- Must visit
Saint Louis Art Museum
Vast art museum in Forest Park with global collections from antiquity to modern works and strong free general admission.
Cheapest price on Sep 06
$223
Average ticket price on Sep 06
$223
Fastest journey on Sep 06
17 h 5 m
Average journey duration on Sep 06
18 h 20 m
Buses on Sep 06
2
Distance
1157 km
The best way to find a cheap bus ticket from Harrisburg, PA to St. Louis, MO is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Harrisburg, PA to St. Louis, MO will cost around $223 if you buy it on the day, but the cheapest tickets can be found for only $223.
On Sun, Sep 06, we found 2 buses from Harrisburg, PA to St. Louis, MO, including 2 direct services.
On Sun, Sep 06 the direct buses cover the 1157 km distance in an average of 18 h 20 m but if you time it right, some buses will get you there in just 17 h 5 m .
On Sun, Sep 06 the slowest buses will take 19 h 35 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.




Omio recommends booking the bus as it is the most popular option from Harrisburg, PA to St. Louis, MO among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $138 For those with little time, consider booking a bus, which has an average total journey time of 19h 51m. Average ticket prices depend on the travel mode: a bus costs an average of $138, while a train costs an average of $467.
Distance: 718 miles (1157 km)
Most popular Bus | Train | Driving |
|---|---|---|
$138 Average price Cheapest | $467 Average price | $163 Average price (fuel + tolls) |
19h 51m Average total duration Fastest 19h 21m Onboard + 30m Additional time* | 20h 52m Average total duration 20h 22m Onboard + 30m Additional time* | 12h 37m Average total duration (door-to-door) |
![]() Most popular bus company | ![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Harrisburg, PA to St. Louis, MO:
A bus is $329 less than a train for this route with tickets for a train from Harrisburg, PA to St. Louis, MO costing on average $467.
A bus is $508 less than a flight for this route with tickets for a flight from Harrisburg, PA to St. Louis, MO costing on average $646.
Other travel options to St. Louis, MO take longer:
Bus takes on average 19h 21m.
Train takes on average 20h 22m.
Tickets start at around $138 compared to roughly $163 in fuel and tolls — a saving of about $25. The journey takes 19h 21m versus 12h 37m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by Greyhound.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 02:15AM | Arrival Time 11:15PM | Duration 22h00 | Departure days Mon, Wed, Sat | Cheapest price $96 |
Operator Greyhound | Departure Time 02:30AM | Arrival Time 11:15PM | Duration 21h45 | Departure days Thu | Cheapest price $103 |
Operator FlixBus | Departure Time 02:30AM | Arrival Time 11:15PM | Duration 21h45 | Departure days Fri | Cheapest price $92 |
Operator Greyhound | Departure Time 02:35PM | Arrival Time 07:45AM | Duration 18h10 | Departure days Mon, Sat | Cheapest price $99 |
Operator Greyhound | Departure Time 02:40PM | Arrival Time 07:45AM | Duration 18h05 | Departure days Mon, Sat | Cheapest price $104 |
Operator Greyhound | Departure Time 02:50PM | Arrival Time 07:55AM | Duration 18h05 | Departure days Tue, Wed, Thu, Fri, Sun | Cheapest price $92 |
Operator Greyhound USA | Departure Time 07:45PM | Arrival Time 03:20PM | Duration 19h35 | Departure days Tue, Sun | Cheapest price $223 |
Operator Greyhound | Departure Time 07:50PM | Arrival Time 03:10PM | Duration 20h20 | Departure days Mon, Wed, Thu, Fri, Sat | Cheapest price $92 |
Operator Greyhound | Departure Time 08:05PM | Arrival Time 03:10PM | Duration 20h05 | Departure days Mon, Wed, Thu, Fri, Sat | Cheapest price $92 |
Operator Greyhound | Departure Time 11:20PM | Arrival Time 11:15PM | Duration 24h55 | Departure days Wed | Cheapest price $109 |
Operator Greyhound | Departure Time 11:30PM | Arrival Time 11:15PM | Duration 24h45 | Departure days Thu, Fri | Cheapest price $106 |
Operator Greyhound | Departure Time 11:40PM | Arrival Time 11:15PM | Duration 24h35 | Departure days Mon | Cheapest price $114 |
Operator Greyhound | Departure Time 11:50PM | Arrival Time 11:15PM | Duration 24h25 | Departure days Sat | Cheapest price $117 |
The table below shows live departures for Harrisburg, PA to St. Louis, MO buses for today, Saturday, September 5. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus+![]() | 2:15 AM Harrisburg, Market St (Bus Station), PA | 22h00 | 11:15 PM St. Louis, S 15th St (Civic center) | 1 transfer | |
![]() | 2:35 PM Harrisburg, Market St (Bus Station), PA | 18h10 | 7:45 AM St. Louis, S 15th St (Civic center) | 0 transfersDirect | |
FlixBus+![]() | 2:40 PM Harrisburg, Market St (Bus Station), PA | 18h05 | 7:45 AM St. Louis, S 15th St (Civic center) | 1 transfer | |
![]() | 7:50 PM Harrisburg, Market St (Bus Station), PA | 20h20 | 3:10 PM St. Louis, S 15th St (Civic center) | 0 transfersDirect | |
· | 8:05 PM Harrisburg, Market St (Bus Station), PA | 20h05 | 3:10 PM St. Louis, S 15th St (Civic center) | 1 transfer |
Find all the dates and times for this journey
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Harrisburg, PA to St. Louis, MO run on average 6 times per day, taking around 19h 21m. Cheap bus tickets for this journey start at $88 if you book in advance.
