- Must visit
Saint Louis Art Museum
Vast art museum in Forest Park with global collections from antiquity to modern works and strong free general admission.
2,000+ travel companies
2,000+ travel companies
Scan to get our free app
Use our app to get live travel updates and book mobile tickets for trains, buses, flights, and ferries.
App Store
4.942K ratings
Google Play
4.6136K reviews
The cheapest and fastest buses from Milwaukee, WI to St. Louis, MO
Showing times and prices for Jul 22
Cheapest price
$53
Average price
$60
Fastest journey
9 h 10 m
Average duration
12 h 39 m
Buses per day
5
Distance
527 km
Cheap tickets
The best way to find a cheap bus ticket from Milwaukee, WI to St. Louis, MO is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Milwaukee, WI to St. Louis, MO will cost around $60 if you buy it on the day, but the cheapest tickets can be found for only $53.
Fast buses
It's difficult to get from Milwaukee, WI to St. Louis, MO without transferring at least once.
FlixBus+
· 9:20 AM13h55Milwaukee, General Mitchell International Airport (Wisconsin Coach ORD-MKE Bus Stop), WI11:15 PMSt. Louis, S 15th St (Civic center)$531One-way2 transfers- FlixBus+ · 9:00 AM14h15Milwaukee, Intermodal Station11:15 PMSt. Louis, S 15th St (Civic center)$531One-way2 transfers
- FlixBus+8:35 PM9h50Milwaukee, Intermodal Station6:25 AMSt. Louis, S 15th St (Civic center)$531One-way1 transfer
- FlixBus+ · 3:40 PM16h05Milwaukee, General Mitchell International Airport (Wisconsin Coach ORD-MKE Bus Stop), WI7:45 AMSt. Louis, S 15th St (Civic center)$641One-way2 transfers
- FlixBus+6:30 AM9h10Milwaukee, Intermodal Station3:40 PMSt. Louis, S 15th St (Civic center)$791One-way1 transfer
- FlixBus+6:30 AM9h10Milwaukee, Intermodal Station3:40 PMSt. Louis, S 15th St (Civic center)$791One-way1 transfer
- FlixBus+8:35 PM9h50Milwaukee, Intermodal Station6:25 AMSt. Louis, S 15th St (Civic center)$531One-way1 transfer
- FlixBus+ · 9:20 AM13h55Milwaukee, General Mitchell International Airport (Wisconsin Coach ORD-MKE Bus Stop), WI11:15 PMSt. Louis, S 15th St (Civic center)$531One-way2 transfers
- FlixBus+ · 9:00 AM14h15Milwaukee, Intermodal Station11:15 PMSt. Louis, S 15th St (Civic center)$531One-way2 transfers
- FlixBus+ · 3:40 PM16h05Milwaukee, General Mitchell International Airport (Wisconsin Coach ORD-MKE Bus Stop), WI7:45 AMSt. Louis, S 15th St (Civic center)$641One-way2 transfers
Travel Information
Compare train, bus, and flight for Milwaukee, WI to St. Louis, MO
Omio recommends booking the train as it is the most popular option from Milwaukee, WI to St. Louis, MO among Omio's users. If you are prioritising price take the bus with prices starting from $42. For those with little time consider booking a flight which can get you there in 4h 58m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.2 - 0.5kg. The ticket price range depends on the travel mode: a bus costs an average of $42, and a flight costs an average of $97.
Distance: 327 miles (527 km)
Compare bus with
| Bus | Most popular Train | Flight |
|---|---|---|
$81 Average price Cheapest | $86 Average price | $279 Average price |
9h 20m Average total duration 8h 50m Onboard + 30m Additional time* | 7h 5m Average total duration 6h 35m Onboard + 30m Additional time* | 7h 58m Average total duration Fastest 4h 58m Onboard + 3h 0m Additional time* |
0.5 - 1.3kg CO2 emissions | 0.2 - 0.5kg CO2 emissions Lowest | 1.6 - 3.2kg CO2 emissions |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
The cheapest way to travel from Milwaukee, WI to St. Louis, MO is a bus with an average price of $81 (€67).
