St. Louis, MO to Durham, NC bus with FlixBus

Fri, May 29
+ Add return
FlixBus
Alsa
BlaBlaCar Bus
Rede Expressos
Costa Verde
2,000+ travel companies
FlixBus
Alsa
BlaBlaCar Bus
Rede Expressos
Costa Verde
2,000+ travel companies
QR-Code
Scan to get our free app
Use our app to get live travel updates and book mobile tickets for trains, buses, flights, and ferries.
App Store
rate4.9
42K ratings
Google Play
rate4.6
136K reviews

The cheapest and fastest buses from St. Louis, MO to Durham, NC

Showing times and prices for May 29

Cheapest price

$175

Average price

$175

Fastest journey

21 h 40 m

Average duration

21 h 40 m

Buses per day

1

Distance

1041 km

Cheap tickets

The best way to find a cheap bus ticket from St. Louis, MO to Durham, NC is to book your journey as far in advance as possible and to avoid traveling at rush hour.

The average ticket from St. Louis, MO to Durham, NC will cost around $175 if you buy it on the day, but the cheapest tickets can be found for only $175.

Fast buses

It's difficult to get from St. Louis, MO to Durham, NC without transferring at least once.

  • Flixbus USA
    11:30 PM21h40
    St. Louis, MO
    9:10 PMDurham, NC
    $1751One-way
    1 transfer

Travel Information

Compare train and bus for St. Louis, MO to Durham, NC

Omio recommends booking the bus as it is the most popular option from St. Louis, MO to Durham, NC among Omio's users. If you are prioritising price take the bus with prices starting from $213. For those with little time consider booking a bus which can get you there in 23h 25m. The ticket price range depends on the travel mode: a bus costs an average of $213, and a train costs an average of $537.

Distance: 646 miles (1041 km)

Compare bus with

Most popular
Bus
Train
Driving

$213

Average price

Cheapest

$537

Average price

$155

Average price

(fuel + tolls)

23h 55m

Average total duration

Fastest

23h 25m

Onboard

+

30m

Additional time*

47h 20m

Average total duration

46h 50m

Onboard

+

30m

Additional time*

11h 47m

Average total duration

(door-to-door)

Direct Options

Direct Options

Direct Options

The cheapest way to travel from St. Louis, MO to Durham, NC is a bus with an average price of $213 (€171).

This is compared to other travel options from St. Louis, MO to Durham, NC:

A bus is $324 (€262) less than a train for this route with tickets for a train from St. Louis, MO to Durham, NC costing on average $537 (€433).

The fastest way to travel from St. Louis, MO to Durham, NC is by bus with an average journey time of 23h 25m.

Other travel options to Durham, NC take longer:

Train takes on average 46h 50m.

It's helpful to compare your options as there are 2 ways to travel between St. Louis, MO and Durham, NC including taking a train and bus.
We recommend using the train as it is the most popular way to get from St. Louis, MO to Durham, NC among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.

You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.

Direct coaches are operated by {directProviders}.

Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.

St. Louis, MO to Durham, NC Bus Timetables

OperatorDeparture TimeArrival TimeDurationDeparture daysCheapest price
Operator
Greyhound
Departure Time
06:45PM
Arrival Time
06:10PM
Duration
23h25
Departure days
Tue
Cheapest price
$213
Operator
Flixbus USA
Departure Time
11:30PM
Arrival Time
09:10PM
Duration
21h40
Departure days
Mon, Wed, Thu, Fri, Sun
Cheapest price
$175

Live departures

St. Louis, MO to Durham, NC bus times

The table below shows live departures for St. Louis, MO to Durham, NC buses for today, Thursday, May 28. You can also manually refresh the results below to see updated bus journeys.

Last updated at
ProviderDepartsDurationArrivesTransfers
Tickets
Flixbus USA11:30 PM St. Louis, MO
21h40
9:10 PM Durham, NC1 transfer

This is the last bus of the day.

Find all the dates and times for this journey

Compare prices and tickets St. Louis, MO to Durham, NC by train or bus

Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

Fri
May 29
Sat
May 30
Sun
May 31
Mon
Jun 01
Tue
Jun 02
Wed
Jun 03
Thu
Jun 04

Why should you book St. Louis, MO to Durham, NC buses with Omio?

FlixBus operates all buses services from St. Louis, MO to Durham, NC.
Omio is an official ticket reseller for all your travel options from St. Louis, MO to Durham, NC.

Why book with Omio vs FlixBus?

  • Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
  • Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are train and bus to ensure you get the best deal for traveling from St. Louis, MO to Durham, NC.

Why book with Omio over Wanderu or Trainline?

  • Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from St. Louis, MO to Durham, NC.

Journey information

Overview: Bus from St. Louis, MO to Durham, NC

USAUSA
USAUSA
Icon of bus

Buses from St. Louis, MO to Durham, NC run on average 4 times per day, taking around 23h 25m. Cheap bus tickets for this journey start at $213 (€171) if you book in advance.

The earliest bus runs at 01:00, the last at 23:30. The fastest bus covers the 646 miles (1041 km) distance in 23h 25m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance
646 miles (1041 km)
Average bus duration
23h 25m
Cheapest ticket price
$213 (€171)
Buses per day
4
Fastest bus
23h 25m
First bus
1:00 AM
Last bus
11:30 PM
Cheapest Month
Sep
Cheapest Day
Tue
High Season
Jul - Sep
Low Season
Jan - Mar
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information

Bus providers: FlixBus from St. Louis, MO to Durham, NCYou can travel by bus between St. Louis, MO to Durham, NC with FlixBus for as low as $213 (€171). When you search for schedules and tickets, Omio will show you the best journey

FlixBus

About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average Duration
21h 40m
Cheapest Price
$175 (€141)
FlixBus frequency
2 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Learn more about FlixBus

FAQs: Bus from St. Louis, MO to Durham, NC

Find answers to the most common questions about traveling from St. Louis, MO to Durham, NC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Durham, NC, this guide helps you travel smarter and with confidence.

