- Must visit
Saint Louis Art Museum
Major art museum in Forest Park with strong collections spanning ancient to contemporary works. A top cultural stop in the city.
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The cheapest and fastest buses from Harrisburg, PA to St. Louis, MO
Showing times and prices for Jun 06
Cheapest price
$223
Average price
$223
Fastest journey
17 h 5 m
Average duration
18 h 20 m
Buses per day
2
Distance
1157 km
Cheap tickets
The best way to find a cheap bus ticket from Harrisburg, PA to St. Louis, MO is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Harrisburg, PA to St. Louis, MO will cost around $223 if you buy it on the day, but the cheapest tickets can be found for only $223.
Fast buses
Of the 2 buses that leave Harrisburg, PA for St. Louis, MO on Sat, Jun 06, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sat, Jun 06 the direct buses cover the 1157 km distance in an average of 18 h 20 m but if you time it right, some buses will get you there in just 17 h 5 m .
On Sat, Jun 06 the slowest buses will take 19 h 35 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
2:50 PM17h05Harrisburg, PA7:55 AMSt. Louis, MO$2231One-way0 transfers- 7:45 PM19h35Harrisburg, PA3:20 PMSt. Louis, MO$2231One-way0 transfers
- 2:50 PM17h05Harrisburg, PA7:55 AMSt. Louis, MO$2231One-way0 transfers
- 7:45 PM19h35Harrisburg, PA3:20 PMSt. Louis, MO$2231One-way0 transfers
Travel Information
Compare train, bus, and flight for Harrisburg, PA to St. Louis, MO
Omio recommends booking the flight as it is the most popular option from Harrisburg, PA to St. Louis, MO among Omio's users. If you are prioritising price take the bus with prices starting from $97. For those with little time consider booking a flight which can get you there in 3h 27m. The ticket price range depends on the travel mode: a bus costs an average of $97, and a flight costs an average of $234.
Distance: 718 miles (1157 km)
Compare bus with
| Bus | Most popular Flight | Train | Driving |
|---|---|---|---|
$116 Average price Cheapest | $234 Average price | $164 Average price | $160 Average price (fuel + tolls) |
18h 40m Average total duration 18h 10m Onboard + 30m Additional time* | 6h 27m Average total duration Fastest 3h 27m Onboard + 3h 0m Additional time* | 35h 3m Average total duration 34h 33m Onboard + 30m Additional time* | 12h 37m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Harrisburg, PA to St. Louis, MO is a bus with an average price of $116 (€94).
This is compared to other travel options from Harrisburg, PA to St. Louis, MO:
A bus is $47 (€38) less than a train for this route with tickets for a train from Harrisburg, PA to St. Louis, MO costing on average $164 (€133).
A bus is $118 (€95) less than a flight for this route with tickets for a flight from Harrisburg, PA to St. Louis, MO costing on average $234 (€190).
The fastest way to travel from Harrisburg, PA to St. Louis, MO is by flight with an average journey time of 3h 27m.
Other travel options to St. Louis, MO take longer:
Bus takes on average 18h 10m.
Train takes on average 34h 33m.
It's helpful to compare your options as there are 3 ways to travel between Harrisburg, PA and St. Louis, MO including taking a train, bus, and flight.
We recommend using the flight as it is the most popular way to get from Harrisburg, PA to St. Louis, MO among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.
