- Must visit
Saint Louis Art Museum
Vast art museum in Forest Park with global collections from antiquity to modern works and strong free general admission.
Cheapest price
zł216
Average price
zł255
Fastest journey
5 h 55 m
Average duration
7 h 4 m
Buses per day
6
Distance
419 km
The best way to find a cheap bus ticket from Chicago, IL to St. Louis, MO is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Chicago, IL to St. Louis, MO will cost around zł255 if you buy it on the day, but the cheapest tickets can be found for only zł216.
Of the 6 buses that leave Chicago, IL for St. Louis, MO on Mon, Aug 24, 3 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Mon, Aug 24 the direct buses cover the 419 km distance in an average of 7 h 4 m but if you time it right, some buses will get you there in just 5 h 55 m .
On Mon, Aug 24 the slowest buses will take 8 h 35 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
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· Omio recommends booking the train as it is the most popular option from Chicago, IL to St. Louis, MO among Omio's users. If you are prioritising price take the train with prices starting from zł110. For those with little time consider booking a flight which can get you there in 1h 22m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.1 - 0.4kg. The ticket price range depends on the travel mode: a train costs an average of zł110, and a flight costs an average of zł228.
Distance: 260 miles (419 km)
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
zł210 Average price | zł193 Average price Cheapest | zł1018 Average price | zł228 Average price (fuel + tolls) |
7h 3m Average total duration 6h 33m Onboard + 30m Additional time* | 5h 30m Average total duration 5h 0m Onboard + 30m Additional time* | 4h 22m Average total duration Fastest 1h 22m Onboard + 3h 0m Additional time* | 4h 11m Average total duration (door-to-door) |
0.4 - 1.0kg CO2 emissions | 0.1 - 0.4kg CO2 emissions Lowest | 1.3 - 2.5kg CO2 emissions | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Chicago, IL to St. Louis, MO:
A train is zł17 less than a bus for this route with tickets for a bus from Chicago, IL to St. Louis, MO costing on average zł210.
A train is zł824 less than a flight for this route with tickets for a flight from Chicago, IL to St. Louis, MO costing on average zł1018.
Other travel options to St. Louis, MO take longer:
Train takes on average 5h 0m.
Bus takes on average 6h 33m.
Tickets start at around zł210 compared to roughly zł228 in fuel and tolls — a saving of about zł18. The journey takes 6h 33m versus 4h 11m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by FlixBus, Greyhound.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 12:15AM | Arrival Time 06:20AM | Duration 6h05 | Departure days Everyday | Cheapest price zł172 |
Operator FlixBus | Departure Time 09:45AM | Arrival Time 03:40PM | Duration 5h55 | Departure days Everyday | Cheapest price zł180 |
Operator Greyhound | Departure Time 02:45PM | Arrival Time 11:15PM | Duration 8h30 | Departure days Everyday | Cheapest price zł222 |
Operator FlixBus | Departure Time 05:05PM | Arrival Time 11:20PM | Duration 6h15 | Departure days Everyday | Cheapest price zł172 |
Operator Greyhound | Departure Time 10:50PM | Arrival Time 07:45AM | Duration 8h55 | Departure days Everyday | Cheapest price zł228 |
Operator Greyhound | Departure Time 11:10PM | Arrival Time 07:45AM | Duration 8h35 | Departure days Everyday | Cheapest price zł228 |
The table below shows live departures for Chicago, IL to St. Louis, MO buses for today, Sunday, August 23. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus | 5:05 PM Chicago, Greyhound Bus Station | 6h15 | 11:20 PM St. Louis, S 15th St (Civic center) | 0 transfersDirect | |
· | 10:50 PM Chicago, Greyhound Bus Station | 8h55 | 7:45 AM St. Louis, S 15th St (Civic center) | 1 transfer | |
· | 11:10 PM Chicago, Union Station (Amtrak), IL | 8h35 | 7:45 AM St. Louis, S 15th St (Civic center) | 1 transfer | |
| Monday, August 24 | |||||
FlixBus | 12:15 AM Chicago, Greyhound Bus Station | 6h05 | 6:20 AM St. Louis, S 15th St (Civic center) | 0 transfersDirect | |
FlixBus | 9:45 AM Chicago, Greyhound Bus Station | 5h55 | 3:40 PM St. Louis, S 15th St (Civic center) | 0 transfersDirect | |
· | 2:45 PM Chicago, Greyhound Bus Station | 8h30 | 11:15 PM St. Louis, S 15th St (Civic center) | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Chicago, IL to St. Louis, MO run on average 5 times per day, taking around 6h 33m. Cheap bus tickets for this journey start at zł147 but you can travel from only zł110 by train.
