- Must visit
Buffalo AKG Art Museum
Major regional art museum with modern, contemporary, and historic works, plus a growing campus and frequent exhibitions.
2,000+ travel companies
2,000+ travel companies
Scan to get our free app
Use our app to get live travel updates and book mobile tickets for trains, buses, flights, and ferries.
App Store
4.942K ratings
Google Play
4.6136K reviews
The cheapest and fastest buses from St. Louis, MO to Buffalo, NY
Showing times, prices and bookable tickets for Sep 15
Cheapest price on Sep 15
$83
Average ticket price on Sep 15
$84
Fastest journey on Sep 15
21 h
Average journey duration on Sep 15
1 d 5 h 16 m
Buses on Sep 15
4
Distance
1063 km
Cheap tickets
The best way to find a cheap bus ticket from St. Louis, MO to Buffalo, NY is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from St. Louis, MO to Buffalo, NY will cost around $84 if you buy it on the day, but the cheapest tickets can be found for only $83.
Fast buses
It's difficult to get from St. Louis, MO to Buffalo, NY without transferring at least once.
FlixBus+
· 10:00 AM21h00St. Louis, S 15th St (Civic center)8:00 AMBuffalo, NFTA Metro Center$831One-way2 transfers- +FlixBus8:45 AM32h45St. Louis, S 15th St (Civic center)6:30 PMCheektowaga, BNIA Drway & BNIA Terminal$841One-way1 transfer
- · · 2:05 PM25h40St. Louis, S 15th St (Civic center)4:45 PMBuffalo, NFTA Metro Center$851One-way2 transfers
- · +FlixBus2:00 AM37h40St. Louis, S 15th St (Civic center)4:40 PMCheektowaga, BNIA Drway & BNIA Terminal$851One-way2 transfers
- FlixBus+ · 10:00 AM21h00St. Louis, S 15th St (Civic center)8:00 AMBuffalo, NFTA Metro Center$831One-way2 transfers
- · · 2:05 PM25h40St. Louis, S 15th St (Civic center)4:45 PMBuffalo, NFTA Metro Center$851One-way2 transfers
- +FlixBus8:45 AM32h45St. Louis, S 15th St (Civic center)6:30 PMCheektowaga, BNIA Drway & BNIA Terminal$841One-way1 transfer
- · +FlixBus2:00 AM37h40St. Louis, S 15th St (Civic center)4:40 PMCheektowaga, BNIA Drway & BNIA Terminal$851One-way2 transfers
Travel Information
Compare train, bus, and flight for St. Louis, MO to Buffalo, NY
Omio recommends booking the train as it is the most popular option from St. Louis, MO to Buffalo, NY among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $150 For those with little time, consider booking a flight, which has an average total journey time of 6h 14m. Average ticket prices depend on the travel mode: a bus costs an average of $150, while a flight costs an average of $549.
Distance: 660 miles (1063 km)
Compare bus with
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
$150 Average price Cheapest | $255 Average price | $549 Average price | $158 Average price (fuel + tolls) |
27h 19m Average total duration 26h 49m Onboard + 30m Additional time* | 16h 15m Average total duration 15h 45m Onboard + 30m Additional time* | 6h 14m Average total duration Fastest 4h 14m Onboard + 2h 0m Additional time* | 11h 7m Average total duration (door-to-door) |
Most popular bus company |  Most popular train company |  Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from St. Louis, MO to Buffalo, NY is a bus with an average price of $150 (€122).
This is compared to other travel options from St. Louis, MO to Buffalo, NY:
A bus is $106 (€86) less than a train for this route with tickets for a train from St. Louis, MO to Buffalo, NY costing on average $255 (€208).
A bus is $399 (€325) less than a flight for this route with tickets for a flight from St. Louis, MO to Buffalo, NY costing on average $549 (€447).
The fastest way to travel from St. Louis, MO to Buffalo, NY is by flight with an average journey time of 4h 14m.