Tickets start at around $116 (€94) compared to roughly $160 (€130) in fuel and tolls — a saving of about $44 (€35). The journey takes 18h 10m versus 12h 37m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by Greyhound.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
Harrisburg, PA to St. Louis, MO Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound USA | Departure Time 02:50PM | Arrival Time 07:55AM | Duration 17h05 | Departure days Tue, Thu, Fri, Sat, Sun | Cheapest price $223 |
Operator Greyhound | Departure Time 06:50PM | Arrival Time 12:55PM | Duration 18h05 | Departure days Mon | Cheapest price $136 |
Operator Greyhound USA | Departure Time 07:45PM | Arrival Time 03:20PM | Duration 19h35 | Departure days Tue, Thu, Fri, Sat, Sun | Cheapest price $223 |
Operator Greyhound | Departure Time 07:50PM | Arrival Time 01:55PM | Duration 18h05 | Departure days Wed | Cheapest price $97 |
Live departures
Harrisburg, PA to St. Louis, MO bus times
The table below shows live departures for Harrisburg, PA to St. Louis, MO buses for today, Friday, June 5. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 2:50 PM Harrisburg, PA | 17h05 | 7:55 AM St. Louis, MO | 0 transfersDirect | |
| 7:45 PM Harrisburg, PA | 19h35 | 3:20 PM St. Louis, MO | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Harrisburg, PA to St. Louis, MO by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Harrisburg, PA to St. Louis, MO buses with Omio?
Greyhound operates all buses services from Harrisburg, PA to St. Louis, MO.
Omio is an official ticket reseller for all your travel options from Harrisburg, PA to St. Louis, MO.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Harrisburg, PA to St. Louis, MO.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Harrisburg, PA to St. Louis, MO.
Journey information
Overview: Bus from Harrisburg, PA to St. Louis, MO
USAUSA
Buses from Harrisburg, PA to St. Louis, MO run on average 5 times per day, taking around 18h 10m. Cheap bus tickets for this journey start at $97 (€78) if you book in advance.
There are 2 buses per day. The earliest bus runs at 02:00, the last at 23:30. The fastest bus covers the 718 miles (1157 km) distance in 18h 5m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 718 miles (1157 km) |
Average bus duration 18h 10m |
Cheapest ticket price $97 (€78) |
Buses per day 5 |
Direct buses 2 |
Fastest bus 18h 5m |
First bus 2:00 AM |
Last bus 11:30 PM |
Cheapest Month Mar |
Cheapest Day Wed |
High Season Jul - Sep |
Low Season Apr - Jun |
Best time to book 2 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound from Harrisburg, PA to St. Louis, MOYou can travel by bus between Harrisburg, PA to St. Louis, MO with Greyhound for as low as $97 (€78). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
18h 5m
Cheapest Price
$97 (€78)
Greyhound frequency
5 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to St. Louis
Things to do in St. Louis
Discover the best of St. Louis — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect St. Louis trip today.
- Must visit
City Museum
Highly original artist-built museum and playground with architectural salvage, tunnels, slides, and installations. One of St. Louis's most famous attractions.
- Recommended
Missouri History Museum
History museum in Forest Park covering St. Louis, Missouri, and regional stories through permanent and rotating exhibitions.
- Must visit
Forest Park
Huge urban park with museums, trails, lakes, and major attractions. One of the city's essential places for walking and relaxing.
- Recommended
Laclede's Landing
Historic riverfront district with cobblestone streets, old warehouses, and easy access to the Arch and Mississippi views.
- Recommended
Delmar Loop
Popular entertainment and walking district known for public art, music history, shops, and a lively street atmosphere.
- Vegetarian
St. Louis-Style Pizza
A local pizza style with a very thin, cracker-like crust, square-cut slices, and signature Provel cheese. It is one of the city’s most recognizable comfort foods.
Toasted Ravioli
Breaded and fried ravioli, usually filled with meat or cheese and served with marinara. Despite the name, it is fried, not toasted, and is a classic St. Louis starter.
- Vegetarian
Gooey Butter Cake
A rich, sweet cake with a dense, buttery topping over a soft base. It is a beloved St. Louis dessert found in bakeries across the city.
Pappy's Smokehouse
Popular barbecue restaurant known for Memphis-style ribs, pulled pork, and smoky sides in a lively, casual setting.
Ted Drewes Frozen Custard
Historic St. Louis dessert stand famous for frozen custard concretes and a nostalgic roadside feel.
Sidney Street Cafe
Established fine-dining restaurant serving refined American cuisine in a polished but welcoming atmosphere.
United States Dollar
St. Louis is generally affordable by U.S. city standards, with moderate hotel and restaurant prices and many low-cost attractions.