There are 2 buses per day. The earliest bus runs at 02:00, the last at 23:30. The fastest bus covers the 718 miles (1157 km) distance in 17h 15m.
Distance 718 miles (1157 km) |
Average bus duration 19h 21m |
Cheapest ticket price $88 |
Buses per day 6 |
Direct buses 2 |
Fastest bus 17h 15m |
First bus 2:00 AM |
Last bus 11:30 PM |
Cheapest Month Mar |
Cheapest Day Tue |
High Season Jul - Sep |
Low Season Jan - Mar |
Best time to book 5 days |
Discover the best of St. Louis, MO — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect St. Louis, MO trip today.
Vast art museum in Forest Park with global collections from antiquity to modern works and strong free general admission.
Leading history museum covering St. Louis, Missouri, and national stories through rotating exhibitions in Forest Park.
Interactive science museum with hands-on exhibits, planetarium, and family-friendly displays near Forest Park.
Lively downtown riverfront district with trails, views of the Arch, public art, and access to major historic sites.
Large urban park with trails, lakes, zoo access, and major museums, ideal for walking between top attractions.
Beloved neighborhood park with formal lily ponds, pavilions, and one of the city's most photographed landscapes.
A thin, cracker-like crust pizza cut into squares and topped with Provel cheese, a St. Louis original loved for its distinct texture and tangy flavor.
Crisp, breaded ravioli said to be born on The Hill, usually served with marinara. It is a signature St. Louis Italian-American appetizer.
Sticky butter cake with a dense base and gooey sweet top. A longtime St. Louis bakery favorite often enjoyed for breakfast or dessert.
Refined contemporary restaurant with tasting menus and strong national acclaim. Elegant fine dining focused on seasonal Midwestern ingredients.
Beloved frozen custard stand serving concretes and sundaes since 1929. Casual, nostalgic, and one of the city's iconic dessert stops.
Popular smokehouse known for St. Louis barbecue, especially ribs, brisket, and pork steak, in a polished but relaxed atmosphere.
Moderate for U.S. city breaks: hotels and dining are reasonable, transit is limited, and attractions often cost less than in larger U.S. tourist cities.
Tip 18-20% at restaurants, $1-2 per drink at bars, and 10-15% for taxis. Cafes often have tip jars or screen prompts.
Find answers to the most common questions about traveling from Harrisburg, PA to St. Louis, MO by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at St. Louis, MO, this guide helps you travel smarter and with confidence.

Most Harrisburg, PA to St. Louis, MO buses use the Harrisburg, Market St (Bus Station) to St. Louis, S 15th St (Civic center) station pair. Use this guide to compare Harrisburg, PA and St. Louis, MO bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Harrisburg, Market St (Bus Station) is 1 km from Harrisburg city centre. Public transport options include:
Harrisburg, Market St (Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Free WiFi inside the station. ATMs are available at Harrisburg, Market St (Bus Station).
Ticket office support is available at Harrisburg, Market St (Bus Station).
Available at Harrisburg, Market St (Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Harrisburg, Market St (Bus Station): Wheelchair accessible with ramps.
Harrisburg, Chestnut Street / South 4th Street is 1 km from Harrisburg city centre. Public transport options include:
Harrisburg, Chestnut Street / South 4th Street has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Harrisburg, Chestnut Street / South 4th Street. ATMs are available at Harrisburg, Chestnut Street / South 4th Street.
Ticket office support is available at Harrisburg, Chestnut Street / South 4th Street.
Available at Harrisburg, Chestnut Street / South 4th Street: Parking, Taxis, WC.
Accessibility facilities are available at Harrisburg, Chestnut Street / South 4th Street: Accessible by wheelchair via main entrance.
St. Louis, S 15th St (Civic center) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at St. Louis, S 15th St (Civic center). ATMs are available at St. Louis, S 15th St (Civic center).
Ticket office support is available at St. Louis, S 15th St (Civic center).
Available at St. Louis, S 15th St (Civic center): Parking, Taxis, WC.
Accessibility facilities are available at St. Louis, S 15th St (Civic center): Wheelchair accessible routes available.
Here are some other resources that might have the information you need