- Must visit
Nasher Museum of Art
Major art museum at Duke with global collections, rotating exhibitions, and strong programs in modern and classical art.
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Journey information
Overview: Bus from St. Louis, MO to Durham, NC
USAUSA
Take a bus from St. Louis, MO to Durham, NC and enjoy the approximately 646 miles (1041 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
The earliest bus runs at 01:00, the last at 23:30.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 646 miles (1041 km) |
First bus 1:00 AM |
Last bus 11:30 PM |
Cheapest Month Apr |
Cheapest Day Wed |
High Season Apr - Jun |
Low Season Jan - Mar |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
St. Louis, MO to Durham, NC Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 06:45PM | Arrival Time 06:10PM | Duration 23h25 | Departure days Tue | Cheapest price $205 |
Operator Flixbus USA | Departure Time 11:30PM | Arrival Time 09:10PM | Duration 21h40 | Departure days Mon, Wed, Thu, Fri, Sun | Cheapest price $169 |
Live departures
St. Louis, MO to Durham, NC bus times
The table below shows live departures for St. Louis, MO to Durham, NC buses for today, Friday, October 16. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
 | 11:30 PM St. Louis, MO | 21h40 | 9:10 PM Durham, NC | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Bus providers: FlixBus from St. Louis, MO to Durham, NCYou can travel by bus between St. Louis, MO to Durham, NC with FlixBus. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average FlixBus Duration
21h 40m
Cheapest FlixBus Price
$169 (€141)
FlixBus frequency
1 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Complete guide to Durham, NC
Things to do in Durham, NC
Discover the best of Durham, NC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Durham, NC trip today.
- Must visit
Museum of Life and Science
Hands-on science museum with aerospace, physics, wildlife, and family exhibits in downtown Durham.
- Recommended
Duke Homestead State Historic Site
Historic site and museum exploring Washington Duke, tobacco farming, and Durham's industrial origins.
- Must visit
Sarah P. Duke Gardens
Beloved public garden with terraces, woodland paths, and seasonal blooms, ideal for a scenic walk near Duke.
- Must visit
Downtown Durham
Lively downtown district for walking among warehouses, public art, music venues, and restored tobacco-era spaces.
- Must visit
American Tobacco Trail
Scenic riverside greenway for walking and cycling, connecting downtown with quiet stretches of restored nature.
- Gluten-free
Eastern NC Pork Barbecue
Eastern North Carolina chopped pork barbecue with a tangy vinegar-pepper sauce. A defining regional staple widely loved across Durham and the Triangle.
Pulled Pork Plate
Slow-cooked pork shoulder or whole hog, often served on a plate with slaw and hush puppies. It reflects the area’s deep barbecue tradition.
- Vegetarian
Hush Puppies
Fried cornmeal batter balls served with barbecue or seafood. They are a classic Southern side found on many Durham menus.
M Pocha
Refined restaurant showcasing seasonal North Carolina ingredients with polished service. Known for elevated Southern cooking and a stylish setting.
Guglhupf Bakery & Cafe
Beloved local bakery and café serving excellent pastries, breads, and coffee. A dependable stop for breakfast, lunch, or a quick snack.
True Flavors Diner
Popular casual spot for inventive biscuit sandwiches, shrimp and grits, and Southern brunch favorites in a lively downtown atmosphere.
US Dollar ($)
Moderate for a US college city; hotels and dining are mid-priced, transit is limited, but many casual meals and coffee shops are affordable.
Average meal costs
- Budget
- $10-15 for fast food or casual lunch.
- Mid-range
- $20-40 per person for a mid-range meal.
- Fine dining
- $60+ per person for upscale dining.
- Coffee
- $3-6 for coffee or cappuccino.
Tipping culture
Tip 18-20% at restaurants, 15-20% for taxis, and $1-2 per drink or café order if service is provided.
FAQs: Bus from St. Louis, MO to Durham, NC
Find answers to the most common questions about traveling from St. Louis, MO to Durham, NC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Durham, NC, this guide helps you travel smarter and with confidence.
The earliest bus from St. Louis, MO to Durham, NC leaves at 1:00 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from St. Louis, MO to Durham, NC leaves at 11:30 PM.
When taking a bus from St. Louis, MO to Durham, NC, you can count on FlixBus for the best way to get you to Durham, NC. You can also check all possible bus companies who offer a service between St. Louis, MO and Durham, NC and compare the amenities they offer before buying a bus ticket.
It's helpful to compare your options as there are 3 ways to travel between St. Louis, MO and Durham, NC including taking a train, bus, and flight.
Yes, the following accessibility options are available when taking the bus from St. Louis, MO to Durham, NC:
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from St. Louis, MO to Durham, NC for bus company FlixBus.
Whether you can cancel your bus ticket from St. Louis, MO to Durham, NC depends on the bus companies:
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from St. Louis, MO to Durham, NC.
Yes, the following luggage options are included when booking a bus ticket from St. Louis, MO to Durham, NC:
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from St. Louis, MO to Durham, NC:
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from St. Louis, MO to Durham, NC. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from St. Louis, MO to Durham, NC with the following bus company: FlixBus
Yes, there are USB plugs on board the bus from St. Louis, MO to Durham, NC with the following bus company: FlixBus.
Yes, there is Wifi on board the bus from St. Louis, MO to Durham, NC with the following bus company: FlixBus.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Durham, NC, travelers should stay alert to common urban safety concerns such as petty theft, especially in crowded areas and public transit. Scams may include overcharging by unofficial taxi services or ride-share drivers, so using reputable transportation apps is advised. It's also important to avoid isolated areas after dark and keep personal belongings secure to reduce risk.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from St. Louis, MO to Durham, NC
Most St. Louis, MO to Durham, NC buses use the St. Louis, S 15th St (Civic center) to Durham, W Pettigrew St (Greyhound Bus Station) station pair. Use this guide to compare St. Louis, MO and Durham, NC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in St. Louis
Arrival bus stations in Durham
Which St. Louis, MO station do buses to Durham, NC leave from?
Buses from St. Louis, MO to Durham, NC leave from St. Louis, S 15th St (Civic center). The station is 0 miles (1 km) from St. Louis, MO city centre at S 15th St, St. Louis, MO, USA.
St. Louis, S 15th St (Civic center)S 15th St, St. Louis, MO, USA
City-centre transport
Getting to St. Louis, S 15th St (Civic center) from St. Louis city centre
TrainMlb, Mlr · 4m · $4 · every ~14 min
Bus19, 32, 40 · 8m · $2 · every ~9 min
St. Louis, S 15th St (Civic center) bus station facilities and services
St. Louis, S 15th St (Civic center) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at St. Louis, S 15th St (Civic center). ATMs are available at St. Louis, S 15th St (Civic center).
Tickets and information
Ticket office support is available at St. Louis, S 15th St (Civic center).
Parking, taxis and toilets
Available at St. Louis, S 15th St (Civic center): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at St. Louis, S 15th St (Civic center): Wheelchair accessible routes available.
Durham, W Pettigrew St (Greyhound Bus Station)Durham W Pettigrew St Bus Station,515 W Pettigrew St,27701
City-centre transport
Getting to Durham, W Pettigrew St (Greyhound Bus Station) from Durham city centre
Bus2, 9, 12, 12B · 5m · $2 · every ~12 min
Most popular bus connections from St. Louis, MO
More options for your journey from St. Louis, MO to Durham, NC
Here are some other resources that might have the information you need
Most popular buses to and from Durham, NC and St. Louis, MO
Most popular bus connections to Durham, NC
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