- Must visit
Florida Museum of Natural History
The state’s official natural history museum, known for Florida fossils, biodiversity exhibits, and family-friendly displays. A top cultural stop in Gainesville.
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The cheapest and fastest buses from St. Louis, MO to Gainesville, FL
Showing times and prices for Jun 16
Cheapest price
$168
Average price
$168
Fastest journey
18 h 30 m
Average duration
18 h 30 m
Buses per day
1
Distance
1232 km
Cheap tickets
The best way to find a cheap bus ticket from St. Louis, MO to Gainesville, FL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from St. Louis, MO to Gainesville, FL will cost around $168 if you buy it on the day, but the cheapest tickets can be found for only $168.
Fast buses
It's difficult to get from St. Louis, MO to Gainesville, FL without transferring at least once.
11:30 PM18h30St. Louis, MO6:00 PMGainesville, FL$1681One-way1 transfer
- 11:30 PM18h30St. Louis, MO6:00 PMGainesville, FL$1681One-way1 transfer
Travel Information
Compare bus, train, and flight for St. Louis, MO to Gainesville, FL
Omio recommends booking the bus as it is the most popular option from St. Louis, MO to Gainesville, FL among Omio's users. If you are prioritising price take the bus with prices starting from $107. For those with little time consider booking a flight which can get you there in 7h 7m. The ticket price range depends on the travel mode: a bus costs an average of $107, and a flight costs an average of $340.
Distance: 765 miles (1232 km)
Compare bus with
Most popular Bus | Train | Flight | Driving |
|---|---|---|---|
$107 Average price Cheapest | $196 Average price | $340 Average price | $181 Average price (fuel + tolls) |
16h 45m Average total duration 16h 15m Onboard + 30m Additional time* | 48h 10m Average total duration 47h 40m Onboard + 30m Additional time* | 10h 7m Average total duration Fastest 7h 7m Onboard + 3h 0m Additional time* | 13h 4m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from St. Louis, MO to Gainesville, FL is a bus with an average price of $107 (€86).
This is compared to other travel options from St. Louis, MO to Gainesville, FL:
A bus is $89 (€72) less than a train for this route with tickets for a train from St. Louis, MO to Gainesville, FL costing on average $196 (€158).
A bus is $233 (€188) less than a flight for this route with tickets for a flight from St. Louis, MO to Gainesville, FL costing on average $340 (€275).
The fastest way to travel from St. Louis, MO to Gainesville, FL is by flight with an average journey time of 7h 7m.
Other travel options to Gainesville, FL take longer:
Bus takes on average 16h 15m.
Train takes on average 47h 40m.
It's helpful to compare your options as there are 3 ways to travel between St. Louis, MO and Gainesville, FL including taking a bus, train, and flight.
We recommend using the bus as it is the most popular way to get from St. Louis, MO to Gainesville, FL among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
St. Louis, MO to Gainesville, FL Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 10:00PM | Arrival Time 07:55PM | Duration 21h55 | Departure days Sun | Cheapest price $107 |
Operator Flixbus USA | Departure Time 11:30PM | Arrival Time 06:00PM | Duration 18h30 | Departure days Mon, Tue, Wed, Thu, Fri | Cheapest price $168 |
Live departures
St. Louis, MO to Gainesville, FL bus times
The table below shows live departures for St. Louis, MO to Gainesville, FL buses for today, Monday, June 15. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 11:30 PM St. Louis, MO | 18h30 | 6:00 PM Gainesville, FL | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets St. Louis, MO to Gainesville, FL by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book St. Louis, MO to Gainesville, FL buses with Omio?
Greyhound as well as FlixBus offer buses services from St. Louis, MO to Gainesville, FL.
Omio is an official ticket reseller for all your travel options from St. Louis, MO to Gainesville, FL.
Why book with Omio vs Greyhound?
- Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of FlixBus to find the best option for your trip from St. Louis, MO to Gainesville, FL.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from St. Louis, MO to Gainesville, FL.
Why book with Omio over Wanderu or Trainline?
- Compare with other providers: On Omio, you can also compare tickets for the likes of FlixBus to find the best option for your trip from St. Louis, MO to Gainesville, FL.
- Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from St. Louis, MO to Gainesville, FL.
