The cheapest and fastest buses from Syracuse, NY to Chicago, IL
Cheapest price
$385
Average price
$385
Fastest journey
15 h 35 m
Average duration
15 h 35 m
Buses per day
1
Distance
952 km
The best way to find a cheap bus ticket from Syracuse, NY to Chicago, IL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Syracuse, NY to Chicago, IL will cost around $385 if you buy it on the day, but the cheapest tickets can be found for only $385.
It's difficult to get from Syracuse, NY to Chicago, IL without transferring at least 2 times.


Travel Information
Compare bus, train, and flight for Syracuse, NY to Chicago, IL
Omio recommends booking the train as it is the most popular option from Syracuse, NY to Chicago, IL among Omio's users. If you are prioritising price take the bus with prices starting from €77. For those with little time consider booking a train which can get you there in 13h 7m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.3 - 0.9kg. The ticket price range depends on the travel mode: a bus costs an average of €77, and a train costs an average of €183.
Distance: 591 miles (952 km)
Compare bus with
| Bus | Most popular Train |
|---|---|
€94 Average price Cheapest | €183 Average price |
16h 0m Average total duration 15h 30m Onboard + 30m Additional time* | 13h 37m Average total duration Fastest 13h 7m Onboard + 30m Additional time* |
1.0 - 2.4kg CO2 emissions | 0.3 - 0.9kg CO2 emissions Lowest |
![]() Most popular bus company | ![]() Most popular train company |
Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Live departures
Syracuse, NY to Chicago, IL bus times
The table below shows live departures for Syracuse, NY to Chicago, IL buses for tomorrow, Thursday, December 4. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 4:30 AM Syracuse, NY | 15h35 | 8:05 PM Chicago, IL | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Syracuse, NY to Chicago, IL by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Bus from Syracuse, NY to Chicago, IL
Buses from Syracuse, NY to Chicago, IL run on average 3 times per day, taking around 15h 30m. Cheap bus tickets for this journey start at $96 (€77) if you book in advance.
The earliest bus runs at 01:30, the last at 23:15. The fastest bus covers the 591 miles (952 km) distance in 16h 35m.
Distance 591 miles (952 km) |
Average bus duration 15h 30m |
Cheapest ticket price $96 (€77) |
Buses per day 3 |
Fastest bus 16h 35m |
First bus 01:30 |
Last bus 23:15 |
Bus providers: Greyhound from Syracuse, NY to Chicago, ILYou can travel by bus between Syracuse, NY to Chicago, IL with Greyhound for as low as $96 (€77). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from Syracuse, NY to Chicago, IL
Find answers to the most common questions about traveling from Syracuse, NY to Chicago, IL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Millennium Park, a public park known for its modern art installations and the iconic Cloud Gate sculpture
- Art Institute of Chicago, a renowned museum housing an extensive collection of art from around the world
- Navy Pier, a popular entertainment destination featuring rides, restaurants, and lakefront views
- Willis Tower Skydeck, an observation deck offering panoramic views of the city from one of the tallest buildings in the Western Hemisphere
- Field Museum, a natural history museum with vast exhibits including the famous T. Rex skeleton, Sue.
- Museum of Science and Industry, an interactive museum featuring exhibits on science, technology, and industry
- Explore the vibrant neighborhoods of Chicago, such as Wicker Park and Lincoln Park, known for their unique shops and eateries
- Take a river cruise to see the city's iconic architecture from a different perspective
- Attend a live performance at the historic Chicago Theatre
- Enjoy a day at Lincoln Park Zoo, one of the oldest zoos in the U. S. Offering free admission.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
To find the cheapest bus tickets for your trip from Syracuse, NY to Chicago, IL, follow these tips:
Start your search now and compare ticket prices to find the best deal!
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from Syracuse, NY to Chicago, IL
Most popular bus connections from Syracuse, NY
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