Travel Information
Compare train and bus for Karlsruhe to Prague
Omio recommends booking the train as it is the most popular option from Karlsruhe to Prague among Omio's users. If you are prioritising price, take the bus, with an average ticket price of lei265 For those with little time, consider booking a train, which has an average total journey time of 8h 36m. If you are seeking to minimise your carbon footprint, the train is your best option, with estimated CO2 emissions of 0.1 - 0.4kg. Average ticket prices depend on the travel mode: a bus costs an average of lei265, while a train costs an average of lei693.
Distance: 280 miles (452 km)
Compare train with
Most popular Train | Bus | Driving |
|---|---|---|
lei693 Average price | lei265 Average price Cheapest | lei536 Average price (fuel + tolls) |
8h 36m Average total duration Fastest 8h 6m Onboard + 30m Additional time* | 9h 16m Average total duration 8h 46m Onboard + 30m Additional time* | 5h 45m Average total duration (door-to-door) |
0.1 - 0.4kg CO2 emissions Lowest | 0.5 - 1.1kg CO2 emissions | - CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Karlsruhe to Prague:
A bus is lei429 less than a train for this route with tickets for a train from Karlsruhe to Prague costing on average lei693.
Other travel options to Prague take longer:
Bus takes on average 9h 16m.
Tickets start at around lei693 compared to roughly lei536 in fuel and tolls — a saving of about lei-156.93. The journey takes 8h 6m versus 5h 45m by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.
Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.
Travel optionsfrom Karlsruhe to Prague
How to get from Karlsruhe to Prague by train, bus or flight.
Our recommendation
The best way to travel from Karlsruhe to Prague is by taking a train because it’s the best combination of price and speed.
FlixTrain+
FlixBus2:23 PM11h17Karlsruhe Hbf1:40 AMPrague, Central Train Stationlei1761One-way1 transfer
Cheapest
FlixTrain+
FlixBus2:23 PM11h17Karlsruhe Hbf1:40 AMPrague, Central Train Stationlei1761One-way1 transfer
Fastest
ICE 376 · ICE 614+
LH13967:59 AM5h31Karlsruhe Hbf1:30 PMPrague Vaclav Havel Airportlei18041One-way2 transfers
Other options
STR 3 · IC 2069 · 3571+
36110:44 AM9h37Europaplatz/Post Galerie (Karlstraße)8:21 PMPrague hlavní nádražílei2981One-way3 transfers
STR 3 · IC 2067 · 3569+
3598:44 AM9h37Europaplatz/Post Galerie (Karlstraße)6:21 PMPrague hlavní nádražílei3381One-way3 transfers
STR 3 · ICE 565 · 88619 · 357311:44 AM8h37Europaplatz/Post Galerie (Karlstraße)8:21 PMPrague hlavní nádražílei3951One-way4 transfers
FlixBus11:25 PM8h05Karlsruhe Hbf7:30 AMPraha, M. Horákové (Hradčanská)lei1931One-way0 transfers
FlixBus11:25 PM8h25Karlsruhe Hbf7:50 AMPraha, ÚAN Florenclei1931One-way0 transfers
FlixBus1:20 PM8h30Karlsruhe Hbf9:50 PMPraha, ÚAN Florenclei1991One-way0 transfers
ICE 106+
DE44112:59 PM6h26Karlsruhe Hbf9:25 PMPrague Vaclav Havel Airportlei9591One-way1 transfer
ICE 202+
DE44078:59 AM7h01Karlsruhe Hbf4:00 PMPrague Vaclav Havel Airportlei9591One-way1 transfer
ECE 8 · ICE 1012+
DE44078:37 AM7h23Karlsruhe Hbf4:00 PMPrague Vaclav Havel Airportlei9591One-way2 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
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FAQs: Travel from Karlsruhe to Prague
Travel to Prague easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Karlsruhe to Prague.

This is compared to other travel options from Karlsruhe to Prague:
A bus is lei429 less than a train for this route with tickets for a train from Karlsruhe to Prague costing on average lei693.
Other travel options to Prague take longer:
Bus takes on average 9h 16m.
- Around 24 buses per day.
- Around 10 trains per day.
However, we recommend checking specific travel dates for your route between Karlsruhe and Prague as scheduled services by train and bus can vary by season or day of the week.
- Trains mostly depart from Karlsruhe Hbf and arrive in Prague hlavní nádraží.
- Buses mostly depart from Karlsruhe Hbf and arrive in Praha, ÚAN Florenc.
- Travel with FlixBus, Infobus, BlaBlaCar Bus, AMI-Tour to go to Prague by bus.
- Travel with alex-Länderbahn und Vogtlandbahn-GmbH, Deutsche Bahn, České dráhy to go to Prague by train.
- 8 direct buses per day with FlixBus, Infobus, AMI-Tour.
Travelling from Karlsruhe to Prague: related information
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