- Must visit
Saint Louis Art Museum
Major fine arts museum in Forest Park with collections spanning ancient to modern works. A top cultural stop known for strong European, American, and global holdings.
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The cheapest and fastest buses from San Diego, CA to St. Louis, MO
Showing times and prices for Jun 21
Cheapest price
$230
Average price
$304
Fastest journey
1 d 22 h 15 m
Average duration
1 d 23 h 53 m
Buses per day
2
Distance
2512 km
Cheap tickets
The best way to find a cheap bus ticket from San Diego, CA to St. Louis, MO is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from San Diego, CA to St. Louis, MO will cost around $304 if you buy it on the day, but the cheapest tickets can be found for only $230.
Fast buses
Of the 2 buses that leave San Diego, CA for St. Louis, MO on Sun, Jun 21, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sun, Jun 21 the direct buses cover the 2512 km distance in an average of 1 d 23 h 53 m but if you time it right, some buses will get you there in just 1 d 22 h 15 m .
On Sun, Jun 21 the slowest buses will take 2 d 1 h 30 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
8:40 PM46h15San Diego, CA6:55 PMSt. Louis, MO$2301One-way0 transfers- 4:25 PM49h30San Diego, CA5:55 PMSt. Louis, MO$3791One-way0 transfers
- 8:40 PM46h15San Diego, CA6:55 PMSt. Louis, MO$2301One-way0 transfers
- 4:25 PM49h30San Diego, CA5:55 PMSt. Louis, MO$3791One-way0 transfers
Travel Information
Compare train, bus, and flight for San Diego, CA to St. Louis, MO
Omio recommends booking the flight as it is the most popular option from San Diego, CA to St. Louis, MO among Omio's users. If you are prioritising price take the bus with prices starting from $143. For those with little time consider booking a flight which can get you there in 5h 30m. The ticket price range depends on the travel mode: a bus costs an average of $143, and a train costs an average of $215.
Distance: 1560 miles (2512 km)
Compare bus with
| Bus | Most popular Flight | Train | Driving |
|---|---|---|---|
$248 Average price Cheapest | $250 Average price | $322 Average price | $379 Average price (fuel + tolls) |
47h 40m Average total duration 47h 10m Onboard + 30m Additional time* | 8h 30m Average total duration Fastest 5h 30m Onboard + 3h 0m Additional time* | 48h 5m Average total duration 47h 35m Onboard + 30m Additional time* | 26h 25m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from San Diego, CA to St. Louis, MO is a bus with an average price of $248 (€203).
This is compared to other travel options from San Diego, CA to St. Louis, MO:
A bus is $2 (€1) less than a flight for this route with tickets for a flight from San Diego, CA to St. Louis, MO costing on average $250 (€205).
A bus is $74 (€60) less than a train for this route with tickets for a train from San Diego, CA to St. Louis, MO costing on average $322 (€264).
The fastest way to travel from San Diego, CA to St. Louis, MO is by flight with an average journey time of 5h 30m.
Other travel options to St. Louis, MO take longer:
Bus takes on average 47h 10m.
Train takes on average 47h 35m.
It's helpful to compare your options as there are 3 ways to travel between San Diego, CA and St. Louis, MO including taking a train, bus, and flight.
We recommend using the flight as it is the most popular way to get from San Diego, CA to St. Louis, MO among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
San Diego, CA to St. Louis, MO Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 02:35AM | Arrival Time 03:45AM | Duration 49h10 | Departure days Sat | Cheapest price $180 |
Operator Greyhound Mexico | Departure Time 07:00AM | Arrival Time 07:10AM | Duration 48h10 | Departure days Sat | Cheapest price $530 |
Operator Greyhound | Departure Time 02:35PM | Arrival Time 12:10PM | Duration 45h35 | Departure days Wed | Cheapest price $143 |
Operator Greyhound | Departure Time 04:15PM | Arrival Time 12:10PM | Duration 43h55 | Departure days Thu | Cheapest price $250 |
Operator Greyhound | Departure Time 04:25PM | Arrival Time 05:55PM | Duration 49h30 | Departure days Sun | Cheapest price $379 |
Operator Greyhound Mexico | Departure Time 07:25PM | Arrival Time 10:45PM | Duration 51h20 | Departure days Sat | Cheapest price $530 |
Operator Greyhound | Departure Time 07:40PM | Arrival Time 05:55PM | Duration 46h15 | Departure days Mon, Thu, Fri | Cheapest price $229 |
Operator Greyhound | Departure Time 08:10PM | Arrival Time 03:15AM | Duration 55h05 | Departure days Thu | Cheapest price $354 |
Operator Greyhound | Departure Time 08:40PM | Arrival Time 06:55PM | Duration 46h15 | Departure days Tue, Wed, Sun | Cheapest price $230 |
Operator Greyhound | Departure Time 08:45PM | Arrival Time 05:55PM | Duration 45h10 | Departure days Mon | Cheapest price $147 |
Live departures
San Diego, CA to St. Louis, MO bus times
The table below shows live departures for San Diego, CA to St. Louis, MO buses for today, Saturday, June 20. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 7:25 PM San Diego, CA | 51h20 | 10:45 PM St. Louis, MO | 2 transfers | |
| 7:25 PM San Diego, CA | 51h20 | 10:45 PM St. Louis, MO | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets San Diego, CA to St. Louis, MO by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book San Diego, CA to St. Louis, MO buses with Omio?
