St. Louis, MO to Winston Salem, NC bus with Greyhound

Fri, Dec 19
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Greyhound
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1,000+ travel companies
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FlixBus
Alsa
BlaBlaCar Bus
Rede Expressos
1,000+ travel companies
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Travel Information

Compare bus and flight for St. Louis, MO to Winston Salem, NC

Omio recommends booking the flight as it is the most popular option from St. Louis, MO to Winston Salem, NC among Omio's users. If you are prioritising price take the bus with prices starting from €69. For those with little time consider booking a flight which can get you there in 1h 59m. The ticket price range depends on the travel mode: a bus costs an average of €69, and a flight costs an average of €157.

Distance: 573 miles (923 km)

Compare bus with

Bus
Most popular
Flight

€69

Average price

Cheapest

€157

Average price

28h 35m

Average total duration

28h 5m

Onboard

+

30m

Additional time*

4h 59m

Average total duration

Fastest

1h 59m

Onboard

+

3h 0m

Additional time*

Direct Options

Direct Options

Compare prices and tickets St. Louis, MO to Winston Salem, NC by bus or flight

Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

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Journey information

Overview: Bus from St. Louis, MO to Winston Salem, NC

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Icon of bus

Buses from St. Louis, MO to Winston Salem, NC run on average 3 times per day, taking around 28h 5m. Cheap bus tickets for this journey start at $86 (€69) if you book in advance.

The earliest bus runs at 08:30, the last at 23:30. The fastest bus covers the 573 miles (923 km) distance in 28h 5m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance
573 miles (923 km)
Average bus duration
28h 5m
Cheapest ticket price
$86 (€69)
Buses per day
3
Fastest bus
28h 5m
First bus
08:30
Last bus
23:30
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information

Bus providers: Greyhound from St. Louis, MO to Winston Salem, NCYou can travel by bus between St. Louis, MO to Winston Salem, NC with Greyhound for as low as $86 (€69). When you search for schedules and tickets, Omio will show you the best journey

Greyhound

About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
28h 5m
Cheapest Price
$86 (€69)
Greyhound frequency
2 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Learn more about Greyhound

FAQs: Bus from St. Louis, MO to Winston Salem, NC

Find answers to the most common questions about traveling from St. Louis, MO to Winston Salem, NC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Winston Salem, NC, this guide helps you travel smarter and with confidence.

FAQs
Cheap bus tickets from St. Louis, MO to Winston Salem, NC can start from as little as $155 (€124) when you book in advance. The average bus ticket price for St. Louis, MO to Winston Salem, NC is $191 (€153); however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
On average the St. Louis, MO to Winston Salem, NC bus travel time is 19 h 15 min   for the 572 mile (922 km) long route, but the duration can vary if you travel on weekends and holidays.
The first bus from St. Louis, MO to Winston Salem, NC leaves at 10: 20AM. Plan your trip with the Journey Planner   from Omio.
The last bus from St. Louis, MO to Winston Salem, NC leaves at 9: 25PM.
There are 2 buses a day from St. Louis, MO to Winston Salem, NC which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from St. Louis, MO to Winston Salem, NC, you can count on Greyhound for the best way to get you to Winston Salem, NC. You can also check all possible bus companies who offer a service to Winston Salem, NC from St. Louis, MO and compare the amenities they offer before buying a bus ticket.
The cheapest month for a bus from St. Louis, MO to Winston Salem, NC is January.
You have options as you can travel from St. Louis, MO to Winston Salem, NC 3 different ways: bus, train or flight.
Yes, the following accessibility options are available when taking the bus from St. Louis, MO to Winston Salem, NC:
  • Greyhound
    • Assistance
    • Priority seating
    • Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from St. Louis, MO to Winston Salem, NC for bus company Greyhound.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Whether you can cancel your bus ticket from St. Louis, MO to Winston Salem, NC depends on the bus company:
  • Greyhound
    • You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.

To find the cheapest bus tickets for your trip from St. Louis, MO to Winston Salem, NC, follow these tips:

  • Book in advance: Tickets are often cheaper when booked early.
  • Be flexible with dates and times: Traveling during off-peak hours or on weekdays can help you save money.
  • Use our search filters: Sort results by price to quickly identify the most affordable options.
  • Look for special deals or discounts: Check for promotions or discounts available on our website and app.

    • Start your search now and compare ticket prices to find the best deal!

    Yes, there is food available to purchase on board the bus from St. Louis, MO to Winston Salem, NC.
    Yes, the following luggage options are included when booking a bus ticket from St. Louis, MO to Winston Salem, NC:
    • Greyhound
      • One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
    Yes, the following additional luggage options are available when booking a bus ticket from St. Louis, MO to Winston Salem, NC:
    • Greyhound
      • $15 per additional bag.
    Unfortunately, pets are not allowed on the bus from St. Louis, MO to Winston Salem, NC.
    You can reserve your seat on the bus from St. Louis, MO to Winston Salem, NC with the following bus company: Greyhound
    Yes, there are USB plugs on board the bus from St. Louis, MO to Winston Salem, NC with the following bus company: Greyhound.
    Yes, there is Wifi on board the bus from St. Louis, MO to Winston Salem, NC with the following bus company: Greyhound.

    popular bus stations

    Popular bus stations from St. Louis, MO to Winston Salem, NC

    St. Louis
    Winston Salem
    The major bus station for departures in St. Louis is St. Louis, S 15th St (Civic center). Find all the information you need to know about services, amenities and connections at St. Louis, S 15th St (Civic center) for your trip from St. Louis to Winston Salem.
    St. Louis, S 15th St (Civic center)
    information

    More options for your journey from St. Louis, MO to Winston Salem, NC

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    Return journeys for buses from Winston Salem, NC to St. Louis, MO
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    Tickets and more information for coaches to Winston Salem, NC

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