The cheapest and fastest buses from Harrisburg, PA to Des Moines, IA
Cheapest price
$402
Average price
$402
Fastest journey
2 d 55 m
Average duration
2 d 55 m
Buses per day
1
Distance
1410 km
The best way to find a cheap bus ticket from Harrisburg, PA to Des Moines, IA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Harrisburg, PA to Des Moines, IA will cost around $402 if you buy it on the day, but the cheapest tickets can be found for only $402.
It's difficult to get from Harrisburg, PA to Des Moines, IA without transferring at least 2 times.


Compare prices and tickets Harrisburg, PA to Des Moines, IA by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Feb 05
Feb 06
Feb 07
Feb 08
Feb 09
Feb 10
Feb 11
Why should you book Harrisburg, PA to Des Moines, IA buses with Omio?
Why book with Omio vs FlixBus?
- Compare with other providers: On Omio, you can not only buy tickets for FlixBus, but also compare tickets for the likes of to find the best option for your trip from Harrisburg, PA to Des Moines, IA.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are bus and flight to ensure you get the best deal for traveling from Harrisburg, PA to Des Moines, IA.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from Harrisburg, PA to Des Moines, IA.
Journey information
Overview: Bus from Harrisburg, PA to Des Moines, IA
Buses from Harrisburg, PA to Des Moines, IA run on average 2 times per day, taking around 49h 19m. Cheap bus tickets for this journey start at $405 (€322) if you book in advance.
The earliest bus runs at 02:30, the last at 12:25. The fastest bus covers the 876 miles (1410 km) distance in 48h 55m.
Distance 876 miles (1410 km) |
Average bus duration 49h 19m |
Cheapest ticket price $405 (€322) |
Buses per day 2 |
Fastest bus 48h 55m |
First bus 02:30 |
Last bus 12:25 |
Bus providers: FlixBus from Harrisburg, PA to Des Moines, IAYou can travel by bus between Harrisburg, PA to Des Moines, IA with FlixBus for as low as $405 (€322). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
FAQs: Bus from Harrisburg, PA to Des Moines, IA
Find answers to the most common questions about traveling from Harrisburg, PA to Des Moines, IA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Des Moines, IA, this guide helps you travel smarter and with confidence.

- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- FlixBus
- Additional luggage can be purchased for a fee.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
Most popular bus connections from Harrisburg, PA
More options for your journey from Harrisburg, PA to Des Moines, IA
Here are some other resources that might have the information you need
