- Must visit
National Museum
Major museum of Czech history and natural sciences in a monumental Neo-Renaissance building overlooking Wenceslas Square.
Cheapest price
$49
Average price
$189
Fastest journey
8 h 22 m
Average duration
8 h 28 m
Trains per day
69
Distance
536 km
The best way to find a cheap train ticket from Cologne to Prague is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Cologne to Prague will cost around $189 if you buy it on the day, but the cheapest tickets can be found for only $49.
It's difficult to get from Cologne to Prague without transferring at least 2 times.
ICE 619 · ICE 698 · IC 2449 · BUS 10171
ICE 957 · RJ 479
ICE 19 · ICE 590 · 16501 · S1
ICE 319 · ICE 1272 · EC 459
ICE 957 · rj 479
ICE 611 · ICE 1655 · NJ 457
ICE 623 · ICE 2590 · IC 2441 · RJ 177
ICE 623 · ICE 2590 · IC 2441 · rj 177
ICE 525 · ICE 2594 · IC 2445 · rj 175
ICE 525 · ICE 2594 · IC 2445 · RJ 175Omio recommends booking the train as it is the most popular option from Cologne to Prague among Omio's users. If you are prioritising price take the bus with prices starting from $38. For those with little time consider booking a flight which can get you there in 1h 47m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.2 - 0.5kg. The ticket price range depends on the travel mode: a bus costs an average of $38, and a flight costs an average of $137.
Distance: 333 miles (536 km)
Most popular Train | Bus | Flight | Driving |
|---|---|---|---|
$96 Average price | $59 Average price Cheapest | $539 Average price | $142 Average price (fuel + tolls) |
9h 54m Average total duration 9h 24m Onboard + 30m Additional time* | 9h 53m Average total duration 9h 23m Onboard + 30m Additional time* | 4h 47m Average total duration Fastest 1h 47m Onboard + 3h 0m Additional time* | 7h 17m Average total duration (door-to-door) |
0.2 - 0.5kg CO2 emissions Lowest | 0.5 - 1.3kg CO2 emissions | 1.6 - 3.2kg CO2 emissions | - CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Cologne to Prague:
A bus is $37 (€30) less than a train for this route with tickets for a train from Cologne to Prague costing on average $96 (€78).
A bus is $480 (€390) less than a flight for this route with tickets for a flight from Cologne to Prague costing on average $539 (€438).
Other travel options to Prague take longer:
Bus takes on average 9h 23m.
Train takes on average 9h 24m.
Tickets start at around $96 (€78) compared to roughly $142 (€115) in fuel and tolls — a saving of about $45 (€37). The journey takes 9h 24m versus 7h 17m by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.
Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.
The table below shows live departures for Cologne to Prague trains for today, Saturday, August 1. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
ICE 627 · ICE 2588 · IC 2049 · RJ 385 | On time 12:45 PM Cologne Messe/Deutz | 8h40 | 9:25 PM Prague hlavní nádraží | 3 transfers | |
ICE 627 · ICE 2588 · IC 2049 · rj 385 | On time 12:45 PM Cologne Messe/Deutz | 8h40 | 9:25 PM Prague hlavní nádraží | 3 transfers | |
ICE 629 · R 3577 · EC 363 | On time 1:45 PM Cologne Messe/Deutz | 8h37 | 10:22 PM Prague hlavní nádraží | 2 transfers | |
