The cheapest and fastest buses from Philadelphia, PA to St. Louis, MO
Cheapest price
$146
Average price
$146
Fastest journey
20 h 45 m
Average duration
20 h 45 m
Buses per day
1
Distance
1301 km
The best way to find a cheap bus ticket from Philadelphia, PA to St. Louis, MO is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Philadelphia, PA to St. Louis, MO will cost around $146 if you buy it on the day, but the cheapest tickets can be found for only $146.
Of the 1 buses that leave Philadelphia, PA for St. Louis, MO on Wed, Dec 10, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Wed, Dec 10 the direct buses cover the 1301 km distance in an average of 20 h 45 m but if you time it right, some buses will get you there in just 20 h 45 m .
On Wed, Dec 10 the slowest buses will take 20 h 45 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.


Travel Information
Compare bus, train, and flight for Philadelphia, PA to St. Louis, MO
Omio recommends booking the train as it is the most popular option from Philadelphia, PA to St. Louis, MO among Omio's users. If you are prioritising price take the bus with prices starting from €60. For those with little time consider booking a flight which can get you there in 2h 23m. The ticket price range depends on the travel mode: a bus costs an average of €60, and a flight costs an average of €85.
Distance: 808 miles (1301 km)
Compare bus with
| Bus | Most popular Train | Flight |
|---|---|---|
€104 Average price Cheapest | €234 Average price | €253 Average price |
21h 20m Average total duration 20h 50m Onboard + 30m Additional time* | 26h 39m Average total duration 26h 9m Onboard + 30m Additional time* | 5h 23m Average total duration Fastest 2h 23m Onboard + 3h 0m Additional time* |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline |
Direct Options | Direct Options | Direct Options |
Philadelphia, PA to St. Louis, MO Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 02:00AM | Arrival Time 07:55AM | Duration 30h55 | Departure days Mon | Cheapest price $130 |
Operator Greyhound | Departure Time 03:55AM | Arrival Time 11:25PM | Duration 20h30 | Departure days Mon | Cheapest price $150 |
Operator Greyhound | Departure Time 08:30AM | Arrival Time 07:55AM | Duration 24h25 | Departure days Mon | Cheapest price $129 |
Operator Greyhound | Departure Time 12:05PM | Arrival Time 07:55AM | Duration 20h50 | Departure days Mon | Cheapest price $104 |
Operator Greyhound | Departure Time 01:45PM | Arrival Time 03:20PM | Duration 26h35 | Departure days Mon | Cheapest price $126 |
Operator Greyhound | Departure Time 02:00PM | Arrival Time 03:20PM | Duration 26h20 | Departure days Mon | Cheapest price $126 |
Operator Greyhound | Departure Time 05:30PM | Arrival Time 03:20PM | Duration 22h50 | Departure days Mon | Cheapest price $102 |
Operator Greyhound | Departure Time 08:00PM | Arrival Time 11:25PM | Duration 28h25 | Departure days Mon | Cheapest price $152 |
Operator Greyhound | Departure Time 08:30PM | Arrival Time 11:25PM | Duration 27h55 | Departure days Mon | Cheapest price $155 |
Operator Greyhound | Departure Time 10:00PM | Arrival Time 11:25PM | Duration 26h25 | Departure days Mon | Cheapest price $152 |
Live departures
Philadelphia, PA to St. Louis, MO bus times
The table below shows live departures for Philadelphia, PA to St. Louis, MO buses for today, Tuesday, December 9. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 9:05 AM Philadelphia, PA | 29h20 | 2:25 PM St. Louis, MO | 0 transfersDirect | |
![]() | 2:40 PM Philadelphia, PA | 20h45 | 11:25 AM St. Louis, MO | 0 transfersDirect | |
![]() | 10:30 PM Philadelphia, PA | 27h55 | 2:25 AM St. Louis, MO | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Philadelphia, PA to St. Louis, MO by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Dec 16
Journey information
Overview: Bus from Philadelphia, PA to St. Louis, MO
Buses from Philadelphia, PA to St. Louis, MO run on average 11 times per day, taking around 20h 50m. Cheap bus tickets for this journey start at $75 (€60) if you book in advance.
There are 2 buses per day. The earliest bus runs at 00:50, the last at 23:30. The fastest bus covers the 808 miles (1301 km) distance in 20h 45m.
Distance 808 miles (1301 km) |
Average bus duration 20h 50m |
Cheapest ticket price $75 (€60) |
Buses per day 11 |
Direct buses 2 |
Fastest bus 20h 45m |
First bus 00:50 |
Last bus 23:30 |
Bus providers: Greyhound from Philadelphia, PA to St. Louis, MOYou can travel by bus between Philadelphia, PA to St. Louis, MO with Greyhound for as low as $75 (€60). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from Philadelphia, PA to St. Louis, MO
Find answers to the most common questions about traveling from Philadelphia, PA to St. Louis, MO by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at St. Louis, MO, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
To find the cheapest bus tickets for your trip from Philadelphia, PA to St. Louis, MO, follow these tips:
Start your search now and compare ticket prices to find the best deal!
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from Philadelphia, PA to St. Louis, MO
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