San Diego, CA to St. Louis, MO bus with Greyhound

Thu, May 07
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2,000+ travel companies
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The cheapest and fastest buses from San Diego, CA to St. Louis, MO

Showing times and prices for May 07

Cheapest price

$221

Average price

$247

Fastest journey

2 d 6 h 30 m

Average duration

2 d 6 h 48 m

Buses per day

2

Distance

2512 km

Cheap tickets

The best way to find a cheap bus ticket from San Diego, CA to St. Louis, MO is to book your journey as far in advance as possible and to avoid traveling at rush hour.

The average ticket from San Diego, CA to St. Louis, MO will cost around $247 if you buy it on the day, but the cheapest tickets can be found for only $221.

Fast buses

Of the 2 buses that leave San Diego, CA for St. Louis, MO on Thu, May 07, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.

On Thu, May 07 the direct buses cover the 2512 km distance in an average of 2 d 6 h 48 m but if you time it right, some buses will get you there in just 2 d 6 h 30 m .

On Thu, May 07 the slowest buses will take 2 d 7 h 5 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

  • Greyhound
    9:45 PM54h30
    San Diego, CA
    4:15 AMSt. Louis, MO
    $2211One-way
    0 transfers
  • Greyhound
    9:10 PM55h05
    San Diego, CA
    4:15 AMSt. Louis, MO
    $2741One-way
    0 transfers

Travel Information

Compare train, bus, and flight for San Diego, CA to St. Louis, MO

Omio recommends booking the train as it is the most popular option from San Diego, CA to St. Louis, MO among Omio's users. If you are prioritising price take the bus with prices starting from $176. For those with little time consider booking a flight which can get you there in 7h 56m. The ticket price range depends on the travel mode: a bus costs an average of $176, and a train costs an average of $303.

Distance: 1560 miles (2512 km)

Compare bus with

Bus
Most popular
Train
Flight

$254

Average price

Cheapest

$320

Average price

$270

Average price

50h 35m

Average total duration

50h 5m

Onboard

+

30m

Additional time*

46h 46m

Average total duration

46h 16m

Onboard

+

30m

Additional time*

10h 56m

Average total duration

Fastest

7h 56m

Onboard

+

3h 0m

Additional time*

Direct Options

Direct Options

Direct Options

Compare prices and tickets San Diego, CA to St. Louis, MO by train, bus, or flight

Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

Thu
May 07
Fri
May 08
Sat
May 09
Sun
May 10
Mon
May 11
Tue
May 12
Wed
May 13

Why should you book San Diego, CA to St. Louis, MO buses with Omio?

Greyhound operates all buses services from San Diego, CA to St. Louis, MO.
Omio is an official ticket reseller for all your travel options from San Diego, CA to St. Louis, MO.

Why book with Omio vs Greyhound?

  • Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
  • Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from San Diego, CA to St. Louis, MO.

Why book with Omio over Wanderu?

  • Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from San Diego, CA to St. Louis, MO.

Journey information

Overview: Bus from San Diego, CA to St. Louis, MO

USAUSA
USAUSA
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Buses from San Diego, CA to St. Louis, MO run on average 11 times per day, taking around 50h 5m. Cheap bus tickets for this journey start at $176 (€141) but you can travel from only $173 (€139) by flight.

The earliest bus runs at 01:15, the last at 23:30. The fastest bus covers the 1560 miles (2512 km) distance in 46h 15m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from $173 (€139)
Distance
1560 miles (2512 km)
Average bus duration
50h 5m
Cheapest ticket price
$176 (€141)
Buses per day
11
Fastest bus
46h 15m
First bus
1:15 AM
Last bus
11:30 PM
Cheapest Month
Aug
Cheapest Day
Sat
High Season
Jan - Mar
Low Season
Apr - Jun
Best time to book
42 days
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from $173 (€139)

Bus providers: Greyhound from San Diego, CA to St. Louis, MOYou can travel by bus between San Diego, CA to St. Louis, MO with Greyhound for as low as $173 (€139). When you search for schedules and tickets, Omio will show you the best journey

Greyhound

About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
46h 15m
Cheapest Price
$176 (€141)
Greyhound frequency
11 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.

FAQs: Bus from San Diego, CA to St. Louis, MO

Find answers to the most common questions about traveling from San Diego, CA to St. Louis, MO by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at St. Louis, MO, this guide helps you travel smarter and with confidence.

FAQs
Cheap bus tickets from San Diego, CA to St. Louis, MO can start from as little as $176 (€141) when you book in advance. The average bus ticket price for San Diego, CA to St. Louis, MO is $254 (€204) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from San Diego, CA to St. Louis, MO is 46h 15m to travel the 1560 miles (2512 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from San Diego, CA to St. Louis, MO leaves at 1:15 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from San Diego, CA to St. Louis, MO leaves at 11:30 PM.
There are 11 buses a day from San Diego, CA to St. Louis, MO which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from San Diego, CA to St. Louis, MO, you can count on Greyhound for the best way to get you to St. Louis, MO. You can also check all possible bus companies who offer a service between San Diego, CA and St. Louis, MO and compare the amenities they offer before buying a bus ticket.
A trip to St. Louis, MO from San Diego, CA is worth doing but not as a day trip with a journey time of 46h 15m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from San Diego, CA to St. Louis, MO is August.
It's helpful to compare your options as there are 3 ways to travel between San Diego, CA and St. Louis, MO including taking a train, bus, and flight.
Yes, the following accessibility options are available when taking the bus from San Diego, CA to St. Louis, MO:
  • Greyhound
    • Assistance
    • Priority seating
    • Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from San Diego, CA to St. Louis, MO for bus company Greyhound.
Whether you can cancel your bus ticket from San Diego, CA to St. Louis, MO depends on the bus companies:
  • Greyhound
    • You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from San Diego, CA to St. Louis, MO.
Yes, the following luggage options are included when booking a bus ticket from San Diego, CA to St. Louis, MO:
  • Greyhound
    • One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from San Diego, CA to St. Louis, MO:
  • Greyhound
    • $15 per additional bag.
Unfortunately, pets are not allowed on the bus from San Diego, CA to St. Louis, MO.
You can reserve your seat on the bus from San Diego, CA to St. Louis, MO with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from San Diego, CA to St. Louis, MO with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from San Diego, CA to St. Louis, MO with the following bus company: Greyhound.
Since neither San Diego, CA nor St. Louis, MO are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the train as it is the most popular way to get from San Diego, CA to St. Louis, MO among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In St. Louis, MO, travelers should be cautious in certain neighborhoods with higher crime rates, especially after dark. Common safety concerns include petty theft, pickpocketing, and occasional scams targeting visitors near popular attractions like the Gateway Arch. It’s advisable to stay in well-populated areas, avoid displaying valuables openly, and use reputable transportation services to minimize risks.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.

popular bus stations

Popular bus stations from San Diego, CA to St. Louis, MO

San Diego
St. Louis
The major bus station for departures in San Diego is San Diego, Congress Street (Old Town Park). Find all the information you need to know about services, amenities and connections at San Diego, Congress Street (Old Town Park) for your trip from San Diego to St. Louis.
San Diego, Congress Street (Old Town Park)
information
San Diego, San Ysidro Transit Center
information
San Diego, West Harbor Drive (The Headquarters at Seaport District)
information
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