ICE 951 · NJ 457 | On time 1:45 PM Cologne Hbf | 10h41 | 12:26 AM Prague hlavní nádraží | 1 transfer | |
ICE 629 · R 3577 · EC 363 | On time 1:45 PM Cologne Messe/Deutz | 8h36 | 10:21 PM Prague hlavní nádraží | 2 transfers | |
ICE 629 · R 3577 · EC 363 | On time 1:45 PM Cologne Messe/Deutz | 8h37 | 10:22 PM Prague hlavní nádraží | 2 transfers | |
ICE 629 · 3577+ 363 | On time 1:45 PM Cologne Messe/Deutz | 8h37 | 10:22 PM Prague hlavní nádraží | 2 transfers | |
ICE 651 · rj 179 · rj 10179 · NJ 457 | On time 1:49 PM Cologne Hbf | 10h37 | 12:26 AM Prague hlavní nádraží | 3 transfers | |
FlixTrain+ FlixBus | 4:14 PM Cologne Hbf | 11h26 | 3:40 AM Prague, Central Train Station | 1 transfer | |
FlixTrain+ FlixBus | 4:14 PM Cologne Hbf | 11h16 | 3:30 AM Praha, ÚAN Florenc | 1 transfer | |
FlixTrain+ FlixBus | 4:14 PM Cologne Hbf | 11h26 | 3:40 AM Prague, Central Train Station | 1 transfer | |
FlixTrain+ FlixBus | 4:14 PM Cologne Hbf | 11h16 | 3:30 AM Praha, ÚAN Florenc | 1 transfer | |
ICE 957 · rj 479 · S 31703 · Os 28000 | On time 7:46 PM Cologne Hbf | 13h24 | 9:10 AM Prague hlavní nádraží | 4 transfers | |
ICE 319 · ICE 1272 · EC 459 | Delayed 9:39 PM 10:38 PMCologne Hbf | 10h47 | 9:25 AM Prague hlavní nádraží | 2 transfers | |
| Sunday, August 2 | |||||
S19 · ICE 827 · 3557+ 355 | 3:14 AM Cologne Messe/Deutz | 11h07 | 2:21 PM Prague hlavní nádraží | 3 transfers | |
S19 · ICE 827 · 3559+ 355 | 3:14 AM Cologne Messe/Deutz | 11h07 | 2:21 PM Prague hlavní nádraží | 3 transfers | |
S19 · ICE 827 · 3557+ 357 | 3:14 AM Cologne Messe/Deutz | 13h07 | 4:21 PM Prague hlavní nádraží | 3 transfers | |
ICE 827 · R 3557 · EC 353 | On time 3:21 AM Cologne Hbf | 9h00 | 12:21 PM Prague hlavní nádraží | 2 transfers | |
ICE 827 · 3557+ 353 | On time 3:21 AM Cologne Hbf | 9h00 | 12:21 PM Prague hlavní nádraží | 2 transfers | |
S19 · ICE 521 · 3559+ 359 | 4:07 AM Cologne Messe/Deutz | 14h14 | 6:21 PM Prague hlavní nádraží | 3 transfers | |
S19 · ICE 521 · 3559+ 357 | 4:07 AM Cologne Messe/Deutz | 12h14 | 4:21 PM Prague hlavní nádraží | 3 transfers | |
S19 · ICE 521 · 3559+ 355 | 4:07 AM Cologne Messe/Deutz | 10h14 | 2:21 PM Prague hlavní nádraží | 3 transfers | |
ICE 521 · 3559+ 355 | On time 4:28 AM Cologne Hbf | 9h53 | 2:21 PM Prague hlavní nádraží | 2 transfers | |
ICE 523 · 3561+ 355 | On time 5:20 AM Cologne Messe/Deutz | 9h01 | 2:21 PM Prague hlavní nádraží | 2 transfers | |
ICE 523 · R 3561 · EC 355 | On time 5:30 AM Cologne/Bonn Flughafen | 8h51 | 2:21 PM Prague hlavní nádraží | 2 transfers | |
ICE 511 · ICE 1555 · S 31731 · Os 28006 | On time 5:48 AM Cologne Hbf | 9h22 | 3:10 PM Prague hlavní nádraží | 4 transfers | |
ICE 553 · rj 175 | On time 6:14 AM Cologne Hbf | 9h01 | 3:15 PM Prague-Holešovice | 1 transfer | |
ICE 553 · RJ 175 | On time 6:14 AM Cologne Hbf | 9h01 | 3:15 PM Prague-Holešovice | 1 transfer | |
ICE 525 · 3563+ 357 | On time 6:45 AM Cologne Messe/Deutz | 9h36 | 4:21 PM Prague hlavní nádraží | 2 transfers | |
ICE 525 · 3563+ 359 | On time 6:45 AM Cologne Messe/Deutz | 11h36 | 6:21 PM Prague hlavní nádraží | 2 transfers | |