FAQs
Cheap bus tickets from St. Louis, MO to Durham, NC can start from as little as $213 (€171) when you book in advance. The average bus ticket price for St. Louis, MO to Durham, NC is $213 (€171) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from St. Louis, MO to Durham, NC is 23h 25m to travel the 646 miles (1041 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from St. Louis, MO to Durham, NC leaves at 1:00 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from St. Louis, MO to Durham, NC leaves at 11:30 PM.
There are 4 buses a day from St. Louis, MO to Durham, NC which require at least one change with FlixBus. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from St. Louis, MO to Durham, NC, you can count on FlixBus for the best way to get you to Durham, NC. You can also check all possible bus companies who offer a service between St. Louis, MO and Durham, NC and compare the amenities they offer before buying a bus ticket.
A trip to Durham, NC from St. Louis, MO is worth doing but not as a day trip with a journey time of 23h 25m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from St. Louis, MO to Durham, NC is September.
It's helpful to compare your options as there are 2 ways to travel between St. Louis, MO and Durham, NC including taking a train and bus.
Yes, the following accessibility options are available when taking the bus from St. Louis, MO to Durham, NC:
  • FlixBus
    • Assistance
    • Priority boarding
    • Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from St. Louis, MO to Durham, NC for bus company FlixBus.
Whether you can cancel your bus ticket from St. Louis, MO to Durham, NC depends on the bus companies:
  • FlixBus
    • You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from St. Louis, MO to Durham, NC.
Yes, the following luggage options are included when booking a bus ticket from St. Louis, MO to Durham, NC:
  • FlixBus
    • One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from St. Louis, MO to Durham, NC:
  • FlixBus
    • Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from St. Louis, MO to Durham, NC. The following conditions apply:
  • FlixBus
    • Small pets in carriers allowed
    • guide dogs travel for free.
You can reserve your seat on the bus from St. Louis, MO to Durham, NC with the following bus company: FlixBus
Yes, there are USB plugs on board the bus from St. Louis, MO to Durham, NC with the following bus company: FlixBus.
Yes, there is Wifi on board the bus from St. Louis, MO to Durham, NC with the following bus company: FlixBus.
Since neither St. Louis, MO nor Durham, NC are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the train as it is the most popular way to get from St. Louis, MO to Durham, NC among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Durham, NC, travelers should stay alert to common urban safety concerns such as petty theft, especially in crowded areas and public transit. Scams may include overcharging by unofficial taxi services or ride-share drivers, so using reputable transportation apps is advised. It's also important to avoid isolated areas after dark and keep personal belongings secure to reduce risk.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.

popular bus stations

Popular bus stations from St. Louis, MO to Durham, NC

St. Louis
Durham
The major bus station for departures in St. Louis is St. Louis, S 15th St (Civic center). Find all the information you need to know about services, amenities and connections at St. Louis, S 15th St (Civic center) for your trip from St. Louis to Durham.
St. Louis, S 15th St (Civic center)
information

More options for your journey from St. Louis, MO to Durham, NC

Here are some other resources that might have the information you need

Tickets and more information for coaches to St. Louis, MO
Tickets and more information for coaches to Durham, NC

Most popular buses to and from Durham, NC and St. Louis, MO

Bus St. Louis, MO - Boston, MA
Bus St. Louis, MO - New York, NY
Bus St. Louis, MO - Los Angeles, CA
Bus St. Louis, MO - Chicago, IL
Bus St. Louis, MO - Washington, DC
Bus St. Louis, MO - San Diego, CA
Bus St. Louis, MO - Philadelphia, PA
Bus St. Louis, MO - Dallas, TX
Bus St. Louis, MO - Orlando, FL
Bus St. Louis, MO - Atlanta, GA
Bus St. Louis, MO - Seattle, WA
Bus St. Louis, MO - San Francisco, CA
Bus St. Louis, MO - Miami, FL
Bus St. Louis, MO - Phoenix, AZ
Bus St. Louis, MO - Las Vegas, NV
Bus St. Louis, MO - Houston, TX
Bus St. Louis, MO - Tampa, FL
Bus St. Louis, MO - Sacramento, CA
Bus St. Louis, MO - Portland, OR
Bus St. Louis, MO - Baltimore, MD
Bus St. Louis, MO - San Antonio, TX
Bus St. Louis, MO - Newark, NJ
Bus Boston, MA - Durham, NC
Bus New York, NY - Durham, NC
Bus Washington, DC - Durham, NC
Bus Philadelphia, PA - Durham, NC
Bus Dallas, TX - Durham, NC
Bus Orlando, FL - Durham, NC
Bus Atlanta, GA - Durham, NC
Bus Seattle, WA - Durham, NC
Bus Tampa, FL - Durham, NC
Bus Baltimore, MD - Durham, NC
Bus Newark, NJ - Durham, NC
Bus Austin, TX - Durham, NC
Bus Charlotte, NC - Durham, NC
Bus Nashville, TN - Durham, NC
Bus Raleigh, NC - Durham, NC
Bus Cleveland, OH - Durham, NC
Bus Richmond, VA - Durham, NC
Bus Columbus, OH - Durham, NC
Bus Toronto, ON - Durham, NC
Bus Norfolk, VA - Durham, NC
Bus Albany, NY - Durham, NC
Bus Birmingham, AL - Durham, NC
HomeBusesBuses in USABus tickets to Durham, NCSt. Louis, MO to Durham, NC bus

The Omio App Makes Travel Planning Easy

We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.

ios-badge
android-badge
Hand With Phone