There are 2 buses per day. The earliest bus runs at 00:15, the last at 23:45. The fastest bus covers the 260 miles (419 km) distance in 5h 55m.
Distance 260 miles (419 km) |
Average bus duration 6h 33m |
Cheapest ticket price zł147 |
Buses per day 5 |
Direct buses 2 |
Fastest bus 5h 55m |
First bus 12:15 AM |
Last bus 11:45 PM |
Cheapest Month May |
Cheapest Day Sat |
High Season Jul - Sep |
Low Season Oct - Dec |
Busiest Day Fri |
Least Busy Day Tue |
Best time to book 42 days |
Discover the best of St. Louis, MO — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect St. Louis, MO trip today.
Vast art museum in Forest Park with global collections from antiquity to modern works and strong free general admission.
Leading history museum covering St. Louis, Missouri, and national stories through rotating exhibitions in Forest Park.
Interactive science museum with hands-on exhibits, planetarium, and family-friendly displays near Forest Park.
Lively downtown riverfront district with trails, views of the Arch, public art, and access to major historic sites.
Large urban park with trails, lakes, zoo access, and major museums, ideal for walking between top attractions.
Beloved neighborhood park with formal lily ponds, pavilions, and one of the city's most photographed landscapes.
A thin, cracker-like crust pizza cut into squares and topped with Provel cheese, a St. Louis original loved for its distinct texture and tangy flavor.
Crisp, breaded ravioli said to be born on The Hill, usually served with marinara. It is a signature St. Louis Italian-American appetizer.
Sticky butter cake with a dense base and gooey sweet top. A longtime St. Louis bakery favorite often enjoyed for breakfast or dessert.
Refined contemporary restaurant with tasting menus and strong national acclaim. Elegant fine dining focused on seasonal Midwestern ingredients.
Beloved frozen custard stand serving concretes and sundaes since 1929. Casual, nostalgic, and one of the city's iconic dessert stops.
Popular smokehouse known for St. Louis barbecue, especially ribs, brisket, and pork steak, in a polished but relaxed atmosphere.
Moderate for U.S. city breaks: hotels and dining are reasonable, transit is limited, and attractions often cost less than in larger U.S. tourist cities.
Tip 18-20% at restaurants, $1-2 per drink at bars, and 10-15% for taxis. Cafes often have tip jars or screen prompts.
Find answers to the most common questions about traveling from Chicago, IL to St. Louis, MO by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at St. Louis, MO, this guide helps you travel smarter and with confidence.

Most Chicago, IL to St. Louis, MO buses use the Chicago, Greyhound Bus Station to St. Louis, S 15th St (Civic center) station pair. Use this guide to compare Chicago, IL and St. Louis, MO bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Chicago, Greyhound Bus Station is 2 km from Chicago city centre. Public transport options include:
Chicago, Greyhound Bus Station has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Snack shop and vending machines available
Free Wi-Fi in waiting area. ATMs are located near entrance.
Ticket office support is available at Chicago, Greyhound Bus Station.
Available at Chicago, Greyhound Bus Station: Parking, Taxis, WC.
Accessibility facilities are available at Chicago, Greyhound Bus Station: Wheelchair accessible entrances and seating.
Chicago, Union Station (Amtrak) is 3 km from Chicago city centre. Public transport options include:
Chicago, Union Station (Amtrak) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Multiple dining options are available inside the station.
Free Wi-Fi is available in waiting areas. ATMs are aTMs are located near the main entrance.
Ticket office support is available at Chicago, Union Station (Amtrak).
Available at Chicago, Union Station (Amtrak): Parking, Taxis, WC.
Accessibility facilities are available at Chicago, Union Station (Amtrak): Station is accessible with elevators and ramps.
Chicago, 95th Red Line Station is 14 km from Chicago city centre. Public transport options include:
Chicago, 95th Red Line Station has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Chicago, 95th Red Line Station. ATMs are available at Chicago, 95th Red Line Station.
Ticket office support is available at Chicago, 95th Red Line Station.
Available at Chicago, 95th Red Line Station: Parking, Taxis, WC.
Accessibility facilities are available at Chicago, 95th Red Line Station: Wheelchair accessible entrances available.
St. Louis, S 15th St (Civic center) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at St. Louis, S 15th St (Civic center). ATMs are available at St. Louis, S 15th St (Civic center).
Ticket office support is available at St. Louis, S 15th St (Civic center).
Available at St. Louis, S 15th St (Civic center): Parking, Taxis, WC.
Accessibility facilities are available at St. Louis, S 15th St (Civic center): Wheelchair accessible routes available.
Here are some other resources that might have the information you need