- Must visit
Buffalo AKG Art Museum
Buffalo’s flagship art museum, known for its strong modern and contemporary collection and major architectural expansion. A top choice for art lovers.
2,000+ travel companies
2,000+ travel companies
Scan to get our free app
Use our app to get live travel updates and book mobile tickets for trains, buses, flights, and ferries.
App Store
4.942K ratings
Google Play
4.6136K reviews
Travel Information
Compare train, bus, and flight for San Diego, CA to Buffalo, NY
Omio recommends booking the train as it is the most popular option from San Diego, CA to Buffalo, NY among Omio's users. If you are prioritising price take the bus with prices starting from $263. For those with little time consider booking a flight which can get you there in 5h 36m. The ticket price range depends on the travel mode: a bus costs an average of $263, and a train costs an average of $551.
Distance: 2183 miles (3514 km)
Compare bus with
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
$275 Average price Cheapest | $1101 Average price | $430 Average price | $512 Average price (fuel + tolls) |
64h 55m Average total duration 64h 25m Onboard + 30m Additional time* | 55h 59m Average total duration 55h 29m Onboard + 30m Additional time* | 8h 36m Average total duration Fastest 5h 36m Onboard + 3h 0m Additional time* | 37h 24m Average total duration (door-to-door) |
 Most popular bus company |  Most popular train company |  Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from San Diego, CA to Buffalo, NY is a bus with an average price of $275 (€225).
This is compared to other travel options from San Diego, CA to Buffalo, NY:
A bus is $155 (€127) less than a flight for this route with tickets for a flight from San Diego, CA to Buffalo, NY costing on average $430 (€352).
A bus is $826 (€676) less than a train for this route with tickets for a train from San Diego, CA to Buffalo, NY costing on average $1101 (€902).
The fastest way to travel from San Diego, CA to Buffalo, NY is by flight with an average journey time of 5h 36m.
Other travel options to Buffalo, NY take longer:
Train takes on average 55h 29m.
Bus takes on average 64h 25m.
It's helpful to compare your options as there are 3 ways to travel between San Diego, CA and Buffalo, NY including taking a train, bus, and flight.
We recommend using the train as it is the most popular way to get from San Diego, CA to Buffalo, NY among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
San Diego, CA to Buffalo, NY Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound Mexico | Departure Time 07:00AM | Arrival Time 10:40PM | Duration 87h40 | Departure days Tue, Thu | Cheapest price $756 |
Operator Greyhound | Departure Time 04:50PM | Arrival Time 12:00PM | Duration 67h10 | Departure days Fri | Cheapest price $263 |
Operator Greyhound Mexico | Departure Time 07:25PM | Arrival Time 10:40PM | Duration 75h15 | Departure days Tue, Thu | Cheapest price $768 |
Operator Greyhound | Departure Time 08:10PM | Arrival Time 08:45PM | Duration 72h35 | Departure days Wed | Cheapest price $287 |
Compare prices and tickets San Diego, CA to Buffalo, NY by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Sat
Jun 20
Jun 20
Sun
Jun 21
Jun 21
Mon
Jun 22
Jun 22
Tue
Jun 23
Jun 23
Wed
Jun 24
Jun 24
Thu
Jun 25
Jun 25
Fri
Jun 26
Jun 26
Why should you book San Diego, CA to Buffalo, NY buses with Omio?
Greyhound operates all buses services from San Diego, CA to Buffalo, NY.
Omio is an official ticket reseller for all your travel options from San Diego, CA to Buffalo, NY.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from San Diego, CA to Buffalo, NY.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from San Diego, CA to Buffalo, NY.
Journey information
Overview: Bus from San Diego, CA to Buffalo, NY
USAUSA
Buses from San Diego, CA to Buffalo, NY run on average 9 times per day, taking around 64h 25m. Cheap bus tickets for this journey start at $263 (€216) if you book in advance.
The earliest bus runs at 00:55, the last at 23:20. The fastest bus covers the 2183 miles (3514 km) distance in 67h 10m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 2183 miles (3514 km) |
Average bus duration 64h 25m |
Cheapest ticket price $263 (€216) |
Buses per day 9 |
Fastest bus 67h 10m |
First bus 12:55 AM |
Last bus 11:20 PM |
Cheapest Month Apr |
Cheapest Day Wed |
High Season Jan - Mar |
Low Season Jul - Sep |
Best time to book 28 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound from San Diego, CA to Buffalo, NYYou can travel by bus between San Diego, CA to Buffalo, NY with Greyhound for as low as $263 (€216). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
67h 10m
Cheapest Price
$263 (€216)
Greyhound frequency
10 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Buffalo
Things to do in Buffalo
Discover the best of Buffalo — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Buffalo trip today.
- Must visit
Frank Lloyd Wright’s Martin House
An important architectural museum complex and one of Frank Lloyd Wright’s masterpieces, offering deep insight into Prairie School design.
- Recommended
The Buffalo History Museum
A regional history museum in a landmark 1901 Pan-American Exposition building, with exhibits on Buffalo, Erie County, and Western New York.
- Must visit
Canalside
Buffalo’s revitalized waterfront district, popular for boardwalk walks, harbor views, events, and social-media-friendly public spaces.
- Must visit
Delaware Park
A major Frederick Law Olmsted-designed park with scenic roads, the lake, gardens, and cultural institutions nearby. Ideal for walking and relaxing.
