- Must visit
Vatican Museums
World-famous papal museums with the Sistine Chapel, Raphael Rooms, and major classical collections.
Cheapest price
$393
Average price
$401
Fastest journey
9 h 38 m
Average duration
9 h 51 m
Trains per day
7
Distance
852 km
The best way to find a cheap train ticket from Karlsruhe to Rome is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Karlsruhe to Rome will cost around $401 if you buy it on the day, but the cheapest tickets can be found for only $393.
It's difficult to get from Karlsruhe to Rome without transferring at least 3 times.
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Omio recommends booking the bus as it is the most popular option from Karlsruhe to Rome among Omio's users. If you are prioritising price take the bus with prices starting from $56. For those with little time consider booking a train which can get you there in 12h 28m. In case you are seeking to minimise your carbon footprint the bus is your best bet as it emits only 0.9 - 2.1kg. The ticket price range depends on the travel mode: a bus costs an average of $56, and a train costs an average of $362.
Distance: 529 miles (852 km)
| Train | Most popular Bus | Driving |
|---|---|---|
$393 Average price | $80 Average price Cheapest | $335 Average price (fuel + tolls) |
12h 58m Average total duration Fastest 12h 28m Onboard + 30m Additional time* | 21h 36m Average total duration 21h 6m Onboard + 30m Additional time* | 12h 4m Average total duration (door-to-door) |
- CO2 emissions | 0.9 - 2.1kg CO2 emissions Lowest | - CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Karlsruhe to Rome:
A bus is $313 (€258) less than a train for this route with tickets for a train from Karlsruhe to Rome costing on average $393 (€323).
Other travel options to Rome take longer:
Train takes on average 12h 28m.
Bus takes on average 21h 6m.
Tickets start at around $393 (€323) compared to roughly $335 (€275) in fuel and tolls — a saving of about $-58.67 (€-48.25). The journey takes 12h 28m versus 12h 4m by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.
Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.
The table below shows live departures for Karlsruhe to Rome trains for today, Tuesday, July 21. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 1:01 PM Karlsruhe | 9h38 | 10:39 PM Rome | 3 transfers | |
![]() | 3:01 PM Karlsruhe | 17h39 | 8:40 AM Rome | 3 transfers | |
![]() | 7:01 PM Karlsruhe | 15h40 | 10:41 AM Rome | 3 transfers | |
| Wednesday, July 22 | |||||
![]() | 4:03 AM Karlsruhe | 10h40 | 2:43 PM Rome | 3 transfers | |
![]() | 7:01 AM Karlsruhe | 9h39 | 4:40 PM Rome | 3 transfers | |
![]() | 9:01 AM Karlsruhe | 9h39 | 6:40 PM Rome | 3 transfers | |
![]() | 11:01 AM Karlsruhe | 9h38 | 8:39 PM Rome | 3 transfers | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Trains from Karlsruhe to Rome run on average 2 times per day, taking around 12h 28m. Cheap train tickets for this journey start at $362 (€298) but you can travel from only $56 (€46) by bus.
The earliest train runs at 04:03, the last at 21:00. The fastest train covers the 529 miles (852 km) distance in 9h 38m.
Distance 529 miles (852 km) |
Average train duration 12h 28m |
Cheapest ticket price $362 (€298) |
Trains per day 2 |
Fastest train 9h 38m |
First train 4:03 AM |
Last train 9:00 PM |
High Season Apr - Jun |
Low Season Jan - Mar |
Best time to book 42 days |
Discover the best of Rome — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Rome trip today.
World-famous papal museums with the Sistine Chapel, Raphael Rooms, and major classical collections.
Outstanding ancient sculpture and mosaic museum housed in the Palazzo dei Conservatori and Palazzo Nuovo.
Celebrated villa museum with Bernini sculptures, Caravaggio paintings, and refined garden setting.
Elegant Baroque square with Bernini's fountains, lively atmosphere, and superb people-watching.
Historic square and gathering place at the Spanish Steps, ideal for classic city views and strolls.
Charming cobbled neighborhood filled with ivy-clad lanes, churches, nightlife, and local character.
Classic Roman pasta with guanciale, egg yolk, Pecorino Romano, and black pepper. A city icon known for rich flavor without cream.
Roman pasta with guanciale, tomato, and Pecorino Romano. A traditional Lazio staple tied to shepherd cooking and bold savory flavor.
Pasta with guanciale, Pecorino Romano, and black pepper. Considered one of Rome's oldest pasta dishes and prized for its simplicity.
Three-Michelin-star dining by Niko Romito at Bulgari Hotel Roma, offering refined Italian tasting menus in an elegant setting.
Historic trattoria in Testaccio known for classic Roman pasta and quinto quarto dishes in a lively, traditional setting.
Popular casual spot famed for Roman-style pizzas and fried starters. Bustling atmosphere and a long-standing local reputation.
Moderate for Europe: stays in central Rome are pricey, but transit is cheap and meals range from affordable pizza to costly tourist-area dining.
Service may be included via coperto or servizio. Round up or leave 5-10% at restaurants if service is good; round up in taxis; small change is fine at cafés.
Official public transport app
Roma Termini -> Piazza Di Spagna, Rome
Find answers to the most common questions about traveling from Karlsruhe to Rome by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Rome, this guide helps you travel smarter and with confidence.

Most Karlsruhe to Rome trains use the Karlsruhe Hbf to station pair. Use this guide to compare Karlsruhe and Rome train stations on this route, check city-centre transport, alongside checking practicalities like train station facilities and services.
Karlsruhe Hbf is 1 km from Karlsruhe city centre. Public transport options include:
Karlsruhe Hbf has practical services for this route, including Wifi, Lockers, Shopping, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lounge, Lost and Found Office, Ticket Office, Bike Parking, Bike Rental, Car Rental, and Information Desk.
Food options include: Vinarte, Am Tiergarten, Panorama, Alter Brauhof
Wi-Fi is available at Karlsruhe Hbf. ATMs are available at Karlsruhe Hbf.
Ticket office support is available at Karlsruhe Hbf. Information desks are available at Karlsruhe Hbf.
Luggage storage is available at Karlsruhe Hbf. Lost and found is available at the station.
Available at Karlsruhe Hbf: Parking, Taxis, WC.
Available at Karlsruhe Hbf: Bike Parking, Bike Rental, Car Rental.
Accessibility facilities are available at Karlsruhe Hbf.
Nearby hotels include Hotel Barbarossa, Hotel Avisa, Am Tiergarten, Aparthotel Aijana.
Here are some other resources that might have the information you need