This is compared to other travel options from Milwaukee, WI to St. Louis, MO:
A bus is $5 (€4) less than a train for this route with tickets for a train from Milwaukee, WI to St. Louis, MO costing on average $86 (€71).
A bus is $198 (€163) less than a flight for this route with tickets for a flight from Milwaukee, WI to St. Louis, MO costing on average $279 (€229).
The fastest way to travel from Milwaukee, WI to St. Louis, MO is by flight with an average journey time of 4h 58m.
Other travel options to St. Louis, MO take longer:
Train takes on average 6h 35m.
Bus takes on average 8h 50m.
It's helpful to compare your options as there are 3 ways to travel between Milwaukee, WI and St. Louis, MO including taking a train, bus, and flight.
We recommend using the train as it is the most popular way to get from Milwaukee, WI to St. Louis, MO among Omio's users.
Milwaukee, WI to St. Louis, MO Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 06:30AM | Arrival Time 03:40PM | Duration 9h10 | Departure days Everyday | Cheapest price $72 |
Operator Greyhound | Departure Time 09:00AM | Arrival Time 11:15PM | Duration 14h15 | Departure days Wed, Thu | Cheapest price $53 |
Operator Greyhound | Departure Time 09:20AM | Arrival Time 11:15PM | Duration 13h55 | Departure days Wed, Thu | Cheapest price $53 |
Operator Greyhound | Departure Time 11:50AM | Arrival Time 11:15PM | Duration 11h25 | Departure days Mon, Tue, Fri, Sat, Sun | Cheapest price $51 |
Operator Greyhound | Departure Time 12:10PM | Arrival Time 11:15PM | Duration 11h05 | Departure days Mon, Tue, Fri, Sat, Sun | Cheapest price $52 |
Operator Greyhound | Departure Time 03:40PM | Arrival Time 07:45AM | Duration 16h05 | Departure days Everyday | Cheapest price $56 |
Operator FlixBus | Departure Time 07:55PM | Arrival Time 06:25AM | Duration 10h30 | Departure days Sun | Cheapest price $65 |
Operator FlixBus | Departure Time 08:35PM | Arrival Time 06:25AM | Duration 9h50 | Departure days Mon, Tue, Wed, Thu, Fri, Sat | Cheapest price $51 |
Live departures
Milwaukee, WI to St. Louis, MO bus times
The table below shows live departures for Milwaukee, WI to St. Louis, MO buses for today, Tuesday, July 21. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| +FlixBus | 6:30 AM Milwaukee, Intermodal Station | 9h10 | 3:40 PM St. Louis, S 15th St (Civic center) | 1 transfer | |
| FlixBus+ · | 11:50 AM Milwaukee, Intermodal Station | 11h25 | 11:15 PM St. Louis, S 15th St (Civic center) | 2 transfers | |
| FlixBus+ · | 12:10 PM Milwaukee, General Mitchell International Airport (Wisconsin Coach ORD-MKE Bus Stop), WI | 11h05 | 11:15 PM St. Louis, S 15th St (Civic center) | 2 transfers | |
| FlixBus+ · | 3:40 PM Milwaukee, General Mitchell International Airport (Wisconsin Coach ORD-MKE Bus Stop), WI | 16h05 | 7:45 AM St. Louis, S 15th St (Civic center) | 2 transfers | |
| +FlixBus | 8:35 PM Milwaukee, Intermodal Station | 9h50 | 6:25 AM St. Louis, S 15th St (Civic center) | 1 transfer |
Find all the dates and times for this journey
Compare prices and tickets Milwaukee, WI to St. Louis, MO by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Wed
Jul 22
Jul 22
Thu
Jul 23
Jul 23
Fri
Jul 24
Jul 24
Sat
Jul 25
Jul 25
Sun
Jul 26
Jul 26
Mon
Jul 27
Jul 27
Tue
Jul 28
Jul 28
Why should you book Milwaukee, WI to St. Louis, MO buses with Omio?
Greyhound as well as FlixBus offer buses services from Milwaukee, WI to St. Louis, MO.
Omio is an official ticket reseller for all your travel options from Milwaukee, WI to St. Louis, MO.
Why book with Omio vs Greyhound?
- Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of FlixBus to find the best option for your trip from Milwaukee, WI to St. Louis, MO.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Milwaukee, WI to St. Louis, MO.
