343 (€281).
The fastest way to travel from St. Louis, MO to Harrisburg, PA is by flight with an average journey time of 3h 20m.
Other travel options to Harrisburg, PA take longer:
Bus takes on average 19h 31m.
Train takes on average 30h 40m.
It's helpful to compare your options as there are 3 ways to travel between St. Louis, MO and Harrisburg, PA including taking a train, bus, and flight.
We recommend using the flight as it is the most popular way to get from St. Louis, MO to Harrisburg, PA among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.
Tickets start at around $123 (€101) compared to roughly $157 (€129) in fuel and tolls — a saving of about $34 (€28). The journey takes 19h 31m versus 12h 6m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by Greyhound.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
St. Louis, MO to Harrisburg, PA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound USA | Departure Time 02:00AM | Arrival Time 11:05PM | Duration 21h05 | Departure days Mon, Tue, Wed, Thu | Cheapest price $82 |
Operator Greyhound | Departure Time 08:00AM | Arrival Time 04:05AM | Duration 20h05 | Departure days Sat | Cheapest price $93 |
Operator Greyhound USA | Departure Time 08:45AM | Arrival Time 05:30AM | Duration 20h45 | Departure days Mon, Tue, Wed, Thu, Sun | Cheapest price $82 |
Operator Greyhound | Departure Time 01:45PM | Arrival Time 09:30AM | Duration 19h45 | Departure days Fri | Cheapest price $140 |
Operator Greyhound USA | Departure Time 01:55PM | Arrival Time 10:15AM | Duration 20h20 | Departure days Mon, Tue, Wed, Thu, Sun | Cheapest price $83 |
Operator Greyhound | Departure Time 02:45PM | Arrival Time 10:30AM | Duration 19h45 | Departure days Sat | Cheapest price $127 |
Operator Greyhound | Departure Time 11:30PM | Arrival Time 11:05PM | Duration 22h35 | Departure days Tue | Cheapest price $123 |
Live departures
St. Louis, MO to Harrisburg, PA bus times
The table below shows live departures for St. Louis, MO to Harrisburg, PA buses for tomorrow, Saturday, June 20. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 8:00 AM St. Louis, MO | 20h05 | 4:05 AM Harrisburg, PA | 0 transfersDirect | |
| 2:45 PM St. Louis, MO | 19h45 | 10:30 AM Harrisburg, PA | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets St. Louis, MO to Harrisburg, PA by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Sat
Jun 20
Jun 20
Sun
Jun 21
Jun 21
Mon
Jun 22
Jun 22
Tue
Jun 23
Jun 23
Wed
Jun 24
Jun 24
Thu
Jun 25
Jun 25
Fri
Jun 26
Jun 26
Why should you book St. Louis, MO to Harrisburg, PA buses with Omio?
Greyhound operates all buses services from St. Louis, MO to Harrisburg, PA.
Omio is an official ticket reseller for all your travel options from St. Louis, MO to Harrisburg, PA.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from St. Louis, MO to Harrisburg, PA.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from St. Louis, MO to Harrisburg, PA.
Journey information
Overview: Bus from St. Louis, MO to Harrisburg, PA
USAUSA
Buses from St. Louis, MO to Harrisburg, PA run on average 5 times per day, taking around 19h 31m. Cheap bus tickets for this journey start at $93 (€76) if you book in advance.
There are 3 buses per day. The earliest bus runs at 02:00, the last at 23:30. The fastest bus covers the 718 miles (1157 km) distance in 19h 45m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 718 miles (1157 km) |
Average bus duration 19h 31m |
Cheapest ticket price $93 (€76) |
Buses per day 5 |
Direct buses 3 |
Fastest bus 19h 45m |
First bus 2:00 AM |
Last bus 11:30 PM |
Cheapest Month Dec |
Cheapest Day Sat |
High Season Jan - Mar |
Low Season Jul - Sep |
Best time to book 42 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound from St. Louis, MO to Harrisburg, PAYou can travel by bus between St. Louis, MO to Harrisburg, PA with Greyhound for as low as $93 (€76). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
19h 45m
Cheapest Price
$93 (€76)
Greyhound frequency
4 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Harrisburg
Things to do in Harrisburg
Discover the best of Harrisburg — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Harrisburg trip today.
- Must visit
National Civil War Museum
Major museum interpreting the American Civil War from multiple perspectives, with extensive artifacts, documents, and rotating exhibitions. One of Harrisburg’s best-known cultural attractions.
- Recommended
Susquehanna Art Museum
Contemporary art museum featuring regional, national, and international artists in a modern downtown space. A good choice for travelers interested in current exhibitions and local creative culture.
- Must visit
Riverfront Park
Linear park along the Susquehanna River with walking paths, public art, and excellent skyline views. It is one of Harrisburg’s most pleasant and photogenic places for a stroll.
- Must visit
City Island
Recreational island in the Susquehanna offering river views, trails, and open space between downtown and the west shore. Popular for relaxed walks and classic Harrisburg scenery.
- Must visit
Capitol Complex
The ceremonial and governmental heart of Harrisburg, with landscaped grounds, monuments, and some of the city’s best architecture. A practical and scenic area for sightseeing.
Pennsylvania Dutch Chicken Pot Pie
A regional staple made with broad noodles simmered in rich chicken broth, often with chicken and vegetables. It is a classic Central Pennsylvania comfort dish.
- Gluten-free
Lebanon Bologna
A smoky, tangy cured beef sausage from nearby Lebanon County, traditionally sliced for sandwiches or cheese boards. It is one of the area's best-known local meats.
- Vegetarian
Shoofly Pie
A Pennsylvania Dutch dessert pie with a molasses filling and crumb topping. It is strongly associated with the region's baking traditions.