Greyhound operates all buses services from San Diego, CA to St. Louis, MO.
Omio is an official ticket reseller for all your travel options from San Diego, CA to St. Louis, MO.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from San Diego, CA to St. Louis, MO.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from San Diego, CA to St. Louis, MO.
Journey information
Overview: Bus from San Diego, CA to St. Louis, MO
USAUSA
Buses from San Diego, CA to St. Louis, MO run on average 10 times per day, taking around 47h 10m. Cheap bus tickets for this journey start at $143 (€117) if you book in advance.
The earliest bus runs at 01:15, the last at 23:45. The fastest bus covers the 1560 miles (2512 km) distance in 43h 55m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 1560 miles (2512 km) |
Average bus duration 47h 10m |
Cheapest ticket price $143 (€117) |
Buses per day 10 |
Fastest bus 43h 55m |
First bus 1:15 AM |
Last bus 11:45 PM |
Cheapest Month Aug |
Cheapest Day Sat |
High Season Apr - Jun |
Low Season Jul - Sep |
Best time to book 42 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound from San Diego, CA to St. Louis, MOYou can travel by bus between San Diego, CA to St. Louis, MO with Greyhound for as low as $143 (€117). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
43h 55m
Cheapest Price
$143 (€117)
Greyhound frequency
3 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to St. Louis
Things to do in St. Louis
Discover the best of St. Louis — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect St. Louis trip today.
- Must visit
City Museum
Highly original museum and artist-built environment with architectural salvage, tunnels, slides, and installations. One of the city’s most distinctive and widely shared attractions.
- Recommended
Missouri History Museum
History museum in Forest Park covering St. Louis, Missouri, and regional stories through permanent and rotating exhibitions. Well suited for visitors wanting local context.
- Must visit
Forest Park
One of the largest urban parks in the United States, home to major institutions, lakes, trails, and broad green spaces. Essential for first-time visitors.
- Must visit
Gateway Arch National Park Grounds
Riverfront grounds around the Arch with lawns, paths, and strong skyline views, useful for walking and iconic photos.
- Recommended
The Delmar Loop
Lively entertainment and walking district known for music venues, public art, shops, and the St. Louis Walk of Fame.
- Vegetarian
St. Louis-Style Pizza
A local pizza style with a very thin, cracker-like crust, cut into squares and traditionally topped with Provel cheese. It is one of the city’s signature foods.
Toasted Ravioli
Breaded and fried meat- or cheese-filled ravioli, usually served with marinara sauce. This St. Louis Italian-American specialty is strongly associated with The Hill neighborhood.
- Vegetarian
Gooey Butter Cake
A rich, dense cake with a buttery base and sweet cream cheese-like topping. It is one of the most famous desserts identified with St. Louis.
Charlie Gitto's On The Hill
A long-established Italian restaurant on The Hill, known for classic red-sauce dishes, toasted ravioli, and an old-school fine dining feel.
Ted Drewes Frozen Custard
An iconic St. Louis custard stand famous for thick concretes and nostalgic roadside charm. A must for trying the city’s best-known frozen treat.
Sidney Street Cafe
A respected contemporary American restaurant known for refined cooking, strong wine service, and a polished neighborhood setting.
United States Dollar
Generally moderate by U.S. standards. Hotels and attractions are often reasonable, while dining costs vary by neighborhood and venue.
Average meal costs
- Budget
- USD 10-18 for fast food or casual spots.
- Mid-range
- USD 20-40 per person at a mid-range restaurant.
- Fine dining
- USD 70+ per person before drinks and tip.
