- Must visit
Cummer Museum of Art & Gardens
Major art museum with American and European works, a notable sculpture garden, and one of Jacksonville's top cultural stops.
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The cheapest and fastest buses from St. Louis, MO to Jacksonville, FL
Showing times, prices and bookable tickets for Sep 20
Cheapest price on Sep 20
€84
Average ticket price on Sep 20
€86
Fastest journey on Sep 20
20 h 35 m
Average journey duration on Sep 20
21 h 18 m
Buses on Sep 20
3
Distance
1209 km
Cheap tickets
The best way to find a cheap bus ticket from St. Louis, MO to Jacksonville, FL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from St. Louis, MO to Jacksonville, FL will cost around €86 if you buy it on the day, but the cheapest tickets can be found for only €84.
Fast buses
It's difficult to get from St. Louis, MO to Jacksonville, FL without transferring at least once.
FlixBus+
+FlixBus4:00 PM20h35St. Louis, S 15th St (Civic center)1:35 PMJacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St€841One-way2 transfers- +FlixBus9:00 AM21h00St. Louis, S 15th St (Civic center)7:00 AMJacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St€861One-way1 transfer
- FlixBus · FlixBus11:45 PM22h20St. Louis, S 15th St (Civic center)11:05 PMJacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St€891One-way1 transfer
- FlixBus++FlixBus4:00 PM20h35St. Louis, S 15th St (Civic center)1:35 PMJacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St€841One-way2 transfers
- +FlixBus9:00 AM21h00St. Louis, S 15th St (Civic center)7:00 AMJacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St€861One-way1 transfer
- FlixBus · FlixBus11:45 PM22h20St. Louis, S 15th St (Civic center)11:05 PMJacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St€891One-way1 transfer
Travel Information
Compare bus, train, and flight for St. Louis, MO to Jacksonville, FL
Omio recommends booking the flight as it is the most popular option from St. Louis, MO to Jacksonville, FL among Omio's users. If you are prioritising price, take the bus, with an average ticket price of €113 For those with little time, consider booking a flight, which has an average total journey time of 6h 54m. Average ticket prices depend on the travel mode: a bus costs an average of €113, while a train costs an average of €903.
Distance: 751 miles (1209 km)
Compare bus with
| Bus | Most popular Flight | Train | Driving |
|---|---|---|---|
€113 Average price Cheapest | €421 Average price | €903 Average price | €144 Average price (fuel + tolls) |
18h 44m Average total duration 18h 14m Onboard + 30m Additional time* | 6h 54m Average total duration Fastest 4h 54m Onboard + 2h 0m Additional time* | 39h 27m Average total duration 38h 57m Onboard + 30m Additional time* | 13h 8m Average total duration (door-to-door) |
Most popular bus company |  Most popular airline |  Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from St. Louis, MO to Jacksonville, FL is a bus with an average price of €113.
This is compared to other travel options from St. Louis, MO to Jacksonville, FL:
A bus is €309 less than a flight for this route with tickets for a flight from St. Louis, MO to Jacksonville, FL costing on average €421.
A bus is €791 less than a train for this route with tickets for a train from St. Louis, MO to Jacksonville, FL costing on average €903.
The fastest way to travel from St. Louis, MO to Jacksonville, FL is by flight with an average journey time of 4h 54m.
Other travel options to Jacksonville, FL take longer:
Bus takes on average 18h 14m.
Train takes on average 38h 57m.
It's helpful to compare your options as there are 3 ways to travel between St. Louis, MO and Jacksonville, FL including taking a bus, train, and flight.
We recommend using the flight as it is the most popular way to get from St. Louis, MO to Jacksonville, FL among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.
Tickets start at around €113 compared to roughly €144 in fuel and tolls — a saving of about €32. The journey takes 18h 14m versus 13h 8m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
St. Louis, MO to Jacksonville, FL Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 09:00AM | Arrival Time 07:00AM | Duration 21h00 | Departure days Everyday | Cheapest price €72 |
Operator Greyhound | Departure Time 04:00PM | Arrival Time 01:35PM | Duration 20h35 | Departure days Everyday | Cheapest price €72 |
Operator FlixBus | Departure Time 11:45PM | Arrival Time 11:05PM | Duration 22h20 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price €73 |
Live departures
St. Louis, MO to Jacksonville, FL bus times
The table below shows live departures for St. Louis, MO to Jacksonville, FL buses for today, Saturday, September 19. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| +FlixBus | 9:00 AM St. Louis, S 15th St (Civic center) | 21h00 | 7:00 AM Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St | 1 transfer | |
| FlixBus++FlixBus | 4:00 PM St. Louis, S 15th St (Civic center) | 20h35 | 1:35 PM Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets St. Louis, MO to Jacksonville, FL by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book St. Louis, MO to Jacksonville, FL buses with Omio?
