- Recommended
East Tennessee History Center
Engaging museum on regional history with permanent and rotating exhibits covering people, places, and events from East Tennessee's past.
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Travel Information
Compare bus for Greenville, SC to Knoxville, TN
Omio recommends booking the bus as it is the most popular option from Greenville, SC to Knoxville, TN among Omio's users. If you are prioritising price, take the bus, with an average ticket price of €79 For those with little time, consider booking a bus, which has an average total journey time of 7h 5m. Average ticket prices depend on the travel mode: a bus costs an average of €79, while a bus costs an average of €79.
Distance: 114 miles (185 km)
Compare bus with
Most popular Bus | Driving |
|---|---|
€79 Average price Cheapest | €28 Average price (fuel + tolls) |
7h 5m Average total duration Fastest 6h 35m Onboard + 30m Additional time* | 3h 0m Average total duration (door-to-door) |
 Most popular bus company | Your own car or car rental |
Direct Options | Direct Options |
The cheapest way to travel from Greenville, SC to Knoxville, TN is a bus with an average price of €79.
The fastest way to travel from Greenville, SC to Knoxville, TN is by bus with an average journey time of 6h 35m.
Yes, you can take a bus between Greenville, SC and Knoxville, TN.
We recommend using the bus as it is the most popular way to get from Greenville, SC to Knoxville, TN among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.
Tickets start at around €79 compared to roughly €28 in fuel and tolls — a saving of about €-50.64. The journey takes 6h 35m versus 3h 0m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
Greenville, SC to Knoxville, TN Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 02:45PM | Arrival Time 09:50PM | Duration 7h05 | Departure days Mon, Sat | Cheapest price €39 |
Operator Greyhound | Departure Time 07:45PM | Arrival Time 02:50AM | Duration 7h05 | Departure days Fri | Cheapest price €77 |
Compare prices and tickets Greenville, SC to Knoxville, TN by bus
Compare bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Greenville, SC to Knoxville, TN buses with Omio?
Greyhound operates all buses services from Greenville, SC to Knoxville, TN.
Omio is an official ticket reseller for all your travel options from Greenville, SC to Knoxville, TN.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
Journey information
Overview: Bus from Greenville, SC to Knoxville, TN
USAUSA
Buses from Greenville, SC to Knoxville, TN run on average 1 times per day, taking around 6h 35m. Cheap bus tickets for this journey start at €46 if you book in advance.
The earliest bus runs at 14:45, the last at 19:40. The fastest bus covers the 114 miles (185 km) distance in 6h 35m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 114 miles (185 km) |
Average bus duration 6h 35m |
Cheapest ticket price €46 |
Buses per day 1 |
Fastest bus 6h 35m |
First bus 2:45 PM |
Last bus 7:40 PM |
Cheapest Month Sep |
Cheapest Day Sat |
High Season Jul - Sep |
Low Season Jan - Mar |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound from Greenville, SC to Knoxville, TNYou can travel by bus between Greenville, SC to Knoxville, TN with Greyhound for as low as €46. When you search for schedules and tickets, Omio will show you the best journey
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
6h 35m
Cheapest Greyhound Price
€46
Greyhound frequency
1 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Knoxville, TN
Things to do in Knoxville, TN
Discover the best of Knoxville, TN — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Knoxville, TN trip today.
- Recommended
McClung Museum of Natural History and Culture
University museum featuring changing exhibitions of American and international art in a modern gallery setting near campus.
- Recommended
Mabry-Hazen House
Historic house museum preserving the home of artist Adelia Armstrong Lutz, with decorative arts, local history, and period rooms.
- Must visit
Market Square
Lively pedestrian-friendly square lined with shops, events, and public seating. It is a central gathering place and a great base for exploring downtown.
- Must visit
World's Fair Park
Urban park from the 1982 World's Fair with lawns, walking paths, performance spaces, and easy access to the Sunsphere and museums.
- Recommended
Old City
Historic warehouse district with brick streets, galleries, murals, and nightlife. It blends railroad-era character with a creative local feel.
FAQs: Bus from Greenville, SC to Knoxville, TN
Find answers to the most common questions about traveling from Greenville, SC to Knoxville, TN by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Knoxville, TN, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Greenville, SC to Knoxville, TN can start from as little as €46 when you book in advance. The average bus ticket price for Greenville, SC to Knoxville, TN is €79 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Greenville, SC to Knoxville, TN is 6h 35m to travel the 114 miles (185 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Greenville, SC to Knoxville, TN leaves at 2:45 PM. Plan your trip with the Journey Planner from Omio.
The latest bus from Greenville, SC to Knoxville, TN leaves at 7:40 PM.
