- Must visit
Saint Louis Art Museum
Vast art museum in Forest Park with global collections from antiquity to modern works and strong free general admission.
Cheapest price on Sep 20
$152
Average ticket price on Sep 20
$161
Fastest journey on Sep 20
1 d 19 h 20 m
Average journey duration on Sep 20
1 d 21 h 33 m
Buses on Sep 20
11
Distance
2512 km
The best way to find a cheap bus ticket from San Diego, CA to St. Louis, MO is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from San Diego, CA to St. Louis, MO will cost around $161 if you buy it on the day, but the cheapest tickets can be found for only $152.
It's difficult to get from San Diego, CA to St. Louis, MO without transferring at least once.
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· · Omio recommends booking the flight as it is the most popular option from San Diego, CA to St. Louis, MO among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $318 For those with little time, consider booking a flight, which has an average total journey time of 8h 31m. Average ticket prices depend on the travel mode: a bus costs an average of $318, while a flight costs an average of $582.
Distance: 1560 miles (2512 km)
| Bus | Most popular Flight | Train | Driving |
|---|---|---|---|
$318 Average price Cheapest | $582 Average price | $353 Average price | $384 Average price (fuel + tolls) |
42h 29m Average total duration 41h 59m Onboard + 30m Additional time* | 8h 31m Average total duration Fastest 6h 31m Onboard + 2h 0m Additional time* | 48h 8m Average total duration 47h 38m Onboard + 30m Additional time* | 26h 25m Average total duration (door-to-door) |
![]() Most popular bus company | ![]() Most popular airline | ![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from San Diego, CA to St. Louis, MO:
A bus is $36 (€29) less than a train for this route with tickets for a train from San Diego, CA to St. Louis, MO costing on average $353 (€289).
A bus is $265 (€217) less than a flight for this route with tickets for a flight from San Diego, CA to St. Louis, MO costing on average $582 (€476).
Other travel options to St. Louis, MO take longer:
Bus takes on average 41h 59m.
Train takes on average 47h 38m.
Tickets start at around $318 (€260) compared to roughly $384 (€314) in fuel and tolls — a saving of about $66 (€54). The journey takes 41h 59m versus 26h 25m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 09:15AM | Arrival Time 07:10AM | Duration 43h55 | Departure days Everyday | Cheapest price $149 |
Operator Greyhound | Departure Time 09:25AM | Arrival Time 12:55PM | Duration 49h30 | Departure days Everyday | Cheapest price $153 |
Operator Greyhound | Departure Time 09:50AM | Arrival Time 07:10AM | Duration 43h20 | Departure days Everyday | Cheapest price $164 |
Operator Greyhound | Departure Time 12:40PM | Arrival Time 12:55PM | Duration 46h15 | Departure days Everyday | Cheapest price $150 |
Operator Greyhound | Departure Time 01:10PM | Arrival Time 12:55PM | Duration 45h45 | Departure days Everyday | Cheapest price $152 |
Operator Greyhound | Departure Time 07:10PM | Arrival Time 10:15PM | Duration 49h05 | Departure days Tue, Thu, Fri, Sat, Sun | Cheapest price $169 |
Operator Greyhound | Departure Time 07:45PM | Arrival Time 10:45PM | Duration 49h00 | Departure days Tue, Thu, Fri, Sat, Sun | Cheapest price $166 |
Operator Greyhound | Departure Time 09:45PM | Arrival Time 12:55PM | Duration 61h10 | Departure days Mon, Tue, Wed, Thu, Fri, Sat | Cheapest price $167 |
Operator Greyhound | Departure Time 10:05PM | Arrival Time 10:10PM | Duration 70h05 | Departure days Mon, Tue, Wed, Thu, Fri, Sat | Cheapest price $170 |
The table below shows live departures for San Diego, CA to St. Louis, MO buses for today, Saturday, September 19. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
