- Must visit
Buffalo AKG Art Museum
Major regional art museum with modern, contemporary, and historic works, plus a growing campus and frequent exhibitions.
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The cheapest and fastest buses from St. Louis, MO to Buffalo, NY
Showing times, prices and bookable tickets for Oct 30
- Cheapest price on Oct 30
- $105
- Average ticket price on Oct 30
- $109
- Fastest journey on Oct 30
- 21 h
- Average journey duration on Oct 30
- 1 d 5 h 16 m
- Buses on Oct 30
- 4
- Distance
- 1063 km
Cheap tickets
The best way to find a cheap bus ticket from St. Louis, MO to Buffalo, NY is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from St. Louis, MO to Buffalo, NY will cost around $109 if you buy it on the day, but the cheapest tickets can be found for only $105.
Fast buses
It's difficult to get from St. Louis, MO to Buffalo, NY without transferring at least once.
FlixBus+
· 10:00 AM 21h00 St. Louis, S 15th St (Civic center) 8:00 AM Buffalo, NFTA Metro Center $105 1 One-way 2 transfers- · ·
2:05 PM 25h40 St. Louis, S 15th St (Civic center) 4:45 PM Buffalo, NFTA Metro Center $106 1 One-way 2 transfers - · +FlixBus
2:00 AM 37h40 St. Louis, S 15th St (Civic center) 4:40 PM Cheektowaga, BNIA Drway & BNIA Terminal $106 1 One-way 2 transfers - +FlixBus
8:45 AM 32h45 St. Louis, S 15th St (Civic center) 6:30 PM Cheektowaga, BNIA Drway & BNIA Terminal $120 1 One-way 1 transfer
- FlixBus+ ·
10:00 AM 21h00 St. Louis, S 15th St (Civic center) 8:00 AM Buffalo, NFTA Metro Center $105 1 One-way 2 transfers - · ·
2:05 PM 25h40 St. Louis, S 15th St (Civic center) 4:45 PM Buffalo, NFTA Metro Center $106 1 One-way 2 transfers - +FlixBus
8:45 AM 32h45 St. Louis, S 15th St (Civic center) 6:30 PM Cheektowaga, BNIA Drway & BNIA Terminal $120 1 One-way 1 transfer - · +FlixBus
2:00 AM 37h40 St. Louis, S 15th St (Civic center) 4:40 PM Cheektowaga, BNIA Drway & BNIA Terminal $106 1 One-way 2 transfers
Journey information
Overview: Bus from St. Louis, MO to Buffalo, NY
USAUSA
Buses from St. Louis, MO to Buffalo, NY run on average 4 times per day, taking around 26h 22m. Cheap bus tickets for this journey start at $78 if you book in advance.
The earliest bus runs at 00:55, the last at 23:20. The fastest bus covers the 660 miles (1063 km) distance in 16h 45m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Plan this route
Journey facts
- Distance660 miles (1063 km)
- Average bus duration26h 22m
- Cheapest ticket price$78
- Buses per day4
- Fastest bus16h 45m
- First bus12:55 AM
- Last bus11:20 PM
- Cheapest MonthAug
- Cheapest DayMon
- High SeasonJul - Sep
- Low SeasonJan - Mar
- Best time to book1 day
Understand & plan this route
Explore this journey
Book with confidence
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Frequently asked questions about your St. Louis, MO to Buffalo, NY trip
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from St. Louis, MO to Buffalo, NY.
Cheap bus tickets from St. Louis, MO to Buffalo, NY can start from as little as $78 when you book in advance. The average bus ticket price for St. Louis, MO to Buffalo, NY is $119 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The earliest bus from St. Louis, MO to Buffalo, NY leaves at 12:55 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from St. Louis, MO to Buffalo, NY leaves at 11:20 PM.
