- Must visit
Saint Louis Art Museum
Vast art museum in Forest Park with global collections from antiquity to modern works and strong free general admission.
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The cheapest and fastest buses from San Diego, CA to St. Louis, MO
Showing times and prices for Aug 05
Cheapest price
€117
Average price
€177
Fastest journey
1 d 21 h 35 m
Average duration
1 d 21 h 55 m
Buses per day
2
Distance
2512 km
Cheap tickets
The best way to find a cheap bus ticket from San Diego, CA to St. Louis, MO is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from San Diego, CA to St. Louis, MO will cost around €177 if you buy it on the day, but the cheapest tickets can be found for only €117.
Fast buses
Of the 2 buses that leave San Diego, CA for St. Louis, MO on Wed, Aug 05, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Wed, Aug 05 the direct buses cover the 2512 km distance in an average of 1 d 21 h 55 m but if you time it right, some buses will get you there in just 1 d 21 h 35 m .
On Wed, Aug 05 the slowest buses will take 1 d 22 h 15 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
2:35 PM45h35San Diego, CA12:10 PMSt. Louis, MO€1171One-way0 transfers- 8:40 PM46h15San Diego, CA6:55 PMSt. Louis, MO€2371One-way0 transfers
- 2:35 PM45h35San Diego, CA12:10 PMSt. Louis, MO€1171One-way0 transfers
- 8:40 PM46h15San Diego, CA6:55 PMSt. Louis, MO€2371One-way0 transfers
Travel Information
Compare train, bus, and flight for San Diego, CA to St. Louis, MO
Omio recommends booking the flight as it is the most popular option from San Diego, CA to St. Louis, MO among Omio's users. If you are prioritising price take the bus with prices starting from €117. For those with little time consider booking a flight which can get you there in 5h 30m. The ticket price range depends on the travel mode: a bus costs an average of €117, and a train costs an average of €176.
Distance: 1560 miles (2512 km)
Compare bus with
| Bus | Most popular Flight | Train | Driving |
|---|---|---|---|
€203 Average price Cheapest | €205 Average price | €264 Average price | €310 Average price (fuel + tolls) |
47h 40m Average total duration 47h 10m Onboard + 30m Additional time* | 8h 30m Average total duration Fastest 5h 30m Onboard + 3h 0m Additional time* | 48h 5m Average total duration 47h 35m Onboard + 30m Additional time* | 26h 25m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from San Diego, CA to St. Louis, MO is a bus with an average price of €203.
This is compared to other travel options from San Diego, CA to St. Louis, MO:
A bus is €1 less than a flight for this route with tickets for a flight from San Diego, CA to St. Louis, MO costing on average €205.
A bus is €60 less than a train for this route with tickets for a train from San Diego, CA to St. Louis, MO costing on average €264.
The fastest way to travel from San Diego, CA to St. Louis, MO is by flight with an average journey time of 5h 30m.
Other travel options to St. Louis, MO take longer:
Bus takes on average 47h 10m.
Train takes on average 47h 35m.
It's helpful to compare your options as there are 3 ways to travel between San Diego, CA and St. Louis, MO including taking a train, bus, and flight.
We recommend using the flight as it is the most popular way to get from San Diego, CA to St. Louis, MO among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
San Diego, CA to St. Louis, MO Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 02:35AM | Arrival Time 03:45AM | Duration 49h10 | Departure days Sat | Cheapest price €147 |
Operator Greyhound Mexico | Departure Time 07:00AM | Arrival Time 07:10AM | Duration 48h10 | Departure days Sat | Cheapest price €434 |
Operator Greyhound | Departure Time 02:35PM | Arrival Time 12:10PM | Duration 45h35 | Departure days Wed | Cheapest price €117 |
Operator Greyhound | Departure Time 04:15PM | Arrival Time 12:10PM | Duration 43h55 | Departure days Thu | Cheapest price €205 |
Operator Greyhound | Departure Time 04:25PM | Arrival Time 05:55PM | Duration 49h30 | Departure days Sun | Cheapest price €310 |
Operator Greyhound Mexico | Departure Time 07:25PM | Arrival Time 10:45PM | Duration 51h20 | Departure days Sat | Cheapest price €434 |
Operator Greyhound | Departure Time 07:40PM | Arrival Time 05:55PM | Duration 46h15 | Departure days Mon, Thu, Fri | Cheapest price €187 |
Operator Greyhound | Departure Time 08:10PM | Arrival Time 03:15AM | Duration 55h05 | Departure days Thu | Cheapest price €289 |
Operator Greyhound | Departure Time 08:40PM | Arrival Time 06:55PM | Duration 46h15 | Departure days Tue, Wed, Sun | Cheapest price €188 |
Operator Greyhound | Departure Time 08:45PM | Arrival Time 05:55PM | Duration 45h10 | Departure days Mon | Cheapest price €120 |
Live departures
San Diego, CA to St. Louis, MO bus times
The table below shows live departures for San Diego, CA to St. Louis, MO buses for today, Tuesday, August 4. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 8:40 PM San Diego, CA | 46h15 | 6:55 PM St. Louis, MO | 0 transfersDirect | |
| Wednesday, August 5 | |||||
| 2:35 PM San Diego, CA | 45h35 | 12:10 PM St. Louis, MO | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets San Diego, CA to St. Louis, MO by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book San Diego, CA to St. Louis, MO buses with Omio?