· | 9:15 AM San Diego, San Ysidro Transit Center | 43h55 | 7:10 AM St. Louis, S 15th St (Civic center) | 1 transfer | |
FlixBus · FlixBus+ · | 9:25 AM San Diego, Congress Street (Old Town Park), CA | 49h30 | 12:55 PM St. Louis, S 15th St (Civic center) | 4 transfers | |
FlixBus · FlixBus+ · | 9:25 AM San Diego, Congress Street (Old Town Park), CA | 58h45 | 10:10 PM St. Louis, Lambert International Airport | 4 transfers | |
· | 9:50 AM San Diego, Congress Street (Old Town Park), CA | 43h20 | 7:10 AM St. Louis, S 15th St (Civic center) | 1 transfer | |
FlixBus+ · · | 12:40 PM San Diego, San Ysidro Transit Center | 46h15 | 12:55 PM St. Louis, S 15th St (Civic center) | 3 transfers | |
FlixBus+ · · | 1:10 PM San Diego, West Harbor Drive (The Headquarters at Seaport District), CA | 55h00 | 10:10 PM St. Louis, Lambert International Airport | 3 transfers | |
FlixBus+ · · | 1:10 PM San Diego, West Harbor Drive (The Headquarters at Seaport District), CA | 45h45 | 12:55 PM St. Louis, S 15th St (Civic center) | 3 transfers | |
· · | 7:10 PM San Diego, San Ysidro Transit Center | 49h00 | 10:10 PM St. Louis, Lambert International Airport | 2 transfers | |
· · | 7:10 PM San Diego, San Ysidro Transit Center | 49h35 | 10:45 PM St. Louis, S 15th St (Civic center) | 2 transfers | |
· · | 7:45 PM San Diego, Congress Street (Old Town Park), CA | 48h25 | 10:10 PM St. Louis, Lambert International Airport | 2 transfers | |
· · | 7:45 PM San Diego, Congress Street (Old Town Park), CA | 49h00 | 10:45 PM St. Louis, S 15th St (Civic center) | 2 transfers | |
FlixBus+ · · | 9:45 PM San Diego, West Harbor Drive (The Headquarters at Seaport District), CA | 61h10 | 12:55 PM St. Louis, S 15th St (Civic center) | 3 transfers | |
FlixBus+ · · | 9:45 PM San Diego, West Harbor Drive (The Headquarters at Seaport District), CA | 70h25 | 10:10 PM St. Louis, Lambert International Airport | 4 transfers | |
FlixBus+ · · | 10:05 PM San Diego, Congress Street (Old Town Park), CA | 60h50 | 12:55 PM St. Louis, S 15th St (Civic center) | 3 transfers | |
FlixBus+ · · | 10:05 PM San Diego, Congress Street (Old Town Park), CA | 70h05 | 10:10 PM St. Louis, Lambert International Airport | 4 transfers | |
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from San Diego, CA to St. Louis, MO run on average 8 times per day, taking around 41h 59m. Cheap bus tickets for this journey start at $275 (€225) but you can travel from only $240 (€196) by flight.
The earliest bus runs at 01:15, the last at 23:45. The fastest bus covers the 1560 miles (2512 km) distance in 37h 40m.
Distance 1560 miles (2512 km) |
Average bus duration 41h 59m |
Cheapest ticket price $275 (€225) |
Buses per day 8 |
Fastest bus 37h 40m |
First bus 1:15 AM |
Last bus 11:45 PM |
Cheapest Month Aug |
Cheapest Day Sat |
High Season Apr - Jun |
Low Season Jul - Sep |
Best time to book 42 days |
Discover the best of St. Louis, MO — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect St. Louis, MO trip today.
Vast art museum in Forest Park with global collections from antiquity to modern works and strong free general admission.
Leading history museum covering St. Louis, Missouri, and national stories through rotating exhibitions in Forest Park.
Interactive science museum with hands-on exhibits, planetarium, and family-friendly displays near Forest Park.
Lively downtown riverfront district with trails, views of the Arch, public art, and access to major historic sites.
Large urban park with trails, lakes, zoo access, and major museums, ideal for walking between top attractions.
Beloved neighborhood park with formal lily ponds, pavilions, and one of the city's most photographed landscapes.
A thin, cracker-like crust pizza cut into squares and topped with Provel cheese, a St. Louis original loved for its distinct texture and tangy flavor.
