The cheapest and fastest buses from San Diego, CA to St. Louis, MO
Cheapest price
$713
Average price
$713
Fastest journey
2 d
Average duration
2 d 1 h 38 m
Buses per day
2
Distance
2512 km
The best way to find a cheap bus ticket from San Diego, CA to St. Louis, MO is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from San Diego, CA to St. Louis, MO will cost around $713 if you buy it on the day, but the cheapest tickets can be found for only $713.
It's difficult to get from San Diego, CA to St. Louis, MO without transferring at least once.




Travel Information
Compare train, bus, and flight for San Diego, CA to St. Louis, MO
Omio recommends booking the train as it is the most popular option from San Diego, CA to St. Louis, MO among Omio's users. If you are prioritising price take the bus with prices starting from €128. For those with little time consider booking a flight which can get you there in 7h 23m. The ticket price range depends on the travel mode: a bus costs an average of €128, and a flight costs an average of €253.
Distance: 1560 miles (2512 km)
Compare bus with
| Bus | Most popular Train | Flight |
|---|---|---|
€188 Average price Cheapest | €275 Average price | €276 Average price |
46h 3m Average total duration 45h 33m Onboard + 30m Additional time* | 46h 46m Average total duration 46h 16m Onboard + 30m Additional time* | 10h 23m Average total duration Fastest 7h 23m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options | Direct Options |
San Diego, CA to St. Louis, MO Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 06:45AM | Arrival Time 07:10AM | Duration 46h25 | Departure days Wed | Cheapest price $365 |
Operator Greyhound | Departure Time 06:55AM | Arrival Time 07:10AM | Duration 46h15 | Departure days Wed | Cheapest price $374 |
Operator Greyhound | Departure Time 07:35AM | Arrival Time 07:10AM | Duration 45h35 | Departure days Wed | Cheapest price $380 |
Operator Greyhound | Departure Time 09:25AM | Arrival Time 12:55PM | Duration 49h30 | Departure days Wed | Cheapest price $305 |
Operator Greyhound | Departure Time 01:15PM | Arrival Time 12:55PM | Duration 45h40 | Departure days Wed | Cheapest price $299 |
Operator Greyhound | Departure Time 01:45PM | Arrival Time 12:55PM | Duration 45h10 | Departure days Wed | Cheapest price $303 |
Live departures
San Diego, CA to St. Louis, MO bus times
The table below shows live departures for San Diego, CA to St. Louis, MO buses for tomorrow, Thursday, November 6. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 7:05 AM San Diego, CA | 48h00 | 7:05 AM St. Louis, MO | 1 transfer | |
![]() | 7:25 PM San Diego, CA | 51h15 | 10:40 PM St. Louis, MO | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets San Diego, CA to St. Louis, MO by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Nov 06
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Nov 12
Journey information
Overview: Bus from San Diego, CA to St. Louis, MO
Buses from San Diego, CA to St. Louis, MO run on average 13 times per day, taking around 45h 33m. Cheap bus tickets for this journey start at $157 (€128) if you book in advance.
The earliest bus runs at 00:55, the last at 23:30. The fastest bus covers the 1560 miles (2512 km) distance in 45h 30m.
Distance 1560 miles (2512 km) |
Average bus duration 45h 33m |
Cheapest ticket price $157 (€128) |
Buses per day 13 |
Fastest bus 45h 30m |
First bus 00:55 |
Last bus 23:30 |
Bus providers: Greyhound from San Diego, CA to St. Louis, MOYou can travel by bus between San Diego, CA to St. Louis, MO with Greyhound for as low as $157 (€128). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from San Diego, CA to St. Louis, MO
Find answers to the most common questions about traveling from San Diego, CA to St. Louis, MO by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at St. Louis, MO, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
To find the cheapest bus tickets for your trip from San Diego, CA to St. Louis, MO, follow these tips:
Start your search now and compare ticket prices to find the best deal!
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from San Diego, CA to St. Louis, MO
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