- Recommended
Spartanburg Science Center
Science and history museum with regional exhibits, a planetarium, and family-friendly programs in downtown Spartanburg.
The best way to find a cheap bus ticket from Durham, NC to Spartanburg, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Durham, NC to Spartanburg, SC will cost around $39 if you buy it on the day, but the cheapest tickets can be found for only $39.
On Thu, Nov 05, we found 1 buses from Durham, NC to Spartanburg, SC, including 1 direct services.
On Thu, Nov 05 the direct buses cover the 298 km distance in an average of 5 h 5 m but if you time it right, some buses will get you there in just 5 h 5 m .
On Thu, Nov 05 the slowest buses will take 5 h 5 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

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Buses from Durham, NC to Spartanburg, SC run on average 4 times per day, taking around 4h 39m. Cheap bus tickets for this journey start at $42 if you book in advance.
There are 3 buses per day. The earliest bus runs at 00:50, the last at 22:05. The fastest bus covers the 185 miles (298 km) distance in 3h 35m.
Distance 185 miles (298 km) |
Average bus duration 4h 39m |
Cheapest ticket price $42 |
Buses per day 4 |
Direct buses 3 |
Fastest bus 3h 35m |
First bus 12:50 AM |
Last bus 10:05 PM |
Cheapest Month Oct |
Cheapest Day Wed |
High Season Jan - Mar |
Low Season Apr - Jun |
Busiest Day Sat |
Least Busy Day Sat |
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Durham, NC to Spartanburg, SC.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 05:10AM | Arrival Time 10:15AM | Duration 5h05 | Departure days Wed | Cheapest price $33 |
Operator Greyhound | Departure Time 06:10AM | Arrival Time 11:15AM | Duration 5h05 | Departure days Thu | Cheapest price $39 |
Operator Greyhound | Departure Time 07:20PM | Arrival Time 12:45AM | Duration 5h25 | Departure days Mon | Cheapest price $41 |
The table below shows live departures for Durham, NC to Spartanburg, SC buses for tomorrow, Thursday, November 5. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 6:10 AM Durham, NC | 5h05 | 11:15 AM Spartanburg, SC | 0 transfersDirect | |
This is the last bus of the day. | |||||
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Discover the best of Spartanburg, SC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Spartanburg, SC trip today.
Science and history museum with regional exhibits, a planetarium, and family-friendly programs in downtown Spartanburg.
Art museum and gallery space on the Chapman Cultural Center campus, featuring rotating exhibitions and local artists.
Rail museum with historic locomotives, cars, and exhibits on regional railroad history near downtown Spartanburg.
Central downtown square with shops, public art, seating, and frequent events; a practical starting point for exploring Spartanburg.
Popular urban greenway for walking and cycling, linking downtown with parks, public art, and neighborhood views.
Large city park with trails, sports areas, gardens, and open space for a relaxed outdoor break close to downtown.
South Carolina-style pulled pork smoked low and slow, then finished with a tangy mustard barbecue sauce common across the Upstate and Midlands.
Pork shoulder smoked whole over wood, then chopped or pulled. It is a cornerstone of local barbecue culture in Spartanburg and the Upstate.
Stone-ground corn grits simmered until creamy, often served at breakfast or with seafood. Grits are a longstanding Southern staple in local homes and diners.
Upscale downtown restaurant focused on contemporary American dishes, steaks, and cocktails in a polished historic space.
Established Southern meat-and-three restaurant with fried chicken, vegetables, casseroles, and homestyle desserts in a simple setting.
Lively neighborhood restaurant serving burgers, sandwiches, salads, and broad craft beer selection in a relaxed downtown setting.
Moderate for a U.S. city. Hotels and dining are usually cheaper than major metros, but car use and limited transit can raise total trip costs.
Tip 18-20% at restaurants, 10-15% for taxis, and $1-2 per drink or cafe order if there is table service.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Spartanburg, SC.
Find answers to the most common questions about traveling from Durham, NC to Spartanburg, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Spartanburg, SC, this guide helps you travel smarter and with confidence.

Most Durham, NC to Spartanburg, SC buses use the Durham, W Pettigrew St (Greyhound Bus Station) to station pair. Use this guide to compare Durham, NC and Spartanburg, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
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