The cheapest and fastest trains from Karlsruhe to Prague
Cheapest price
$37
Average price
$145
Fastest journey
8 h 16 m
Average duration
8 h 27 m
Trains per day
18
Distance
452 km
The best way to find a cheap train ticket from Karlsruhe to Prague is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Karlsruhe to Prague will cost around $145 if you buy it on the day, but the cheapest tickets can be found for only $37.
It's difficult to get from Karlsruhe to Prague without transferring at least 3 times.
FlixTrain+
FlixBus
FlixTrain+
FlixBus
IC 2067 · 3569+
359
ICE 202 · ICE 692 · IC 2443 · rj 383
ICE 376 · ICE 1557 · RJ 383
ICE 267 · 89685 · 3565+
357
ICE 267 · R 89685 · R 3565 · EC 357
ICE 202 · ICE 692 · IC 2443 · rj 383
ICE 202 · ICE 692 · IC 2443 · RJ 383
19009 · 88617 · 3569+
359Travel Information
Compare bus and train for Karlsruhe to Prague
Omio recommends booking the train as it is the most popular option from Karlsruhe to Prague among Omio's users. If you are prioritising price take the bus with prices starting from €26. For those with little time consider booking a bus which can get you there in 7h 19m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.1 - 0.4kg. The ticket price range depends on the travel mode: a bus costs an average of €26, and a train costs an average of €28.
Distance: 280 miles (452 km)
Compare train with
Most popular Train | Bus |
|---|---|
€79 Average price | €43 Average price Cheapest |
9h 25m Average total duration 8h 55m Onboard + 30m Additional time* | 7h 49m Average total duration Fastest 7h 19m Onboard + 30m Additional time* |
0.1 - 0.4kg CO2 emissions Lowest | 0.5 - 1.1kg CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company |
Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Live departures
Karlsruhe to Prague train times
The table below shows live departures for Karlsruhe to Prague trains for today, Sunday, January 18. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 6:51 AM Karlsruhe | 8h31 | 3:22 PM Prague | 0 transfersDirect | |
![]() | 7:06 AM Karlsruhe | 9h16 | 4:22 PM Prague | 0 transfersDirect | |
![]() | 7:28 AM Karlsruhe | 8h54 | 4:22 PM Prague | 0 transfersDirect | |
![]() | 9:05 AM Karlsruhe | 8h17 | 5:22 PM Prague | 0 transfersDirect | |
![]() | 9:32 AM Karlsruhe | 8h50 | 6:22 PM Prague | 0 transfersDirect |
Find all the dates and times for this journey
Compare prices and tickets Karlsruhe to Prague by bus or train
Compare bus and train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Jan 19
Jan 20
Jan 21
Jan 22
Jan 23
Jan 24
Jan 25
Why should you book Karlsruhe to Prague trains with Omio?
Deutsche Bahn (RE,IC,EC,ICE) as well as Alex offer trains services from Karlsruhe to Prague. Omio is an official ticket reseller for all your travel options from Karlsruhe to Prague.
Why book with Omio vs Deutsche Bahn (RE,IC,EC,ICE)?
- Compare with other providers: On Omio, you can not only buy tickets for Deutsche Bahn (RE,IC,EC,ICE), but also compare tickets for the likes of Alex to find the best option for your trip from Karlsruhe to Prague.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Deutsche Bahn (RE,IC,EC,ICE) with all available travel options, which are bus and train to ensure you get the best deal for traveling from Karlsruhe to Prague.
Why book with Omio over Trainline and Rail Europe?
- Multiple travel company options: While Deutsche Bahn (RE,IC,EC,ICE) tickets can be bought on Deutsche Bahn (RE,IC,EC,ICE)'s website or third party sellers, Omio allows you to compare with the likes of Alex to help you choose the right option for your journey from Karlsruhe to Prague.
- Multiple modes of transport: Omio allows you to compare travel options including bus and train to find the ideal travel option from Karlsruhe to Prague.
How far in advance should I book train tickets from Karlsruhe to Prague?
Journey information
Overview: Train from Karlsruhe to Prague
Train Ticket Prices
- Budget Options: Train tickets from Karlsruhe to Prague start from as low as $35 (€28) if booked well in advance.
- Standard Fares: Typically, trains cost $97 (€79) depending on the train type and class.
Journey Duration & Frequency
- On average there are 8 daily trains from Karlsruhe to Prague with 0 direct service.