Other travel options to Buffalo, NY take longer:
Train takes on average 15h 45m.
Bus takes on average 26h 49m.
It's helpful to compare your options as there are 3 ways to travel between St. Louis, MO and Buffalo, NY including taking a train, bus, and flight.
We recommend using the train as it is the most popular way to get from St. Louis, MO to Buffalo, NY among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.
Tickets start at around $150 (€122) compared to roughly $158 (€128) in fuel and tolls — a saving of about $8 (€7). The journey takes 26h 49m versus 11h 7m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
St. Louis, MO to Buffalo, NY Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 02:00AM | Arrival Time 04:40PM | Duration 37h40 | Departure days Everyday | Cheapest price $85 |
Operator Greyhound | Departure Time 08:45AM | Arrival Time 06:30PM | Duration 32h45 | Departure days Everyday | Cheapest price $84 |
Operator Greyhound | Departure Time 10:00AM | Arrival Time 08:00AM | Duration 21h00 | Departure days Mon, Tue, Fri, Sat, Sun | Cheapest price $83 |
Operator Greyhound | Departure Time 02:05PM | Arrival Time 04:45PM | Duration 25h40 | Departure days Everyday | Cheapest price $85 |
Live departures
St. Louis, MO to Buffalo, NY bus times
The table below shows live departures for St. Louis, MO to Buffalo, NY buses for today, Monday, September 14. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| +FlixBus | 8:45 AM St. Louis, S 15th St (Civic center) | 32h45 | 6:30 PM Cheektowaga, BNIA Drway & BNIA Terminal | 1 transfer | |
| FlixBus+ · | 10:00 AM St. Louis, S 15th St (Civic center) | 21h00 | 8:00 AM Buffalo, NFTA Metro Center | 2 transfers | |
| · · | 2:05 PM St. Louis, S 15th St (Civic center) | 25h40 | 4:45 PM Buffalo, NFTA Metro Center | 2 transfers | |
| Tuesday, September 15 | |||||
| · +FlixBus | 2:00 AM St. Louis, S 15th St (Civic center) | 37h40 | 4:40 PM Cheektowaga, BNIA Drway & BNIA Terminal | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets St. Louis, MO to Buffalo, NY by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Tue
Sep 15
Sep 15
Wed
Sep 16
Sep 16
Thu
Sep 17
Sep 17
Fri
Sep 18
Sep 18
Sat
Sep 19
Sep 19
Sun
Sep 20
Sep 20
Mon
Sep 21
Sep 21
Why should you book St. Louis, MO to Buffalo, NY buses with Omio?
Greyhound operates all buses services from St. Louis, MO to Buffalo, NY.
Omio is an official ticket reseller for all your travel options from St. Louis, MO to Buffalo, NY.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from St. Louis, MO to Buffalo, NY.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from St. Louis, MO to Buffalo, NY.
Journey information
Overview: Bus from St. Louis, MO to Buffalo, NY
USAUSA
Buses from St. Louis, MO to Buffalo, NY run on average 5 times per day, taking around 26h 49m. Cheap bus tickets for this journey start at $100 (€81) if you book in advance.
The earliest bus runs at 00:55, the last at 23:20. The fastest bus covers the 660 miles (1063 km) distance in 16h 45m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 660 miles (1063 km) |
Average bus duration 26h 49m |
Cheapest ticket price $100 (€81) |
Buses per day 5 |
Fastest bus 16h 45m |
First bus 12:55 AM |
Last bus 11:20 PM |
Cheapest Month Aug |
Cheapest Day Mon |
High Season Jul - Sep |
Low Season Jan - Mar |
Best time to book 1 day |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound from St. Louis, MO to Buffalo, NYYou can travel by bus between St. Louis, MO to Buffalo, NY with Greyhound for as low as $100 (€81). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
16h 45m
Cheapest Greyhound Price
$100 (€81)
Greyhound frequency
5 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Buffalo, NY
Things to do in Buffalo, NY
Discover the best of Buffalo, NY — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Buffalo, NY trip today.