ICE 525 · ICE 2594 · IC 2445 · rj 175 | On time 6:45 AM Cologne Messe/Deutz | 8h30 | 3:15 PM Prague-Holešovice | 3 transfers | |
ICE 525 · ICE 2594 · IC 2445 · RJ 175 | On time 6:45 AM Cologne Messe/Deutz | 8h30 | 3:15 PM Prague-Holešovice | 3 transfers | |
ICE 527 · 3565+ 357 | On time 7:45 AM Cologne Messe/Deutz | 8h36 | 4:21 PM Prague hlavní nádraží | 2 transfers | |
ICE 527 · R 3565 · EC 357 | On time 7:45 AM Cologne Messe/Deutz | 8h36 | 4:21 PM Prague hlavní nádraží | 2 transfers | |
ICE 513 · ICE 1557 · S 31739 · Os 28008 | On time 7:54 AM Cologne Hbf | 9h16 | 5:10 PM Prague hlavní nádraží | 4 transfers | |
ICE 545 · RJ 383 | On time 8:25 AM Cologne Hbf | 9h00 | 5:25 PM Prague hlavní nádraží | 1 transfer | |
ICE 545 · rj 383 | On time 8:25 AM Cologne Hbf | 9h00 | 5:25 PM Prague hlavní nádraží | 1 transfer | |
ICE 529 · ICE 2592 · IC 2443 · rj 383 | On time 8:45 AM Cologne Messe/Deutz | 8h40 | 5:25 PM Prague hlavní nádraží | 3 transfers | |
ICE 529 · ICE 2592 · IC 2443 · RJ 383 | On time 8:45 AM Cologne Messe/Deutz | 8h40 | 5:25 PM Prague hlavní nádraží | 3 transfers | |
ICE 529 · 3567+ 359 | On time 8:45 AM Cologne Messe/Deutz | 9h36 | 6:21 PM Prague hlavní nádraží | 2 transfers | |
ICE 529 · 3567+ 361 | On time 8:45 AM Cologne Messe/Deutz | 11h36 | 8:21 PM Prague hlavní nádraží | 2 transfers | |
ICE 621 · 3569+ 359 | On time 9:45 AM Cologne Messe/Deutz | 8h36 | 6:21 PM Prague hlavní nádraží | 2 transfers | |
ICE 621 · R 3569 · EC 359 | On time 9:45 AM Cologne Messe/Deutz | 8h36 | 6:21 PM Prague hlavní nádraží | 2 transfers | |
ICE 557 · RJ 177 | On time 9:49 AM Cologne Hbf | 9h26 | 7:15 PM Prague-Holešovice | 1 transfer | |
ICE 557 · rj 177 | On time 9:49 AM Cologne Hbf | 9h26 | 7:15 PM Prague-Holešovice | 1 transfer | |
ICE 27 · 3571+ 361 | 9:53 AM Cologne Hbf | 10h28 | 8:21 PM Prague hlavní nádraží | 2 transfers | |
ICE 623 · ICE 2590 · IC 2441 · RJ 177 | On time 10:45 AM Cologne Messe/Deutz | 8h30 | 7:15 PM Prague-Holešovice | 3 transfers | |
ICE 623 · ICE 2590 · IC 2441 · rj 177 | On time 10:45 AM Cologne Messe/Deutz | 8h30 | 7:15 PM Prague-Holešovice | 3 transfers | |
ICE 625 · 3573+ 361 | On time 11:45 AM Cologne Messe/Deutz | 8h36 | 8:21 PM Prague hlavní nádraží | 2 transfers | |
ICE 625 · R 3573 · EC 361 | On time 11:45 AM Cologne Messe/Deutz | 8h36 | 8:21 PM Prague hlavní nádraží | 2 transfers | |
FlixTrain+ FlixBus | 12:14 PM Cologne Hbf | 11h41 | 11:55 PM Prague, Central Train Station | 1 transfer | |
FlixTrain+ FlixBus | 12:14 PM Cologne Hbf | 11h21 | 11:35 PM Praha, ÚAN Florenc | 1 transfer | |
FlixTrain+ FlixBus | 12:14 PM Cologne Hbf | 11h41 | 11:55 PM Prague, Central Train Station | 1 transfer | |
FlixTrain+ FlixBus | 12:14 PM Cologne Hbf | 11h21 | 11:35 PM Praha, ÚAN Florenc | 1 transfer | |
RE 17416 · ICE 549 · rj 385 | 12:21 PM Cologne Hbf | 9h04 | 9:25 PM Prague hlavní nádraží | 2 transfers | |
17416 · ICE 549 · RJ 385 | On time 12:21 PM Cologne Hbf | 9h04 | 9:25 PM Prague hlavní nádraží | 2 transfers | |