- Coffee
- USD 3-6 for regular coffee or a latte.
Tipping culture
Tip 18-20% at restaurants. Tip USD 1-2 per drink at bars, round up taxis, and tip hotel staff and delivery drivers.
FAQs: Bus from San Diego, CA to St. Louis, MO
Find answers to the most common questions about traveling from San Diego, CA to St. Louis, MO by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at St. Louis, MO, this guide helps you travel smarter and with confidence.
Cheap bus tickets from San Diego, CA to St. Louis, MO can start from as little as $143 (€117) when you book in advance. The average bus ticket price for San Diego, CA to St. Louis, MO is $248 (€203) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from San Diego, CA to St. Louis, MO is 43h 55m to travel the 1560 miles (2512 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from San Diego, CA to St. Louis, MO leaves at 1:15 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from San Diego, CA to St. Louis, MO leaves at 11:45 PM.
There are 10 buses a day from San Diego, CA to St. Louis, MO which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from San Diego, CA to St. Louis, MO, you can count on Greyhound for the best way to get you to St. Louis, MO. You can also check all possible bus companies who offer a service between San Diego, CA and St. Louis, MO and compare the amenities they offer before buying a bus ticket.
A trip to St. Louis, MO from San Diego, CA is worth doing but not as a day trip with a journey time of 43h 55m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from San Diego, CA to St. Louis, MO is August.
It's helpful to compare your options as there are 3 ways to travel between San Diego, CA and St. Louis, MO including taking a train, bus, and flight.
Yes, the following accessibility options are available when taking the bus from San Diego, CA to St. Louis, MO:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from San Diego, CA to St. Louis, MO for bus company Greyhound.
Whether you can cancel your bus ticket from San Diego, CA to St. Louis, MO depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from San Diego, CA to St. Louis, MO.
Yes, the following luggage options are included when booking a bus ticket from San Diego, CA to St. Louis, MO:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from San Diego, CA to St. Louis, MO:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from San Diego, CA to St. Louis, MO.
You can reserve your seat on the bus from San Diego, CA to St. Louis, MO with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from San Diego, CA to St. Louis, MO with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from San Diego, CA to St. Louis, MO with the following bus company: Greyhound.
Since neither San Diego, CA nor St. Louis, MO are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the flight as it is the most popular way to get from San Diego, CA to St. Louis, MO among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In St. Louis, MO, travelers should be cautious in certain neighborhoods with higher crime rates, especially after dark. Common safety concerns include petty theft, pickpocketing, and occasional scams targeting visitors near popular attractions like the Gateway Arch. It’s advisable to stay in well-populated areas, avoid displaying valuables openly, and use reputable transportation services to minimize risks.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from San Diego, CA to St. Louis, MO
Most San Diego, CA to St. Louis, MO buses use the San Diego, Congress Street (Old Town Park) to St. Louis, S 15th St (Civic center) station pair, with some services arriving at St. Louis, Lambert International Airport. Use this guide to compare San Diego, CA and St. Louis, MO bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in San Diego
Arrival bus stations in St. Louis
San Diego, Congress Street (Old Town Park)
City-centre transport
Getting to San Diego, Congress Street (Old Town Park) from San Diego city centre
BusFlixBus 2017 · 20m · $1
83 · 26m · $6
TramGreen, Blue, Event · 16m · every ~18 min
Blue · 21m · every ~9 min
San Diego, San Ysidro Transit Center
City-centre transport
Getting to San Diego, San Ysidro Transit Center from San Diego city centre
BusFlixBus 2017 · 25m · $2
910 · 41m · $6
TramBlue · 41m · $17 · every ~14 min
Blue · 43m · $17 · every ~14 min
San Diego, West Harbor Drive (The Headquarters at Seaport District)
St. Louis, S 15th St (Civic center)
City-centre transport
Getting to St. Louis, S 15th St (Civic center) from St. Louis city centre
TrainMlb, Mlr · 4m · $4 · every ~14 min
Bus19, 32, 40 · 8m · $1 · every ~9 min
St. Louis, Lambert International Airport
City-centre transport
Getting to St. Louis, Lambert International Airport from St. Louis city centre
TrainMlr · 31m · $4 · every ~7 min
Bus4 · 1h 3m · $31 · every ~4 min
More options for your journey from San Diego, CA to St. Louis, MO
Here are some other resources that might have the information you need
Most popular buses to and from St. Louis, MO and San Diego, CA
Most popular bus connections to St. Louis, MO
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