The cheapest and fastest buses from Harrisburg, PA to San Diego, CA
Cheapest price
$245
Average price
$294
Fastest journey
2 d 18 h 15 m
Average duration
3 d 10 m
Buses per day
2
Distance
3664 km
The best way to find a cheap bus ticket from Harrisburg, PA to San Diego, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Harrisburg, PA to San Diego, CA will cost around $294 if you buy it on the day, but the cheapest tickets can be found for only $245.
Of the 2 buses that leave Harrisburg, PA for San Diego, CA on Sat, Jan 31, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sat, Jan 31 the direct buses cover the 3664 km distance in an average of 3 d 10 m but if you time it right, some buses will get you there in just 2 d 18 h 15 m .
On Sat, Jan 31 the slowest buses will take 3 d 6 h 5 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.




Travel Information
Compare train, bus, and flight for Harrisburg, PA to San Diego, CA
Omio recommends booking the train as it is the most popular option from Harrisburg, PA to San Diego, CA among Omio's users. If you are prioritising price take the bus with prices starting from €193. For those with little time consider booking a flight which can get you there in 8h 18m. The ticket price range depends on the travel mode: a bus costs an average of €193, and a flight costs an average of €247.
Distance: 2276 miles (3664 km)
Compare bus with
| Bus | Most popular Train | Flight |
|---|---|---|
€228 Average price Cheapest | €377 Average price | €382 Average price |
70h 13m Average total duration 69h 43m Onboard + 30m Additional time* | 61h 47m Average total duration 61h 17m Onboard + 30m Additional time* | 11h 18m Average total duration Fastest 8h 18m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options | Direct Options |
Harrisburg, PA to San Diego, CA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 02:50PM | Arrival Time 10:35AM | Duration 70h45 | Departure days Fri | Cheapest price $365 |
Operator Greyhound | Departure Time 08:15PM | Arrival Time 02:40PM | Duration 69h25 | Departure days Fri | Cheapest price $283 |
Operator Greyhound | Departure Time 09:10PM | Arrival Time 10:15PM | Duration 76h05 | Departure days Fri | Cheapest price $584 |
Live departures
Harrisburg, PA to San Diego, CA bus times
The table below shows live departures for Harrisburg, PA to San Diego, CA buses for today, Friday, January 30. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
undefined · undefined · undefined · undefined | 7:50 PM Harrisburg, Market St (Bus Station), PA | 70h45 | 6:35 PM San Diego, San Ysidro Transit Center | 4 transfers | |
undefined · undefined · undefined · undefined | 7:50 PM Harrisburg, Market St (Bus Station), PA | 70h15 | 6:05 PM San Diego, West Harbor Drive (The Headquarters at Seaport District), CA | 4 transfers | |
undefined · undefined · undefined · undefined | 7:50 PM Harrisburg, Market St (Bus Station), PA | 71h55 | 7:45 PM San Diego, Congress Street (Old Town Park), CA | 4 transfers | |
| Saturday, January 31 | |||||
undefined · undefined · undefined · undefined | 1:15 AM Harrisburg, Market St (Bus Station), PA | 68h55 | 10:10 PM San Diego, Congress Street (Old Town Park), CA | 5 transfers | |
undefined · undefined · undefined · undefined | 1:15 AM Harrisburg, Market St (Bus Station), PA | 69h25 | 10:40 PM San Diego, San Ysidro Transit Center | 5 transfers | |
undefined · undefined · undefined · undefined | 1:15 AM Harrisburg, Market St (Bus Station), PA | 71h55 | 1:10 AM San Diego, Rail Ct / E San Ysidro Blvd (McDonald`s), CA | 5 transfers | |
undefined · undefined · undefined+ FlixBus | 2:10 AM Harrisburg, Market St (Bus Station), PA | 72h00 | 2:10 AM San Diego, Congress Street (Old Town Park), CA | 4 transfers | |
undefined · undefined · undefined+ FlixBus | 2:10 AM Harrisburg, Market St (Bus Station), PA | 76h05 | 6:15 AM San Diego, West Harbor Drive (The Headquarters at Seaport District), CA | 3 transfers | |
undefined · undefined · undefined · undefined | 2:10 AM Harrisburg, Market St (Bus Station), PA | 71h35 | 1:45 AM San Diego, Congress Street (Old Town Park), CA | 3 transfers | |
![]() | 6:30 AM Harrisburg, PA | 66h15 | 12:45 AM San Diego, CA | 0 transfersDirect | |
Find all the dates and times for this journey
Compare prices and tickets Harrisburg, PA to San Diego, CA by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Jan 31
Feb 01
Feb 02
Feb 03
Feb 04
Feb 05
Feb 06
Why should you book Harrisburg, PA to San Diego, CA buses with Omio?
Why book with Omio vs Greyhound?
- Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of to find the best option for your trip from Harrisburg, PA to San Diego, CA.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Harrisburg, PA to San Diego, CA.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Harrisburg, PA to San Diego, CA.
Journey information
Overview: Bus from Harrisburg, PA to San Diego, CA
Buses from Harrisburg, PA to San Diego, CA run on average 12 times per day, taking around 69h 43m. Cheap bus tickets for this journey start at $245 (€193) if you book in advance.
The earliest bus runs at 02:30, the last at 23:20. The fastest bus covers the 2276 miles (3664 km) distance in 66h 15m.
Distance 2276 miles (3664 km) |
Average bus duration 69h 43m |
Cheapest ticket price $245 (€193) |
Buses per day 12 |
Fastest bus 66h 15m |
First bus 02:30 |
Last bus 23:20 |
Bus providers: Greyhound from Harrisburg, PA to San Diego, CAYou can travel by bus between Harrisburg, PA to San Diego, CA with Greyhound for as low as $245 (€193). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from Harrisburg, PA to San Diego, CA
Find answers to the most common questions about traveling from Harrisburg, PA to San Diego, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at San Diego, CA, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Balboa Park, a sprawling urban park with museums, gardens, and the San Diego Zoo
- USS Midway Museum, a historic naval aircraft carrier museum offering interactive exhibits and tours
- La Jolla Cove, a picturesque coastal area known for its stunning views and marine life
- Gaslamp Quarter, a lively historic district with Victorian architecture, dining, and entertainment options
- Coronado Beach, a beautiful sandy beach known for its gentle waves and iconic hotel.
- Explore the vibrant art scene at the Museum of Contemporary Art San Diego
- enjoy a harbor cruise for stunning views of the skyline and naval ships
- hike the scenic trails at Torrey Pines State Natural Reserve
- visit the Birch Aquarium to learn about marine life and ocean conservation
- experience the thrill of a whale watching tour off the coast.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from Harrisburg, PA to San Diego, CA
Most popular bus connections from Harrisburg, PA
More options for your journey from Harrisburg, PA to San Diego, CA
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