ICE 15 · ICE 2588 · IC 2049 · RJ 385 | On time 12:35 PM Cologne Hbf | 8h50 | 9:25 PM Prague hlavní nádraží | 3 transfers | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Trains from Cologne to Prague run on average 14 times per day, taking around 9h 24m. Cheap train tickets for this journey start at $50 (€41) but you can travel from only $38 (€31) by bus.
The earliest train runs at 00:02, the last at 23:58. The fastest train covers the 333 miles (536 km) distance in 8h 30m.
Distance 333 miles (536 km) |
Average train duration 9h 24m |
Cheapest ticket price $50 (€41) |
Trains per day 14 |
Fastest train 8h 30m |
First train 12:02 AM |
Last train 11:58 PM |
Cheapest Month Oct |
Cheapest Day Sat |
High Season Oct - Dec |
Low Season Jan - Mar |
Busiest Day Wed |
Least Busy Day Tue |
Best time to book 77 days |
Discover the best of Prague — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Prague trip today.
Major museum of Czech history and natural sciences in a monumental Neo-Renaissance building overlooking Wenceslas Square.
Well-curated Jewish history museum across several historic sites. Important for understanding Prague's Jewish heritage and resilience.
Leading Czech art museum with medieval to modern works in a grand historic palace. Essential for fine art and decorative arts lovers.
Historic square at Prague's core, surrounded by Gothic and Baroque landmarks. A must for first-time visitors and classic city views.
Lively boulevard of Czech modern history, lined with shops and major buildings. Worth visiting for atmosphere and historic significance.
Romantic quarter of palaces, lanes, and church domes beneath Prague Castle. Ideal for wandering, photography, and quieter historic charm.
Slow-braised beef in a creamy root-vegetable sauce, usually served with bread dumplings. A classic Czech Sunday dish strongly linked to Bohemian home cooking.
Crisp roasted pork knuckle, often served with mustard, horseradish, and pickles. A hearty pub staple popular with Czech beer culture.
Roast pork with sauerkraut and dumplings. This iconic Czech combination is a cornerstone of traditional pub and family meals.
Traditional Czech restaurant and brewery by Prague Castle, praised for roast meats, dumplings, and polished historic interiors.
Upscale restaurant focused on Czech ingredients and game, with sophisticated service in an Art Nouveau municipal house setting.
Elegant Michelin-starred restaurant known for modern Czech tasting menus in a refined setting near the Vltava.
Moderate for Europe: transit is cheap, casual meals are reasonable, and hotels in the center can raise daily costs in peak season.
Service is often not included. Tip about 5-10% in restaurants, round up for cafes, and round up or add about 10% for taxis if service is good.
Official public transport app
Praha hlavní nádraží -> Václavské náměstí, Prague
Traveling between Cologne and Prague offers a scenic journey through the heart of Europe, with several train providers ensuring a comfortable ride. You can choose from Deutsche Bahn, alex-Länderbahn und Vogtlandbahn-GmbH, and FlixTrain for your trip. Each provider offers unique services that cater to different travel preferences, making it easy to find an option that suits your needs as you explore these two cities.
