- Must visit
The State Museum of Pennsylvania
Major regional museum with American art, natural history, and science exhibits. It is Harrisburg's best-known museum and a strong all-ages visit.
The best way to find a cheap bus ticket from St. Louis, MO to Harrisburg, PA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from St. Louis, MO to Harrisburg, PA will cost around NOK 1,183 if you buy it on the day, but the cheapest tickets can be found for only NOK 1,183.
On Tue, Nov 03, we found 1 buses from St. Louis, MO to Harrisburg, PA, including 1 direct services.
On Tue, Nov 03 the direct buses cover the 1157 km distance in an average of 19 h 45 m but if you time it right, some buses will get you there in just 19 h 45 m .
On Tue, Nov 03 the slowest buses will take 19 h 45 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

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Buses from St. Louis, MO to Harrisburg, PA run on average 4 times per day, taking around 20h 37m. Cheap bus tickets for this journey start at NOK 701 if you book in advance.
There are 3 buses per day. The earliest bus runs at 02:00, the last at 23:30. The fastest bus covers the 718 miles (1157 km) distance in 19h 20m.
Distance 718 miles (1157 km) |
Average bus duration 20h 37m |
Cheapest ticket price NOK 701 |
Buses per day 4 |
Direct buses 3 |
Fastest bus 19h 20m |
First bus 2:00 AM |
Last bus 11:30 PM |
Cheapest Month Sep |
Cheapest Day Sun |
High Season Jul - Sep |
Low Season Oct - Dec |
Best time to book 42 days |
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from St. Louis, MO to Harrisburg, PA.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound USA | Departure Time 02:00AM | Arrival Time 11:05PM | Duration 21h05 | Departure days Mon, Wed, Thu | Cheapest price NOK 887 |
Operator Greyhound | Departure Time 08:00AM | Arrival Time 04:05AM | Duration 20h05 | Departure days Sat | Cheapest price NOK 830 |
Operator Greyhound USA | Departure Time 08:45AM | Arrival Time 05:30AM | Duration 20h45 | Departure days Mon, Wed, Thu, Sun | Cheapest price NOK 887 |
Operator Greyhound | Departure Time 01:45PM | Arrival Time 09:30AM | Duration 19h45 | Departure days Fri | Cheapest price NOK 1,258 |
Operator Greyhound USA | Departure Time 01:55PM | Arrival Time 10:15AM | Duration 20h20 | Departure days Mon, Thu, Sun | Cheapest price NOK 2,081 |
Operator Greyhound | Departure Time 02:05PM | Arrival Time 10:25AM | Duration 19h20 | Departure days Wed | Cheapest price NOK 887 |
Operator Greyhound | Departure Time 02:45PM | Arrival Time 10:30AM | Duration 19h45 | Departure days Tue, Sat | Cheapest price NOK 1,139 |
The table below shows live departures for St. Louis, MO to Harrisburg, PA buses for today, Monday, November 2. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 8:45 AM St. Louis, MO | 20h45 | 5:30 AM Harrisburg, PA | 0 transfersDirect | |
![]() | 1:55 PM St. Louis, MO | 20h20 | 10:15 AM Harrisburg, PA | 0 transfersDirect | |
This is the last bus of the day. | |||||
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Discover the best of Harrisburg, PA — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Harrisburg, PA trip today.
Major regional museum with American art, natural history, and science exhibits. It is Harrisburg's best-known museum and a strong all-ages visit.
National Civil War museum with broad exhibits on soldiers, civilians, and the war's legacy. It is one of the city's most important history stops.
Museum at Fort Hunter highlighting local river history, mansion life, and the Susquehanna landscape. A quieter favorite with a scenic setting.
Riverfront promenade and park system with skyline views, paths, and event spaces. It is one of the most pleasant walks in central Harrisburg.
Car-free island in the Susquehanna with walking paths, recreation, and broad water views. A classic local escape close to downtown.
Victorian neighborhood known for colorful homes, local shops, and a creative atmosphere. It is ideal for strolling and seeing everyday Harrisburg charm.
Pennsylvania Dutch chicken pot pie is a rich stew with square noodles, chicken, and vegetables. It is a regional comfort food common around Harrisburg.
Shoofly pie is a classic Pennsylvania Dutch dessert made with molasses crumb filling. Its deep sweetness makes it a traditional local bakery staple.
Whoopie pie features two soft chocolate cake rounds with creamy filling. It is a beloved Amish and Pennsylvania Dutch treat found across the region.
Long-running local favorite serving creative American dishes and seafood in a comfortable, polished neighborhood setting.
Historic market with many established local vendors for Pennsylvania Dutch baked goods, pretzels, sandwiches, and regional specialties in a lively setting.
Popular casual tavern and brewery pouring local beer with pub fare. It is well known for a relaxed atmosphere and central location.
Moderate for US state capitals; hotels and dining are usually below major East Coast cities, while transit needs and limited cheap tourist areas can raise daily costs.
Tip 18-20% at restaurants, 15-20% for taxis, and $1-2 per drink or café order if service is provided.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Harrisburg, PA.
Find answers to the most common questions about traveling from St. Louis, MO to Harrisburg, PA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Harrisburg, PA, this guide helps you travel smarter and with confidence.

Most St. Louis, MO to Harrisburg, PA buses use the St. Louis, S 15th St (Civic center) to Harrisburg, Market St (Bus Station) station pair. Use this guide to compare St. Louis, MO and Harrisburg, PA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
St. Louis, S 15th St (Civic center) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at St. Louis, S 15th St (Civic center). ATMs are available at St. Louis, S 15th St (Civic center).
Ticket office support is available at St. Louis, S 15th St (Civic center).
Available at St. Louis, S 15th St (Civic center): Parking, Taxis, WC.
Accessibility facilities are available at St. Louis, S 15th St (Civic center): Wheelchair accessible routes available.
Harrisburg, Market St (Bus Station) is 1 km from Harrisburg city centre. Public transport options include:
Harrisburg, Market St (Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Free WiFi inside the station. ATMs are available at Harrisburg, Market St (Bus Station).
Ticket office support is available at Harrisburg, Market St (Bus Station).
Available at Harrisburg, Market St (Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Harrisburg, Market St (Bus Station): Wheelchair accessible with ramps.
Check bus stations information for St. Louis, MO and Harrisburg, PA, including where buses depart and arrive on this route.
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