Greyhound as well as FlixBus offer buses services from St. Louis, MO to Jacksonville, FL.
Omio is an official ticket reseller for all your travel options from St. Louis, MO to Jacksonville, FL.
Why book with Omio vs Greyhound?
- Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of FlixBus to find the best option for your trip from St. Louis, MO to Jacksonville, FL.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from St. Louis, MO to Jacksonville, FL.
Why book with Omio over Wanderu or Trainline?
- Compare with other providers: On Omio, you can also compare tickets for the likes of FlixBus to find the best option for your trip from St. Louis, MO to Jacksonville, FL.
- Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from St. Louis, MO to Jacksonville, FL.
Journey information
Overview: Bus from St. Louis, MO to Jacksonville, FL
USAUSA
Buses from St. Louis, MO to Jacksonville, FL run on average 3 times per day, taking around 18h 14m. Cheap bus tickets for this journey start at €81 if you book in advance.
The earliest bus runs at 02:00, the last at 23:30. The fastest bus covers the 751 miles (1209 km) distance in 16h 30m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 751 miles (1209 km) |
Average bus duration 18h 14m |
Cheapest ticket price €81 |
Buses per day 3 |
Fastest bus 16h 30m |
First bus 2:00 AM |
Last bus 11:30 PM |
Cheapest Month Jul |
Cheapest Day Sun |
High Season Jul - Sep |
Low Season Jan - Mar |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound, FlixBus from St. Louis, MO to Jacksonville, FLYou can travel by bus between St. Louis, MO to Jacksonville, FL with Greyhound, FlixBus for as low as €81. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average FlixBus Duration
16h 30m
Cheapest FlixBus Price
€82
FlixBus frequency
1 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
18h 15m
Cheapest Greyhound Price
€81
Greyhound frequency
2 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Jacksonville, FL
Things to do in Jacksonville, FL
Discover the best of Jacksonville, FL — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Jacksonville, FL trip today.
- Recommended
Museum of Science & History
Regional history museum covering Northeast Florida through engaging exhibits on city growth, culture, and key local events.
- Recommended
Museum of Contemporary Art Jacksonville
Contemporary art museum in the university district, presenting rotating exhibitions and thoughtful programs by living artists.
- Must visit
Northbank Riverwalk
Lively riverfront district with museums, restaurants nearby, public art, and one of Jacksonville's best skyline strolls.
- Must visit
Southbank Riverwalk
Scenic promenade across the river from downtown, ideal for walks, bridge views, and sunset photos along the Southbank.
- Recommended
Five Points
Creative historic neighborhood known for murals, local shops, nightlife, and a walkable mix of old Jacksonville character.
- Gluten-free
Mayport Shrimp
Mayport shrimp are local Atlantic shrimp, prized for their sweet flavor. They are a Jacksonville seafood staple, often served fried, grilled, or in baskets near the coast.
- Gluten-free
Low Country Boil
A Low Country boil with shrimp, sausage, corn, and potatoes reflects Northeast Florida’s coastal Southern cooking and is popular at casual local seafood spots.
- Gluten-free
Florida Oysters
Fresh local oysters from nearby Florida waters are served raw, baked, or chargrilled. They are a classic Jacksonville choice tied to the region’s seafood culture.
Safe Harbor Seafood Restaurant
Popular casual seafood restaurant in Mayport, best known for fresh local shrimp, fried seafood platters, and a laid-back dockside feel.
Ruth's Chris Steak House
Refined riverfront steakhouse known for prime steaks, seafood, and polished service in an upscale setting on the Southbank.
Blue Fish Restaurant and Oyster Bar
Established upscale seafood restaurant with an extensive wine list, elegant atmosphere, and strong reputation for fresh fish and fine dining.
US dollar ($)
Moderate for US beach cities. Hotels vary by season; meals and coffee are typical US prices, and most visitors need a car as transit is limited.
Average meal costs
- Budget
- $10-18 for fast food or casual takeout.
- Mid-range
- $20-40 per person for a restaurant meal.
- Fine dining
- $60+ per person for upscale restaurants.
- Coffee
- $3-6 for drip coffee or cappuccino.
Tipping culture
Tip 18-20% at restaurants, more for great service. Taxis usually get 10-15%. Cafes often use tip jars or screens; $1-2 is common.
FAQs: Bus from St. Louis, MO to Jacksonville, FL
Find answers to the most common questions about traveling from St. Louis, MO to Jacksonville, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Jacksonville, FL, this guide helps you travel smarter and with confidence.
Cheap bus tickets from St. Louis, MO to Jacksonville, FL can start from as little as €81 when you book in advance. The average bus ticket price for St. Louis, MO to Jacksonville, FL is €113 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from St. Louis, MO to Jacksonville, FL is 16h 30m to travel the 751 miles (1209 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from St. Louis, MO to Jacksonville, FL leaves at 2:00 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from St. Louis, MO to Jacksonville, FL leaves at 11:30 PM.
