The cheapest and fastest trains from Karlsruhe to Prague
Cheapest price
$47
Average price
$209
Fastest journey
8 h 16 m
Average duration
8 h 37 m
Trains per day
10
Distance
452 km
The best way to find a cheap train ticket from Karlsruhe to Prague is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Karlsruhe to Prague will cost around $209 if you buy it on the day, but the cheapest tickets can be found for only $47.
It's difficult to get from Karlsruhe to Prague without transferring at least 3 times.
TGV 9571+
88617 · 3569+
3599:28 AM8h53Karlsruhe Hbf6:21 PMPrague hlavní nádraží$471One-way3 transfers
ICE 374 · ICE 1559 · rj 10177 · rj 1779:59 AM9h16Karlsruhe Hbf7:15 PMPrague-Holešovice$1061One-way3 transfers
IC 2067 · 3569+
3599:06 AM9h15Karlsruhe Hbf6:21 PMPrague hlavní nádraží$1591One-way2 transfers
19009 · 88617 · 3569+
3599:32 AM8h49Karlsruhe Hbf6:21 PMPrague hlavní nádraží$1891One-way3 transfers
ICE 374 · ICE 1559 · BUS 10177 · R 6959:59 AM10h11Karlsruhe Hbf8:10 PMPrague hlavní nádraží$2291One-way3 transfers
ICE 267 · 89685 · 3565+
3578:05 AM8h16Karlsruhe Hbf4:21 PMPrague hlavní nádraží$2361One-way3 transfers
ICE 267 · R 89685 · R 3565 · EC 3578:05 AM8h16Karlsruhe Hbf4:21 PMPrague hlavní nádraží$2731One-way3 transfers
19009 · 88617 · 3569+
3599:32 AM8h49Karlsruhe Hbf6:21 PMPrague hlavní nádraží$1891One-way3 transfers
R 19009 · R 88617 · R 3569 · EC 3599:32 AM8h49Karlsruhe Hbf6:21 PMPrague hlavní nádraží$2731One-way3 transfers
TGV 9571+
88617 · 3569+
3599:28 AM8h53Karlsruhe Hbf6:21 PMPrague hlavní nádraží$471One-way3 transfers
Travel Information
Compare train and bus for Karlsruhe to Prague
Omio recommends booking the train as it is the most popular option from Karlsruhe to Prague among Omio's users. If you are prioritising price take the bus with prices starting from $34. For those with little time consider booking a bus which can get you there in 7h 25m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.1 - 0.4kg. The ticket price range depends on the travel mode: a bus costs an average of $34, and a train costs an average of $37.
Distance: 280 miles (452 km)
Compare train with
Most popular Train | Bus |
|---|---|
$77 Average price | $53 Average price Cheapest |
9h 49m Average total duration 9h 19m Onboard + 30m Additional time* | 7h 55m Average total duration Fastest 7h 25m Onboard + 30m Additional time* |
0.1 - 0.4kg CO2 emissions Lowest | 0.5 - 1.1kg CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company |
Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Live departures
Karlsruhe to Prague train times
The table below shows live departures for Karlsruhe to Prague trains for tomorrow, Monday, May 4. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
ICE 267 · 89685 · 3565+ 357 | On time 8:05 AM Karlsruhe Hbf | 8h16 | 4:21 PM Prague hlavní nádraží | 3 transfers | |
ICE 267 · R 89685 · R 3565 · EC 357 | On time 8:05 AM Karlsruhe Hbf | 8h16 | 4:21 PM Prague hlavní nádraží | 3 transfers | |
IC 2067 · 3569+ 359 | On time 9:06 AM Karlsruhe Hbf | 9h15 | 6:21 PM Prague hlavní nádraží | 2 transfers | |
TGV 9571+ 88617 · 3569+ 359 | Delayed 7:44 AM 9:28 AMKarlsruhe Hbf | 8h53 | 6:21 PM Prague hlavní nádraží | 3 transfers | |
R 19009 · R 88617 · R 3569 · EC 359 | 9:32 AM Karlsruhe Hbf | 8h49 | 6:21 PM Prague hlavní nádraží | 3 transfers | |