Why book with Omio over Wanderu or Trainline?
- Compare with other providers: On Omio, you can also compare tickets for the likes of FlixBus to find the best option for your trip from Milwaukee, WI to St. Louis, MO.
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Milwaukee, WI to St. Louis, MO.
Journey information
Overview: Bus from Milwaukee, WI to St. Louis, MO
USAUSA
Buses from Milwaukee, WI to St. Louis, MO run on average 6 times per day, taking around 8h 50m. Cheap bus tickets for this journey start at $42 (€34) if you book in advance.
The earliest bus runs at 01:55, the last at 23:30. The fastest bus covers the 327 miles (527 km) distance in 9h 10m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 327 miles (527 km) |
Average bus duration 8h 50m |
Cheapest ticket price $42 (€34) |
Buses per day 6 |
Fastest bus 9h 10m |
First bus 1:55 AM |
Last bus 11:30 PM |
Cheapest Month Jul |
Cheapest Day Wed |
High Season Jan - Mar |
Low Season Apr - Jun |
Busiest Day Sat |
Least Busy Day Wed |
Best time to book 4 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound, FlixBus from Milwaukee, WI to St. Louis, MOYou can travel by bus between Milwaukee, WI to St. Louis, MO with Greyhound, FlixBus for as low as $42 (€34). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average Duration
9h 10m
Cheapest Price
$42 (€34)
FlixBus frequency
4 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
11h 15m
Cheapest Price
$56 (€46)
Greyhound frequency
2 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to St. Louis, MO
Things to do in St. Louis, MO
Discover the best of St. Louis, MO — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect St. Louis, MO trip today.
- Recommended
Missouri History Museum
Leading history museum covering St. Louis, Missouri, and national stories through rotating exhibitions in Forest Park.
- Recommended
Saint Louis Science Center
Interactive science museum with hands-on exhibits, planetarium, and family-friendly displays near Forest Park.
- Must visit
Gateway Arch National Park Grounds
Lively downtown riverfront district with trails, views of the Arch, public art, and access to major historic sites.
- Must visit
Forest Park
Large urban park with trails, lakes, zoo access, and major museums, ideal for walking between top attractions.
- Recommended
Tower Grove Park
Beloved neighborhood park with formal lily ponds, pavilions, and one of the city's most photographed landscapes.
- Vegetarian
St. Louis-Style Pizza
A thin, cracker-like crust pizza cut into squares and topped with Provel cheese, a St. Louis original loved for its distinct texture and tangy flavor.
- Vegetarian
Toasted Ravioli
Crisp, breaded ravioli said to be born on The Hill, usually served with marinara. It is a signature St. Louis Italian-American appetizer.
- Vegetarian
Gooey Butter Cake
Sticky butter cake with a dense base and gooey sweet top. A longtime St. Louis bakery favorite often enjoyed for breakfast or dessert.
Bulrush
Refined contemporary restaurant with tasting menus and strong national acclaim. Elegant fine dining focused on seasonal Midwestern ingredients.
Ted Drewes Frozen Custard
Beloved frozen custard stand serving concretes and sundaes since 1929. Casual, nostalgic, and one of the city's iconic dessert stops.
Pappy's Smokehouse
Popular smokehouse known for St. Louis barbecue, especially ribs, brisket, and pork steak, in a polished but relaxed atmosphere.
United States dollar ($)
Moderate for U.S. city breaks: hotels and dining are reasonable, transit is limited, and attractions often cost less than in larger U.S. tourist cities.
Average meal costs
- Budget
- $10-15 for fast food or casual lunch.
- Mid-range
- $20-35 per person for a mid-range restaurant meal.
- Fine dining
- $60+ per person at upscale restaurants.
- Coffee
- $3-5 for coffee or cappuccino.
Tipping culture
Tip 18-20% at restaurants, $1-2 per drink at bars, and 10-15% for taxis. Cafes often have tip jars or screen prompts.
