- Must visit
Nasher Museum of Art
Major art museum at Duke with global collections, rotating exhibitions, and strong programs in modern and classical art.
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The cheapest and fastest buses from St. Louis, MO to Durham, NC
Showing times, prices and bookable tickets for Sep 01
Cheapest price on Sep 01
$212
Average ticket price on Sep 01
$212
Fastest journey on Sep 01
23 h 25 m
Average journey duration on Sep 01
23 h 25 m
Buses on Sep 01
1
Distance
1041 km
Cheap tickets
The best way to find a cheap bus ticket from St. Louis, MO to Durham, NC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from St. Louis, MO to Durham, NC will cost around $212 if you buy it on the day, but the cheapest tickets can be found for only $212.
Fast buses
On Tue, Sep 01, we found 1 buses from St. Louis, MO to Durham, NC, including 1 direct services.
On Tue, Sep 01 the direct buses cover the 1041 km distance in an average of 23 h 25 m but if you time it right, some buses will get you there in just 23 h 25 m .
On Tue, Sep 01 the slowest buses will take 23 h 25 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
6:45 PM23h25St. Louis, MO6:10 PMDurham, NC$2121One-way0 transfers
- 6:45 PM23h25St. Louis, MO6:10 PMDurham, NC$2121One-way0 transfers
Travel Information
Compare train, bus, and flight for St. Louis, MO to Durham, NC
Omio recommends booking the flight as it is the most popular option from St. Louis, MO to Durham, NC among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $204 For those with little time, consider booking a flight, which has an average total journey time of 5h 37m. Average ticket prices depend on the travel mode: a bus costs an average of $204, while a train costs an average of $510.
Distance: 646 miles (1041 km)
Compare bus with
| Bus | Most popular Flight | Train | Driving |
|---|---|---|---|
$204 Average price Cheapest | $449 Average price | $510 Average price | $157 Average price (fuel + tolls) |
20h 4m Average total duration 19h 34m Onboard + 30m Additional time* | 5h 37m Average total duration Fastest 3h 37m Onboard + 2h 0m Additional time* | 30h 30m Average total duration 30h 0m Onboard + 30m Additional time* | 11h 47m Average total duration (door-to-door) |
 Most popular bus company |  Most popular airline |  Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from St. Louis, MO to Durham, NC is a bus with an average price of $204.
This is compared to other travel options from St. Louis, MO to Durham, NC:
A bus is $245 less than a flight for this route with tickets for a flight from St. Louis, MO to Durham, NC costing on average $449.
A bus is $305 less than a train for this route with tickets for a train from St. Louis, MO to Durham, NC costing on average $510.
The fastest way to travel from St. Louis, MO to Durham, NC is by flight with an average journey time of 3h 37m.
Other travel options to Durham, NC take longer:
Bus takes on average 19h 34m.
Train takes on average 30h 0m.
It's helpful to compare your options as there are 3 ways to travel between St. Louis, MO and Durham, NC including taking a train, bus, and flight.
We recommend using the bus as it is the most popular way to get from St. Louis, MO to Durham, NC among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
St. Louis, MO to Durham, NC Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 06:45PM | Arrival Time 06:10PM | Duration 23h25 | Departure days Tue | Cheapest price $212 |
Operator Flixbus USA | Departure Time 11:30PM | Arrival Time 09:10PM | Duration 21h40 | Departure days Mon, Wed, Thu, Fri, Sun | Cheapest price $174 |
Live departures
St. Louis, MO to Durham, NC bus times
The table below shows live departures for St. Louis, MO to Durham, NC buses for today, Monday, August 31. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 11:30 PM St. Louis, MO | 21h40 | 9:10 PM Durham, NC | 1 transfer | |
| Tuesday, September 1 | |||||
| 6:45 PM St. Louis, MO | 23h25 | 6:10 PM Durham, NC | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets St. Louis, MO to Durham, NC by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book St. Louis, MO to Durham, NC buses with Omio?
FlixBus operates all buses services from St. Louis, MO to Durham, NC.
Omio is an official ticket reseller for all your travel options from St. Louis, MO to Durham, NC.
