- Must visit
Newfields
Major campus combining the Indianapolis Museum of Art, gardens, and seasonal installations. Strong all-around choice for art, design, and outdoor strolling.
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The cheapest and fastest buses from Knoxville, TN to Indianapolis, IN
Showing times and prices for Jun 22
Cheapest price
$106
Average price
$112
Fastest journey
13 h
Average duration
13 h 50 m
Buses per day
2
Distance
467 km
Cheap tickets
The best way to find a cheap bus ticket from Knoxville, TN to Indianapolis, IN is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Knoxville, TN to Indianapolis, IN will cost around $112 if you buy it on the day, but the cheapest tickets can be found for only $106.
Fast buses
It's difficult to get from Knoxville, TN to Indianapolis, IN without transferring at least 2 times.
5:45 PM14h40Knoxville, TN8:25 AMIndianapolis, IN$1061One-way2 transfers- 9:15 PM13h00Knoxville, TN10:15 AMIndianapolis, IN$1191One-way2 transfers
- 9:15 PM13h00Knoxville, TN10:15 AMIndianapolis, IN$1191One-way2 transfers
- 5:45 PM14h40Knoxville, TN8:25 AMIndianapolis, IN$1061One-way2 transfers
Travel Information
Compare bus for Knoxville, TN to Indianapolis, IN
Omio recommends booking the bus as it is the most popular option from Knoxville, TN to Indianapolis, IN among Omio's users. If you are prioritising price take the bus with prices starting from $159. For those with little time consider booking a bus which can get you there in 9h 15m. The ticket price range depends on the travel mode: a bus costs an average of $159, and a bus costs an average of $159.
Distance: 290 miles (467 km)
Compare bus with
Most popular Bus | Driving |
|---|---|
$159 Average price Cheapest | $71 Average price (fuel + tolls) |
9h 45m Average total duration Fastest 9h 15m Onboard + 30m Additional time* | 5h 13m Average total duration (door-to-door) |
 Most popular bus company | Your own car or car rental |
Direct Options | Direct Options |
The cheapest way to travel from Knoxville, TN to Indianapolis, IN is a bus with an average price of $159 (€130).
The fastest way to travel from Knoxville, TN to Indianapolis, IN is by bus with an average journey time of 9h 15m.
Yes, you can take a bus between Knoxville, TN and Indianapolis, IN.
We recommend using the bus as it is the most popular way to get from Knoxville, TN to Indianapolis, IN among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Knoxville, TN to Indianapolis, IN Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Tahoe Transportation | Departure Time 05:45PM | Arrival Time 08:25AM | Duration 14h40 | Departure days Mon, Tue, Wed | Cheapest price $106 |
Operator Greyhound | Departure Time 06:10PM | Arrival Time 04:45AM | Duration 10h35 | Departure days Fri, Sun | Cheapest price $87 |
Operator FlixBus | Departure Time 06:10PM | Arrival Time 08:25AM | Duration 14h15 | Departure days Fri, Sun | Cheapest price $80 |
Operator Greyhound | Departure Time 07:40PM | Arrival Time 12:05PM | Duration 16h25 | Departure days Fri, Sun | Cheapest price $81 |
Operator Tahoe Transportation | Departure Time 09:15PM | Arrival Time 09:15AM | Duration 12h00 | Departure days Mon, Tue, Wed | Cheapest price $119 |
Operator Greyhound | Departure Time 11:40PM | Arrival Time 04:05PM | Duration 16h25 | Departure days Thu | Cheapest price $159 |
Live departures
Knoxville, TN to Indianapolis, IN bus times
The table below shows live departures for Knoxville, TN to Indianapolis, IN buses for today, Sunday, June 21. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| · | 6:10 PM Knoxville, Kirkwood Street, TN | 10h35 | 4:45 AM Indianapolis, Illinois St (Greyhound Bus Station) | 1 transfer | |
 FlixBus+ | 6:10 PM Knoxville, Kirkwood Street, TN | 14h15 | 8:25 AM Indianapolis, E Washington St / N Delaware St (City/County Building), IN | 1 transfer | |
| · | 7:40 PM Knoxville, Kirkwood Street, TN | 16h25 | 12:05 PM Indianapolis, Illinois St (Greyhound Bus Station) | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Knoxville, TN to Indianapolis, IN by bus
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Why should you book Knoxville, TN to Indianapolis, IN buses with Omio?
