- Must visit
Cummer Museum of Art & Gardens
Major art museum with a strong permanent collection and historic riverfront gardens; one of Jacksonville’s signature cultural attractions.
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The cheapest and fastest buses from St. Louis, MO to Jacksonville, FL
Showing times and prices for Jun 21
Cheapest price
$118
Average price
$121
Fastest journey
20 h 35 m
Average duration
21 h 18 m
Buses per day
3
Distance
1209 km
Cheap tickets
The best way to find a cheap bus ticket from St. Louis, MO to Jacksonville, FL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from St. Louis, MO to Jacksonville, FL will cost around $121 if you buy it on the day, but the cheapest tickets can be found for only $118.
Fast buses
It's difficult to get from St. Louis, MO to Jacksonville, FL without transferring at least once.
FlixBus · FlixBus11:45 PM22h20St. Louis, S 15th St (Civic center)11:05 PMJacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St$1181One-way1 transfer- FlixBus+
+FlixBus4:00 PM20h35St. Louis, S 15th St (Civic center)1:35 PMJacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St$1211One-way2 transfers - +FlixBus9:00 AM21h00St. Louis, S 15th St (Civic center)7:00 AMJacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St$1221One-way1 transfer
- FlixBus++FlixBus4:00 PM20h35St. Louis, S 15th St (Civic center)1:35 PMJacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St$1211One-way2 transfers
- +FlixBus9:00 AM21h00St. Louis, S 15th St (Civic center)7:00 AMJacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St$1221One-way1 transfer
- FlixBus · FlixBus11:45 PM22h20St. Louis, S 15th St (Civic center)11:05 PMJacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St$1181One-way1 transfer
Travel Information
Compare bus, train, and flight for St. Louis, MO to Jacksonville, FL
Omio recommends booking the flight as it is the most popular option from St. Louis, MO to Jacksonville, FL among Omio's users. If you are prioritising price take the bus with prices starting from $139. For those with little time consider booking a flight which can get you there in 3h 41m. The ticket price range depends on the travel mode: a bus costs an average of $139, and a train costs an average of $326.
Distance: 751 miles (1209 km)
Compare bus with
| Bus | Most popular Flight | Train | Driving |
|---|---|---|---|
$196 Average price Cheapest | $244 Average price | $1023 Average price | $174 Average price (fuel + tolls) |
24h 7m Average total duration 23h 37m Onboard + 30m Additional time* | 6h 41m Average total duration Fastest 3h 41m Onboard + 3h 0m Additional time* | 46h 26m Average total duration 45h 56m Onboard + 30m Additional time* | 13h 8m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from St. Louis, MO to Jacksonville, FL is a bus with an average price of $196 (€161).
This is compared to other travel options from St. Louis, MO to Jacksonville, FL:
A bus is $48 (€39) less than a flight for this route with tickets for a flight from St. Louis, MO to Jacksonville, FL costing on average $244 (€200).
A bus is $827 (€677) less than a train for this route with tickets for a train from St. Louis, MO to Jacksonville, FL costing on average $1023 (€837).
The fastest way to travel from St. Louis, MO to Jacksonville, FL is by flight with an average journey time of 3h 41m.
Other travel options to Jacksonville, FL take longer:
Bus takes on average 23h 37m.
Train takes on average 45h 56m.
It's helpful to compare your options as there are 3 ways to travel between St. Louis, MO and Jacksonville, FL including taking a bus, train, and flight.
We recommend using the flight as it is the most popular way to get from St. Louis, MO to Jacksonville, FL among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
St. Louis, MO to Jacksonville, FL Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 09:00AM | Arrival Time 07:00AM | Duration 21h00 | Departure days Everyday | Cheapest price $104 |
Operator Greyhound | Departure Time 04:00PM | Arrival Time 01:35PM | Duration 20h35 | Departure days Everyday | Cheapest price $103 |
Operator FlixBus | Departure Time 11:45PM | Arrival Time 11:05PM | Duration 22h20 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $104 |
Live departures
St. Louis, MO to Jacksonville, FL bus times
The table below shows live departures for St. Louis, MO to Jacksonville, FL buses for today, Saturday, June 20. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| FlixBus++FlixBus | 4:00 PM St. Louis, S 15th St (Civic center) | 20h35 | 1:35 PM Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St | 2 transfers | |
| FlixBus · FlixBus | 11:45 PM St. Louis, S 15th St (Civic center) | 22h20 | 11:05 PM Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St | 1 transfer | |
| Sunday, June 21 | |||||
| +FlixBus | 9:00 AM St. Louis, S 15th St (Civic center) | 21h00 | 7:00 AM Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets St. Louis, MO to Jacksonville, FL by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book St. Louis, MO to Jacksonville, FL buses with Omio?
