- Must visit
Musée des Confluences
A major science and anthropology museum in a striking contemporary building at the confluence of the Rhône and Saône. One of Lyon’s signature cultural sites with strong temporary exhibitions.
Cheapest price
$125
Average price
$203
Fastest journey
4 h 45 m
Average duration
5 h 4 m
Trains per day
21
Distance
449 km
The best way to find a cheap train ticket from Karlsruhe to Lyon is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Karlsruhe to Lyon will cost around $203 if you buy it on the day, but the cheapest tickets can be found for only $125.
Of the 21 trains that leave Karlsruhe for Lyon on Wed, Jun 03, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Wed, Jun 03 the direct trains cover the 449 km distance in an average of 5 h 4 m but if you time it right, some trains will get you there in just 4 h 45 m .
On Wed, Jun 03 the slowest trains will take 5 h 31 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
ICE 9568+
12177
ICE 9568+
5537
TGV 9574+
5537
TGV 9574+
12177
TGV 9576+
12177
ICE 9568+
9877
9580
9877+
9568
9574 · 6619
TGV 9574+
9879Omio recommends booking the train as it is the most popular option from Karlsruhe to Lyon among Omio's users. If you are prioritising price take the bus with prices starting from $26. For those with little time consider booking a train which can get you there in 5h 2m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.1 - 0.4kg. The ticket price range depends on the travel mode: a bus costs an average of $26, and a train costs an average of $73.
Distance: 278 miles (449 km)
Most popular Train | Bus | Driving |
|---|---|---|
$139 Average price | $38 Average price Cheapest | $152 Average price (fuel + tolls) |
5h 32m Average total duration Fastest 5h 2m Onboard + 30m Additional time* | 8h 8m Average total duration 7h 38m Onboard + 30m Additional time* | 5h 54m Average total duration (door-to-door) |
0.1 - 0.4kg CO2 emissions Lowest | 0.4 - 1.1kg CO2 emissions | - CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Karlsruhe to Lyon:
A bus is $101 (€81) less than a train for this route with tickets for a train from Karlsruhe to Lyon costing on average $139 (€112).
Other travel options to Lyon take longer:
Bus takes on average 7h 38m.
The journey is about 52m faster (5h 2m by train vs 5h 54m by car) and roughly $13 (€11) cheaper once you factor in fuel and tolls ($139 (€112) vs $152 (€123)). You'll also arrive in the city centre rather than hunting for parking, and you can work, read, or watch the landscape go by instead of concentrating on the road.
Direct services run with TGV, SNCF | TGV INOUI.
Driving is still worth considering if you want to stop along the way or need a car once you arrive.
The table below shows live departures for Karlsruhe to Lyon trains for today, Tuesday, June 2. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
9877+ 9568 | Delayed 7:54 AM 8:06 AMKarlsruhe Hbf | 4h54 | 1:00 PM Lyon Part Dieu | 1 transfer | |
TGV 9576+ 9879 | 9:53 AM Karlsruhe Hbf | 7h10 | 5:03 PM Lyon Part Dieu | 1 transfer | |
TGV 9576+ 5537 | 9:53 AM Karlsruhe Hbf | 8h06 | 5:59 PM Lyon Part Dieu | 1 transfer | |
TGV 9576+ 12177 | 9:53 AM Karlsruhe Hbf | 8h06 | 5:59 PM Lyon Part Dieu | 1 transfer | |
TGV 9574+ 5537 | 11:32 AM Karlsruhe Hbf | 6h27 | 5:59 PM Lyon Part Dieu | 1 transfer | |
TGV 9574+ 12177 | 11:32 AM Karlsruhe Hbf | 6h27 | 5:59 PM Lyon Part Dieu | 1 transfer | |
TGV 9574+ 9879 | 11:32 AM Karlsruhe Hbf | 5h31 | 5:03 PM Lyon Part Dieu | 1 transfer | |
12177+ 9590 | On time 12:08 PM Karlsruhe Hbf | 5h51 | 5:59 PM Lyon Part Dieu | 1 transfer | |
9580 | 3:12 PM Karlsruhe Hbf | 4h46 | 7:58 PM Lyon Part Dieu | 0 transfersDirect | |
9572+ 6633 | 3:32 PM Karlsruhe Hbf | 7h38 | 11:10 PM Lyon Part Dieu | 1 transfer | |
