- Must visit
The Charleston Museum
Often called America's first museum, it covers Charleston and Lowcountry history, decorative arts, natural history, and regional culture.
Cheapest price
$0.00
Average price
$-0.01
Fastest journey
1 d 39 m
Average duration
1 d 39 m
Buses per day
1
Distance
370 km
The best way to find a cheap bus ticket from Durham, NC to Charleston, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
It's difficult to get from Durham, NC to Charleston, SC without transferring at least 3 times.


Omio recommends booking the train as it is the most popular option from Durham, NC to Charleston, SC among Omio's users. If you are prioritising price take the train with prices starting from $59. For those with little time consider booking a flight which can get you there in 3h 46m. The ticket price range depends on the travel mode: a train costs an average of $59, and a flight costs an average of $114.
Distance: 229 miles (370 km)
Most popular Train | Flight | Driving |
|---|---|---|
$86 Average price Cheapest | $323 Average price | $53 Average price (fuel + tolls) |
7h 9m Average total duration 6h 39m Onboard + 30m Additional time* | 6h 46m Average total duration Fastest 3h 46m Onboard + 3h 0m Additional time* | 4h 31m Average total duration (door-to-door) |
![]() Most popular train company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Durham, NC to Charleston, SC:
A train is $236 (€193) less than a flight for this route with tickets for a flight from Durham, NC to Charleston, SC costing on average $323 (€264).
Other travel options to Charleston, SC take longer:
Train takes on average 6h 39m.
Bus takes on average 14h 53m.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Wanda Coach | Departure Time 06:30AM | Arrival Time 07:43PM | Duration 13h13 | Departure days Everyday | Cheapest price $0.00 |
The table below shows live departures for Durham, NC to Charleston, SC buses for today, Saturday, June 20. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 6:30 AM Durham, NC | 13h24 | 7:54 PM Charleston, SC | 3 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Take a bus from Durham, NC to Charleston, SC and enjoy the approximately 229 miles (370 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
The earliest bus runs at 11:15, the last at 22:10. The fastest bus covers the 229 miles (370 km) distance in 13h 13m.
Distance 229 miles (370 km) |
Average bus duration 14h 53m |
Buses per day 2 |
Fastest bus 13h 13m |
First bus 11:15 AM |
Last bus 10:10 PM |
Cheapest Month Jul |
Cheapest Day Sun |
High Season Apr - Jun |
Low Season Jul - Sep |
Discover the best of Charleston — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Charleston trip today.
Often called America's first museum, it covers Charleston and Lowcountry history, decorative arts, natural history, and regional culture.
A small but important museum interpreting the domestic slave trade in Charleston through exhibits in a historic market building.
Charleston's leading art museum, known for American art with strong ties to the South, rotating exhibitions, and a distinguished permanent collection.
Charleston's famous waterfront promenade is lined with grand historic homes, harbor views, and classic postcard scenery.
A popular riverfront park known for its pier, lawns, and the photogenic Pineapple Fountain.
Charleston's best-known commercial corridor, mixing historic architecture, shopping, nightlife, and frequent social media visibility.
A Lowcountry classic of sautéed shrimp served over creamy grits, often with bacon or gravy. It is one of Charleston’s signature dishes.
A rich Charleston soup made with crab meat, crab roe, cream, and sherry. It is a historic local specialty associated with the city’s coastal cuisine.
A traditional rice and field pea dish, usually cooked with pork for flavor. It is an iconic Southern and Lowcountry comfort food.
One of Charleston’s most acclaimed restaurants, serving ingredient-driven Southern cuisine with a polished but approachable feel. Reservations are highly sought after.
A popular waterfront restaurant known for Lowcountry seafood, shrimp and grits, and relaxed harbor views. It is a dependable choice for classic Charleston flavors.
A celebrated restaurant focused on refined Southern cooking using seasonal local ingredients. Stylish and upscale, it is one of Charleston’s best-known dining rooms.
Prices are moderate by U.S. standards. Historic district dining and hotels cost more, while casual food and transport stay manageable.
Tip 18-20% in restaurants. Tip USD 1-2 per drink at bars, round up taxis, and tip hotel staff and valet. Tipping is expected for most service roles.
Find answers to the most common questions about traveling from Durham, NC to Charleston, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Charleston, SC, this guide helps you travel smarter and with confidence.

Most Durham, NC to Charleston, SC buses use the Durham, W Pettigrew St (Greyhound Bus Station) to Charleston, Gaynor Avenue (Greyhound Bus Station) station pair. Use this guide to compare Durham, NC and Charleston, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Here are some other resources that might have the information you need