19009 · 88617 · 3569+ 359 | 9:32 AM Karlsruhe Hbf | 8h49 | 6:21 PM Prague hlavní nádraží | 3 transfers | |
ICE 374 · ICE 1559 · BUS 10177 · R 695 | On time 9:59 AM Karlsruhe Hbf | 10h11 | 8:10 PM Prague hlavní nádraží | 3 transfers | |
ICE 374 · ICE 1559 · BUS 10177 · RJ 177 | On time 9:59 AM Karlsruhe Hbf | 9h16 | 7:15 PM Prague-Holešovice | 3 transfers | |
ICE 374 · ICE 1559 · rj 10177 · rj 177 | On time 9:59 AM Karlsruhe Hbf | 9h16 | 7:15 PM Prague-Holešovice | 3 transfers | |
R 19675 · ICE 593 · R 4072 · WBA 83923 | 10:06 AM Karlsruhe Hbf | 9h47 | 7:53 PM Prague hlavní nádraží | 4 transfers | |
Find all the dates and times for this journey
Compare prices and tickets Karlsruhe to Prague by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
May 04
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Why should you book Karlsruhe to Prague trains with Omio?
Why book with Omio vs Deutsche Bahn?
- Compare with other providers: On Omio, you can not only buy tickets for Deutsche Bahn, but also compare tickets for the likes of alex-Länderbahn und Vogtlandbahn-GmbH or České dráhy to find the best option for your trip from Karlsruhe to Prague.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Deutsche Bahn with all available travel options, which are train and bus to ensure you get the best deal for traveling from Karlsruhe to Prague.
Why book with Omio over Trainline, Wanderu or Raileurope?
- Compare with other providers: On Omio, you can also compare tickets for the likes of alex-Länderbahn und Vogtlandbahn-GmbH or České dráhy to find the best option for your trip from Karlsruhe to Prague.
- Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from Karlsruhe to Prague.
How far in advance should I book train tickets from Karlsruhe to Prague?
Journey information
Overview: Train from Karlsruhe to Prague
Trains from Karlsruhe to Prague run on average 9 times per day, taking around 9h 19m. Cheap train tickets for this journey start at $37 (€30) but you can travel from only $34 (€27) by bus.
The earliest train runs at 00:19, the last at 23:50. The fastest train covers the 280 miles (452 km) distance in 8h 16m.
Distance 280 miles (452 km) |
Average train duration 9h 19m |
Cheapest ticket price $37 (€30) |
Trains per day 9 |
Fastest train 8h 16m |
First train 12:19 AM |
Last train 11:50 PM |
Cheapest Month Feb |
Cheapest Day Wed |
High Season Oct - Dec |
Low Season Jan - Mar |
Busiest Day Fri |
Least Busy Day Wed |
Best time to book 42 days |
Train companies: Deutsche Bahn, alex-Länderbahn und Vogtlandbahn-GmbH, České dráhy from Karlsruhe to Prague trainsDeutsche Bahn, alex-Länderbahn und Vogtlandbahn-GmbH, České dráhy trains will get you between Karlsruhe and Prague from $34 (€27). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Deutsche Bahn
A Bordrestaurant (restaurant car) where you can sit and eat.
A Bordbistro (bistro bar) with snacks, hot meals, and drinks to-go.
At-seat service in 1st class: staff will take your order and serve food/drinks directly to your seat.
Regional trains (RE / RB / S-Bahn):
No onboard catering.
You’re welcome to bring your own food and drinks.
Not included by default.
You can add a seat reservation when booking (recommended for busy routes).
Costs around €4.90 per seat (or €5.90 if booked separately later).
First Class:
Yes, always included in the ticket price.