- Recommended
Theodore Roosevelt Inaugural National Historic Site
Former presidential inaugural site with exhibits on Theodore Roosevelt, the Pan-American Exposition, and Buffalo politics.
- Recommended
Michigan Street African American Heritage Corridor
Community museum preserving Buffalo’s African American heritage through local history, culture, and rotating exhibitions.
- Must visit
Canalside
Waterfront district with canal history, public art, seasonal events, skating, and frequent family-friendly activities downtown.
- Must visit
Elmwood Village
Lively walkable neighborhood known for boutiques, galleries, architecture, and one of Buffalo’s most popular main streets.
- Must visit
Outer Harbor
Long urban trail and greenway connecting waterfront areas, parks, and neighborhoods for walking, biking, and sightseeing.
Buffalo Wings
Crisp fried chicken wings coated in spicy butter-hot sauce. Created in Buffalo, they are the city’s signature bar food and a must-try local classic.
Beef On Weck
Thin-sliced roast beef on a kummelweck roll topped with coarse salt and caraway, usually dipped in jus. It is a longtime Western New York sandwich staple.
- Gluten-free
Buffalo-Style Bean Soup
Slow-cooked bean soup with ham, tomatoes, and vegetables. It is strongly associated with Buffalo’s old taverns and Friday lunch traditions.
Oliver's Restaurant
Refined fine-dining restaurant known for seasonal New American tasting menus, polished service, and an elegant special-occasion atmosphere.
Schwabl's
Traditional German restaurant celebrated for beef on weck, sausages, and old-world charm. A Buffalo dining landmark with a cozy historic feel.
Duff's Famous Wings
Long-standing wing institution known for crispy, saucy chicken wings in a classic neighborhood bar setting with a devoted local following.
United States dollar ($)
Moderate for U.S. city travel; hotels are often cheaper than NYC, while dining and local transit stay fairly manageable for visitors.
Average meal costs
- Budget
- $10-18 for fast food or casual takeout.
- Mid-range
- $20-40 per person for a mid-range restaurant meal.
- Fine dining
- $60+ per person for upscale dining.
- Coffee
- $3-6 for a coffee or cappuccino.
Tipping culture
Tip 18-20% at restaurants, more for great service. Taxis usually 10-15%. For cafes, round up or add $1 per drink.
FAQs: Bus from St. Louis, MO to Buffalo, NY
Find answers to the most common questions about traveling from St. Louis, MO to Buffalo, NY by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Buffalo, NY, this guide helps you travel smarter and with confidence.
Cheap bus tickets from St. Louis, MO to Buffalo, NY can start from as little as $100 (€81) when you book in advance. The average bus ticket price for St. Louis, MO to Buffalo, NY is $150 (€122) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from St. Louis, MO to Buffalo, NY is 16h 45m to travel the 660 miles (1063 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from St. Louis, MO to Buffalo, NY leaves at 12:55 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from St. Louis, MO to Buffalo, NY leaves at 11:20 PM.
There are 5 buses a day from St. Louis, MO to Buffalo, NY which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from St. Louis, MO to Buffalo, NY, you can count on Greyhound for the best way to get you to Buffalo, NY. You can also check all possible bus companies who offer a service between St. Louis, MO and Buffalo, NY and compare the amenities they offer before buying a bus ticket.
A trip to Buffalo, NY from St. Louis, MO is worth doing but not as a day trip with a journey time of 16h 45m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from St. Louis, MO to Buffalo, NY is August.
It's helpful to compare your options as there are 3 ways to travel between St. Louis, MO and Buffalo, NY including taking a train, bus, and flight.
