St. Louis, MO to Winston Salem, NC bus with Greyhound

Fri, Mar 20
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2,000+ travel companies
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The cheapest and fastest buses from St. Louis, MO to Winston Salem, NC

Showing times and prices for Mar 22

Cheapest price

$192

Average price

$201

Fastest journey

1 d 1 h 30 m

Average duration

1 d 4 h 30 m

Buses per day

2

Distance

923 km

Cheap tickets

The best way to find a cheap bus ticket from St. Louis, MO to Winston Salem, NC is to book your journey as far in advance as possible and to avoid traveling at rush hour.

The average ticket from St. Louis, MO to Winston Salem, NC will cost around $201 if you buy it on the day, but the cheapest tickets can be found for only $192.

Fast buses

It's difficult to get from St. Louis, MO to Winston Salem, NC without transferring at least once.

Flixbus USA
11:30PM31h30
St. Louis, MO
07:00AMWinston Salem, NC
$1921One-way
1 transfer
Greyhound USA
08:45AM25h30
St. Louis, MO
10:15AMWinston Salem, NC
$2111One-way
3 transfers

Travel Information

Compare bus and flight for St. Louis, MO to Winston Salem, NC

Omio recommends booking the bus as it is the most popular option from St. Louis, MO to Winston Salem, NC among Omio's users. If you are prioritising price take the bus with prices starting from $218. For those with little time consider booking a flight which can get you there in 5h 43m. The ticket price range depends on the travel mode: a bus costs an average of $218, and a flight costs an average of $308.

Distance: 573 miles (923 km)

Compare bus with

Most popular
Bus
Flight

$228

Average price

Cheapest

$308

Average price

25h 18m

Average total duration

24h 48m

Onboard

+

30m

Additional time*

8h 43m

Average total duration

Fastest

5h 43m

Onboard

+

3h 0m

Additional time*

Direct Options

Direct Options

Compare prices and tickets St. Louis, MO to Winston Salem, NC by bus or flight

Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

Sun
Mar 22
Mon
Mar 23
Tue
Mar 24
Wed
Mar 25
Thu
Mar 26
Fri
Mar 27
Sat
Mar 28

Why should you book St. Louis, MO to Winston Salem, NC buses with Omio?

Greyhound operates all buses services from St. Louis, MO to Winston Salem, NC.
Omio is an official ticket reseller for all your travel options from St. Louis, MO to Winston Salem, NC.

Why book with Omio vs Greyhound?

  • Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
  • Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus and flight to ensure you get the best deal for traveling from St. Louis, MO to Winston Salem, NC.

Why book with Omio over Wanderu?

  • Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from St. Louis, MO to Winston Salem, NC.

Journey information

Overview: Bus from St. Louis, MO to Winston Salem, NC

USAUSA
USAUSA
Icon of bus

Buses from St. Louis, MO to Winston Salem, NC run on average 3 times per day, taking around 24h 48m. Cheap bus tickets for this journey start at $218 (€177) if you book in advance.

The earliest bus runs at 08:30, the last at 23:30. The fastest bus covers the 573 miles (923 km) distance in 19h 20m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance
573 miles (923 km)
Average bus duration
24h 48m
Cheapest ticket price
$218 (€177)
Buses per day
3
Fastest bus
19h 20m
First bus
08:30
Last bus
23:30
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information

Bus providers: Greyhound from St. Louis, MO to Winston Salem, NCYou can travel by bus between St. Louis, MO to Winston Salem, NC with Greyhound for as low as $218 (€177). When you search for schedules and tickets, Omio will show you the best journey

Greyhound

About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
19h 20m
Cheapest Price
$218 (€177)
Greyhound frequency
2 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Learn more about Greyhound

FAQs: Bus from St. Louis, MO to Winston Salem, NC

Find answers to the most common questions about traveling from St. Louis, MO to Winston Salem, NC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Winston Salem, NC, this guide helps you travel smarter and with confidence.