Greyhound operates all buses services from San Diego, CA to St. Louis, MO.
Omio is an official ticket reseller for all your travel options from San Diego, CA to St. Louis, MO.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from San Diego, CA to St. Louis, MO.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from San Diego, CA to St. Louis, MO.
Journey information
Overview: Bus from San Diego, CA to St. Louis, MO
USAUSA
Buses from San Diego, CA to St. Louis, MO run on average 10 times per day, taking around 47h 10m. Cheap bus tickets for this journey start at €117 if you book in advance.
The earliest bus runs at 01:15, the last at 23:45. The fastest bus covers the 1560 miles (2512 km) distance in 43h 55m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 1560 miles (2512 km) |
Average bus duration 47h 10m |
Cheapest ticket price €117 |
Buses per day 10 |
Fastest bus 43h 55m |
First bus 1:15 AM |
Last bus 11:45 PM |
Cheapest Month Aug |
Cheapest Day Sat |
High Season Apr - Jun |
Low Season Jul - Sep |
Best time to book 42 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound from San Diego, CA to St. Louis, MOYou can travel by bus between San Diego, CA to St. Louis, MO with Greyhound for as low as €117. When you search for schedules and tickets, Omio will show you the best journey
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
43h 55m
Cheapest Price
€117
Greyhound frequency
3 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to St. Louis, MO
Things to do in St. Louis, MO
Discover the best of St. Louis, MO — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect St. Louis, MO trip today.
- Recommended
Missouri History Museum
Leading history museum covering St. Louis, Missouri, and national stories through rotating exhibitions in Forest Park.
- Recommended
Saint Louis Science Center
Interactive science museum with hands-on exhibits, planetarium, and family-friendly displays near Forest Park.
- Must visit
Gateway Arch National Park Grounds
Lively downtown riverfront district with trails, views of the Arch, public art, and access to major historic sites.
- Must visit
Forest Park
Large urban park with trails, lakes, zoo access, and major museums, ideal for walking between top attractions.
- Recommended
Tower Grove Park
Beloved neighborhood park with formal lily ponds, pavilions, and one of the city's most photographed landscapes.
- Vegetarian
St. Louis-Style Pizza
A thin, cracker-like crust pizza cut into squares and topped with Provel cheese, a St. Louis original loved for its distinct texture and tangy flavor.
- Vegetarian
Toasted Ravioli
Crisp, breaded ravioli said to be born on The Hill, usually served with marinara. It is a signature St. Louis Italian-American appetizer.
- Vegetarian
Gooey Butter Cake
Sticky butter cake with a dense base and gooey sweet top. A longtime St. Louis bakery favorite often enjoyed for breakfast or dessert.
Bulrush
Refined contemporary restaurant with tasting menus and strong national acclaim. Elegant fine dining focused on seasonal Midwestern ingredients.
Ted Drewes Frozen Custard
Beloved frozen custard stand serving concretes and sundaes since 1929. Casual, nostalgic, and one of the city's iconic dessert stops.
Pappy's Smokehouse
Popular smokehouse known for St. Louis barbecue, especially ribs, brisket, and pork steak, in a polished but relaxed atmosphere.
United States dollar ($)
Moderate for U.S. city breaks: hotels and dining are reasonable, transit is limited, and attractions often cost less than in larger U.S. tourist cities.
Average meal costs
- Budget
- $10-15 for fast food or casual lunch.
- Mid-range
- $20-35 per person for a mid-range restaurant meal.
- Fine dining
- $60+ per person at upscale restaurants.
- Coffee
- $3-5 for coffee or cappuccino.
Tipping culture
Tip 18-20% at restaurants, $1-2 per drink at bars, and 10-15% for taxis. Cafes often have tip jars or screen prompts.
