- Recommended
Greenville County Museum of Art
A major art museum in downtown Greenville with American art, Southern works, and rotating exhibitions in a bright riverfront setting.
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The cheapest and fastest buses from Knoxville, TN to Greenville, SC
Showing times, prices and bookable tickets for Sep 20
Cheapest price on Sep 20
€53
Average ticket price on Sep 20
€53
Fastest journey on Sep 20
7 h 15 m
Average journey duration on Sep 20
7 h 15 m
Buses on Sep 20
1
Distance
185 km
Cheap tickets
The best way to find a cheap bus ticket from Knoxville, TN to Greenville, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Knoxville, TN to Greenville, SC will cost around €53 if you buy it on the day, but the cheapest tickets can be found for only €53.
Fast buses
It's difficult to get from Knoxville, TN to Greenville, SC without transferring at least once.
· 8:00 PM7h15Knoxville, Kirkwood Street, TN3:15 AMGreenville, Woodruff Rd ("Raceway" gas station), SC€531One-way1 transfer
- · 8:00 PM7h15Knoxville, Kirkwood Street, TN3:15 AMGreenville, Woodruff Rd ("Raceway" gas station), SC€531One-way1 transfer
Travel Information
Compare bus for Knoxville, TN to Greenville, SC
Omio recommends booking the bus as it is the most popular option from Knoxville, TN to Greenville, SC among Omio's users. If you are prioritising price, take the bus, with an average ticket price of €96 For those with little time, consider booking a bus, which has an average total journey time of 6h 40m. Average ticket prices depend on the travel mode: a bus costs an average of €96, while a bus costs an average of €96.
Distance: 114 miles (185 km)
Compare bus with
Most popular Bus | Driving |
|---|---|
€96 Average price Cheapest | €28 Average price (fuel + tolls) |
6h 40m Average total duration Fastest 6h 10m Onboard + 30m Additional time* | 2h 58m Average total duration (door-to-door) |
Most popular bus company | Your own car or car rental |
Direct Options | Direct Options |
The cheapest way to travel from Knoxville, TN to Greenville, SC is a bus with an average price of €96.
The fastest way to travel from Knoxville, TN to Greenville, SC is by bus with an average journey time of 6h 10m.
Yes, you can take a bus between Knoxville, TN and Greenville, SC.
We recommend using the bus as it is the most popular way to get from Knoxville, TN to Greenville, SC among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.
Tickets start at around €96 compared to roughly €28 in fuel and tolls — a saving of about €-67.97. The journey takes 6h 10m versus 2h 58m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
Knoxville, TN to Greenville, SC Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 12:40AM | Arrival Time 12:00PM | Duration 11h20 | Departure days Tue | Cheapest price €124 |
Operator Greyhound | Departure Time 08:00PM | Arrival Time 03:15AM | Duration 7h15 | Departure days Fri, Sun | Cheapest price €53 |
Compare prices and tickets Knoxville, TN to Greenville, SC by bus
Compare bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Knoxville, TN to Greenville, SC buses with Omio?
Greyhound operates all buses services from Knoxville, TN to Greenville, SC.
Omio is an official ticket reseller for all your travel options from Knoxville, TN to Greenville, SC.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
Journey information
Overview: Bus from Knoxville, TN to Greenville, SC
USAUSA
Buses from Knoxville, TN to Greenville, SC run on average 1 times per day, taking around 6h 10m. Cheap bus tickets for this journey start at €61 if you book in advance.
The earliest bus runs at 14:45, the last at 19:25. The fastest bus covers the 114 miles (185 km) distance in 6h 10m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 114 miles (185 km) |
Average bus duration 6h 10m |
Cheapest ticket price €61 |
Buses per day 1 |
Fastest bus 6h 10m |
First bus 2:45 PM |
Last bus 7:25 PM |
Cheapest Month Aug |
Cheapest Day Tue |
High Season Jul - Sep |
Low Season Jan - Mar |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound from Knoxville, TN to Greenville, SCYou can travel by bus between Knoxville, TN to Greenville, SC with Greyhound for as low as €61. When you search for schedules and tickets, Omio will show you the best journey
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
6h 10m
Cheapest Greyhound Price
€61
Greyhound frequency
1 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Greenville, SC
Things to do in Greenville, SC
Discover the best of Greenville, SC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Greenville, SC trip today.
Greenville Center for Creative Arts
A contemporary art center showing regional and international artists through rotating exhibitions in a modern downtown gallery space.
Metropolitan Arts Council Gallery
A local gallery and arts space featuring exhibitions, classes, and community-focused programming in Greenville's Village area.
- Must visit
Falls Park on the Reedy
A signature downtown park with waterfalls, gardens, river trails, and lawns. It is Greenville's most popular public space for walking and views.
- Must visit
Main Street
Greenville's central street lined with shops, public art, and historic buildings. It is ideal for strolling between downtown attractions.
- Recommended
Prisma Health Swamp Rabbit Trail
A swamp rabbit-themed riverside greenway popular for walking and cycling, linking downtown Greenville with parks and nearby districts.
