Travel Information
Compare train and bus for Karlsruhe to Prague
Omio recommends booking the train as it is the most popular option from Karlsruhe to Prague among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $48 For those with little time, consider booking a bus, which has an average total journey time of 7h 59m. If you are seeking to minimise your carbon footprint, the train is your best option, with estimated CO2 emissions of 0.1 - 0.4kg. Average ticket prices depend on the travel mode: a bus costs an average of $48, while a train costs an average of $76.
Distance: 280 miles (452 km)
Compare train with
Most popular Train | Bus | Driving |
|---|---|---|
$76 Average price | $48 Average price Cheapest | $117 Average price (fuel + tolls) |
9h 42m Average total duration 9h 12m Onboard + 30m Additional time* | 7h 59m Average total duration Fastest 7h 29m Onboard + 30m Additional time* | 5h 45m Average total duration (door-to-door) |
0.1 - 0.4kg CO2 emissions Lowest | 0.5 - 1.1kg CO2 emissions | - CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Karlsruhe to Prague:
A bus is $28 less than a train for this route with tickets for a train from Karlsruhe to Prague costing on average $76.
Other travel options to Prague take longer:
Train takes on average 9h 42m.
Travel optionsfrom Karlsruhe to Prague
How to get from Karlsruhe to Prague by train, bus or flight.
Our recommendation
The best way to travel from Karlsruhe to Prague is by taking a bus because it’s the best combination of price and speed.
FlixBus1:20 PM8h30Karlsruhe Hbf9:50 PMPraha, ÚAN Florenc$511One-way0 transfers
Cheapest
FlixBus1:20 PM8h30Karlsruhe Hbf9:50 PMPraha, ÚAN Florenc$511One-way0 transfers
Fastest
ICE 376 · ICE 614+
LH13967:59 AM5h41Karlsruhe Hbf1:40 PMPrague Vaclav Havel Airport$2511One-way2 transfers
Other options
IC 2067 · 3569+
3599:06 AM9h15Karlsruhe Hbf6:21 PMPrague hlavní nádraží$531One-way2 transfers
ICE 200 · ICE 2590 · IC 2441 · RJ 17710:59 AM8h16Karlsruhe Hbf7:15 PMPrague-Holešovice$611One-way3 transfers
IC 60402 · ICE 619+
3531:24 AM10h57Karlsruhe12:21 PMPrague hlavní nádraží$611One-way2 transfers
FlixBus6:25 AM9h00Karlsruhe Hbf3:25 PMPraha, ÚAN Florenc$521One-way0 transfers
FlixBus6:25 AM9h45Karlsruhe Hbf4:10 PMPraha, Černý Most$521One-way0 transfers
FlixBus11:25 PM8h05Karlsruhe Hbf7:30 AMPraha, M. Horákové (Hradčanská)$551One-way0 transfers
ICE 76 · ICE 1014+
LH14006:37 AM11h13Karlsruhe Hbf5:50 PMPrague Vaclav Havel Airport$1841One-way2 transfers
ICE 72 · ICE 916+
LH14022:37 PM8h33Karlsruhe Hbf11:10 PMPrague Vaclav Havel Airport$1861One-way2 transfers
ICE 202+
LH14008:59 AM8h51Karlsruhe Hbf5:50 PMPrague Vaclav Havel Airport$1861One-way1 transfer
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
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FAQs: Travel from Karlsruhe to Prague
Travel to Prague easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Karlsruhe to Prague.

This is compared to other travel options from Karlsruhe to Prague:
A bus is $28 less than a train for this route with tickets for a train from Karlsruhe to Prague costing on average $76.
Other travel options to Prague take longer:
Train takes on average 9h 42m.
- Around 24 buses per day.
- Around 10 trains per day.
However, we recommend checking specific travel dates for your route between Karlsruhe and Prague as scheduled services by train and bus can vary by season or day of the week.
- Trains mostly depart from Karlsruhe Hbf and arrive in Prague hlavní nádraží.
- Buses mostly depart from Karlsruhe Hbf and arrive in Praha, ÚAN Florenc.
- Travel with alex-Länderbahn und Vogtlandbahn-GmbH, Deutsche Bahn, České dráhy, ÖBB to go to Prague by train.
- Travel with FlixBus, BlaBlaCar to go to Prague by bus.
- 0 direct trains per day with České dráhy, ÖBB.
- 8 direct buses per day with FlixBus, BlaBlaCar.
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