Harrisburg, PA to Des Moines, IA bus with FlixBus

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The cheapest and fastest buses from Harrisburg, PA to Des Moines, IA

Showing times and prices for Feb 05

Cheapest price

$402

Average price

$402

Fastest journey

2 d 55 m

Average duration

2 d 55 m

Buses per day

1

Distance

1410 km

Cheap tickets

The best way to find a cheap bus ticket from Harrisburg, PA to Des Moines, IA is to book your journey as far in advance as possible and to avoid traveling at rush hour.

The average ticket from Harrisburg, PA to Des Moines, IA will cost around $402 if you buy it on the day, but the cheapest tickets can be found for only $402.

Fast buses

It's difficult to get from Harrisburg, PA to Des Moines, IA without transferring at least 2 times.

Flixbus USA
03:00PM48h55
Harrisburg, PA
03:55PMDes Moines, IA
$4021One-way
2 transfers

Live departures

Harrisburg, PA to Des Moines, IA bus times

The table below shows live departures for Harrisburg, PA to Des Moines, IA buses for tomorrow, Thursday, February 5. You can also manually refresh the results below to see updated bus journeys.

Last updated at 3:41 PM
ProviderDepartsDurationArrivesTransfers
Tickets
meinfernbus_flixbus3:00 PM Harrisburg, PA
48h55
3:55 PM Des Moines, IA2 transfers

This is the last bus of the day.

Find all the dates and times for this journey

Compare prices and tickets Harrisburg, PA to Des Moines, IA by bus or flight

Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

Thu
Feb 05
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Feb 06
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Feb 07
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Feb 08
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Feb 09
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Feb 10
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Feb 11

Why should you book Harrisburg, PA to Des Moines, IA buses with Omio?

FlixBus operates all buses services from Harrisburg, PA to Des Moines, IA.
Omio is an official ticket reseller for all your travel options from Harrisburg, PA to Des Moines, IA.

Why book with Omio vs FlixBus?

  • Compare with other providers: On Omio, you can not only buy tickets for FlixBus, but also compare tickets for the likes of to find the best option for your trip from Harrisburg, PA to Des Moines, IA.
  • Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
  • Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are bus and flight to ensure you get the best deal for traveling from Harrisburg, PA to Des Moines, IA.

Why book with Omio over Wanderu?

  • Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from Harrisburg, PA to Des Moines, IA.

Journey information

Overview: Bus from Harrisburg, PA to Des Moines, IA

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Buses from Harrisburg, PA to Des Moines, IA run on average 2 times per day, taking around 49h 19m. Cheap bus tickets for this journey start at $405 (€322) if you book in advance.

The earliest bus runs at 02:30, the last at 12:25. The fastest bus covers the 876 miles (1410 km) distance in 48h 55m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance
876 miles (1410 km)
Average bus duration
49h 19m
Cheapest ticket price
$405 (€322)
Buses per day
2
Fastest bus
48h 55m
First bus
02:30
Last bus
12:25
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information

Bus providers: FlixBus from Harrisburg, PA to Des Moines, IAYou can travel by bus between Harrisburg, PA to Des Moines, IA with FlixBus for as low as $405 (€322). When you search for schedules and tickets, Omio will show you the best journey

FlixBus

About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average Duration
48h 50m
Cheapest Price
$263 (€209)
FlixBus frequency
1 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.

FAQs: Bus from Harrisburg, PA to Des Moines, IA

Find answers to the most common questions about traveling from Harrisburg, PA to Des Moines, IA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Des Moines, IA, this guide helps you travel smarter and with confidence.

FAQs
Cheap bus tickets from Harrisburg, PA to Des Moines, IA can start from as little as $405 (€322) when you book in advance. The average bus ticket price for Harrisburg, PA to Des Moines, IA is $405 (€322) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Harrisburg, PA to Des Moines, IA is 48h 55m to travel the 876 miles (1410 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Harrisburg, PA to Des Moines, IA leaves at 2:30 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Harrisburg, PA to Des Moines, IA leaves at 12:25 PM.
There are 2 buses a day from Harrisburg, PA to Des Moines, IA which require at least one change with FlixBus. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Harrisburg, PA to Des Moines, IA, you can count on FlixBus for the best way to get you to Des Moines, IA. You can also check all possible bus companies who offer a service between Harrisburg, PA and Des Moines, IA and compare the amenities they offer before buying a bus ticket.
A trip to Des Moines, IA from Harrisburg, PA is worth doing but not as a day trip with a journey time of 48h 55m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Harrisburg, PA to Des Moines, IA is November.
It's helpful to compare your options as there are 2 ways to travel between Harrisburg, PA and Des Moines, IA including taking a bus and flight.
Yes, there are bathrooms on board the bus from Harrisburg, PA to Des Moines, IA for bus company FlixBus.
Yes, the following accessibility options are available when taking the bus from Harrisburg, PA to Des Moines, IA:
  • FlixBus
    • Assistance
    • Priority boarding
    • Wheelchair-accessible buses.
Whether you can cancel your bus ticket from Harrisburg, PA to Des Moines, IA depends on the bus companies:
  • FlixBus
    • You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Harrisburg, PA to Des Moines, IA.
Yes, the following luggage options are included when booking a bus ticket from Harrisburg, PA to Des Moines, IA:
  • FlixBus
    • One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Harrisburg, PA to Des Moines, IA:
  • FlixBus
    • Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Harrisburg, PA to Des Moines, IA. The following conditions apply:
  • FlixBus
    • Small pets in carriers allowed
    • guide dogs travel for free.
You can reserve your seat on the bus from Harrisburg, PA to Des Moines, IA with the following bus company: FlixBus
Yes, there are USB plugs on board the bus from Harrisburg, PA to Des Moines, IA with the following bus company: FlixBus.
Yes, there is Wifi on board the bus from Harrisburg, PA to Des Moines, IA with the following bus company: FlixBus.

More options for your journey from Harrisburg, PA to Des Moines, IA

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Most popular bus connections to Des Moines, IA

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