- Recommended
East Tennessee History Center
Engaging museum on regional history with permanent and rotating exhibits covering people, places, and events from East Tennessee's past.
2,000+ travel companies
2,000+ travel companies
Scan to get our free app
Use our app to get live travel updates and book mobile tickets for trains, buses, flights, and ferries.
App Store
4.942K ratings
Google Play
4.6136K reviews
Journey information
Overview: Bus from Greenville, SC to Knoxville, TN
USAUSA
Buses from Greenville, SC to Knoxville, TN run on average 1 times per day, taking around 6h 35m. Cheap bus tickets for this journey start at $49 if you book in advance.
The earliest bus runs at 14:45, the last at 19:40. The fastest bus covers the 114 miles (185 km) distance in 6h 30m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Plan this route
Journey facts
- Distance114 miles (185 km)
- Average bus duration6h 35m
- Cheapest ticket price$49
- Buses per day1
- Fastest bus6h 30m
- First bus2:45 PM
- Last bus7:40 PM
- Cheapest MonthAug
- Cheapest DaySat
- High SeasonJul - Sep
- Low SeasonJan - Mar
Understand & plan this route
Explore this journey
Book with confidence
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Frequently asked questions about your Greenville, SC to Knoxville, TN trip
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Greenville, SC to Knoxville, TN.
Cheap bus tickets from Greenville, SC to Knoxville, TN can start from as little as $49 when you book in advance. The average bus ticket price for Greenville, SC to Knoxville, TN is $79 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The earliest bus from Greenville, SC to Knoxville, TN leaves at 2:45 PM. Plan your trip with the Journey Planner from Omio.
The latest bus from Greenville, SC to Knoxville, TN leaves at 7:40 PM.
There are 1 buses a day from Greenville, SC to Knoxville, TN which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
Greenville, SC to Knoxville, TN Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 02:45PM | Arrival Time 09:50PM | Duration 7h05 | Departure days Fri | Cheapest price $64 |
Operator Greyhound | Departure Time 02:50PM | Arrival Time 09:50PM | Duration 7h00 | Departure days Tue | Cheapest price $62 |
Why should you book Greenville, SC to Knoxville, TN buses with Omio?
Greyhound operates all buses services from Greenville, SC to Knoxville, TN.
Omio is an official ticket reseller for all your travel options from Greenville, SC to Knoxville, TN.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
Bus companies
Bus companies from Greenville, SC to Knoxville, TN
Buses from Greenville, SC to Knoxville, TN with Greyhound. Overnight buses available on this route with Greyhound. Use the details below to compare onboard facilities.
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
6h 30m
Cheapest Greyhound Price
$49
Greyhound frequency
1 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Companies, tickets, and onboard amenities between Greenville, SC and Knoxville, TN
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
When taking a bus from Greenville, SC to Knoxville, TN, you can count on Greyhound for the best way to get you to Knoxville, TN. You can also check all possible bus companies who offer a service between Greenville, SC and Knoxville, TN and compare the amenities they offer before buying a bus ticket.
Yes, there are bathrooms on board the bus from Greenville, SC to Knoxville, TN for bus company Greyhound.
Yes, the following accessibility options are available when taking the bus from Greenville, SC to Knoxville, TN:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Whether you can cancel your bus ticket from Greenville, SC to Knoxville, TN depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company {providersWithBike}.
Yes, there is food available to purchase on board the bus from Greenville, SC to Knoxville, TN.
Yes, the following luggage options are included when booking a bus ticket from Greenville, SC to Knoxville, TN:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from Greenville, SC to Knoxville, TN:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from Greenville, SC to Knoxville, TN.
You can reserve your seat on the bus from Greenville, SC to Knoxville, TN with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from Greenville, SC to Knoxville, TN with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from Greenville, SC to Knoxville, TN with the following bus company: Greyhound.
Complete guide to Knoxville, TN
Things to do in Knoxville, TN
Discover the best of Knoxville, TN — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Knoxville, TN trip today.
- Recommended
McClung Museum of Natural History and Culture
University museum featuring changing exhibitions of American and international art in a modern gallery setting near campus.
- Recommended
Mabry-Hazen House
Historic house museum preserving the home of artist Adelia Armstrong Lutz, with decorative arts, local history, and period rooms.
- Must visit
Market Square
Lively pedestrian-friendly square lined with shops, events, and public seating. It is a central gathering place and a great base for exploring downtown.
- Must visit
World's Fair Park
Urban park from the 1982 World's Fair with lawns, walking paths, performance spaces, and easy access to the Sunsphere and museums.
- Recommended
Old City
Historic warehouse district with brick streets, galleries, murals, and nightlife. It blends railroad-era character with a creative local feel.
Pulled Pork Barbecue
Smoky pulled pork barbecue is a regional staple in East Tennessee, usually hickory-smoked and served with slaw and sauce at local cookouts and barbecue joints.
Fried Catfish
Fried catfish is a longtime Tennessee favorite, coated in cornmeal and served with hush puppies or sides, especially popular in casual Southern eateries.
Biscuits And Sausage Gravy
Biscuits with sausage gravy are a classic Southern breakfast in Knoxville, featuring flaky biscuits topped with rich peppery gravy made with pork drippings and milk.
Litton's Market Restaurant
Long-running neighborhood restaurant known for hearty Southern comfort food, pies, and a warm, traditional dining room.
Stock & Barrel
Upscale Southern restaurant in Market Square known for shrimp and grits, steaks, and a polished downtown atmosphere.
Sweet P's Barbeque And Soul House
Casual old-school barbecue spot serving hickory-smoked pork, ribs, and classic East Tennessee sides in a relaxed setting.
$ US dollar
Moderate for U.S. city breaks: hotels and dining are reasonable, while car travel is common and public transit is limited for tourists.
Average meal costs
- Budget
- $10-15 for fast food or a casual lunch.
- Mid-range
- $18-35 per person for a restaurant meal.
- Fine dining
- $50+ per person for upscale dining.
- Coffee
- $3-5 for a coffee or cappuccino.
Tipping culture
Tip 18-20% at restaurants, 10-15% for taxis, and $1-2 per drink or coffee is appreciated at cafes.
Plan your visit to Knoxville, TN
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Knoxville, TN.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Knoxville, TN, travelers should be cautious of pickpocketing and vehicle break-ins, especially in crowded areas and parking lots. Avoid accepting unsolicited offers for transportation or tours, as unlicensed operators may overcharge or provide unsafe services. It's also advisable to stay in well-lit areas at night and be aware of local traffic patterns when using ride-share or public transportation to ensure safety.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
FAQs: Bus from Greenville, SC to Knoxville, TN
Find answers to the most common questions about traveling from Greenville, SC to Knoxville, TN by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Knoxville, TN, this guide helps you travel smarter and with confidence.
Yes, you can take a bus between Greenville, SC and Knoxville, TN.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Most popular bus connections from Greenville, SC
Most popular buses to and from Knoxville, TN and Greenville, SC
Most popular bus connections to Knoxville, TN
The Omio App Makes Travel Planning Easy
We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.