FAQs: Bus from Knoxville, TN to Greenville, SC
Find answers to the most common questions about traveling from Knoxville, TN to Greenville, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Greenville, SC, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Knoxville, TN to Greenville, SC can start from as little as €61 when you book in advance. The average bus ticket price for Knoxville, TN to Greenville, SC is €96 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Knoxville, TN to Greenville, SC is 6h 10m to travel the 114 miles (185 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Knoxville, TN to Greenville, SC leaves at 2:45 PM. Plan your trip with the Journey Planner from Omio.
The latest bus from Knoxville, TN to Greenville, SC leaves at 7:25 PM.
There are 1 buses a day from Knoxville, TN to Greenville, SC which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Knoxville, TN to Greenville, SC, you can count on Greyhound for the best way to get you to Greenville, SC. You can also check all possible bus companies who offer a service between Knoxville, TN and Greenville, SC and compare the amenities they offer before buying a bus ticket.
Passengers board the bus most frequently from Knoxville, Kirkwood Street, TN, which is located around 3 miles (5 km) away from the city centre, and they get off the bus at Greenville, Woodruff Rd ("Raceway" gas station), SC, located 8 away from the city centre.
A trip to Greenville, SC from Knoxville, TN is worth doing but not as a day trip with a journey time of 6h 10m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Knoxville, TN to Greenville, SC is August.
Yes, you can take a bus between Knoxville, TN and Greenville, SC.
Yes, the following accessibility options are available when taking the bus from Knoxville, TN to Greenville, SC:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Knoxville, TN to Greenville, SC for bus company Greyhound.
Whether you can cancel your bus ticket from Knoxville, TN to Greenville, SC depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Knoxville, TN to Greenville, SC.
Yes, the following luggage options are included when booking a bus ticket from Knoxville, TN to Greenville, SC:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from Knoxville, TN to Greenville, SC:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from Knoxville, TN to Greenville, SC.
You can reserve your seat on the bus from Knoxville, TN to Greenville, SC with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from Knoxville, TN to Greenville, SC with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from Knoxville, TN to Greenville, SC with the following bus company: Greyhound.
Since neither Knoxville, TN nor Greenville, SC are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the bus as it is the most popular way to get from Knoxville, TN to Greenville, SC among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Greenville, SC, travelers should be cautious of pickpocketing and petty theft, especially in crowded areas like downtown and popular events. Common scams include overcharging by unofficial taxi or ride-share drivers and fake charity solicitations. It is advisable to use authorized transportation services, avoid displaying valuables openly, and stay aware of surroundings, particularly at night.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Knoxville, TN to Greenville, SC
Most Knoxville, TN to Greenville, SC buses use the Knoxville, Kirkwood Street to Greenville, Woodruff Rd ("Raceway" gas station) station pair. Use this guide to compare Knoxville, TN and Greenville, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Knoxville
Arrival bus stations in Greenville
Which Knoxville, TN station do buses to Greenville, SC leave from?
Buses from Knoxville, TN to Greenville, SC leave from Knoxville, Kirkwood Street. The station is 3 miles (6 km) from Knoxville, TN city centre at Kirkwood St, Knoxville, TN 37914, USA.
Knoxville, Kirkwood StreetKirkwood St, Knoxville, TN 37914, USA
City-centre transport
Getting to Knoxville, Kirkwood Street from Knoxville city centre
Knoxville, Kirkwood Street is 5 km from Knoxville city centre. Public transport options include:
Bus31, 33 · 20m · €2 · every ~6 min
Knoxville, Kirkwood Street bus station facilities and services
Knoxville, Kirkwood Street has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Knoxville, Kirkwood Street. ATMs are available at Knoxville, Kirkwood Street.
Tickets and information
Ticket office support is available at Knoxville, Kirkwood Street.
Parking, taxis and toilets
Available at Knoxville, Kirkwood Street: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Knoxville, Kirkwood Street: Wheelchair accessible buses available.
Which Greenville, SC station do buses from Knoxville, TN arrive at?
Buses from Knoxville, TN to Greenville, SC arrive at Greenville, Woodruff Rd ("Raceway" gas station). Greenville, Woodruff Rd ("Raceway" gas station) is 4 miles (8 km) from Greenville, SC city centre.
Greenville, Woodruff Rd ("Raceway" gas station)Woodruff Rd, Greenville, SC, USA
City-centre transport
Getting to Greenville, Woodruff Rd ("Raceway" gas station) from Greenville city centre
Greenville, Woodruff Rd ("Raceway" gas station) is 8 km from Greenville city centre. Public transport options include:
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Greenville, Woodruff Rd ("Raceway" gas station) bus station facilities and services
Greenville, Woodruff Rd ("Raceway" gas station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Limited dining options available in adjacent areas.
Wi-Fi and ATMs
Wi-Fi is available at Greenville, Woodruff Rd ("Raceway" gas station). ATMs are available at Greenville, Woodruff Rd ("Raceway" gas station).
Tickets and information
Ticket office support is available at Greenville, Woodruff Rd ("Raceway" gas station).
Parking, taxis and toilets
Available at Greenville, Woodruff Rd ("Raceway" gas station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Greenville, Woodruff Rd ("Raceway" gas station): Basic access available for persons with disabilities.
Most popular bus connections from Knoxville, TN
More options for your journey from Knoxville, TN to Greenville, SC
Here are some other resources that might have the information you need
Most popular buses to and from Greenville, SC and Knoxville, TN
Most popular bus connections to Greenville, SC
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