FlixBus operates all buses services from St. Louis, MO to Jacksonville, FL.
Omio is an official ticket reseller for all your travel options from St. Louis, MO to Jacksonville, FL.
Why book with Omio vs FlixBus?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from St. Louis, MO to Jacksonville, FL.
Why book with Omio over Wanderu or Trainline?
- Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from St. Louis, MO to Jacksonville, FL.
Journey information
Overview: Bus from St. Louis, MO to Jacksonville, FL
USAUSA
Buses from St. Louis, MO to Jacksonville, FL run on average 3 times per day, taking around 23h 37m. Cheap bus tickets for this journey start at $139 (€114) if you book in advance.
The earliest bus runs at 02:00, the last at 23:30. The fastest bus covers the 751 miles (1209 km) distance in 20h 35m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 751 miles (1209 km) |
Average bus duration 23h 37m |
Cheapest ticket price $139 (€114) |
Buses per day 3 |
Fastest bus 20h 35m |
First bus 2:00 AM |
Last bus 11:30 PM |
Cheapest Month Dec |
Cheapest Day Thu |
High Season Jul - Sep |
Low Season Apr - Jun |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: FlixBus from St. Louis, MO to Jacksonville, FLYou can travel by bus between St. Louis, MO to Jacksonville, FL with FlixBus for as low as $139 (€114). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average Duration
22h 35m
Cheapest Price
$268 (€220)
FlixBus frequency
1 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Complete guide to Jacksonville
Things to do in Jacksonville
Discover the best of Jacksonville — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Jacksonville trip today.
- Recommended
Museum of Science & History (MOSH)
Family-friendly science museum on the Southbank with interactive exhibits, regional history, and a planetarium.
- Recommended
MOCA Jacksonville
Downtown contemporary art museum affiliated with the University of North Florida, known for rotating exhibitions and a central urban location.
- Must visit
Riverside Avondale Historic District
One of Jacksonville’s most beloved areas for walking, historic homes, independent shops, and riverfront parks.
- Must visit
Jacksonville Riverwalk
Scenic pedestrian route along both sides of the St. Johns River, popular for skyline views, photos, and evening walks.
- Must visit
Jacksonville Beach
The city’s best-known beach area, popular for ocean views, the fishing pier area, and a lively coastal atmosphere.
- Gluten-free
Mayport Shrimp
Wild-caught shrimp from nearby Mayport, served boiled, fried, blackened, or in baskets and platters. It is one of Jacksonville’s best-known local seafood specialties.
Minorcan Clam Chowder
A Northeast Florida chowder with tomatoes, clams, and the region’s famous datil pepper for heat. It reflects the area’s old Minorcan and coastal heritage.
- Vegetarian
- Vegan
- Gluten-free
Datil Pepper Hot Sauce
A sweet-hot pepper sauce closely associated with Northeast Florida. Locals use it on seafood, sandwiches, and grilled foods for a distinctive regional kick.
Orsay
Upscale bistro blending French technique with Southern influences. Well known for refined cooking, cocktails, and a lively fine-dining setting.
Safe Harbor Seafood Restaurant
Casual Mayport favorite known for very fresh local seafood, especially shrimp and fried platters, with a laid-back working-waterfront feel.
The Blue Fish Restaurant and Oyster Bar
Established seafood spot in Avondale known for oysters, fresh fish, and a polished but relaxed neighborhood atmosphere.
United States Dollar
Costs are moderate by U.S. standards. Dining and coffee are reasonable, while hotels vary by season and beach area.
Average meal costs
- Budget
- USD 10-15 for fast food or a casual lunch.
- Mid-range
- USD 20-40 per person at a mid-range restaurant.
- Fine dining
- USD 60+ per person before drinks and tip.
- Coffee
- USD 4-6 for a standard café coffee.
