- Must visit
Art Institute of Chicago
World-class art museum with masterpieces from Monet to Hopper and the famous Modern Wing.
Cheapest price on Oct 21
$95
Average ticket price on Oct 21
$111
Fastest journey on Oct 21
16 h 30 m
Average journey duration on Oct 21
16 h 30 m
Buses on Oct 21
2
Distance
919 km
The best way to find a cheap bus ticket from Harrisburg, PA to Chicago, IL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Harrisburg, PA to Chicago, IL will cost around $111 if you buy it on the day, but the cheapest tickets can be found for only $95.
On Wed, Oct 21, we found 2 buses from Harrisburg, PA to Chicago, IL, including 2 direct services.
On Wed, Oct 21 the direct buses cover the 919 km distance in an average of 16 h 30 m but if you time it right, some buses will get you there in just 16 h 30 m .
On Wed, Oct 21 the slowest buses will take 16 h 30 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.




Buses from Harrisburg, PA to Chicago, IL run on average 5 times per day, taking around 16h 14m. Cheap bus tickets for this journey start at $64 if you book in advance.
There are 2 buses per day. The earliest bus runs at 02:30, the last at 23:35. The fastest bus covers the 571 miles (919 km) distance in 14h 5m.
Distance 571 miles (919 km) |
Average bus duration 16h 14m |
Cheapest ticket price $64 |
Buses per day 5 |
Direct buses 2 |
Fastest bus 14h 5m |
First bus 2:30 AM |
Last bus 11:35 PM |
Cheapest Month Sep |
Cheapest Day Wed |
High Season Jul - Sep |
Low Season Oct - Dec |
Busiest Day Wed |
Least Busy Day Wed |
Best time to book 14 days |
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 12:05AM | Arrival Time 03:00PM | Duration 14h55 | Departure days Tue | Cheapest price $192 |
Operator Greyhound | Departure Time 01:05AM | Arrival Time 08:10PM | Duration 19h05 | Departure days Tue | Cheapest price $147 |
Operator Greyhound | Departure Time 02:30AM | Arrival Time 08:05PM | Duration 18h35 | Departure days Tue, Thu, Fri | Cheapest price $81 |
Operator FlixBus | Departure Time 02:30AM | Arrival Time 06:55PM | Duration 17h25 | Departure days Sat, Sun | Cheapest price $102 |
Operator Greyhound | Departure Time 07:30AM | Arrival Time 02:05AM | Duration 18h35 | Departure days Mon | Cheapest price $207 |
Operator FlixBus | Departure Time 02:40PM | Arrival Time 06:10AM | Duration 16h30 | Departure days Thu, Fri, Sat, Sun | Cheapest price $91 |
Operator FlixBus | Departure Time 02:50PM | Arrival Time 06:10AM | Duration 16h20 | Departure days Thu, Fri, Sat, Sun | Cheapest price $81 |
Operator Greyhound | Departure Time 02:50PM | Arrival Time 08:00AM | Duration 18h10 | Departure days Tue, Thu, Fri, Sat, Sun | Cheapest price $87 |
Operator FlixBus | Departure Time 06:40PM | Arrival Time 11:10AM | Duration 16h30 | Departure days Wed | Cheapest price $95 |
Operator FlixBus | Departure Time 07:40PM | Arrival Time 12:10PM | Duration 16h30 | Departure days Mon, Wed | Cheapest price $128 |
Operator Greyhound | Departure Time 08:05PM | Arrival Time 01:45PM | Duration 18h40 | Departure days Tue, Thu, Fri, Sat, Sun | Cheapest price $82 |
The table below shows live departures for Harrisburg, PA to Chicago, IL buses for today, Tuesday, October 20. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus+![]() | 2:30 AM Harrisburg, Market St (Bus Station), PA | 18h35 | 8:05 PM Chicago, Greyhound Bus Station | 1 transfer | |
· | 2:50 PM Harrisburg, Market St (Bus Station), PA | 18h10 | 8:00 AM Chicago, Union Station (Amtrak), IL | 1 transfer | |
· | 2:50 PM Harrisburg, Market St (Bus Station), PA | 18h35 | 8:25 AM Chicago, Greyhound Bus Station | 1 transfer | |
· · | 8:05 PM Harrisburg, Market St (Bus Station), PA | 18h40 | 1:45 PM Chicago, Union Station (Amtrak), IL | 2 transfers | |
· | 8:05 PM Harrisburg, Market St (Bus Station), PA | 14h55 | 10:00 AM Chicago, Greyhound Bus Station | 1 transfer |
Find all the dates and times for this journey
Discover the best of Chicago, IL — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Chicago, IL trip today.