Crisp, breaded ravioli said to be born on The Hill, usually served with marinara. It is a signature St. Louis Italian-American appetizer.
Sticky butter cake with a dense base and gooey sweet top. A longtime St. Louis bakery favorite often enjoyed for breakfast or dessert.
Refined contemporary restaurant with tasting menus and strong national acclaim. Elegant fine dining focused on seasonal Midwestern ingredients.
Beloved frozen custard stand serving concretes and sundaes since 1929. Casual, nostalgic, and one of the city's iconic dessert stops.
Popular smokehouse known for St. Louis barbecue, especially ribs, brisket, and pork steak, in a polished but relaxed atmosphere.
Moderate for U.S. city breaks: hotels and dining are reasonable, transit is limited, and attractions often cost less than in larger U.S. tourist cities.
Tip 18-20% at restaurants, $1-2 per drink at bars, and 10-15% for taxis. Cafes often have tip jars or screen prompts.
Find answers to the most common questions about traveling from San Diego, CA to St. Louis, MO by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at St. Louis, MO, this guide helps you travel smarter and with confidence.

Most San Diego, CA to St. Louis, MO buses use the San Diego, Congress Street (Old Town Park) to St. Louis, S 15th St (Civic center) station pair, with some services arriving at St. Louis, Lambert International Airport. Use this guide to compare San Diego, CA and St. Louis, MO bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
San Diego, Congress Street (Old Town Park) is 5 km from San Diego city centre. Public transport options include:
San Diego, Congress Street (Old Town Park) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Several dining options nearby.
Wi-Fi is available at San Diego, Congress Street (Old Town Park). ATMs are available at San Diego, Congress Street (Old Town Park).
Ticket office support is available at San Diego, Congress Street (Old Town Park).
Available at San Diego, Congress Street (Old Town Park): Parking, Taxis, WC.
Accessibility facilities are available at San Diego, Congress Street (Old Town Park): Wheelchair accessible routes available.
San Diego, San Ysidro Transit Center is 22 km from San Diego city centre. Public transport options include:
San Diego, San Ysidro Transit Center has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Several fast food eateries located nearby.
Wi-Fi is available at San Diego, San Ysidro Transit Center. ATMs are available near the entrance.
Ticket office support is available at San Diego, San Ysidro Transit Center.
Available at San Diego, San Ysidro Transit Center: Parking, Taxis, WC.
Accessibility facilities are available at San Diego, San Ysidro Transit Center: Wheelchair accessible with ramps.
San Diego, West Harbor Drive (The Headquarters at Seaport District) is 1 km from San Diego city centre. Public transport options include:
San Diego, West Harbor Drive (The Headquarters at Seaport District) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Several dining options are in the area.
Wi-Fi is available at San Diego, West Harbor Drive (The Headquarters at Seaport District). ATMs are available at San Diego, West Harbor Drive (The Headquarters at Seaport District).
Ticket office support is available at San Diego, West Harbor Drive (The Headquarters at Seaport District).
Available at San Diego, West Harbor Drive (The Headquarters at Seaport District): Parking, Taxis, WC.
Accessibility facilities are available at San Diego, West Harbor Drive (The Headquarters at Seaport District): Accessible for persons with disabilities.
St. Louis, S 15th St (Civic center) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at St. Louis, S 15th St (Civic center). ATMs are available at St. Louis, S 15th St (Civic center).
Ticket office support is available at St. Louis, S 15th St (Civic center).
Available at St. Louis, S 15th St (Civic center): Parking, Taxis, WC.
Accessibility facilities are available at St. Louis, S 15th St (Civic center): Wheelchair accessible routes available.
St. Louis, Lambert International Airport is 19 km from St. Louis city centre. Public transport options include:
St. Louis, Lambert International Airport has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Multiple dining options available in terminals.
Free Wi-Fi available throughout the airport. ATMs are aTMs available in terminal areas.
Ticket office support is available at St. Louis, Lambert International Airport.
Available at St. Louis, Lambert International Airport: Parking, Taxis, WC.
Accessibility facilities are available at St. Louis, Lambert International Airport: Wheelchair accessible facilities available.
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