Greyhound as well as Tahoe Transportation offer buses services from Knoxville, TN to Indianapolis, IN.
Omio is an official ticket reseller for all your travel options from Knoxville, TN to Indianapolis, IN.
Why book with Omio vs Greyhound?
- Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of Tahoe Transportation to find the best option for your trip from Knoxville, TN to Indianapolis, IN.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
Journey information
Overview: Bus from Knoxville, TN to Indianapolis, IN
USAUSA
Buses from Knoxville, TN to Indianapolis, IN run on average 3 times per day, taking around 9h 15m. Cheap bus tickets for this journey start at $159 (€130) if you book in advance.
The earliest bus runs at 04:50, the last at 19:25. The fastest bus covers the 290 miles (467 km) distance in 16h 25m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 290 miles (467 km) |
Average bus duration 9h 15m |
Cheapest ticket price $159 (€130) |
Buses per day 3 |
Fastest bus 16h 25m |
First bus 4:50 AM |
Last bus 7:25 PM |
Cheapest Month Oct |
Cheapest Day Sun |
High Season Jan - Mar |
Low Season Oct - Dec |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound, Tahoe Transportation from Knoxville, TN to Indianapolis, INYou can travel by bus between Knoxville, TN to Indianapolis, IN with Greyhound, Tahoe Transportation for as low as $159 (€130). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
16h 25m
Cheapest Price
$159 (€130)
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Tahoe Transportation
Luggage & cancellation policy
Average Duration
12h 0m
Cheapest Price
$106 (€87)
Tahoe Transportation frequency
2 a day
Complete guide to Indianapolis
Things to do in Indianapolis
Discover the best of Indianapolis — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Indianapolis trip today.
- Must visit
The Children's Museum of Indianapolis
One of the world’s largest children’s museums, known for immersive science, history, and culture exhibits that also appeal to many adults.
- Recommended
Eiteljorg Museum
Respected museum focused on Native American and Western art, with strong permanent collections and rotating exhibitions.
- Must visit
Monument Circle
Iconic downtown circle and gathering place centered on the city’s best-known monument. A top orientation point and classic Indianapolis photo stop.
- Must visit
Canal Walk
Popular pedestrian route along the downtown canal, lined with museums, public art, paddle boats, and skyline views.
- Recommended
White River State Park
Large urban park complex connecting major attractions, trails, green spaces, and event venues near downtown.
Pork Tenderloin Sandwich
Indiana’s signature sandwich: a breaded and fried pork cutlet served on a bun, often comically larger than the bread. It is a classic Central Indiana comfort food.
- Gluten-free
Shrimp Cocktail
A St. Elmo Steak House staple in Indianapolis, known for jumbo shrimp served with an intensely spicy horseradish cocktail sauce. It is one of the city’s most famous signature dishes.
- Vegetarian
Sugar Cream Pie
Often called Indiana’s state pie, this simple custard-style pie is made with cream, sugar, and nutmeg. It is a beloved Hoosier dessert with deep local roots.
St. Elmo Steak House
Historic downtown steakhouse famous for shrimp cocktail, steaks, and classic old-school service. One of Indianapolis’s most iconic dining rooms.
Bluebeard
Well-known modern restaurant in Fletcher Place serving seasonal American cooking with a chef-driven menu in a stylish, industrial space.
Harry & Izzy's
Established upscale-casual spot related to St. Elmo, known for steaks, shrimp cocktail, and polished service in a more relaxed setting.
United States Dollar
Generally moderate for U.S. travel. Hotels vary by events; dining and transport are usually manageable.
Average meal costs
- Budget
- USD 10-15 for fast food or casual takeout.
- Mid-range
- USD 20-40 per person at a mid-range restaurant.
- Fine dining
- USD 75+ per person before drinks and tax.
- Coffee
- USD 4-6 for a regular coffee or latte.
Tipping culture
Tip 18-20% at restaurants; 20%+ for great service. Tip bartenders USD 1-2 per drink, taxis 10-15%, hotel staff USD 2-5, and round up for cafes if desired.