FAQs: Bus from San Diego, CA to St. Louis, MO
Find answers to the most common questions about traveling from San Diego, CA to St. Louis, MO by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at St. Louis, MO, this guide helps you travel smarter and with confidence.
Cheap bus tickets from San Diego, CA to St. Louis, MO can start from as little as €117 when you book in advance. The average bus ticket price for San Diego, CA to St. Louis, MO is €203 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from San Diego, CA to St. Louis, MO is 43h 55m to travel the 1560 miles (2512 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from San Diego, CA to St. Louis, MO leaves at 1:15 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from San Diego, CA to St. Louis, MO leaves at 11:45 PM.
There are 10 buses a day from San Diego, CA to St. Louis, MO which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from San Diego, CA to St. Louis, MO, you can count on Greyhound for the best way to get you to St. Louis, MO. You can also check all possible bus companies who offer a service between San Diego, CA and St. Louis, MO and compare the amenities they offer before buying a bus ticket.
When departing from San Diego, CA , you have various bus station options to start your journey from including San Diego, Congress Street (Old Town Park), CA, San Diego, San Ysidro Transit Center, San Diego, West Harbor Drive (The Headquarters at Seaport District), CA, La Jolla, UCSD Health La Jolla Station, CA . When arriving in St. Louis, MO , you can end your journey in bus stations like St. Louis, S 15th St (Civic center), St. Louis, Lambert International Airport .Passengers board the bus most frequently from San Diego, Congress Street (Old Town Park), CA, which is located around 3 miles (5 km) away from the city centre, and they get off the bus at St. Louis, S 15th St (Civic center), located 0 away from the city centre.
A trip to St. Louis, MO from San Diego, CA is worth doing but not as a day trip with a journey time of 43h 55m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from San Diego, CA to St. Louis, MO is August.
It's helpful to compare your options as there are 3 ways to travel between San Diego, CA and St. Louis, MO including taking a train, bus, and flight.
Yes, the following accessibility options are available when taking the bus from San Diego, CA to St. Louis, MO:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from San Diego, CA to St. Louis, MO for bus company Greyhound.
Whether you can cancel your bus ticket from San Diego, CA to St. Louis, MO depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from San Diego, CA to St. Louis, MO.
Yes, the following luggage options are included when booking a bus ticket from San Diego, CA to St. Louis, MO:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from San Diego, CA to St. Louis, MO:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from San Diego, CA to St. Louis, MO.
You can reserve your seat on the bus from San Diego, CA to St. Louis, MO with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from San Diego, CA to St. Louis, MO with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from San Diego, CA to St. Louis, MO with the following bus company: Greyhound.
Since neither San Diego, CA nor St. Louis, MO are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the flight as it is the most popular way to get from San Diego, CA to St. Louis, MO among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In St. Louis, MO, travelers should be cautious in certain neighborhoods with higher crime rates, especially after dark. Common safety concerns include petty theft, pickpocketing, and occasional scams targeting visitors near popular attractions like the Gateway Arch. It’s advisable to stay in well-populated areas, avoid displaying valuables openly, and use reputable transportation services to minimize risks.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from San Diego, CA to St. Louis, MO
Most San Diego, CA to St. Louis, MO buses use the San Diego, Congress Street (Old Town Park) to St. Louis, S 15th St (Civic center) station pair, with some services arriving at St. Louis, Lambert International Airport. Use this guide to compare San Diego, CA and St. Louis, MO bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in San Diego
Arrival bus stations in St. Louis
Which San Diego, CA station do buses to St. Louis, MO leave from?
Buses from San Diego, CA to St. Louis, MO leave from San Diego, Congress Street (Old Town Park). The station is 3 miles (6 km) from San Diego, CA city centre at Congress St, San Diego, CA 92110, USA.
San Diego, Congress Street (Old Town Park)Congress St, San Diego, CA 92110, USA
City-centre transport
Getting to San Diego, Congress Street (Old Town Park) from San Diego city centre
San Diego, Congress Street (Old Town Park) is 5 km from San Diego city centre. Public transport options include:
BusFlixBus 2017 · 20m · €1
83 · 26m · €5
TramGreen, Blue, Event · 16m · every ~18 min
Blue · 21m · every ~9 min
San Diego, Congress Street (Old Town Park) bus station facilities and services
San Diego, Congress Street (Old Town Park) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Several dining options nearby.
Wi-Fi and ATMs
Wi-Fi is available at San Diego, Congress Street (Old Town Park). ATMs are available at San Diego, Congress Street (Old Town Park).