Why book with Omio vs FlixBus?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from St. Louis, MO to Durham, NC.
Why book with Omio over Wanderu or Trainline?
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from St. Louis, MO to Durham, NC.
Journey information
Overview: Bus from St. Louis, MO to Durham, NC
USAUSA
Buses from St. Louis, MO to Durham, NC run on average 4 times per day, taking around 19h 34m. Cheap bus tickets for this journey start at $165 if you book in advance.
The earliest bus runs at 01:00, the last at 23:30. The fastest bus covers the 646 miles (1041 km) distance in 17h 40m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 646 miles (1041 km) |
Average bus duration 19h 34m |
Cheapest ticket price $165 |
Buses per day 4 |
Fastest bus 17h 40m |
First bus 1:00 AM |
Last bus 11:30 PM |
Cheapest Month Sep |
Cheapest Day Tue |
High Season Apr - Jun |
Low Season Jan - Mar |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound, FlixBus from St. Louis, MO to Durham, NCYou can travel by bus between St. Louis, MO to Durham, NC with Greyhound, FlixBus for as low as $165. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average FlixBus Duration
17h 40m
Cheapest FlixBus Price
$165
FlixBus frequency
2 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
20h 20m
Cheapest Greyhound Price
$178
Greyhound frequency
2 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Durham, NC
Things to do in Durham, NC
Discover the best of Durham, NC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Durham, NC trip today.
- Must visit
Museum of Life and Science
Hands-on science museum with aerospace, physics, wildlife, and family exhibits in downtown Durham.
- Recommended
Duke Homestead State Historic Site
Historic site and museum exploring Washington Duke, tobacco farming, and Durham's industrial origins.
- Must visit
Sarah P. Duke Gardens
Beloved public garden with terraces, woodland paths, and seasonal blooms, ideal for a scenic walk near Duke.
- Must visit
Downtown Durham
Lively downtown district for walking among warehouses, public art, music venues, and restored tobacco-era spaces.
- Must visit
American Tobacco Trail
Scenic riverside greenway for walking and cycling, connecting downtown with quiet stretches of restored nature.
- Gluten-free
Eastern NC Pork Barbecue
Eastern North Carolina chopped pork barbecue with a tangy vinegar-pepper sauce. A defining regional staple widely loved across Durham and the Triangle.
Pulled Pork Plate
Slow-cooked pork shoulder or whole hog, often served on a plate with slaw and hush puppies. It reflects the area’s deep barbecue tradition.
- Vegetarian
Hush Puppies
Fried cornmeal batter balls served with barbecue or seafood. They are a classic Southern side found on many Durham menus.
M Pocha
Refined restaurant showcasing seasonal North Carolina ingredients with polished service. Known for elevated Southern cooking and a stylish setting.
Guglhupf Bakery & Cafe
Beloved local bakery and café serving excellent pastries, breads, and coffee. A dependable stop for breakfast, lunch, or a quick snack.
True Flavors Diner
Popular casual spot for inventive biscuit sandwiches, shrimp and grits, and Southern brunch favorites in a lively downtown atmosphere.
US Dollar ($)
Moderate for a US college city; hotels and dining are mid-priced, transit is limited, but many casual meals and coffee shops are affordable.
Average meal costs
- Budget
- $10-15 for fast food or casual lunch.
- Mid-range
- $20-40 per person for a mid-range meal.
- Fine dining
- $60+ per person for upscale dining.
- Coffee
- $3-6 for coffee or cappuccino.
Tipping culture
Tip 18-20% at restaurants, 15-20% for taxis, and $1-2 per drink or café order if service is provided.
FAQs: Bus from St. Louis, MO to Durham, NC
Find answers to the most common questions about traveling from St. Louis, MO to Durham, NC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Durham, NC, this guide helps you travel smarter and with confidence.
Cheap bus tickets from St. Louis, MO to Durham, NC can start from as little as $165 when you book in advance. The average bus ticket price for St. Louis, MO to Durham, NC is $204 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from St. Louis, MO to Durham, NC is 17h 40m to travel the 646 miles (1041 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from St. Louis, MO to Durham, NC leaves at 1:00 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from St. Louis, MO to Durham, NC leaves at 11:30 PM.
