Travel Information
Compare train and bus for Karlsruhe to Prague
Omio recommends booking the train as it is the most popular option from Karlsruhe to Prague among Omio's users. If you are prioritising price take the bus with prices starting from $34. For those with little time consider booking a bus which can get you there in 7h 25m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.1 - 0.4kg. The ticket price range depends on the travel mode: a bus costs an average of $34, and a train costs an average of $37.
Distance: 280 miles (452 km)
Compare train with
Most popular Train | Bus |
|---|---|
$78 Average price | $53 Average price Cheapest |
9h 49m Average total duration 9h 19m Onboard + 30m Additional time* | 7h 55m Average total duration Fastest 7h 25m Onboard + 30m Additional time* |
0.1 - 0.4kg CO2 emissions Lowest | 0.5 - 1.1kg CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company |
Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Travel optionsfrom Karlsruhe to Prague
How to get from Karlsruhe to Prague by train, bus or flight.
Our recommendation
The best way to travel from Karlsruhe to Prague is by taking a bus because it’s the best combination of price and speed.
FlixBus6:25 AM9h00Karlsruhe Hbf3:25 PMPraha, ÚAN Florenc$491One-way0 transfers
Cheapest
FlixBus6:25 AM9h00Karlsruhe Hbf3:25 PMPraha, ÚAN Florenc$491One-way0 transfers
Fastest
ICE 106+
DE44072:59 PM6h26Karlsruhe Hbf9:25 PMPrague Vaclav Havel Airport$5801One-way1 transfer
Other options
15839 · 19064 · ICE 585 · 35699:15 AM9h06Karlsruhe Hbf6:21 PMPrague hlavní nádraží$951One-way4 transfers
FlixTrain+
FlixBus2:23 PM11h17Karlsruhe Hbf1:40 AMPrague, Central Train Station$841One-way1 transfer
EC 45911:09 PM10h16Karlsruhe Hbf9:25 AMPrague hlavní nádraží$1071One-way0 transfers
FlixBus8:35 AM8h55Karlsruhe Hbf5:30 PMPrague, Central Train Station$571One-way0 transfers
FlixBus8:35 AM9h10Karlsruhe Hbf5:45 PMPraha, ÚAN Florenc$571One-way0 transfers
FlixBus6:25 AM9h45Karlsruhe Hbf4:10 PMPraha, Černý Most$491One-way0 transfers
ICE 108+
DE440712:59 PM8h26Karlsruhe Hbf9:25 PMPrague Vaclav Havel Airport$5801One-way1 transfer
ICE 370 · ICE 518+
DE44071:59 PM7h26Karlsruhe Hbf9:25 PMPrague Vaclav Havel Airport$5801One-way2 transfers
ICE 72 · ICE 916+
DE44072:37 PM6h48Karlsruhe Hbf9:25 PMPrague Vaclav Havel Airport$5801One-way2 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
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FAQs: Travel from Karlsruhe to Prague
Travel to Prague easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Karlsruhe to Prague.

This is compared to other travel options from Karlsruhe to Prague:
A bus is $3 (€3) less than a train for this route with tickets for a train from Karlsruhe to Prague costing on average $37 (€30).
Other travel options to Prague take longer:
Train takes on average 8h 16m.
- Around 24 buses per day.
- Around 9 trains per day.
However, we recommend checking specific travel dates for your route between Karlsruhe and Prague as scheduled services by train and bus can vary by season or day of the week.
- Trains mostly depart from Karlsruhe Hbf and arrive in Prague hlavní nádraží.
- Buses mostly depart from Karlsruhe Hbf and arrive in Prague, Central Train Station.
- Travel with FlixBus, BlaBlaCar to go to Prague by bus.
- Travel with Deutsche Bahn, alex-Länderbahn und Vogtlandbahn-GmbH, České dráhy to go to Prague by train.
- 8 direct buses per day with FlixBus, BlaBlaCar.
Travelling from Karlsruhe to Prague: related information
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