- Must visit
Saint Louis Art Museum
Vast art museum in Forest Park with global collections from antiquity to modern works and strong free general admission.
2,000+ travel companies
2,000+ travel companies
Scan to get our free app
Use our app to get live travel updates and book mobile tickets for trains, buses, flights, and ferries.
App Store
4.942K ratings
Google Play
4.6136K reviews
The cheapest and fastest buses from Harrisburg, PA to St. Louis, MO
Showing times and prices for Jul 22
Cheapest price
$88
Average price
$114
Fastest journey
18 h 5 m
Average duration
19 h 44 m
Buses per day
6
Distance
1157 km
Cheap tickets
The best way to find a cheap bus ticket from Harrisburg, PA to St. Louis, MO is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Harrisburg, PA to St. Louis, MO will cost around $114 if you buy it on the day, but the cheapest tickets can be found for only $88.
Fast buses
Of the 6 buses that leave Harrisburg, PA for St. Louis, MO on Wed, Jul 22, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Wed, Jul 22 the direct buses cover the 1157 km distance in an average of 19 h 44 m but if you time it right, some buses will get you there in just 18 h 5 m .
On Wed, Jul 22 the slowest buses will take 22 h and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
2:35 PM18h10Harrisburg, Market St (Bus Station), PA7:45 AMSt. Louis, S 15th St (Civic center)$881One-way0 transfers- 7:50 PM20h20Harrisburg, Market St (Bus Station), PA3:10 PMSt. Louis, S 15th St (Civic center)$1021One-way0 transfers
FlixBus+2:15 AM22h00Harrisburg, Market St (Bus Station), PA11:15 PMSt. Louis, S 15th St (Civic center)$1051One-way1 transfer- FlixBus+2:40 PM18h05Harrisburg, Market St (Bus Station), PA7:45 AMSt. Louis, S 15th St (Civic center)$1241One-way1 transfer
- · 11:40 PM24h35Harrisburg, Market St (Bus Station), PA11:15 PMSt. Louis, S 15th St (Civic center)$1331One-way1 transfer
- FlixBus+2:40 PM18h05Harrisburg, Market St (Bus Station), PA7:45 AMSt. Louis, S 15th St (Civic center)$1241One-way1 transfer
- 2:35 PM18h10Harrisburg, Market St (Bus Station), PA7:45 AMSt. Louis, S 15th St (Civic center)$881One-way0 transfers
- · 8:05 PM20h05Harrisburg, Market St (Bus Station), PA3:10 PMSt. Louis, S 15th St (Civic center)$1341One-way1 transfer
- 7:50 PM20h20Harrisburg, Market St (Bus Station), PA3:10 PMSt. Louis, S 15th St (Civic center)$1021One-way0 transfers
- FlixBus+2:15 AM22h00Harrisburg, Market St (Bus Station), PA11:15 PMSt. Louis, S 15th St (Civic center)$1051One-way1 transfer
Travel Information
Compare train, bus, and flight for Harrisburg, PA to St. Louis, MO
Omio recommends booking the flight as it is the most popular option from Harrisburg, PA to St. Louis, MO among Omio's users. If you are prioritising price take the bus with prices starting from $78. For those with little time consider booking a flight which can get you there in 3h 27m. The ticket price range depends on the travel mode: a bus costs an average of $78, and a flight costs an average of $190.
Distance: 718 miles (1157 km)
Compare bus with
| Bus | Most popular Flight | Train | Driving |
|---|---|---|---|
$94 Average price Cheapest | $190 Average price | $133 Average price | $130 Average price (fuel + tolls) |
18h 40m Average total duration 18h 10m Onboard + 30m Additional time* | 6h 27m Average total duration Fastest 3h 27m Onboard + 3h 0m Additional time* | 35h 3m Average total duration 34h 33m Onboard + 30m Additional time* | 12h 37m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Harrisburg, PA to St. Louis, MO is a bus with an average price of $94 (€94).
This is compared to other travel options from Harrisburg, PA to St. Louis, MO:
A bus is $38 (€38) less than a train for this route with tickets for a train from Harrisburg, PA to St. Louis, MO costing on average $133 (€133).