Traveling from Cologne to Prague takes approximately 8 hours and 28 minutes, with a total of 4 connections available each day. The journey is not direct, requiring one transfer along the way.
The first daily train journey from Cologne to Prague departs at 05:55 AM, providing an early start for travelers eager to explore the beautiful landscapes along the route. The last departure of the day is scheduled for 09:58 PM, allowing visitors ample time to enjoy their adventures in both cities before returning.
The cheapest ticket price for the train connection from Cologne to Prague is €15. The average ticket price typically hovers around €50, making it a budget-friendly option for travelers looking to explore these two cities.
Prague Castle, a UNESCO World Heritage site, has stood as the seat of Czech kings and presidents for over a thousand years, making it one of the largest ancient castles in the world. Its significance lies not only in its architectural grandeur but also as a symbol of Czech history and culture; within its walls are stunning examples of Gothic architecture like St. Vitus Cathedral. Unique features include the changing of the guard ceremony that takes place every hour and breathtaking views overlooking Prague’s picturesque skyline.
The Charles Bridge is an iconic stone structure completed in 1402 that connects Old Town with Lesser Town across the Vltava River, serving as both a functional crossing and an artistic masterpiece adorned with 30 statues depicting saints. This bridge holds historical significance as it was once lined with merchants selling their wares, becoming a bustling hub for trade during medieval times. What makes this landmark truly unique are its atmospheric cobblestones which echo centuries past while offering visitors enchanting views at sunrise or sunset.
Old Town Square is often considered the heart of Prague's historic district; it's surrounded by colorful baroque buildings and home to significant landmarks such as the Astronomical Clock installed in 1410—one of Europe’s oldest functioning clocks still captivating onlookers today. The square serves not just as a tourist attraction but also reflects centuries worth of political events including public speeches and celebrations throughout Czech history. A standout feature here is definitely Týn Church whose gothic spires dominate your view—a perfect backdrop for capturing unforgettable memories amidst vibrant street performances year-round.
Find answers to the most common questions about traveling from Cologne to Prague by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Prague, this guide helps you travel smarter and with confidence.

Most Cologne to Prague trains use the Köln Hbf to Praha hlavní nádraží station pair, with some services arriving at Praha-Holesovice. Use this guide to compare Cologne and Prague train stations on this route, check city-centre transport, alongside checking practicalities like train station facilities and services.
Köln Hbf is 1 km from Cologne city centre. Public transport options include:
Köln Hbf has practical services for this route, including Wifi, Lockers, Shopping, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lounge, Lost and Found Office, Ticket Office, Bike Parking, Bike Rental, Car Rental, and Information Desk.
Food options include: asiagourmet, Coffee Fellows, dean&david, Dunkin' Donuts, KFC, McDonald's, Pizza Hut, Nordsee, Starbucks, Schweinske, & more
Free Wi-Fi for 30 minutes only. ATMs are available at Köln Hbf.
Ticket office support is available at Köln Hbf. Information desks are one near the departure/arrival board and another near the escalators close to Platforms 4 and 5.
Luggage storage is there are luggage lockers in the station. Lost and found is available at the station.
Available at Köln Hbf: Parking, Taxis, WC.
Available at Köln Hbf: Bike Parking, Bike Rental, Car Rental.
Accessibility facilities are available at Köln Hbf: Wheelchair accessible & mobility assistance staff. Contact the Mobility Service Centre at +49 3065212888 or [email protected].
Nearby hotels include Wyndham Koeln, Hilton Cologne, Excelsior Hotel Ernst.
Köln Messe/Deutz is 1 km from Cologne city centre. Public transport options include:
Köln Messe/Deutz has practical services for this route, including Wifi, Lockers, Shopping, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lounge, Lost and Found Office, Ticket Office, Bike Parking, Bike Rental, Car Rental, and Information Desk.