- The fastest trains can take as little as 8h 16m but the average duration is 8h 55m
Train Operators
- Travel from Karlsruhe to Prague with Deutsche Bahn and Alex
- The most booked train company for this route on Omio is Deutsche Bahn.
Stations & Schedule
- Most trains depart from Karlsruhe Hbf and arrive in Prague hlavní nádraží
- First train typically departs at 12:19 AM and the last at 11:50 PM
Distance 280 miles (452 km) |
Average train duration 8h 55m |
Cheapest ticket price $35 (€28) |
Trains per day 8 |
Fastest train 8h 16m |
First train 00:19 |
Last train 23:50 |
Train companies: Deutsche Bahn, Alex from Karlsruhe to Prague trainsDeutsche Bahn, Alex trains will get you between Karlsruhe and Prague from $32 (€26). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Deutsche Bahn
A Bordrestaurant (restaurant car) where you can sit and eat.
A Bordbistro (bistro bar) with snacks, hot meals, and drinks to-go.
At-seat service in 1st class: staff will take your order and serve food/drinks directly to your seat.
Regional trains (RE / RB / S-Bahn):
No onboard catering.
You’re welcome to bring your own food and drinks.
Not included by default.
You can add a seat reservation when booking (recommended for busy routes).
Costs around €4.90 per seat (or €5.90 if booked separately later).
First Class:
Yes, always included in the ticket price.
Allowed for free if they can fit in a transport box (max. size: hand luggage).
Must stay in the box for the entire journey.
Large dogs:
Require a separate (paid) ticket — typically half the price of a regular second-class ticket.
Must be leashed and wear a muzzle while on the train.
Cannot sit on seats.
Assistance dogs:
Travel free of charge.
Do not need a muzzle or leash if medically not required.
Allowed to accompany the passenger at all times.
Alex
FAQs: Trains from Karlsruhe to Prague
Find answers to the most common questions about traveling from Karlsruhe to Prague by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Prague, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Karlsruhe to Prague
- Monday: 06:30 - 21:00
- Tuesday: 06:30 - 21:00
- Wednesday: 06:30 - 21:00
- Thursday: 06:30 - 21:00
- Friday: 06:30 - 21:00
- Saturday: 08:00 - 19:00
- Sunday: 09:00 - 20:00
- Vinarte
- Am Tiergarten
- Panorama
- Alter Brauhof
- Hotel Barbarossa
- Hotel Avisa
- Am Tiergarten
- Aparthotel Aijana
- Monday: 08:00 13:30 - 12:30 18:00
- Tuesday: 08:00 13:30 - 12:30 18:00
- Wednesday: 08:00 13:30 - 12:30 18:00
- Thursday: 08:00 13:30 - 12:30 18:00
- Friday: 08:00 13:30 - 12:30 18:00
- Saturday: 09:00 - 13:00
- Hubraum
- Vogel Hausbräu Durlach
- Asia Gourmet
- Borsalino
- Hotel Große Linde
- Zum Erwin
- Der Blaue Reiter
- Beim Schupi
- Rosenstüble 2.0
- Saloniki
- Rote Taube
- Beim Schupi
- 6:00 AM - 10:00 PM Monday - Sunday
- Free
- The car park is open 7 days a week, 24 hours a day. Access via Wilsonova Street.
- Restaurant Fantova Kavárna
- Sushi Time
- Outside the main entrance.
- Elevators, ramps.
- CZK 10
- Hotel Esplanade Prague
- Falkensteiner Hotel Maria Prag
- Hotel City Central
- Cost CZK 100
- Located in the main hall
- Located in the main hall
- Avis
- Europcar
- Hertz
- Located in the main hall
- Free
- Hall 1: main entrance, platform 1-7 for trains to Germany, Austria, Slovakia, and regional destinations
- Hall 2: Metro connections
- Metro: Line C
- Tram: Lines 5, 9, 26
- Bus: Several lines available
- 6:00 AM - 10:00 PM Monday - Sunday
- Free
- Parking is available nearby with several public parking options.
- Restaurant Kotleta
- Café Imperial
- Outside the main entrance.
- Ramps.
- CZK 10
- Hotel Kings Court
- Grand Hotel Bohemia
- Hotel Paris Prague
- Located in the main hall
- Avis
- Europcar
- Located in the main hall
- Free
- Hall 1: main entrance, platform 1-5 for regional and suburban trains
- Metro: Line B
- Tram: Lines 3, 5, 14, 24
- Bus: Several lines available
Most popular train connections from Karlsruhe
More options for your journey from Karlsruhe to Prague
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