Travel Information
Compare train and bus for Karlsruhe to Prague
Omio recommends booking the train as it is the most popular option from Karlsruhe to Prague among Omio's users. If you are prioritising price take the bus with prices starting from $31. For those with little time consider booking a bus which can get you there in 7h 29m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.1 - 0.4kg. The ticket price range depends on the travel mode: a bus costs an average of $31, and a train costs an average of $34.
Distance: 280 miles (452 km)
Compare train with
Most popular Train | Bus | Driving |
|---|---|---|
$78 Average price | $48 Average price Cheapest | $114 Average price (fuel + tolls) |
9h 35m Average total duration 9h 5m Onboard + 30m Additional time* | 7h 59m Average total duration Fastest 7h 29m Onboard + 30m Additional time* | 5h 45m Average total duration (door-to-door) |
0.1 - 0.4kg CO2 emissions Lowest | 0.5 - 1.1kg CO2 emissions | - CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Karlsruhe to Prague:
A bus is $29 (€24) less than a train for this route with tickets for a train from Karlsruhe to Prague costing on average $78 (€64).
Other travel options to Prague take longer:
Train takes on average 9h 5m.
Travel optionsfrom Karlsruhe to Prague
How to get from Karlsruhe to Prague by train, bus or flight.
Our recommendation
The best way to travel from Karlsruhe to Prague is by taking a bus because it’s the best combination of price and speed.
FlixBus6:25 AM9h00Karlsruhe Hbf3:25 PMPraha, ÚAN Florenc$491One-way0 transfers
Cheapest
FlixBus6:25 AM9h00Karlsruhe Hbf3:25 PMPraha, ÚAN Florenc$491One-way0 transfers
Fastest
ECE 8 · ICE 1012+
LH13968:37 AM5h23Karlsruhe Hbf2:00 PMPrague Vaclav Havel Airport$3981One-way2 transfers
Other options
ICE 567 · 88621 · 3577+
3632:05 PM8h17Karlsruhe Hbf10:22 PMPrague hlavní nádraží$591One-way3 transfers
IC 2161 · 3597+
3631:06 PM9h16Karlsruhe Hbf10:22 PMPrague hlavní nádraží$591One-way2 transfers
IC 2069 · 3571+
36111:06 AM9h15Karlsruhe Hbf8:21 PMPrague hlavní nádraží$691One-way2 transfers
FlixBus6:25 AM9h45Karlsruhe Hbf4:10 PMPraha, Černý Most$491One-way0 transfers
FlixBus11:25 PM8h05Karlsruhe Hbf7:30 AMPraha, M. Horákové (Hradčanská)$501One-way0 transfers
FlixBus11:25 PM8h25Karlsruhe Hbf7:50 AMPraha, ÚAN Florenc$501One-way0 transfers
ICE 106+
DE44112:59 PM6h11Karlsruhe Hbf9:10 PMPrague Vaclav Havel Airport$2241One-way1 transfer
ICE 72 · ICE 916+
DE44112:37 PM6h33Karlsruhe Hbf9:10 PMPrague Vaclav Havel Airport$2241One-way2 transfers
ICE 370 · ICE 518+
DE44111:59 PM7h11Karlsruhe Hbf9:10 PMPrague Vaclav Havel Airport$2241One-way2 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
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FAQs: Travel from Karlsruhe to Prague
Travel to Prague easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Karlsruhe to Prague.

This is compared to other travel options from Karlsruhe to Prague:
A bus is $29 (€24) less than a train for this route with tickets for a train from Karlsruhe to Prague costing on average $78 (€64).
Other travel options to Prague take longer:
Train takes on average 9h 5m.
- Around 24 buses per day.
- Around 9 trains per day.
However, we recommend checking specific travel dates for your route between Karlsruhe and Prague as scheduled services by train and bus can vary by season or day of the week.
- Trains mostly depart from Karlsruhe Hbf and arrive in Prague hlavní nádraží.
- Buses mostly depart from Karlsruhe Hbf and arrive in Prague, Central Train Station.
- Travel with FlixBus, BlaBlaCar to go to Prague by bus.
- Travel with alex-Länderbahn und Vogtlandbahn-GmbH, Deutsche Bahn, České dráhy, ÖBB to go to Prague by train.
- 8 direct buses per day with FlixBus, BlaBlaCar.
- 0 direct trains per day with ÖBB.
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