A bus is $95 (€95) less than a flight for this route with tickets for a flight from Harrisburg, PA to St. Louis, MO costing on average $190 (€190).
The fastest way to travel from Harrisburg, PA to St. Louis, MO is by flight with an average journey time of 3h 27m.
Other travel options to St. Louis, MO take longer:
Bus takes on average 18h 10m.
Train takes on average 34h 33m.
It's helpful to compare your options as there are 3 ways to travel between Harrisburg, PA and St. Louis, MO including taking a train, bus, and flight.
We recommend using the flight as it is the most popular way to get from Harrisburg, PA to St. Louis, MO among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.
Tickets start at around $94 (€94) compared to roughly $130 (€130) in fuel and tolls — a saving of about $35 (€35). The journey takes 18h 10m versus 12h 37m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by Greyhound.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
Harrisburg, PA to St. Louis, MO Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 02:15AM | Arrival Time 11:15PM | Duration 22h00 | Departure days Mon, Tue, Wed, Thu, Sat | Cheapest price $88 |
Operator FlixBus | Departure Time 02:30AM | Arrival Time 11:15PM | Duration 21h45 | Departure days Sun | Cheapest price $91 |
Operator Greyhound | Departure Time 02:35PM | Arrival Time 07:45AM | Duration 18h10 | Departure days Mon, Tue, Wed, Thu, Sat | Cheapest price $83 |
Operator Greyhound | Departure Time 02:40PM | Arrival Time 07:45AM | Duration 18h05 | Departure days Mon, Wed, Thu, Sat | Cheapest price $91 |
Operator Greyhound USA | Departure Time 02:50PM | Arrival Time 07:55AM | Duration 17h05 | Departure days Fri, Sun | Cheapest price $84 |
Operator Greyhound USA | Departure Time 07:45PM | Arrival Time 03:20PM | Duration 19h35 | Departure days Fri | Cheapest price $180 |
Operator Greyhound | Departure Time 07:50PM | Arrival Time 03:10PM | Duration 20h20 | Departure days Mon, Tue, Wed, Thu, Sat, Sun | Cheapest price $75 |
Operator Greyhound | Departure Time 08:05PM | Arrival Time 03:10PM | Duration 20h05 | Departure days Mon, Tue, Wed, Thu, Sat, Sun | Cheapest price $86 |
Operator Greyhound | Departure Time 11:20PM | Arrival Time 11:15PM | Duration 24h55 | Departure days Sun | Cheapest price $98 |
Operator Greyhound | Departure Time 11:40PM | Arrival Time 11:15PM | Duration 24h35 | Departure days Mon, Tue, Wed, Thu, Sat | Cheapest price $97 |
Live departures
Harrisburg, PA to St. Louis, MO bus times
The table below shows live departures for Harrisburg, PA to St. Louis, MO buses for today, Tuesday, July 21. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 7:50 PM Harrisburg, Market St (Bus Station), PA | 20h20 | 3:10 PM St. Louis, S 15th St (Civic center) | 0 transfersDirect | |
| · | 8:05 PM Harrisburg, Market St (Bus Station), PA | 20h05 | 3:10 PM St. Louis, S 15th St (Civic center) | 1 transfer | |
| · | 11:40 PM Harrisburg, Market St (Bus Station), PA | 24h35 | 11:15 PM St. Louis, S 15th St (Civic center) | 1 transfer | |
| Wednesday, July 22 | |||||
| FlixBus+ | 2:15 AM Harrisburg, Market St (Bus Station), PA | 22h00 | 11:15 PM St. Louis, S 15th St (Civic center) | 1 transfer | |
| 2:35 PM Harrisburg, Market St (Bus Station), PA | 18h10 | 7:45 AM St. Louis, S 15th St (Civic center) | 0 transfersDirect | |
| FlixBus+ | 2:40 PM Harrisburg, Market St (Bus Station), PA | 18h05 | 7:45 AM St. Louis, S 15th St (Civic center) | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Harrisburg, PA to St. Louis, MO by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Wed
Jul 22
Jul 22
Thu
Jul 23
Jul 23
Fri
Jul 24
Jul 24
Sat
Jul 25
Jul 25
Sun
Jul 26
Jul 26
Mon
Jul 27
Jul 27
Tue
Jul 28
Jul 28
Why should you book Harrisburg, PA to St. Louis, MO buses with Omio?