Rubicon
A well-regarded fine dining spot offering contemporary American cuisine, craft cocktails, and a polished but comfortable atmosphere.
The Millworks
A popular restaurant, brewery, and arts space known for seasonal Pennsylvania ingredients, house beer, and a lively industrial-chic atmosphere.
Bricco
An established downtown Italian restaurant and wine bar known for brick-oven pizzas, handmade pasta, and an intimate urban setting.
United States Dollar
Generally moderate for U.S. travel. Meals and coffee are reasonable, while hotels can rise during events or peak government travel periods.
Average meal costs
- Budget
- USD 10-15 for fast food or a simple lunch.
- Mid-range
- USD 20-35 per person at a casual restaurant.
- Fine dining
- USD 50-90 per person at upscale spots.
- Coffee
- USD 3-6 for drip coffee or a latte.
Tipping culture
Tip 18-20% at restaurants for table service, 15-20% for taxis, USD 1-2 per drink at bars, and a few dollars for hotel staff. Tipping is not expected at most fast-food counters.
FAQs: Bus from St. Louis, MO to Harrisburg, PA
Find answers to the most common questions about traveling from St. Louis, MO to Harrisburg, PA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Harrisburg, PA, this guide helps you travel smarter and with confidence.
Cheap bus tickets from St. Louis, MO to Harrisburg, PA can start from as little as $93 (€76) when you book in advance. The average bus ticket price for St. Louis, MO to Harrisburg, PA is $123 (€101) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from St. Louis, MO to Harrisburg, PA is 19h 45m to travel the 718 miles (1157 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from St. Louis, MO to Harrisburg, PA leaves at 2:00 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from St. Louis, MO to Harrisburg, PA leaves at 11:30 PM.
Yes, there are 3 direct buses a day from St. Louis, MO to Harrisburg, PA with Greyhound. Schedules can vary on holidays or weekends with fewer direct buses.
When taking a bus from St. Louis, MO to Harrisburg, PA, you can count on Greyhound for the best way to get you to Harrisburg, PA. You can also check all possible bus companies who offer a service between St. Louis, MO and Harrisburg, PA and compare the amenities they offer before buying a bus ticket.
A trip to Harrisburg, PA from St. Louis, MO is worth doing but not as a day trip with a journey time of 19h 45m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from St. Louis, MO to Harrisburg, PA is December.
It's helpful to compare your options as there are 3 ways to travel between St. Louis, MO and Harrisburg, PA including taking a train, bus, and flight.
Yes, there are bathrooms on board the bus from St. Louis, MO to Harrisburg, PA for bus company Greyhound.
Yes, the following accessibility options are available when taking the bus from St. Louis, MO to Harrisburg, PA:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Some of the most interesting sights to explore in Harrisburg, PA are:
- Pennsylvania State Capitol, an architectural marvel featuring a grand dome and exquisite interior murals
- National Civil War Museum, a comprehensive museum offering insights into the American Civil War with extensive exhibits
- The State Museum of Pennsylvania, showcasing the state's history, art, and natural sciences through diverse collections
- Fort Hunter Mansion and Park, a historic site with preserved buildings and beautiful grounds reflecting 18th and 19th-century life
- Wildwood Park, a nature preserve offering trails and a nature center for wildlife observation and environmental education.
The best things to do in Harrisburg, PA include:
- City Island, a recreational area featuring sports facilities, walking trails, and riverboat cruises
- Whitaker Center for Science and the Arts, a venue offering interactive science exhibits and live performances
- Broad Street Market, one of the oldest continuously operating farmers' markets in the country, offering diverse local foods and goods
- Susquehanna Art Museum, presenting contemporary art exhibitions and educational programs
- Riverfront Park, ideal for walking, biking, and enjoying views of the Susquehanna River.
Whether you can cancel your bus ticket from St. Louis, MO to Harrisburg, PA depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from St. Louis, MO to Harrisburg, PA.
Yes, the following luggage options are included when booking a bus ticket from St. Louis, MO to Harrisburg, PA:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from St. Louis, MO to Harrisburg, PA:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from St. Louis, MO to Harrisburg, PA.
You can reserve your seat on the bus from St. Louis, MO to Harrisburg, PA with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from St. Louis, MO to Harrisburg, PA with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from St. Louis, MO to Harrisburg, PA with the following bus company: Greyhound.
Since neither St. Louis, MO nor Harrisburg, PA are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the flight as it is the most popular way to get from St. Louis, MO to Harrisburg, PA among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Harrisburg, PA, travelers should be cautious of pickpocketing and vehicle break-ins, especially in crowded areas and parking lots. Common scams include overpriced taxi services and fraudulent ticket sellers near popular attractions. Staying aware of surroundings and using authorized transportation options helps enhance safety.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from St. Louis, MO to Harrisburg, PA
St. Louis
Harrisburg
The major bus station for departures in St. Louis is St. Louis, S 15th St (Civic center). Find all the information you need to know about services, amenities and connections at St. Louis, S 15th St (Civic center) for your trip from St. Louis to Harrisburg.
St. Louis, S 15th St (Civic center)
information
The major bus station for arrivals in Harrisburg is Harrisburg, Market St (Bus Station). Find all the information you need to know about services, amenities and connections at Harrisburg, Market St (Bus Station) for your trip to Harrisburg from St. Louis.
Harrisburg, Market St (Bus Station)
information
Harrisburg, Chestnut Street / South 4th Street
information
Most popular bus connections from St. Louis, MO
More options for your journey from St. Louis, MO to Harrisburg, PA
Here are some other resources that might have the information you need
Most popular buses to and from Harrisburg, PA and St. Louis, MO
Most popular bus connections to Harrisburg, PA
The Omio App Makes Travel Planning Easy
We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.