Journey information
Overview: Bus from St. Louis, MO to Gainesville, FL
USAUSA
Buses from St. Louis, MO to Gainesville, FL run on average 7 times per day, taking around 16h 15m. Cheap bus tickets for this journey start at $107 (€86) if you book in advance.
The earliest bus runs at 01:10, the last at 22:40. The fastest bus covers the 765 miles (1232 km) distance in 21h 55m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 765 miles (1232 km) |
Average bus duration 16h 15m |
Cheapest ticket price $107 (€86) |
Buses per day 7 |
Fastest bus 21h 55m |
First bus 1:10 AM |
Last bus 10:40 PM |
Cheapest Month May |
Cheapest Day Sun |
High Season Apr - Jun |
Low Season Jan - Mar |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound, FlixBus from St. Louis, MO to Gainesville, FLYou can travel by bus between St. Louis, MO to Gainesville, FL with Greyhound, FlixBus for as low as $107 (€86). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average Duration
18h 30m
Cheapest Price
$168 (€136)
FlixBus frequency
1 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
21h 55m
Cheapest Price
$107 (€86)
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Gainesville
Things to do in Gainesville
Discover the best of Gainesville — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Gainesville trip today.
- Must visit
Harn Museum of Art
A major university art museum with strong Asian, African, modern, and contemporary collections. Highly regarded for its quality exhibitions and free admission.
- Recommended
Cade Museum for Creativity and Invention
Interactive science and invention museum inspired by innovation, featuring hands-on exhibits for adults and children. Popular with families and curious visitors.
- Must visit
Depot Park
One of Gainesville’s most popular public spaces, with walking paths, lawns, water features, and frequent community activity. Great for relaxing and photos.
- Must visit
University of Florida Historic Campus
A walkable area with red-brick buildings, mature trees, Century Tower, and classic collegiate atmosphere. Ideal for a first visit to Gainesville.
- Must visit
Paynes Prairie Preserve State Park
A major natural area near Gainesville known for sweeping views, wildlife, trails, and observation opportunities. One of the region’s signature outdoor experiences.
Florida Gator Tail
A North Florida specialty made from alligator tail meat, usually fried or grilled. It is a regional novelty tied to Florida’s wetlands and game cuisine.
Southern Barbecue
Slow-smoked pork or beef served with classic sides such as beans, slaw, and cornbread. It is a staple comfort food across North Florida.
- Vegetarian
Fried Green Tomatoes
Slices of unripe tomato coated and fried until crisp. This Southern favorite is common in North Florida restaurants and farm-style cooking.
Embers Wood Grill
A well-known upscale steakhouse specializing in wood-grilled meats, seafood, and polished service in an elegant setting.
Satchel's Pizza
A beloved Gainesville institution serving pizza, salads, and beer in a quirky, family-friendly space filled with local character.
Dragonfly Sushi & Sake Company
An established Japanese restaurant in downtown Gainesville known for sushi, robata dishes, and a stylish upscale setting.
United States Dollar
Moderate by U.S. standards. Student demand keeps basics reasonable, while hotels and downtown dining can cost more on busy weekends.
Average meal costs
- Budget
- USD 10-15 for fast food or a casual lunch.
- Mid-range
- USD 18-35 per person at a mid-range restaurant.
- Fine dining
- USD 50-90+ per person at upscale spots.
- Coffee
- USD 3-6 for drip coffee or a latte.
Tipping culture
Tip 18-20% at sit-down restaurants; 20%+ for great service. USD 1-2 per drink at bars, round up taxis, and tip delivery USD 3-5 or 15-20%.
FAQs: Bus from St. Louis, MO to Gainesville, FL
Find answers to the most common questions about traveling from St. Louis, MO to Gainesville, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Gainesville, FL, this guide helps you travel smarter and with confidence.
Cheap bus tickets from St. Louis, MO to Gainesville, FL can start from as little as $107 (€86) when you book in advance. The average bus ticket price for St. Louis, MO to Gainesville, FL is $107 (€86) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from St. Louis, MO to Gainesville, FL is 21h 55m to travel the 765 miles (1232 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from St. Louis, MO to Gainesville, FL leaves at 1:10 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from St. Louis, MO to Gainesville, FL leaves at 10:40 PM.