Greyhound operates all buses services from Harrisburg, PA to St. Louis, MO.
Omio is an official ticket reseller for all your travel options from Harrisburg, PA to St. Louis, MO.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Harrisburg, PA to St. Louis, MO.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Harrisburg, PA to St. Louis, MO.
Journey information
Overview: Bus from Harrisburg, PA to St. Louis, MO
USAUSA
Buses from Harrisburg, PA to St. Louis, MO run on average 5 times per day, taking around 18h 10m. Cheap bus tickets for this journey start at $78 (€78) if you book in advance.
There are 2 buses per day. The earliest bus runs at 02:00, the last at 23:30. The fastest bus covers the 718 miles (1157 km) distance in 18h 5m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 718 miles (1157 km) |
Average bus duration 18h 10m |
Cheapest ticket price $78 (€78) |
Buses per day 5 |
Direct buses 2 |
Fastest bus 18h 5m |
First bus 2:00 AM |
Last bus 11:30 PM |
Cheapest Month Mar |
Cheapest Day Wed |
High Season Jul - Sep |
Low Season Apr - Jun |
Best time to book 2 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound from Harrisburg, PA to St. Louis, MOYou can travel by bus between Harrisburg, PA to St. Louis, MO with Greyhound for as low as $78 (€78). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
18h 5m
Cheapest Price
$78 (€78)
Greyhound frequency
5 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to St. Louis, MO
Things to do in St. Louis, MO
Discover the best of St. Louis, MO — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect St. Louis, MO trip today.
- Recommended
Missouri History Museum
Leading history museum covering St. Louis, Missouri, and national stories through rotating exhibitions in Forest Park.
- Recommended
Saint Louis Science Center
Interactive science museum with hands-on exhibits, planetarium, and family-friendly displays near Forest Park.
- Must visit
Gateway Arch National Park Grounds
Lively downtown riverfront district with trails, views of the Arch, public art, and access to major historic sites.
- Must visit
Forest Park
Large urban park with trails, lakes, zoo access, and major museums, ideal for walking between top attractions.
- Recommended
Tower Grove Park
Beloved neighborhood park with formal lily ponds, pavilions, and one of the city's most photographed landscapes.
- Vegetarian
St. Louis-Style Pizza
A thin, cracker-like crust pizza cut into squares and topped with Provel cheese, a St. Louis original loved for its distinct texture and tangy flavor.
- Vegetarian
Toasted Ravioli
Crisp, breaded ravioli said to be born on The Hill, usually served with marinara. It is a signature St. Louis Italian-American appetizer.
- Vegetarian
Gooey Butter Cake
Sticky butter cake with a dense base and gooey sweet top. A longtime St. Louis bakery favorite often enjoyed for breakfast or dessert.
Bulrush
Refined contemporary restaurant with tasting menus and strong national acclaim. Elegant fine dining focused on seasonal Midwestern ingredients.
Ted Drewes Frozen Custard
Beloved frozen custard stand serving concretes and sundaes since 1929. Casual, nostalgic, and one of the city's iconic dessert stops.
Pappy's Smokehouse
Popular smokehouse known for St. Louis barbecue, especially ribs, brisket, and pork steak, in a polished but relaxed atmosphere.
United States dollar ($)
Moderate for U.S. city breaks: hotels and dining are reasonable, transit is limited, and attractions often cost less than in larger U.S. tourist cities.
Average meal costs
- Budget
- $10-15 for fast food or casual lunch.
- Mid-range
- $20-35 per person for a mid-range restaurant meal.
- Fine dining
- $60+ per person at upscale restaurants.
- Coffee
- $3-5 for coffee or cappuccino.
Tipping culture
Tip 18-20% at restaurants, $1-2 per drink at bars, and 10-15% for taxis. Cafes often have tip jars or screen prompts.