World-class art museum with masterpieces from Monet to Hopper and the famous Modern Wing.
Major natural history museum with Sue the T. rex, ancient cultures, and strong family appeal.
Hands-on science museum in a grand former fair building, popular for exhibits and a U-505 submarine.
Lively lakefront park with Cloud Gate, Crown Fountain, gardens, and major public art in central Chicago.
Famous shopping boulevard lined with architecture, hotels, riverfront views, and major city energy.
Scenic pedestrian-friendly riverwalk with boat docks, public art, bridges, and standout skyline perspectives.
Deep-dish pizza is Chicago’s iconic pie with a tall buttery crust, layers of cheese and toppings, and chunky tomato sauce baked on top.
The Chicago-style hot dog is an all-beef frank on a poppy seed bun with mustard, relish, onion, tomato, pickle, peppers, and celery salt.
Italian beef is thin-sliced roast beef piled onto a roll, often dipped in savory juices and topped with sweet peppers or spicy giardiniera.
Classic spot for juicy Italian beef sandwiches, especially dipped and topped with spicy giardiniera, with a casual local feel.
Legendary stand for Chicago-style hot dogs and char-grilled sausages, served fast in a no-frills local landmark.
World-famous fine dining destination offering a highly creative tasting menu and refined service in an elegant setting.
Moderate for a major US city: hotels can be pricey, but transit is affordable and dining ranges from cheap eats to upscale options.
Tip 18-20% at restaurants, $1-2 per drink at bars, 10-15% for taxis, and optional small change at cafes.
Find answers to the most common questions about traveling from Harrisburg, PA to Chicago, IL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.

Most Harrisburg, PA to Chicago, IL buses use the Harrisburg, Market St (Bus Station) to Chicago, Greyhound Bus Station station pair, with some services arriving at Chicago, Union Station (Amtrak). Use this guide to compare Harrisburg, PA and Chicago, IL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Harrisburg, Market St (Bus Station) is 1 km from Harrisburg city centre. Public transport options include:
Harrisburg, Market St (Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Free WiFi inside the station. ATMs are available at Harrisburg, Market St (Bus Station).
Ticket office support is available at Harrisburg, Market St (Bus Station).
Available at Harrisburg, Market St (Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Harrisburg, Market St (Bus Station): Wheelchair accessible with ramps.
Harrisburg, Chestnut Street / South 4th Street is 1 km from Harrisburg city centre. Public transport options include:
Harrisburg, Chestnut Street / South 4th Street has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Harrisburg, Chestnut Street / South 4th Street. ATMs are available at Harrisburg, Chestnut Street / South 4th Street.
Ticket office support is available at Harrisburg, Chestnut Street / South 4th Street.
Available at Harrisburg, Chestnut Street / South 4th Street: Parking, Taxis, WC.
Accessibility facilities are available at Harrisburg, Chestnut Street / South 4th Street: Accessible by wheelchair via main entrance.
Chicago, Greyhound Bus Station is 2 km from Chicago city centre. Public transport options include:
Chicago, Greyhound Bus Station has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Snack shop and vending machines available
Free Wi-Fi in waiting area. ATMs are located near entrance.
Ticket office support is available at Chicago, Greyhound Bus Station.
Available at Chicago, Greyhound Bus Station: Parking, Taxis, WC.
Accessibility facilities are available at Chicago, Greyhound Bus Station: Wheelchair accessible entrances and seating.
Chicago, Union Station (Amtrak) is 3 km from Chicago city centre. Public transport options include:
Chicago, Union Station (Amtrak) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Multiple dining options are available inside the station.
Free Wi-Fi is available in waiting areas. ATMs are aTMs are located near the main entrance.
Ticket office support is available at Chicago, Union Station (Amtrak).
Available at Chicago, Union Station (Amtrak): Parking, Taxis, WC.
Accessibility facilities are available at Chicago, Union Station (Amtrak): Station is accessible with elevators and ramps.
Chicago, 95th Red Line Station is 14 km from Chicago city centre. Public transport options include:
Chicago, 95th Red Line Station has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Chicago, 95th Red Line Station. ATMs are available at Chicago, 95th Red Line Station.
Ticket office support is available at Chicago, 95th Red Line Station.
Available at Chicago, 95th Red Line Station: Parking, Taxis, WC.
Accessibility facilities are available at Chicago, 95th Red Line Station: Wheelchair accessible entrances available.
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