FAQs
Cheap bus tickets from St. Louis, MO to Winston Salem, NC can start from as little as $218 (€177) when you book in advance. The average bus ticket price for St. Louis, MO to Winston Salem, NC is $228 (€185) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from St. Louis, MO to Winston Salem, NC is 19h 20m to travel the 573 miles (923 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from St. Louis, MO to Winston Salem, NC leaves at 8:30 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from St. Louis, MO to Winston Salem, NC leaves at 11:30 PM.
There are 3 buses a day from St. Louis, MO to Winston Salem, NC which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from St. Louis, MO to Winston Salem, NC, you can count on Greyhound for the best way to get you to Winston Salem, NC. You can also check all possible bus companies who offer a service between St. Louis, MO and Winston Salem, NC and compare the amenities they offer before buying a bus ticket.
A trip to Winston Salem, NC from St. Louis, MO is worth doing but not as a day trip with a journey time of 19h 20m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from St. Louis, MO to Winston Salem, NC is July.
It's helpful to compare your options as there are 2 ways to travel between St. Louis, MO and Winston Salem, NC including taking a bus and flight.
Yes, the following accessibility options are available when taking the bus from St. Louis, MO to Winston Salem, NC:
  • Greyhound
    • Assistance
    • Priority seating
    • Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from St. Louis, MO to Winston Salem, NC for bus company Greyhound.
Whether you can cancel your bus ticket from St. Louis, MO to Winston Salem, NC depends on the bus companies:
  • Greyhound
    • You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from St. Louis, MO to Winston Salem, NC.
Yes, the following luggage options are included when booking a bus ticket from St. Louis, MO to Winston Salem, NC:
  • Greyhound
    • One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from St. Louis, MO to Winston Salem, NC:
  • Greyhound
    • $15 per additional bag.
Unfortunately, pets are not allowed on the bus from St. Louis, MO to Winston Salem, NC.
You can reserve your seat on the bus from St. Louis, MO to Winston Salem, NC with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from St. Louis, MO to Winston Salem, NC with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from St. Louis, MO to Winston Salem, NC with the following bus company: Greyhound.

popular bus stations

Popular bus stations from St. Louis, MO to Winston Salem, NC

St. Louis
Winston Salem
The major bus station for departures in St. Louis is St. Louis, S 15th St (Civic center). Find all the information you need to know about services, amenities and connections at St. Louis, S 15th St (Civic center) for your trip from St. Louis to Winston Salem.
St. Louis, S 15th St (Civic center)
information

More options for your journey from St. Louis, MO to Winston Salem, NC

Here are some other resources that might have the information you need

Return journeys for buses from Winston Salem, NC to St. Louis, MO
Tickets and more information for coaches to St. Louis, MO
Tickets and more information for coaches to Winston Salem, NC

Most popular buses to and from Winston Salem, NC and St. Louis, MO

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Bus St. Louis, MO - Sacramento, CA
Bus St. Louis, MO - Tampa, FL
Bus St. Louis, MO - Portland, OR
Bus St. Louis, MO - Baltimore, MD
Bus St. Louis, MO - San Antonio, TX
Bus St. Louis, MO - Newark, NJ
Bus Boston, MA - Winston Salem, NC
Bus New York, NY - Winston Salem, NC
Bus Chicago, IL - Winston Salem, NC
Bus Washington, DC - Winston Salem, NC
Bus Atlanta, GA - Winston Salem, NC
Bus Miami, FL - Winston Salem, NC
Bus Baltimore, MD - Winston Salem, NC
Bus Newark, NJ - Winston Salem, NC
Bus Charlotte, NC - Winston Salem, NC
Bus Nashville, TN - Winston Salem, NC
Bus Raleigh, NC - Winston Salem, NC
Bus Jacksonville, FL - Winston Salem, NC
Bus Oklahoma City, OK - Winston Salem, NC
Bus Detroit, MI - Winston Salem, NC
Bus Greensboro, NC - Winston Salem, NC
Bus Springfield, MA - Winston Salem, NC
Bus Newport News, VA - Winston Salem, NC
Bus Greenville, SC - Winston Salem, NC
Bus Huntsville, AL - Winston Salem, NC
Bus Durham, NC - Winston Salem, NC
Bus Jacksonville, NC - Winston Salem, NC
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