FAQs: Bus from Knoxville, TN to Indianapolis, IN
Find answers to the most common questions about traveling from Knoxville, TN to Indianapolis, IN by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Indianapolis, IN, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Knoxville, TN to Indianapolis, IN can start from as little as $159 (€130) when you book in advance. The average bus ticket price for Knoxville, TN to Indianapolis, IN is $159 (€130) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Knoxville, TN to Indianapolis, IN is 16h 25m to travel the 290 miles (467 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Knoxville, TN to Indianapolis, IN leaves at 4:50 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Knoxville, TN to Indianapolis, IN leaves at 7:25 PM.
There are 3 buses a day from Knoxville, TN to Indianapolis, IN which require at least one change with Greyhound, Tahoe Transportation. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Knoxville, TN to Indianapolis, IN, you can count on Greyhound, Tahoe Transportation for the best way to get you to Indianapolis, IN. You can also check all possible bus companies who offer a service between Knoxville, TN and Indianapolis, IN and compare the amenities they offer before buying a bus ticket.
A trip to Indianapolis, IN from Knoxville, TN is worth doing but not as a day trip with a journey time of 16h 25m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Knoxville, TN to Indianapolis, IN is October.
Yes, you can take a bus between Knoxville, TN and Indianapolis, IN.
Yes, the following accessibility options are available when taking the bus from Knoxville, TN to Indianapolis, IN:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Knoxville, TN to Indianapolis, IN for bus company Greyhound.
Some of the most interesting sights to explore in Indianapolis, IN are:
- Indianapolis Motor Speedway, a historic racing circuit known for hosting the Indianapolis 500
- The Children's Museum of Indianapolis, the world's largest children's museum featuring interactive exhibits
- Indianapolis Zoo, a popular attraction with diverse animal exhibits and a botanical garden
- Indiana State Museum, showcasing the state's history, art, and science through various exhibits
- White River State Park, a sprawling urban park offering trails, gardens, and cultural attractions.
The best things to do in Indianapolis, IN include:
- Indianapolis Museum of Art at Newfields, a vast art museum with extensive collections and beautiful gardens
- Attend a race at the Indianapolis Motor Speedway, home of the iconic Indy 500
- Explore the interactive exhibits and educational programs at The Children's Museum of Indianapolis
- Visit the dolphin pavilion and animal habitats at the Indianapolis Zoo
- Enjoy a walk along the canal and cultural attractions at White River State Park.
Whether you can cancel your bus ticket from Knoxville, TN to Indianapolis, IN depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Knoxville, TN to Indianapolis, IN.
Yes, the following luggage options are included when booking a bus ticket from Knoxville, TN to Indianapolis, IN:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from Knoxville, TN to Indianapolis, IN:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from Knoxville, TN to Indianapolis, IN.
You can reserve your seat on the bus from Knoxville, TN to Indianapolis, IN with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from Knoxville, TN to Indianapolis, IN with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from Knoxville, TN to Indianapolis, IN with the following bus company: Greyhound.
Since neither Knoxville, TN nor Indianapolis, IN are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the bus as it is the most popular way to get from Knoxville, TN to Indianapolis, IN among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Indianapolis, travelers should be cautious of pickpocketing and vehicle break-ins, especially in busy areas like downtown and near major event venues. Common scams include overcharging by unofficial taxi or rideshare drivers and distraction tactics used to steal belongings. It's advised to use authorized transportation services, avoid poorly lit or unfamiliar areas at night, and keep valuables secure.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Knoxville, TN to Indianapolis, IN
Knoxville
Indianapolis
The major bus station for departures in Knoxville is Knoxville, Kirkwood Street. Find all the information you need to know about services, amenities and connections at Knoxville, Kirkwood Street for your trip from Knoxville to Indianapolis.
Knoxville, Kirkwood Street
information
The major bus station for arrivals in Indianapolis is Indianapolis, Illinois St (Greyhound Bus Station). Find all the information you need to know about services, amenities and connections at Indianapolis, Illinois St (Greyhound Bus Station) for your trip to Indianapolis from Knoxville.
Indianapolis, Illinois St (Greyhound Bus Station)
information
Indianapolis, E Washington St / N Delaware St (City/County Building)
information
Most popular bus connections from Knoxville, TN
More options for your journey from Knoxville, TN to Indianapolis, IN
Here are some other resources that might have the information you need
Most popular buses to and from Indianapolis, IN and Knoxville, TN
Most popular bus connections to Indianapolis, IN
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