5488 · 9844+ 9572 | 3:32 PM Karlsruhe Hbf | 6h28 | 10:00 PM Lyon Part Dieu | 2 transfers | |
| Wednesday, June 3 | |||||
9568+ 9877 | 8:06 AM Karlsruhe Hbf | 4h54 | 1:00 PM Lyon Part Dieu | 1 transfer | |
ICE 9568+ 12177 | 8:15 AM Karlsruhe Hbf | 9h44 | 5:59 PM Lyon Part Dieu | 1 transfer | |
ICE 9568+ 5537 | 8:15 AM Karlsruhe Hbf | 9h44 | 5:59 PM Lyon Part Dieu | 1 transfer | |
ICE 9568+ 9877 | 8:15 AM Karlsruhe Hbf | 4h45 | 1:00 PM Lyon Part Dieu | 1 transfer | |
Find all the dates and times for this journey
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Trains from Karlsruhe to Lyon run on average 6 times per day, taking around 5h 2m. Cheap train tickets for this journey start at $73 (€59) but you can travel from only $26 (€21) by bus.
There are 1 trains per day. The earliest train runs at 00:25, the last at 23:00. The fastest train covers the 278 miles (449 km) distance in 4h 38m.
Distance 278 miles (449 km) |
Average train duration 5h 2m |
Cheapest ticket price $73 (€59) |
Trains per day 6 |
Direct trains 1 |
Fastest train 4h 38m |
First train 12:25 AM |
Last train 11:00 PM |
Cheapest Month Sep |
Cheapest Day Sat |
High Season Apr - Jun |
Low Season Jan - Mar |
Busiest Day Fri |
Least Busy Day Tue |
Best time to book 49 days |
Discover the best of Lyon — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Lyon trip today.
A major science and anthropology museum in a striking contemporary building at the confluence of the Rhône and Saône. One of Lyon’s signature cultural sites with strong temporary exhibitions.
Lyon’s premier fine arts museum, housed in a former abbey near Place des Terreaux. Known for strong collections of painting, sculpture, antiquities, and decorative arts.
Museum of Roman Lyon paired with the city’s ancient theaters on Fourvière hill. A key stop for understanding Lugdunum, the Roman origins of Lyon.
Lyon’s atmospheric old quarter with Renaissance lanes, traboules, and riverfront views. It is the city’s classic strolling area and a top priority for first-time visitors.
One of Europe’s largest open squares and a central meeting point in Lyon. It is a practical orientation stop and a key place for city views toward Fourvière.
Lyon’s flagship urban park with broad walking paths, lake, botanical areas, and a zoo. It is one of the best places in the city for relaxation and scenic walks.
Light dumplings made with pike and panade, usually baked in a rich Nantua crayfish sauce. A classic Lyonnais bouchon specialty.
A traditional salad of frisée lettuce with lardons, croutons, and a poached egg. It is one of the city’s most iconic starter dishes.
Lyon’s famous sausage baked inside a soft brioche dough. It is a beloved charcuterie-based specialty found in many bouchons.
A landmark fine dining institution in Lyon, famed for historic prestige and elegant cuisine rooted in the city’s gastronomic heritage.
The city’s celebrated covered food market, ideal for sampling oysters, charcuterie, cheese, pastries, and many iconic Lyonnais products.
A respected traditional restaurant associated with chef Joseph Viola, celebrated for refined Lyonnais classics in a polished but welcoming setting.
Moderate for France: bakeries and bouchons are fair value, while central hotels and fine dining cost more.
Service is included by law. Leaving small change or 5-10% for great service is appreciated, not required. Round up for taxis.
Official public transport app
Lyon Part-Dieu -> Bellecour, Lyon
Find answers to the most common questions about traveling from Karlsruhe to Lyon by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Lyon, this guide helps you travel smarter and with confidence.

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