Allowed for free if they can fit in a transport box (max. size: hand luggage).
Must stay in the box for the entire journey.
Large dogs:
Require a separate (paid) ticket — typically half the price of a regular second-class ticket.
Must be leashed and wear a muzzle while on the train.
Cannot sit on seats.
Assistance dogs:
Travel free of charge.
Do not need a muzzle or leash if medically not required.
Allowed to accompany the passenger at all times.
alex-Länderbahn und Vogtlandbahn-GmbH
České dráhy
FAQs: Trains from Karlsruhe to Prague
Find answers to the most common questions about traveling from Karlsruhe to Prague by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Prague, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Karlsruhe to Prague
- Monday: 06:30 - 21:00
- Tuesday: 06:30 - 21:00
- Wednesday: 06:30 - 21:00
- Thursday: 06:30 - 21:00
- Friday: 06:30 - 21:00
- Saturday: 08:00 - 19:00
- Sunday: 09:00 - 20:00
- Vinarte
- Am Tiergarten
- Panorama
- Alter Brauhof
- Hotel Barbarossa
- Hotel Avisa
- Am Tiergarten
- Aparthotel Aijana
- Monday: 08:00 13:30 - 12:30 18:00
- Tuesday: 08:00 13:30 - 12:30 18:00
- Wednesday: 08:00 13:30 - 12:30 18:00
- Thursday: 08:00 13:30 - 12:30 18:00
- Friday: 08:00 13:30 - 12:30 18:00
- Saturday: 09:00 - 13:00
- Hubraum
- Vogel Hausbräu Durlach
- Asia Gourmet
- Borsalino
- Hotel Große Linde
- Zum Erwin
- Der Blaue Reiter
- Beim Schupi
- Rosenstüble 2.0
- Saloniki
- Rote Taube
- Beim Schupi
- 6:00 AM - 10:00 PM Monday - Sunday
- Free
- The car park is open 7 days a week, 24 hours a day. Access via Wilsonova Street.
- Restaurant Fantova Kavárna
- Sushi Time
- Outside the main entrance.
- Elevators, ramps.
- CZK 10
- Hotel Esplanade Prague
- Falkensteiner Hotel Maria Prag
- Hotel City Central
- Cost CZK 100
- Located in the main hall
- Located in the main hall
- Avis
- Europcar
- Hertz
- Located in the main hall
- Free
- Hall 1: main entrance, platform 1-7 for trains to Germany, Austria, Slovakia, and regional destinations
- Hall 2: Metro connections
- Metro: Line C
- Tram: Lines 5, 9, 26
- Bus: Several lines available
- 6:00 AM - 10:00 PM Monday - Sunday
- Free
- Parking is available 24/7 with access from Partyzánská street.
- Restaurant Na Kovárně
- Cross Club
- Outside the main entrance.
- Ramps, restrooms.
- CZK 10
- Mama Shelter Prague
- Plaza Alta Hotel
- Hotel Belvedere
- Located in the main hall
- Avis
- Budget
- Located in the main hall
- Free
- Hall 1: main entrance, platform 1-4 for trains to Germany, Austria, and regional destinations
- Hall 2: ticket office and waiting area
- Metro: Line C
- Tram: Lines 6, 12, 17
- Bus: Several lines available
- 6:00 AM - 10:00 PM Monday - Sunday
- Free
- Parking is available nearby with several public parking options.
- Restaurant Kotleta
- Café Imperial
- Outside the main entrance.
- Ramps.
- CZK 10
- Hotel Kings Court
- Grand Hotel Bohemia
- Hotel Paris Prague
- Located in the main hall
- Avis
- Europcar
- Located in the main hall
- Free
- Hall 1: main entrance, platform 1-5 for regional and suburban trains
- Metro: Line B
- Tram: Lines 3, 5, 14, 24
- Bus: Several lines available
Most popular train connections from Karlsruhe
More options for your journey from Karlsruhe to Prague
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