- Recommended
Spartanburg Science Center
Science and history museum with regional exhibits, a planetarium, and family-friendly programs in downtown Spartanburg.
Omio recommends booking the bus as it is the most popular option from Durham, NC to Spartanburg, SC among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $60 For those with little time, consider booking a flight, which has an average total journey time of 4h 59m. Average ticket prices depend on the travel mode: a bus costs an average of $60, while a flight costs an average of $598.
Distance: 185 miles (298 km)
Most popular Bus | Train | Flight | Driving |
|---|---|---|---|
$60 Average price Cheapest | $94 Average price | $598 Average price | $44 Average price (fuel + tolls) |
5h 11m Average total duration 4h 41m Onboard + 30m Additional time* | 5h 22m Average total duration 4h 52m Onboard + 30m Additional time* | 4h 59m Average total duration Fastest 2h 59m Onboard + 2h 0m Additional time* | 3h 20m Average total duration (door-to-door) |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Durham, NC to Spartanburg, SC:
A bus is $34 less than a train for this route with tickets for a train from Durham, NC to Spartanburg, SC costing on average $94.
A bus is $538 less than a flight for this route with tickets for a flight from Durham, NC to Spartanburg, SC costing on average $598.
Other travel options to Spartanburg, SC take longer:
Bus takes on average 4h 41m.
Train takes on average 4h 52m.
Tickets start at around $60 compared to roughly $44 in fuel and tolls — a saving of about $-16.19. The journey takes 4h 41m versus 3h 20m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 01:10AM | Arrival Time 06:10AM | Duration 5h00 | Departure days Sat | Cheapest price $46 |
Operator FlixBus | Departure Time 02:45AM | Arrival Time 07:20AM | Duration 4h35 | Departure days Sat | Cheapest price $42 |
Operator Greyhound | Departure Time 04:55AM | Arrival Time 10:10AM | Duration 5h15 | Departure days Sat | Cheapest price $46 |
Operator Greyhound | Departure Time 05:10AM | Arrival Time 10:15AM | Duration 5h05 | Departure days Wed | Cheapest price $33 |
Operator Greyhound | Departure Time 06:10AM | Arrival Time 11:15AM | Duration 5h05 | Departure days Thu | Cheapest price $39 |
Operator FlixBus | Departure Time 08:30AM | Arrival Time 12:35PM | Duration 4h05 | Departure days Sat | Cheapest price $46 |
Operator Greyhound | Departure Time 07:20PM | Arrival Time 12:45AM | Duration 5h25 | Departure days Mon | Cheapest price $42 |
The table below shows live departures for Durham, NC to Spartanburg, SC buses for today, Saturday, September 19. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 1:10 AM Durham Station | 5h00 | 6:10 AM Spartanburg, SC | 0 transfersDirect | |
FlixBus+![]() | 2:45 AM Durham Station | 4h35 | 7:20 AM Spartanburg, SC | 1 transfer | |
![]() | 4:55 AM Durham Station | 5h15 | 10:10 AM Spartanburg, SC | 0 transfersDirect | |
FlixBus | 8:30 AM Durham Station | 4h05 | 12:35 PM Spartanburg, SC | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Durham, NC to Spartanburg, SC run on average 4 times per day, taking around 4h 41m. Cheap bus tickets for this journey start at $47 if you book in advance.
There are 3 buses per day. The earliest bus runs at 00:50, the last at 22:05. The fastest bus covers the 185 miles (298 km) distance in 3h 35m.
Distance 185 miles (298 km) |
Average bus duration 4h 41m |
Cheapest ticket price $47 |
Buses per day 4 |
Direct buses 3 |
Fastest bus 3h 35m |
First bus 12:50 AM |
Last bus 10:05 PM |
Cheapest Month Oct |
Cheapest Day Wed |
High Season Jan - Mar |
Low Season Apr - Jun |
Busiest Day Sat |
Least Busy Day Sat |
Discover the best of Spartanburg, SC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Spartanburg, SC trip today.
Science and history museum with regional exhibits, a planetarium, and family-friendly programs in downtown Spartanburg.
Art museum and gallery space on the Chapman Cultural Center campus, featuring rotating exhibitions and local artists.
Rail museum with historic locomotives, cars, and exhibits on regional railroad history near downtown Spartanburg.
Central downtown square with shops, public art, seating, and frequent events; a practical starting point for exploring Spartanburg.
Popular urban greenway for walking and cycling, linking downtown with parks, public art, and neighborhood views.
Large city park with trails, sports areas, gardens, and open space for a relaxed outdoor break close to downtown.
Find answers to the most common questions about traveling from Durham, NC to Spartanburg, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Spartanburg, SC, this guide helps you travel smarter and with confidence.

Here are some other resources that might have the information you need