FAQs: Bus from Harrisburg, PA to St. Louis, MO
Find answers to the most common questions about traveling from Harrisburg, PA to St. Louis, MO by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at St. Louis, MO, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Harrisburg, PA to St. Louis, MO can start from as little as $78 (€78) when you book in advance. The average bus ticket price for Harrisburg, PA to St. Louis, MO is $94 (€94) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Harrisburg, PA to St. Louis, MO is 18h 5m to travel the 718 miles (1157 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Harrisburg, PA to St. Louis, MO leaves at 2:00 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Harrisburg, PA to St. Louis, MO leaves at 11:30 PM.
Yes, there are 2 direct buses a day from Harrisburg, PA to St. Louis, MO with Greyhound. Schedules can vary on holidays or weekends with fewer direct buses.
When taking a bus from Harrisburg, PA to St. Louis, MO, you can count on Greyhound for the best way to get you to St. Louis, MO. You can also check all possible bus companies who offer a service between Harrisburg, PA and St. Louis, MO and compare the amenities they offer before buying a bus ticket.
A trip to St. Louis, MO from Harrisburg, PA is worth doing but not as a day trip with a journey time of 18h 5m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Harrisburg, PA to St. Louis, MO is March.
It's helpful to compare your options as there are 3 ways to travel between Harrisburg, PA and St. Louis, MO including taking a train, bus, and flight.
Yes, there are bathrooms on board the bus from Harrisburg, PA to St. Louis, MO for bus company Greyhound.
Yes, the following accessibility options are available when taking the bus from Harrisburg, PA to St. Louis, MO:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Whether you can cancel your bus ticket from Harrisburg, PA to St. Louis, MO depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Harrisburg, PA to St. Louis, MO.
Yes, the following luggage options are included when booking a bus ticket from Harrisburg, PA to St. Louis, MO:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from Harrisburg, PA to St. Louis, MO:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from Harrisburg, PA to St. Louis, MO.
You can reserve your seat on the bus from Harrisburg, PA to St. Louis, MO with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from Harrisburg, PA to St. Louis, MO with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from Harrisburg, PA to St. Louis, MO with the following bus company: Greyhound.
Since neither Harrisburg, PA nor St. Louis, MO are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the flight as it is the most popular way to get from Harrisburg, PA to St. Louis, MO among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In St. Louis, MO, travelers should be cautious in certain neighborhoods with higher crime rates, especially after dark. Common safety concerns include petty theft, pickpocketing, and occasional scams targeting visitors near popular attractions like the Gateway Arch. It’s advisable to stay in well-populated areas, avoid displaying valuables openly, and use reputable transportation services to minimize risks.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Harrisburg, PA to St. Louis, MO
Most Harrisburg, PA to St. Louis, MO buses use the Harrisburg, Market St (Bus Station) to St. Louis, S 15th St (Civic center) station pair. Use this guide to compare Harrisburg, PA and St. Louis, MO bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Harrisburg
Arrival bus stations in St. Louis
Harrisburg, Market St (Bus Station)
City-centre transport
Getting to Harrisburg, Market St (Bus Station) from Harrisburg city centre
Bus6/13, W · 29m · $3 · every ~4 min
Harrisburg, Chestnut Street / South 4th Street
City-centre transport
Getting to Harrisburg, Chestnut Street / South 4th Street from Harrisburg city centre
Bus2, 7, 81X, A, B, C, D, M, E · 8m · $2 · every ~6 min
2, M, 7, D, A, B, 81X, C, 322, E · 9m · $2 · every ~6 min
Hbg Com Kng B · 15m · $2
St. Louis, S 15th St (Civic center)
City-centre transport
Getting to St. Louis, S 15th St (Civic center) from St. Louis city centre
TrainMlb, Mlr · 4m · $3 · every ~14 min
Bus19, 32, 40 · 8m · $1 · every ~9 min
Most popular bus connections from Harrisburg, PA
More options for your journey from Harrisburg, PA to St. Louis, MO
Here are some other resources that might have the information you need
Most popular buses to and from St. Louis, MO and Harrisburg, PA
Most popular bus connections to St. Louis, MO
The Omio App Makes Travel Planning Easy
We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.