Tipping culture
Tip 18-20% in restaurants for table service, 20%+ for great service. Tip bartenders USD 1-2 per drink, taxis about 10-15%, hotel staff USD 1-5, and round up for cafés if desired.
FAQs: Bus from St. Louis, MO to Jacksonville, FL
Find answers to the most common questions about traveling from St. Louis, MO to Jacksonville, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Jacksonville, FL, this guide helps you travel smarter and with confidence.
Cheap bus tickets from St. Louis, MO to Jacksonville, FL can start from as little as $139 (€114) when you book in advance. The average bus ticket price for St. Louis, MO to Jacksonville, FL is $196 (€161) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from St. Louis, MO to Jacksonville, FL is 20h 35m to travel the 751 miles (1209 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from St. Louis, MO to Jacksonville, FL leaves at 2:00 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from St. Louis, MO to Jacksonville, FL leaves at 11:30 PM.
There are 3 buses a day from St. Louis, MO to Jacksonville, FL which require at least one change with FlixBus. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from St. Louis, MO to Jacksonville, FL, you can count on FlixBus for the best way to get you to Jacksonville, FL. You can also check all possible bus companies who offer a service between St. Louis, MO and Jacksonville, FL and compare the amenities they offer before buying a bus ticket.
A trip to Jacksonville, FL from St. Louis, MO is worth doing but not as a day trip with a journey time of 20h 35m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from St. Louis, MO to Jacksonville, FL is December.
It's helpful to compare your options as there are 3 ways to travel between St. Louis, MO and Jacksonville, FL including taking a bus, train, and flight.
Yes, there are bathrooms on board the bus from St. Louis, MO to Jacksonville, FL for bus company FlixBus.
Yes, the following accessibility options are available when taking the bus from St. Louis, MO to Jacksonville, FL:
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, bikes are allowed on board the bus with bus company FlixBus.
Whether you can cancel your bus ticket from St. Louis, MO to Jacksonville, FL depends on the bus companies:
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from St. Louis, MO to Jacksonville, FL.
Yes, the following luggage options are included when booking a bus ticket from St. Louis, MO to Jacksonville, FL:
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from St. Louis, MO to Jacksonville, FL:
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from St. Louis, MO to Jacksonville, FL. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from St. Louis, MO to Jacksonville, FL with the following bus company: FlixBus
Yes, there are USB plugs on board the bus from St. Louis, MO to Jacksonville, FL with the following bus company: FlixBus.
Yes, there is Wifi on board the bus from St. Louis, MO to Jacksonville, FL with the following bus company: FlixBus.
Since neither St. Louis, MO nor Jacksonville, FL are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the flight as it is the most popular way to get from St. Louis, MO to Jacksonville, FL among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Jacksonville, FL, travelers should be cautious of pickpocketing and vehicle break-ins, especially in crowded areas and popular tourist spots. Common scams include overcharging by unlicensed taxi or ride-share drivers and fake ticket sellers near attractions. Staying aware of surroundings, using reputable transportation services, and avoiding isolated areas at night can help ensure safety.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from St. Louis, MO to Jacksonville, FL
Most St. Louis, MO to Jacksonville, FL buses use the St. Louis, S 15th St (Civic center) to Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St station pair. Use this guide to compare St. Louis, MO and Jacksonville, FL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in St. Louis
Arrival bus stations in Jacksonville
St. Louis, S 15th St (Civic center)
City-centre transport
Getting to St. Louis, S 15th St (Civic center) from St. Louis city centre
TrainMlb, Mlr · 4m · $4 · every ~14 min
Bus19, 32, 40 · 8m · $1 · every ~9 min
St. Louis, Lambert International Airport
City-centre transport
Getting to St. Louis, Lambert International Airport from St. Louis city centre
TrainMlr · 31m · $4 · every ~7 min
Bus4 · 1h 3m · $31 · every ~4 min
Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St
City-centre transport
Getting to Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St from Jacksonville city centre
Bus1, 11, 18, 205, 3, Nassau, St. Johns, Clay · 12m · $4 · every ~18 min
1, 19, 3 · 17m · $4 · every ~17 min
SubwaySky · 10m · every ~4 min
Most popular bus connections from St. Louis, MO
More options for your journey from St. Louis, MO to Jacksonville, FL
Here are some other resources that might have the information you need
Most popular buses to and from Jacksonville, FL and St. Louis, MO
Most popular bus connections to Jacksonville, FL
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