There are 7 buses a day from St. Louis, MO to Gainesville, FL which require at least one change with Greyhound, FlixBus. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from St. Louis, MO to Gainesville, FL, you can count on Greyhound, FlixBus for the best way to get you to Gainesville, FL. You can also check all possible bus companies who offer a service between St. Louis, MO and Gainesville, FL and compare the amenities they offer before buying a bus ticket.
A trip to Gainesville, FL from St. Louis, MO is worth doing but not as a day trip with a journey time of 21h 55m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from St. Louis, MO to Gainesville, FL is May.
It's helpful to compare your options as there are 3 ways to travel between St. Louis, MO and Gainesville, FL including taking a bus, train, and flight.
Yes, the following accessibility options are available when taking the bus from St. Louis, MO to Gainesville, FL:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from St. Louis, MO to Gainesville, FL for bus company Greyhound, FlixBus.
Some of the most interesting sights to explore in Gainesville, FL are:
- Florida Museum of Natural History, featuring extensive exhibits on Florida's flora, fauna, and cultural heritage
- Kanapaha Botanical Gardens, a 62-acre garden showcasing diverse plant collections and scenic landscapes
- Devil's Millhopper Geological State Park, a unique geological formation with a large sinkhole and nature trails
- Paynes Prairie Preserve State Park, offering wildlife viewing, hiking, and panoramic views of the prairie ecosystem
- Samuel P. Harn Museum of Art, housing a diverse collection of artworks from around the world.
The best things to do in Gainesville, FL include:
- Explore the vibrant local art scene at the Gainesville Artwalk, featuring galleries and live performances
- Visit the Santa Fe College Teaching Zoo, home to a variety of animal species and educational programs
- Enjoy a day of outdoor activities at Lake Wauburg, offering boating, picnicking, and climbing walls
- Discover the historic Haile Homestead, known for its "Talking Walls" filled with writings from the 19th century
- Attend a performance at the Hippodrome Theatre, showcasing plays, films, and special events.
Whether you can cancel your bus ticket from St. Louis, MO to Gainesville, FL depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company Greyhound, FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from St. Louis, MO to Gainesville, FL.
Yes, the following luggage options are included when booking a bus ticket from St. Louis, MO to Gainesville, FL:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from St. Louis, MO to Gainesville, FL:
- Greyhound
- $15 per additional bag.
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from St. Louis, MO to Gainesville, FL. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from St. Louis, MO to Gainesville, FL with the following bus company: Greyhound, FlixBus
Yes, there are USB plugs on board the bus from St. Louis, MO to Gainesville, FL with the following bus company: Greyhound, FlixBus.
Yes, there is Wifi on board the bus from St. Louis, MO to Gainesville, FL with the following bus company: Greyhound, FlixBus.
Since neither St. Louis, MO nor Gainesville, FL are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the bus as it is the most popular way to get from St. Louis, MO to Gainesville, FL among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Gainesville, FL, travelers should be cautious of petty theft, especially in crowded areas like downtown and near the University of Florida campus. Common scams include overcharging by unofficial taxi or ride-share drivers and ticket scams for local events. It's important to use authorized transportation services and stay in well-lit, populated areas at night to enhance personal safety.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from St. Louis, MO to Gainesville, FL
St. Louis
Gainesville
The major bus station for departures in St. Louis is St. Louis, S 15th St (Civic center). Find all the information you need to know about services, amenities and connections at St. Louis, S 15th St (Civic center) for your trip from St. Louis to Gainesville.
St. Louis, S 15th St (Civic center)
information
St. Louis, Lambert International Airport
information
The major bus station for arrivals in Gainesville is Gainesville, Rosa Parks Transfer station. Find all the information you need to know about services, amenities and connections at Gainesville, Rosa Parks Transfer station for your trip to Gainesville from St. Louis.
Gainesville, Rosa Parks Transfer station
information
Gainesville, NW 23rd St (North Walmart Supercenter)
information
Most popular bus connections from St. Louis, MO
More options for your journey from St. Louis, MO to Gainesville, FL
Here are some other resources that might have the information you need
Most popular buses to and from Gainesville, FL and St. Louis, MO
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