There are 4 buses a day from St. Louis, MO to Buffalo, NY which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
St. Louis, MO to Buffalo, NY Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 02:00AM | Arrival Time 04:40PM | Duration 37h40 | Departure days Fri, Sun | Cheapest price $103 |
Operator Greyhound | Departure Time 08:45AM | Arrival Time 06:30PM | Duration 32h45 | Departure days Everyday | Cheapest price $91 |
Operator Greyhound | Departure Time 10:00AM | Arrival Time 08:00AM | Duration 21h00 | Departure days Mon, Tue, Fri, Sun | Cheapest price $91 |
Operator Greyhound | Departure Time 02:05PM | Arrival Time 04:45PM | Duration 25h40 | Departure days Everyday | Cheapest price $91 |
Live departures
St. Louis, MO to Buffalo, NY bus times
The table below shows live departures for St. Louis, MO to Buffalo, NY buses for tomorrow, Friday, October 30. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| · +FlixBus | 2:00 AM St. Louis, S 15th St (Civic center) | 37h40 | 4:40 PM Cheektowaga, BNIA Drway & BNIA Terminal | 2 transfers | |
| +FlixBus | 8:45 AM St. Louis, S 15th St (Civic center) | 32h45 | 6:30 PM Cheektowaga, BNIA Drway & BNIA Terminal | 1 transfer | |
| FlixBus+ · | 10:00 AM St. Louis, S 15th St (Civic center) | 21h00 | 8:00 AM Buffalo, NFTA Metro Center | 2 transfers | |
| · · | 2:05 PM St. Louis, S 15th St (Civic center) | 25h40 | 4:45 PM Buffalo, NFTA Metro Center | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Why should you book St. Louis, MO to Buffalo, NY buses with Omio?
Greyhound operates all buses services from St. Louis, MO to Buffalo, NY.
Omio is an official ticket reseller for all your travel options from St. Louis, MO to Buffalo, NY.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from St. Louis, MO to Buffalo, NY.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from St. Louis, MO to Buffalo, NY.
Bus companies
Bus companies from St. Louis, MO to Buffalo, NY
Buses from St. Louis, MO to Buffalo, NY with Greyhound. Overnight buses available on this route with Greyhound. Use the details below to compare onboard facilities.
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
16h 45m
Cheapest Greyhound Price
$78
Greyhound frequency
4 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Companies, tickets, and onboard amenities between St. Louis, MO and Buffalo, NY
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
When taking a bus from St. Louis, MO to Buffalo, NY, you can count on Greyhound for the best way to get you to Buffalo, NY. You can also check all possible bus companies who offer a service between St. Louis, MO and Buffalo, NY and compare the amenities they offer before buying a bus ticket.
Yes, the following accessibility options are available when taking the bus from St. Louis, MO to Buffalo, NY:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from St. Louis, MO to Buffalo, NY for bus company Greyhound.
Whether you can cancel your bus ticket from St. Louis, MO to Buffalo, NY depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company {providersWithBike}.
Yes, there is food available to purchase on board the bus from St. Louis, MO to Buffalo, NY.
Yes, the following luggage options are included when booking a bus ticket from St. Louis, MO to Buffalo, NY:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from St. Louis, MO to Buffalo, NY:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from St. Louis, MO to Buffalo, NY.
You can reserve your seat on the bus from St. Louis, MO to Buffalo, NY with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from St. Louis, MO to Buffalo, NY with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from St. Louis, MO to Buffalo, NY with the following bus company: Greyhound.
Complete guide to Buffalo, NY
Things to do in Buffalo, NY
Discover the best of Buffalo, NY — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Buffalo, NY trip today.
- Recommended
Theodore Roosevelt Inaugural National Historic Site
Former presidential inaugural site with exhibits on Theodore Roosevelt, the Pan-American Exposition, and Buffalo politics.
- Recommended
Michigan Street African American Heritage Corridor
Community museum preserving Buffalo’s African American heritage through local history, culture, and rotating exhibitions.
- Must visit
Canalside
Waterfront district with canal history, public art, seasonal events, skating, and frequent family-friendly activities downtown.
- Must visit
Elmwood Village
Lively walkable neighborhood known for boutiques, galleries, architecture, and one of Buffalo’s most popular main streets.
- Must visit
Outer Harbor
Long urban trail and greenway connecting waterfront areas, parks, and neighborhoods for walking, biking, and sightseeing.
Buffalo Wings
Crisp fried chicken wings coated in spicy butter-hot sauce. Created in Buffalo, they are the city’s signature bar food and a must-try local classic.
Beef On Weck
Thin-sliced roast beef on a kummelweck roll topped with coarse salt and caraway, usually dipped in jus. It is a longtime Western New York sandwich staple.
- Gluten-free
Buffalo-Style Bean Soup
Slow-cooked bean soup with ham, tomatoes, and vegetables. It is strongly associated with Buffalo’s old taverns and Friday lunch traditions.