There are 3 buses a day from St. Louis, MO to Jacksonville, FL which require at least one change with Greyhound, FlixBus. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from St. Louis, MO to Jacksonville, FL, you can count on Greyhound, FlixBus for the best way to get you to Jacksonville, FL. You can also check all possible bus companies who offer a service between St. Louis, MO and Jacksonville, FL and compare the amenities they offer before buying a bus ticket.
Passengers board the bus most frequently from St. Louis, S 15th St (Civic center), which is located around away from the city centre, and they get off the bus at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St, located 1 away from the city centre.
A trip to Jacksonville, FL from St. Louis, MO is worth doing but not as a day trip with a journey time of 16h 30m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from St. Louis, MO to Jacksonville, FL is July.
It's helpful to compare your options as there are 3 ways to travel between St. Louis, MO and Jacksonville, FL including taking a bus, train, and flight.
Yes, the following accessibility options are available when taking the bus from St. Louis, MO to Jacksonville, FL:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from St. Louis, MO to Jacksonville, FL for bus company Greyhound, FlixBus.
Whether you can cancel your bus ticket from St. Louis, MO to Jacksonville, FL depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company Greyhound, FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from St. Louis, MO to Jacksonville, FL.
Yes, the following luggage options are included when booking a bus ticket from St. Louis, MO to Jacksonville, FL:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from St. Louis, MO to Jacksonville, FL:
- Greyhound
- $15 per additional bag.
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from St. Louis, MO to Jacksonville, FL. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from St. Louis, MO to Jacksonville, FL with the following bus company: Greyhound, FlixBus
Yes, there are USB plugs on board the bus from St. Louis, MO to Jacksonville, FL with the following bus company: Greyhound, FlixBus.
Yes, there is Wifi on board the bus from St. Louis, MO to Jacksonville, FL with the following bus company: Greyhound, FlixBus.
Since neither St. Louis, MO nor Jacksonville, FL are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the flight as it is the most popular way to get from St. Louis, MO to Jacksonville, FL among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Jacksonville, FL, travelers should be cautious of pickpocketing and vehicle break-ins, especially in crowded areas and popular tourist spots. Common scams include overcharging by unlicensed taxi or ride-share drivers and fake ticket sellers near attractions. Staying aware of surroundings, using reputable transportation services, and avoiding isolated areas at night can help ensure safety.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from St. Louis, MO to Jacksonville, FL
Most St. Louis, MO to Jacksonville, FL buses use the St. Louis, S 15th St (Civic center) to Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St station pair. Use this guide to compare St. Louis, MO and Jacksonville, FL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in St. Louis
Arrival bus stations in Jacksonville
Which St. Louis, MO station do buses to Jacksonville, FL leave from?
Buses from St. Louis, MO to Jacksonville, FL leave from St. Louis, S 15th St (Civic center). The station is 0 miles (1 km) from St. Louis, MO city centre at S 15th St, St. Louis, MO, USA.
St. Louis, S 15th St (Civic center)S 15th St, St. Louis, MO, USA
City-centre transport
Getting to St. Louis, S 15th St (Civic center) from St. Louis city centre
TrainMlb, Mlr · 4m · €3 · every ~14 min
Bus19, 32, 40 · 8m · €1 · every ~9 min
St. Louis, S 15th St (Civic center) bus station facilities and services
St. Louis, S 15th St (Civic center) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at St. Louis, S 15th St (Civic center). ATMs are available at St. Louis, S 15th St (Civic center).
Tickets and information
Ticket office support is available at St. Louis, S 15th St (Civic center).
Parking, taxis and toilets
Available at St. Louis, S 15th St (Civic center): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at St. Louis, S 15th St (Civic center): Wheelchair accessible routes available.
Which Jacksonville, FL station do buses from St. Louis, MO arrive at?
Buses from St. Louis, MO to Jacksonville, FL arrive at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St. Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St is 1 miles (2 km) from Jacksonville, FL city centre.
Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St1111 W Forsyth St, Jacksonville, FL 32204, USA
City-centre transport
Getting to Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St from Jacksonville city centre
Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St is 1 km from Jacksonville city centre. Public transport options include:
Bus1, 11, 18, 205, 3, Nassau, St. Johns, Clay · 12m · €3 · every ~18 min
1, 19, 3 · 17m · €3 · every ~17 min
SubwaySky · 10m · every ~4 min
Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St bus station facilities and services
Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St. ATMs are available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St.
Tickets and information
Ticket office support is available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St.
Parking, taxis and toilets
Available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St: Wheelchair accessible entrances.
Most popular bus connections from St. Louis, MO
More options for your journey from St. Louis, MO to Jacksonville, FL
Here are some other resources that might have the information you need
Most popular buses to and from Jacksonville, FL and St. Louis, MO
Most popular bus connections to Jacksonville, FL
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