Average meal costs
- Budget
- USD 10-15 for fast food or a simple lunch.
- Mid-range
- USD 20-40 per person at a casual sit-down restaurant.
- Fine dining
- USD 75+ per person at upscale restaurants.
- Coffee
- USD 4-6 for a latte or cappuccino.
Tipping culture
Tip 18-20% at restaurants, 20%+ for great service. Tip bartenders USD 1-2 per drink, round up taxis, and tip hotel staff and delivery drivers.
FAQs: Bus from Harrisburg, PA to St. Louis, MO
Find answers to the most common questions about traveling from Harrisburg, PA to St. Louis, MO by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at St. Louis, MO, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Harrisburg, PA to St. Louis, MO can start from as little as $97 (€78) when you book in advance. The average bus ticket price for Harrisburg, PA to St. Louis, MO is $116 (€94) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Harrisburg, PA to St. Louis, MO is 18h 5m to travel the 718 miles (1157 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Harrisburg, PA to St. Louis, MO leaves at 2:00 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Harrisburg, PA to St. Louis, MO leaves at 11:30 PM.
Yes, there are 2 direct buses a day from Harrisburg, PA to St. Louis, MO with Greyhound. Schedules can vary on holidays or weekends with fewer direct buses.
When taking a bus from Harrisburg, PA to St. Louis, MO, you can count on Greyhound for the best way to get you to St. Louis, MO. You can also check all possible bus companies who offer a service between Harrisburg, PA and St. Louis, MO and compare the amenities they offer before buying a bus ticket.
A trip to St. Louis, MO from Harrisburg, PA is worth doing but not as a day trip with a journey time of 18h 5m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Harrisburg, PA to St. Louis, MO is March.
It's helpful to compare your options as there are 3 ways to travel between Harrisburg, PA and St. Louis, MO including taking a train, bus, and flight.
Yes, the following accessibility options are available when taking the bus from Harrisburg, PA to St. Louis, MO:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Harrisburg, PA to St. Louis, MO for bus company Greyhound.
Whether you can cancel your bus ticket from Harrisburg, PA to St. Louis, MO depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Harrisburg, PA to St. Louis, MO.
Yes, the following luggage options are included when booking a bus ticket from Harrisburg, PA to St. Louis, MO:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from Harrisburg, PA to St. Louis, MO:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from Harrisburg, PA to St. Louis, MO.
You can reserve your seat on the bus from Harrisburg, PA to St. Louis, MO with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from Harrisburg, PA to St. Louis, MO with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from Harrisburg, PA to St. Louis, MO with the following bus company: Greyhound.
Since neither Harrisburg, PA nor St. Louis, MO are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the flight as it is the most popular way to get from Harrisburg, PA to St. Louis, MO among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In St. Louis, MO, travelers should be cautious in certain neighborhoods with higher crime rates, especially after dark. Common safety concerns include petty theft, pickpocketing, and occasional scams targeting visitors near popular attractions like the Gateway Arch. It’s advisable to stay in well-populated areas, avoid displaying valuables openly, and use reputable transportation services to minimize risks.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Harrisburg, PA to St. Louis, MO
Harrisburg
St. Louis
The major bus station for departures in Harrisburg is Harrisburg, Market St (Bus Station). Find all the information you need to know about services, amenities and connections at Harrisburg, Market St (Bus Station) for your trip from Harrisburg to St. Louis.
Harrisburg, Market St (Bus Station)
information
Harrisburg, Chestnut Street / South 4th Street
information
The major bus station for arrivals in St. Louis is St. Louis, S 15th St (Civic center). Find all the information you need to know about services, amenities and connections at St. Louis, S 15th St (Civic center) for your trip to St. Louis from Harrisburg.
St. Louis, S 15th St (Civic center)
information
Most popular bus connections from Harrisburg, PA
More options for your journey from Harrisburg, PA to St. Louis, MO
Here are some other resources that might have the information you need
Most popular buses to and from St. Louis, MO and Harrisburg, PA
Most popular bus connections to St. Louis, MO
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