Tickets and information
Ticket office support is available at San Diego, Congress Street (Old Town Park).
Parking, taxis and toilets
Available at San Diego, Congress Street (Old Town Park): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at San Diego, Congress Street (Old Town Park): Wheelchair accessible routes available.
San Diego, San Ysidro Transit CenterSan Ysidro Station, San Diego, CA 92173, USA
City-centre transport
Getting to San Diego, San Ysidro Transit Center from San Diego city centre
San Diego, San Ysidro Transit Center is 22 km from San Diego city centre. Public transport options include:
BusFlixBus 2017 · 25m · €2
910 · 41m · €5
TramBlue · 41m · €14 · every ~14 min
Blue · 43m · €14 · every ~14 min
San Diego, San Ysidro Transit Center bus station facilities and services
San Diego, San Ysidro Transit Center has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Several fast food eateries located nearby.
Wi-Fi and ATMs
Wi-Fi is available at San Diego, San Ysidro Transit Center. ATMs are available near the entrance.
Tickets and information
Ticket office support is available at San Diego, San Ysidro Transit Center.
Parking, taxis and toilets
Available at San Diego, San Ysidro Transit Center: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at San Diego, San Ysidro Transit Center: Wheelchair accessible with ramps.
San Diego, West Harbor Drive (The Headquarters at Seaport District)W Harbor Dr, San Diego, CA, USA
City-centre transport
Getting to San Diego, West Harbor Drive (The Headquarters at Seaport District) from San Diego city centre
San Diego, West Harbor Drive (The Headquarters at Seaport District) is 1 km from San Diego city centre. Public transport options include:
TRUE
San Diego, West Harbor Drive (The Headquarters at Seaport District) bus station facilities and services
San Diego, West Harbor Drive (The Headquarters at Seaport District) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Several dining options are in the area.
Wi-Fi and ATMs
Wi-Fi is available at San Diego, West Harbor Drive (The Headquarters at Seaport District). ATMs are available at San Diego, West Harbor Drive (The Headquarters at Seaport District).
Tickets and information
Ticket office support is available at San Diego, West Harbor Drive (The Headquarters at Seaport District).
Parking, taxis and toilets
Available at San Diego, West Harbor Drive (The Headquarters at Seaport District): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at San Diego, West Harbor Drive (The Headquarters at Seaport District): Accessible for persons with disabilities.
Which St. Louis, MO station do buses from San Diego, CA arrive at?
Buses from San Diego, CA to St. Louis, MO most often arrive at St. Louis, S 15th St (Civic center). Some services arrive at St. Louis, Lambert International Airport, so check your ticket before travel to confirm your St. Louis, MO arrival station.
St. Louis, S 15th St (Civic center)S 15th St, St. Louis, MO, USA
City-centre transport
Getting to St. Louis, S 15th St (Civic center) from St. Louis city centre
TrainMlb, Mlr · 4m · €3 · every ~14 min
Bus19, 32, 40 · 8m · €1 · every ~9 min
St. Louis, S 15th St (Civic center) bus station facilities and services
St. Louis, S 15th St (Civic center) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at St. Louis, S 15th St (Civic center). ATMs are available at St. Louis, S 15th St (Civic center).
Tickets and information
Ticket office support is available at St. Louis, S 15th St (Civic center).
Parking, taxis and toilets
Available at St. Louis, S 15th St (Civic center): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at St. Louis, S 15th St (Civic center): Wheelchair accessible routes available.
St. Louis, Lambert International AirportSt. Louis Lambert International Airport (STL), 10701 Lambert International Blvd, St. Louis, MO 63145, USA
City-centre transport
Getting to St. Louis, Lambert International Airport from St. Louis city centre
St. Louis, Lambert International Airport is 19 km from St. Louis city centre. Public transport options include:
TrainMlr · 31m · €3 · every ~7 min
Bus4 · 1h 3m · €25 · every ~4 min
St. Louis, Lambert International Airport bus station facilities and services
St. Louis, Lambert International Airport has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Multiple dining options available in terminals.
Wi-Fi and ATMs
Free Wi-Fi available throughout the airport. ATMs are aTMs available in terminal areas.
Tickets and information
Ticket office support is available at St. Louis, Lambert International Airport.
Parking, taxis and toilets
Available at St. Louis, Lambert International Airport: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at St. Louis, Lambert International Airport: Wheelchair accessible facilities available.
More options for your journey from San Diego, CA to St. Louis, MO
Here are some other resources that might have the information you need
Most popular buses to and from St. Louis, MO and San Diego, CA
Most popular bus connections to St. Louis, MO
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