- Recommended
Greenville County Museum of Art
A major art museum in downtown Greenville with American art, Southern works, and rotating exhibitions in a bright riverfront setting.
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Journey information
Overview: Bus from Knoxville, TN to Greenville, SC
USAUSA
Buses from Knoxville, TN to Greenville, SC run on average 1 times per day, taking around 6h 10m. Cheap bus tickets for this journey start at $54 if you book in advance.
The earliest bus runs at 14:45, the last at 19:25. The fastest bus covers the 114 miles (185 km) distance in 6h 10m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Plan this route
Journey facts
- Distance114 miles (185 km)
- Average bus duration6h 10m
- Cheapest ticket price$54
- Buses per day1
- Fastest bus6h 10m
- First bus2:45 PM
- Last bus7:25 PM
- Cheapest MonthSep
- Cheapest DaySat
- High SeasonJul - Sep
- Low SeasonJan - Mar
Understand & plan this route
Explore this journey
Book with confidence
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Frequently asked questions about your Knoxville, TN to Greenville, SC trip
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Knoxville, TN to Greenville, SC.
Cheap bus tickets from Knoxville, TN to Greenville, SC can start from as little as $54 when you book in advance. The average bus ticket price for Knoxville, TN to Greenville, SC is $87 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The earliest bus from Knoxville, TN to Greenville, SC leaves at 2:45 PM. Plan your trip with the Journey Planner from Omio.
The latest bus from Knoxville, TN to Greenville, SC leaves at 7:25 PM.
There are 1 buses a day from Knoxville, TN to Greenville, SC which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
Knoxville, TN to Greenville, SC Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 12:40AM | Arrival Time 12:00PM | Duration 11h20 | Departure days Tue | Cheapest price $148 |
Operator Greyhound | Departure Time 08:00PM | Arrival Time 03:15AM | Duration 7h15 | Departure days Sun | Cheapest price $68 |
Operator Greyhound | Departure Time 11:40PM | Arrival Time 11:00AM | Duration 11h20 | Departure days Fri | Cheapest price $148 |
Why should you book Knoxville, TN to Greenville, SC buses with Omio?
Greyhound operates all buses services from Knoxville, TN to Greenville, SC.
Omio is an official ticket reseller for all your travel options from Knoxville, TN to Greenville, SC.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
Bus companies
Bus companies from Knoxville, TN to Greenville, SC
Buses from Knoxville, TN to Greenville, SC with Greyhound. Overnight buses available on this route with Greyhound. Use the details below to compare onboard facilities.
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
6h 10m
Cheapest Greyhound Price
$54
Greyhound frequency
1 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Companies, tickets, and onboard amenities between Knoxville, TN and Greenville, SC
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
When taking a bus from Knoxville, TN to Greenville, SC, you can count on Greyhound for the best way to get you to Greenville, SC. You can also check all possible bus companies who offer a service between Knoxville, TN and Greenville, SC and compare the amenities they offer before buying a bus ticket.
Yes, the following accessibility options are available when taking the bus from Knoxville, TN to Greenville, SC:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Knoxville, TN to Greenville, SC for bus company Greyhound.
Whether you can cancel your bus ticket from Knoxville, TN to Greenville, SC depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company {providersWithBike}.
Yes, there is food available to purchase on board the bus from Knoxville, TN to Greenville, SC.
Yes, the following luggage options are included when booking a bus ticket from Knoxville, TN to Greenville, SC:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from Knoxville, TN to Greenville, SC:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from Knoxville, TN to Greenville, SC.
You can reserve your seat on the bus from Knoxville, TN to Greenville, SC with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from Knoxville, TN to Greenville, SC with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from Knoxville, TN to Greenville, SC with the following bus company: Greyhound.
Complete guide to Greenville, SC
Things to do in Greenville, SC
Discover the best of Greenville, SC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Greenville, SC trip today.
Greenville Center for Creative Arts
A contemporary art center showing regional and international artists through rotating exhibitions in a modern downtown gallery space.
Metropolitan Arts Council Gallery
A local gallery and arts space featuring exhibitions, classes, and community-focused programming in Greenville's Village area.
- Must visit
Falls Park on the Reedy
A signature downtown park with waterfalls, gardens, river trails, and lawns. It is Greenville's most popular public space for walking and views.
- Must visit
Main Street
Greenville's central street lined with shops, public art, and historic buildings. It is ideal for strolling between downtown attractions.
- Recommended
Prisma Health Swamp Rabbit Trail
A swamp rabbit-themed riverside greenway popular for walking and cycling, linking downtown Greenville with parks and nearby districts.
- Gluten-free
South Carolina Mustard-Style Barbecue
South Carolina barbecue is slow-smoked pork, often chopped or pulled, and classically served with the state’s distinctive mustard-based sauce.
- Gluten-free
Shrimp And Grits
Shrimp and grits pairs creamy stone-ground grits with shrimp, often enriched with bacon or sausage. It is a Lowcountry staple found across Greenville.
- Vegetarian
Fried Green Tomatoes
Fried green tomatoes are tart unripe tomatoes breaded and fried. They are a beloved Southern side and common on Upstate menus.
Henry's Smokehouse
Casual Greenville barbecue spot serving smoked meats, classic sides, and a relaxed neighborhood atmosphere.
Hall's Chophouse Greenville
Upscale downtown steakhouse and oyster bar with dry-aged beef, seafood, and an elegant supper-club feel.
Soby's
Refined Southern restaurant known for seasonal plates, thoughtful cocktails, and a polished downtown setting.
United States dollar ($)
Moderate for a U.S. city. Hotels and dining are usually cheaper than major metros, but car travel and limited transit can add to visitor costs.
Average meal costs
- Budget
- $10-15 for fast food or a casual meal.
- Mid-range
- $20-35 per person for a restaurant meal.
- Fine dining
- $60+ per person for upscale dining.
- Coffee
- $3-5 for coffee or a cappuccino.
Tipping culture
Tip 18-20% at restaurants, more for excellent service. Taxis usually get 10-15%. Cafes often have tip jars; $1-2 is common for drinks.
Plan your visit to Greenville, SC
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Greenville, SC.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Greenville, SC, travelers should be cautious of pickpocketing and petty theft, especially in crowded areas like downtown and popular events. Common scams include overcharging by unofficial taxi or ride-share drivers and fake charity solicitations. It is advisable to use authorized transportation services, avoid displaying valuables openly, and stay aware of surroundings, particularly at night.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
FAQs: Bus from Knoxville, TN to Greenville, SC
Find answers to the most common questions about traveling from Knoxville, TN to Greenville, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Greenville, SC, this guide helps you travel smarter and with confidence.
Yes, you can take a bus between Knoxville, TN and Greenville, SC.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Most popular buses to and from Greenville, SC and Knoxville, TN
Most popular bus connections to Greenville, SC
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