Yes, the following accessibility options are available when taking the bus from St. Louis, MO to Buffalo, NY:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from St. Louis, MO to Buffalo, NY for bus company Greyhound.
Whether you can cancel your bus ticket from St. Louis, MO to Buffalo, NY depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from St. Louis, MO to Buffalo, NY.
Yes, the following luggage options are included when booking a bus ticket from St. Louis, MO to Buffalo, NY:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from St. Louis, MO to Buffalo, NY:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from St. Louis, MO to Buffalo, NY.
You can reserve your seat on the bus from St. Louis, MO to Buffalo, NY with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from St. Louis, MO to Buffalo, NY with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from St. Louis, MO to Buffalo, NY with the following bus company: Greyhound.
Since neither St. Louis, MO nor Buffalo, NY are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the train as it is the most popular way to get from St. Louis, MO to Buffalo, NY among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Buffalo, NY, travelers should be cautious of pickpocketing and petty theft, especially in crowded areas like downtown and tourist spots. Scams involving overcharging for taxi or rideshare services have been reported, so it's advised to use licensed transportation and confirm fares beforehand. Additionally, travelers should stay aware of their surroundings at night, particularly in less populated neighborhoods, to avoid potential safety risks.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from St. Louis, MO to Buffalo, NY
Most St. Louis, MO to Buffalo, NY buses use the St. Louis, S 15th St (Civic center) to Cheektowaga, BNIA Drway & BNIA Terminal station pair, with some services arriving at Buffalo, NFTA Metro Center. Use this guide to compare St. Louis, MO and Buffalo, NY bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in St. Louis
Arrival bus stations in Buffalo
Which St. Louis, MO station do buses to Buffalo, NY leave from?
Buses from St. Louis, MO to Buffalo, NY leave from St. Louis, S 15th St (Civic center). The station is 0 miles (1 km) from St. Louis, MO city centre at S 15th St, St. Louis, MO, USA.
St. Louis, S 15th St (Civic center)S 15th St, St. Louis, MO, USA
City-centre transport
Getting to St. Louis, S 15th St (Civic center) from St. Louis city centre
TrainMlb, Mlr · 4m · $4 · every ~14 min
Bus19, 32, 40 · 8m · $1 · every ~9 min
St. Louis, S 15th St (Civic center) bus station facilities and services
St. Louis, S 15th St (Civic center) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at St. Louis, S 15th St (Civic center). ATMs are available at St. Louis, S 15th St (Civic center).
Tickets and information
Ticket office support is available at St. Louis, S 15th St (Civic center).
Parking, taxis and toilets
Available at St. Louis, S 15th St (Civic center): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at St. Louis, S 15th St (Civic center): Wheelchair accessible routes available.
Cheektowaga, BNIA Drway & BNIA Terminal
City-centre transport
Getting to Cheektowaga, BNIA Drway & BNIA Terminal from Buffalo city centre
BusAdt N809 · 10m · $7
24, 78 · 31m · $2 · every ~4 min
24, 78 · 46m · $2 · every ~4 min
Buffalo, NFTA Metro CenterBuffalo, NY, USA
City-centre transport
Getting to Buffalo, NFTA Metro Center from Buffalo city centre
TRUE
Buffalo, NFTA Metro Center bus station facilities and services
Buffalo, NFTA Metro Center has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Free WiFi is available in the station. ATMs are aTM services are available near the entrance.
Tickets and information
Ticket office support is available at Buffalo, NFTA Metro Center.
Parking, taxis and toilets
Available at Buffalo, NFTA Metro Center: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Buffalo, NFTA Metro Center: Accessible for passengers with reduced mobility.
Most popular bus connections from St. Louis, MO
More options for your journey from St. Louis, MO to Buffalo, NY
Here are some other resources that might have the information you need
Most popular buses to and from Buffalo, NY and St. Louis, MO
Most popular bus connections to Buffalo, NY
The Omio App Makes Travel Planning Easy
We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.