FAQs: Bus from Milwaukee, WI to St. Louis, MO
Find answers to the most common questions about traveling from Milwaukee, WI to St. Louis, MO by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at St. Louis, MO, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Milwaukee, WI to St. Louis, MO can start from as little as $42 (€34) when you book in advance. The average bus ticket price for Milwaukee, WI to St. Louis, MO is $81 (€67) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Milwaukee, WI to St. Louis, MO is 9h 10m to travel the 327 miles (527 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Milwaukee, WI to St. Louis, MO leaves at 1:55 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Milwaukee, WI to St. Louis, MO leaves at 11:30 PM.
There are 6 buses a day from Milwaukee, WI to St. Louis, MO which require at least one change with Greyhound, FlixBus. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Milwaukee, WI to St. Louis, MO, you can count on Greyhound, FlixBus for the best way to get you to St. Louis, MO. You can also check all possible bus companies who offer a service between Milwaukee, WI and St. Louis, MO and compare the amenities they offer before buying a bus ticket.
A trip to St. Louis, MO from Milwaukee, WI is worth doing but not as a day trip with a journey time of 9h 10m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Milwaukee, WI to St. Louis, MO is July.
It's helpful to compare your options as there are 3 ways to travel between Milwaukee, WI and St. Louis, MO including taking a train, bus, and flight.
Yes, the following accessibility options are available when taking the bus from Milwaukee, WI to St. Louis, MO:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Milwaukee, WI to St. Louis, MO for bus company Greyhound, FlixBus.
Whether you can cancel your bus ticket from Milwaukee, WI to St. Louis, MO depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company Greyhound, FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Milwaukee, WI to St. Louis, MO.
Yes, the following luggage options are included when booking a bus ticket from Milwaukee, WI to St. Louis, MO:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Milwaukee, WI to St. Louis, MO:
- Greyhound
- $15 per additional bag.
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Milwaukee, WI to St. Louis, MO. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from Milwaukee, WI to St. Louis, MO with the following bus company: Greyhound, FlixBus
Yes, there are USB plugs on board the bus from Milwaukee, WI to St. Louis, MO with the following bus company: Greyhound, FlixBus.
Yes, there is Wifi on board the bus from Milwaukee, WI to St. Louis, MO with the following bus company: Greyhound, FlixBus.
Since neither Milwaukee, WI nor St. Louis, MO are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the train as it is the most popular way to get from Milwaukee, WI to St. Louis, MO among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In St. Louis, MO, travelers should be cautious in certain neighborhoods with higher crime rates, especially after dark. Common safety concerns include petty theft, pickpocketing, and occasional scams targeting visitors near popular attractions like the Gateway Arch. It’s advisable to stay in well-populated areas, avoid displaying valuables openly, and use reputable transportation services to minimize risks.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Milwaukee, WI to St. Louis, MO
Most Milwaukee, WI to St. Louis, MO buses use the Milwaukee, Intermodal Station to St. Louis, S 15th St (Civic center) station pair. Use this guide to compare Milwaukee, WI and St. Louis, MO bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Milwaukee
Arrival bus stations in St. Louis
Milwaukee, Intermodal Station
City-centre transport
Getting to Milwaukee, Intermodal Station from Milwaukee city centre
Bus57 · 4m · $5 · every ~4 min
Wisconsin Coach Lines · 6m · $4
Milwaukee, General Mitchell International Airport (Wisconsin Coach ORD-MKE Bus Stop)
City-centre transport
Getting to Milwaukee, General Mitchell International Airport (Wisconsin Coach ORD-MKE Bus Stop) from Milwaukee city centre
BusWisconsin Coach Lines · 10m · $6
Gre · 19m · $4 · every ~8 min
Gre · 27m · $4 · every ~8 min
Gre · 29m · $4 · every ~8 min
St. Louis, S 15th St (Civic center)
City-centre transport
Getting to St. Louis, S 15th St (Civic center) from St. Louis city centre
TrainMlb, Mlr · 4m · $4 · every ~14 min
Bus19, 32, 40 · 8m · $1 · every ~9 min
Most popular bus connections from Milwaukee, WI
More options for your journey from Milwaukee, WI to St. Louis, MO
Here are some other resources that might have the information you need
Most popular buses to and from St. Louis, MO and Milwaukee, WI
Most popular bus connections to St. Louis, MO
The Omio App Makes Travel Planning Easy
We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.