There are 4 buses a day from St. Louis, MO to Durham, NC which require at least one change with FlixBus. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from St. Louis, MO to Durham, NC, you can count on FlixBus for the best way to get you to Durham, NC. You can also check all possible bus companies who offer a service between St. Louis, MO and Durham, NC and compare the amenities they offer before buying a bus ticket.
Passengers board the bus most frequently from St. Louis, S 15th St (Civic center), which is located around away from the city centre, and they get off the bus at Durham Station, located 0 away from the city centre.
A trip to Durham, NC from St. Louis, MO is worth doing but not as a day trip with a journey time of 17h 40m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from St. Louis, MO to Durham, NC is September.
It's helpful to compare your options as there are 3 ways to travel between St. Louis, MO and Durham, NC including taking a train, bus, and flight.
Yes, the following accessibility options are available when taking the bus from St. Louis, MO to Durham, NC:
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from St. Louis, MO to Durham, NC for bus company FlixBus.
Whether you can cancel your bus ticket from St. Louis, MO to Durham, NC depends on the bus companies:
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from St. Louis, MO to Durham, NC.
Yes, the following luggage options are included when booking a bus ticket from St. Louis, MO to Durham, NC:
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from St. Louis, MO to Durham, NC:
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from St. Louis, MO to Durham, NC. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from St. Louis, MO to Durham, NC with the following bus company: FlixBus
Yes, there are USB plugs on board the bus from St. Louis, MO to Durham, NC with the following bus company: FlixBus.
Yes, there is Wifi on board the bus from St. Louis, MO to Durham, NC with the following bus company: FlixBus.
Since neither St. Louis, MO nor Durham, NC are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the bus as it is the most popular way to get from St. Louis, MO to Durham, NC among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Durham, NC, travelers should stay alert to common urban safety concerns such as petty theft, especially in crowded areas and public transit. Scams may include overcharging by unofficial taxi services or ride-share drivers, so using reputable transportation apps is advised. It's also important to avoid isolated areas after dark and keep personal belongings secure to reduce risk.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from St. Louis, MO to Durham, NC
Most St. Louis, MO to Durham, NC buses use the St. Louis, S 15th St (Civic center) to Durham, W Pettigrew St (Greyhound Bus Station) station pair. Use this guide to compare St. Louis, MO and Durham, NC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in St. Louis
Arrival bus stations in Durham
Which St. Louis, MO station do buses to Durham, NC leave from?
Buses from St. Louis, MO to Durham, NC leave from St. Louis, S 15th St (Civic center). The station is 0 miles (1 km) from St. Louis, MO city centre at S 15th St, St. Louis, MO, USA.
St. Louis, S 15th St (Civic center)S 15th St, St. Louis, MO, USA
City-centre transport
Getting to St. Louis, S 15th St (Civic center) from St. Louis city centre
TrainMlb, Mlr · 4m · $4 · every ~14 min
Bus19, 32, 40 · 8m · $1 · every ~9 min
St. Louis, S 15th St (Civic center) bus station facilities and services
St. Louis, S 15th St (Civic center) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at St. Louis, S 15th St (Civic center). ATMs are available at St. Louis, S 15th St (Civic center).
Tickets and information
Ticket office support is available at St. Louis, S 15th St (Civic center).
Parking, taxis and toilets
Available at St. Louis, S 15th St (Civic center): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at St. Louis, S 15th St (Civic center): Wheelchair accessible routes available.
Durham, W Pettigrew St (Greyhound Bus Station)Durham W Pettigrew St Bus Station,515 W Pettigrew St,27701
City-centre transport
Getting to Durham, W Pettigrew St (Greyhound Bus Station) from Durham city centre
Bus2, 9, 12, 12B · 5m · $1 · every ~12 min
Most popular bus connections from St. Louis, MO
More options for your journey from St. Louis, MO to Durham, NC
Here are some other resources that might have the information you need
Most popular buses to and from Durham, NC and St. Louis, MO
Most popular bus connections to Durham, NC
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