There are 1 buses a day from Greenville, SC to Knoxville, TN which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Greenville, SC to Knoxville, TN, you can count on Greyhound for the best way to get you to Knoxville, TN. You can also check all possible bus companies who offer a service between Greenville, SC and Knoxville, TN and compare the amenities they offer before buying a bus ticket.
Passengers board the bus most frequently from Greenville, Woodruff Rd ("Raceway" gas station), SC, which is located around 4 miles (8 km) away from the city centre, and they get off the bus at Knoxville, Kirkwood Street, TN, located 5 away from the city centre.
A trip to Knoxville, TN from Greenville, SC is worth doing but not as a day trip with a journey time of 6h 35m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Greenville, SC to Knoxville, TN is September.
Yes, you can take a bus between Greenville, SC and Knoxville, TN.
Yes, there are bathrooms on board the bus from Greenville, SC to Knoxville, TN for bus company Greyhound.
Yes, the following accessibility options are available when taking the bus from Greenville, SC to Knoxville, TN:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Whether you can cancel your bus ticket from Greenville, SC to Knoxville, TN depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Greenville, SC to Knoxville, TN.
Yes, the following luggage options are included when booking a bus ticket from Greenville, SC to Knoxville, TN:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from Greenville, SC to Knoxville, TN:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from Greenville, SC to Knoxville, TN.
You can reserve your seat on the bus from Greenville, SC to Knoxville, TN with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from Greenville, SC to Knoxville, TN with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from Greenville, SC to Knoxville, TN with the following bus company: Greyhound.
Since neither Greenville, SC nor Knoxville, TN are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the bus as it is the most popular way to get from Greenville, SC to Knoxville, TN among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Knoxville, TN, travelers should be cautious of pickpocketing and vehicle break-ins, especially in crowded areas and parking lots. Avoid accepting unsolicited offers for transportation or tours, as unlicensed operators may overcharge or provide unsafe services. It's also advisable to stay in well-lit areas at night and be aware of local traffic patterns when using ride-share or public transportation to ensure safety.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Greenville, SC to Knoxville, TN
Most Greenville, SC to Knoxville, TN buses use the Greenville, Woodruff Rd ("Raceway" gas station) to Knoxville, Kirkwood Street station pair. Use this guide to compare Greenville, SC and Knoxville, TN bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Greenville
Arrival bus stations in Knoxville
Which Greenville, SC station do buses to Knoxville, TN leave from?
Buses from Greenville, SC to Knoxville, TN leave from Greenville, Woodruff Rd ("Raceway" gas station). The station is 4 miles (8 km) from Greenville, SC city centre at Woodruff Rd, Greenville, SC, USA.
Greenville, Woodruff Rd ("Raceway" gas station)Woodruff Rd, Greenville, SC, USA
City-centre transport
Getting to Greenville, Woodruff Rd ("Raceway" gas station) from Greenville city centre
Greenville, Woodruff Rd ("Raceway" gas station) is 8 km from Greenville city centre. Public transport options include:
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Greenville, Woodruff Rd ("Raceway" gas station) bus station facilities and services
Greenville, Woodruff Rd ("Raceway" gas station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Limited dining options available in adjacent areas.
Wi-Fi and ATMs
Wi-Fi is available at Greenville, Woodruff Rd ("Raceway" gas station). ATMs are available at Greenville, Woodruff Rd ("Raceway" gas station).
Tickets and information
Ticket office support is available at Greenville, Woodruff Rd ("Raceway" gas station).
Parking, taxis and toilets
Available at Greenville, Woodruff Rd ("Raceway" gas station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Greenville, Woodruff Rd ("Raceway" gas station): Basic access available for persons with disabilities.
Which Knoxville, TN station do buses from Greenville, SC arrive at?
Buses from Greenville, SC to Knoxville, TN arrive at Knoxville, Kirkwood Street. Knoxville, Kirkwood Street is 3 miles (6 km) from Knoxville, TN city centre.
Knoxville, Kirkwood StreetKirkwood St, Knoxville, TN 37914, USA
City-centre transport
Getting to Knoxville, Kirkwood Street from Knoxville city centre
Knoxville, Kirkwood Street is 5 km from Knoxville city centre. Public transport options include:
Bus31, 33 · 20m · €2 · every ~6 min
Knoxville, Kirkwood Street bus station facilities and services
Knoxville, Kirkwood Street has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Knoxville, Kirkwood Street. ATMs are available at Knoxville, Kirkwood Street.
Tickets and information
Ticket office support is available at Knoxville, Kirkwood Street.
Parking, taxis and toilets
Available at Knoxville, Kirkwood Street: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Knoxville, Kirkwood Street: Wheelchair accessible buses available.
Most popular bus connections from Greenville, SC
More options for your journey from Greenville, SC to Knoxville, TN
Here are some other resources that might have the information you need
Most popular buses to and from Knoxville, TN and Greenville, SC
Most popular bus connections to Knoxville, TN
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