Oliver's Restaurant
Refined fine-dining restaurant known for seasonal New American tasting menus, polished service, and an elegant special-occasion atmosphere.
Schwabl's
Traditional German restaurant celebrated for beef on weck, sausages, and old-world charm. A Buffalo dining landmark with a cozy historic feel.
Duff's Famous Wings
Long-standing wing institution known for crispy, saucy chicken wings in a classic neighborhood bar setting with a devoted local following.
United States dollar ($)
Moderate for U.S. city travel; hotels are often cheaper than NYC, while dining and local transit stay fairly manageable for visitors.
Average meal costs
- Budget
- $10-18 for fast food or casual takeout.
- Mid-range
- $20-40 per person for a mid-range restaurant meal.
- Fine dining
- $60+ per person for upscale dining.
- Coffee
- $3-6 for a coffee or cappuccino.
Tipping culture
Tip 18-20% at restaurants, more for great service. Taxis usually 10-15%. For cafes, round up or add $1 per drink.
Plan your visit to Buffalo, NY
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Buffalo, NY.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Buffalo, NY, travelers should be cautious of pickpocketing and petty theft, especially in crowded areas like downtown and tourist spots. Scams involving overcharging for taxi or rideshare services have been reported, so it's advised to use licensed transportation and confirm fares beforehand. Additionally, travelers should stay aware of their surroundings at night, particularly in less populated neighborhoods, to avoid potential safety risks.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
FAQs: Bus from St. Louis, MO to Buffalo, NY
Find answers to the most common questions about traveling from St. Louis, MO to Buffalo, NY by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Buffalo, NY, this guide helps you travel smarter and with confidence.
It's helpful to compare your options as there are 3 ways to travel between St. Louis, MO and Buffalo, NY including taking a train, bus, and flight.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
popular bus stations
Popular bus stations from St. Louis, MO to Buffalo, NY
Most St. Louis, MO to Buffalo, NY buses use the St. Louis, S 15th St (Civic center) to Cheektowaga, BNIA Drway & BNIA Terminal station pair, with some services arriving at Buffalo, NFTA Metro Center. Use this guide to compare St. Louis, MO and Buffalo, NY bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in St. Louis
Arrival bus stations in Buffalo
Which St. Louis, MO station do buses to Buffalo, NY leave from?
Buses from St. Louis, MO to Buffalo, NY leave from St. Louis, S 15th St (Civic center). The station is 0 miles (1 km) from St. Louis, MO city centre at S 15th St, St. Louis, MO, USA.
St. Louis, S 15th St (Civic center)S 15th St, St. Louis, MO, USA
City-centre transport
Getting to St. Louis, S 15th St (Civic center) from St. Louis city centre
TrainMlb, Mlr · 4m · $4 · every ~14 min
Bus19, 32, 40 · 8m · $2 · every ~9 min
St. Louis, S 15th St (Civic center) bus station facilities and services
St. Louis, S 15th St (Civic center) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at St. Louis, S 15th St (Civic center). ATMs are available at St. Louis, S 15th St (Civic center).
Tickets and information
Ticket office support is available at St. Louis, S 15th St (Civic center).
Parking, taxis and toilets
Available at St. Louis, S 15th St (Civic center): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at St. Louis, S 15th St (Civic center): Wheelchair accessible routes available.
Cheektowaga, BNIA Drway & BNIA Terminal
City-centre transport
Getting to Cheektowaga, BNIA Drway & BNIA Terminal from Buffalo city centre
BusAdt N809 · 10m · $8
24, 78 · 31m · $3 · every ~4 min
24, 78 · 46m · $3 · every ~4 min
Buffalo, NFTA Metro CenterBuffalo, NY, USA
City-centre transport
Getting to Buffalo, NFTA Metro Center from Buffalo city centre
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Buffalo, NFTA Metro Center bus station facilities and services
Buffalo, NFTA Metro Center has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Free WiFi is available in the station. ATMs are aTM services are available near the entrance.
Tickets and information
Ticket office support is available at Buffalo, NFTA Metro Center.
Parking, taxis and toilets
Available at Buffalo, NFTA Metro Center: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Buffalo, NFTA Metro Center: Accessible for passengers with reduced mobility.
Most popular bus connections from St. Louis, MO
Most popular buses to and from Buffalo, NY and St. Louis, MO
Most popular bus connections to Buffalo, NY
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