- Recommended
Elmwood Village
One of Buffalo’s best-known neighborhoods for strolling, lined with historic homes, local shops, and a lively but relaxed urban atmosphere.
Buffalo Wings
Crispy chicken wings tossed in a buttery cayenne hot sauce, traditionally served with celery and blue cheese. Buffalo’s signature dish originated here and is the city’s must-try food.
Beef on Weck
Thin-sliced roast beef on a kummelweck roll topped with coarse salt and caraway seeds, usually served with horseradish and au jus. It is a classic Western New York sandwich strongly associated with BU
- Vegetarian
- Gluten-free
Sponge Candy
A regional confection made from airy honeycomb toffee coated in chocolate. Buffalo is especially known for it, and local chocolatiers have made it a beloved traditional sweet.
The Left Bank
A long-running bistro on the West Side with a more refined atmosphere, known for consistently good American and European-inspired dishes. A solid option beyond tavern fare.
Schwabl's
A classic Buffalo restaurant renowned for beef on weck, old-school service, and a traditional dining room atmosphere. One of the best-known places to try this regional specialty.
Gabriel's Gate
A beloved neighborhood tavern in a historic building, known for wings, hearty pub food, and a warm local atmosphere. Popular with both residents and visitors.
United States Dollar
Moderate by U.S. standards. Hotels vary by season, while casual dining, coffee, and local transport are fairly affordable.
Average meal costs
- Budget
- USD 10-18 for fast food or a simple lunch.
- Mid-range
- USD 20-40 per person at a mid-range restaurant.
- Fine dining
- USD 60+ per person at upscale restaurants.
- Coffee
- USD 3-6 for a regular coffee or latte.
Tipping culture
Tip 18-20% at restaurants if service is not included; 15-20% for taxis and rideshares. USD 1-2 per drink at bars, USD 1-2 per bag for hotel porters, and a few dollars daily for housekeeping.
FAQs: Bus from San Diego, CA to Buffalo, NY
Find answers to the most common questions about traveling from San Diego, CA to Buffalo, NY by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Buffalo, NY, this guide helps you travel smarter and with confidence.
Cheap bus tickets from San Diego, CA to Buffalo, NY can start from as little as $263 (€216) when you book in advance. The average bus ticket price for San Diego, CA to Buffalo, NY is $275 (€225) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from San Diego, CA to Buffalo, NY is 67h 10m to travel the 2183 miles (3514 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from San Diego, CA to Buffalo, NY leaves at 12:55 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from San Diego, CA to Buffalo, NY leaves at 11:20 PM.
There are 9 buses a day from San Diego, CA to Buffalo, NY which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from San Diego, CA to Buffalo, NY, you can count on Greyhound for the best way to get you to Buffalo, NY. You can also check all possible bus companies who offer a service between San Diego, CA and Buffalo, NY and compare the amenities they offer before buying a bus ticket.
A trip to Buffalo, NY from San Diego, CA is worth doing but not as a day trip with a journey time of 67h 10m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from San Diego, CA to Buffalo, NY is April.
It's helpful to compare your options as there are 3 ways to travel between San Diego, CA and Buffalo, NY including taking a train, bus, and flight.
Yes, the following accessibility options are available when taking the bus from San Diego, CA to Buffalo, NY:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from San Diego, CA to Buffalo, NY for bus company Greyhound.
Whether you can cancel your bus ticket from San Diego, CA to Buffalo, NY depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from San Diego, CA to Buffalo, NY.
Yes, the following luggage options are included when booking a bus ticket from San Diego, CA to Buffalo, NY:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from San Diego, CA to Buffalo, NY:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from San Diego, CA to Buffalo, NY.
You can reserve your seat on the bus from San Diego, CA to Buffalo, NY with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from San Diego, CA to Buffalo, NY with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from San Diego, CA to Buffalo, NY with the following bus company: Greyhound.
Since neither San Diego, CA nor Buffalo, NY are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the train as it is the most popular way to get from San Diego, CA to Buffalo, NY among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Buffalo, NY, travelers should be cautious of pickpocketing and petty theft, especially in crowded areas like downtown and tourist spots. Scams involving overcharging for taxi or rideshare services have been reported, so it's advised to use licensed transportation and confirm fares beforehand. Additionally, travelers should stay aware of their surroundings at night, particularly in less populated neighborhoods, to avoid potential safety risks.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from San Diego, CA to Buffalo, NY
San Diego
Buffalo
The major bus station for departures in San Diego is San Diego, Congress Street (Old Town Park). Find all the information you need to know about services, amenities and connections at San Diego, Congress Street (Old Town Park) for your trip from San Diego to Buffalo.
San Diego, Congress Street (Old Town Park)
information
San Diego, San Ysidro Transit Center
information
San Diego, West Harbor Drive (The Headquarters at Seaport District)
information
The major bus station for arrivals in Buffalo is Cheektowaga, BNIA Drway & BNIA Terminal. Find all the information you need to know about services, amenities and connections at Cheektowaga, BNIA Drway & BNIA Terminal for your trip to Buffalo from San Diego.
Cheektowaga, BNIA Drway & BNIA Terminal
information
Buffalo, NFTA Metro Center
information
More options for your journey from San Diego, CA to Buffalo, NY
Here are some other resources that might have the information you need
Most popular buses to and from Buffalo, NY and San Diego, CA
The Omio App Makes Travel Planning Easy
We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.