Food options include: Imbiss Athena, Arena Grill, Cafe Especial, Joe Champs
Wi-Fi is available at Köln Messe/Deutz. ATMs are available at Köln Messe/Deutz.
Ticket office support is available at Köln Messe/Deutz. Information desks are available at Köln Messe/Deutz.
Luggage storage is available at Köln Messe/Deutz. Lost and found is available at the station.
Available at Köln Messe/Deutz: Parking, Taxis, WC.
Available at Köln Messe/Deutz: Bike Parking, Bike Rental, Car Rental.
Accessibility facilities are available at Köln Messe/Deutz.
Nearby hotels include Pension Helenenwall, Zur guten Quelle, Zum Goldenen Hut, Merlin.
Köln Süd is 1 km from Cologne city centre. Public transport options include:
Köln Süd has practical services for this route, including Wifi, Lockers, Shopping, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lounge, Lost and Found Office, Ticket Office, Bike Parking, Bike Rental, Car Rental, and Information Desk.
Food options include: Subway, Ganesha, Magnus, Borsalino
Wi-Fi is available at Köln Süd. ATMs are available at Köln Süd.
Ticket office support is available at Köln Süd. Information desks are available at Köln Süd.
Luggage storage is available at Köln Süd. Lost and found is available at the station.
Available at Köln Süd: Parking, Taxis, WC.
Available at Köln Süd: Bike Parking, Bike Rental, Car Rental.
Accessibility facilities are available at Köln Süd.
Nearby hotels include Hotel Chelsea, Hotel Mado, Elite Hotel, Blacksheep Hostel.
Praha hlavní nádraží is 1 km from Prague city centre. Public transport options include:
Praha hlavní nádraží has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Shower, Lounge, Lost and Found Office, Ticket Office, Bike Parking, Bike Rental, Car Rental, Information Desk, and Luggage Carts.
Food options include: Restaurant Fantova Kavárna, Sushi Time
Free. ATMs are available in the train station.
Ticket office support is available at Praha hlavní nádraží. Information desks are located in the main hall.
Luggage storage is available at Praha hlavní nádraží. Lost and found is available at the station.
Available at Praha hlavní nádraží: Parking, Taxis, WC.
Available at Praha hlavní nádraží: Bike Parking, Bike Rental, Car Rental.
Accessibility facilities are available at Praha hlavní nádraží: Elevators, ramps.
Nearby hotels include Hotel Esplanade Prague, Falkensteiner Hotel Maria Prag, Hotel City Central.
Praha-Holesovice is 2 km from Prague city centre. Public transport options include:
Praha-Holesovice has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Bike Parking, Bike Rental, Car Rental, Information Desk, and Luggage Carts.
Food options include: Restaurant Na Kovárně, Cross Club
Free. ATMs are available in the train station.
Ticket office support is available at Praha-Holesovice. Information desks are located in the main hall.
Luggage storage is available at Praha-Holesovice. Lost and found is available at the station.
Available at Praha-Holesovice: Parking, Taxis, WC.
Available at Praha-Holesovice: Bike Parking, Bike Rental, Car Rental.
Accessibility facilities are available at Praha-Holesovice: Ramps, restrooms.
Nearby hotels include Mama Shelter Prague, Plaza Alta Hotel, Hotel Belvedere.
Praha Masarykovo Nádraží has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Bike Parking, Bike Rental, Car Rental, Information Desk, and Luggage Carts.
Food options include: Restaurant Kotleta, Café Imperial
Free. ATMs are available in the train station.
Ticket office support is available at Praha Masarykovo Nádraží. Information desks are located in the main hall.
Luggage storage is available at Praha Masarykovo Nádraží. Lost and found is available at the station.
Available at Praha Masarykovo Nádraží: Parking, Taxis, WC.
Available at Praha Masarykovo Nádraží: Bike Parking, Bike Rental, Car Rental.
Accessibility facilities are available at Praha Masarykovo Nádraží: Ramps.
Nearby hotels include Hotel Kings Court, Grand Hotel Bohemia, Hotel Paris Prague.
Here are some other resources that might have the information you need